CN116889575A - Selenium disulfide lotion composition and preparation method thereof - Google Patents
Selenium disulfide lotion composition and preparation method thereof Download PDFInfo
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- 229960005265 selenium sulfide Drugs 0.000 title claims abstract description 51
- 239000006210 lotion Substances 0.000 title claims abstract description 30
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- JNMWHTHYDQTDQZ-UHFFFAOYSA-N selenium sulfide Chemical compound S=[Se]=S JNMWHTHYDQTDQZ-UHFFFAOYSA-N 0.000 title abstract description 43
- 229910000338 selenium disulfide Inorganic materials 0.000 title abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 21
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 claims description 17
- -1 alkyl ether sulfate Chemical class 0.000 claims description 16
- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims description 15
- 239000000440 bentonite Substances 0.000 claims description 13
- 229910000278 bentonite Inorganic materials 0.000 claims description 13
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 13
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 239000008213 purified water Substances 0.000 claims description 11
- 150000004676 glycans Chemical class 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 229920001282 polysaccharide Polymers 0.000 claims description 10
- 239000005017 polysaccharide Substances 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 229940071089 sarcosinate Drugs 0.000 claims description 9
- WECGLUPZRHILCT-GSNKCQISSA-N 1-linoleoyl-sn-glycerol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](O)CO WECGLUPZRHILCT-GSNKCQISSA-N 0.000 claims description 7
- QVBODZPPYSSMEL-UHFFFAOYSA-N dodecyl sulfate;2-hydroxyethylazanium Chemical compound NCCO.CCCCCCCCCCCCOS(O)(=O)=O QVBODZPPYSSMEL-UHFFFAOYSA-N 0.000 claims description 7
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000004408 titanium dioxide Substances 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
- 125000002091 cationic group Chemical group 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229940070782 myristoyl sarcosinate Drugs 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- LIFHMKCDDVTICL-UHFFFAOYSA-N 6-(chloromethyl)phenanthridine Chemical compound C1=CC=C2C(CCl)=NC3=CC=CC=C3C2=C1 LIFHMKCDDVTICL-UHFFFAOYSA-N 0.000 claims description 2
- 229940071145 lauroyl sarcosinate Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940069822 monoethanolamine lauryl sulfate Drugs 0.000 claims 1
- 229940083575 sodium dodecyl sulfate Drugs 0.000 claims 1
- 208000001840 Dandruff Diseases 0.000 abstract description 13
- 239000003814 drug Substances 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 12
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract description 9
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 abstract description 6
- 230000006870 function Effects 0.000 abstract description 6
- 230000007547 defect Effects 0.000 abstract description 5
- 210000004761 scalp Anatomy 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- 201000004624 Dermatitis Diseases 0.000 abstract description 3
- 206010039792 Seborrhoea Diseases 0.000 abstract description 3
- 238000009960 carding Methods 0.000 abstract description 3
- 230000006378 damage Effects 0.000 abstract description 3
- 230000003670 easy-to-clean Effects 0.000 abstract description 3
- 241000233866 Fungi Species 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 229920002907 Guar gum Polymers 0.000 description 9
- 239000000665 guar gum Substances 0.000 description 9
- 229960002154 guar gum Drugs 0.000 description 9
- 235000010417 guar gum Nutrition 0.000 description 9
- 210000003491 skin Anatomy 0.000 description 9
- 230000007794 irritation Effects 0.000 description 8
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 8
- 235000019799 monosodium phosphate Nutrition 0.000 description 8
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical group [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 206010015150 Erythema Diseases 0.000 description 5
- 231100000321 erythema Toxicity 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 206010033733 Papule Diseases 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000555676 Malassezia Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- JZKFHQMONDVVNF-UHFFFAOYSA-N dodecyl sulfate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCOS(O)(=O)=O JZKFHQMONDVVNF-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000003700 hair damage Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001238 wet grinding Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
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- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention relates to the technical field of medicines for preventing or treating skin seborrheic dermatitis, in particular to a selenium disulfide lotion composition and a preparation method thereof. Compared with the prior art, the selenium sulfide lotion composition prepared by the invention solves the defects that the selenium sulfide lotion is not easy to clean and damage hair after use, and the hair is not easy to comb after use, has fine paste, strong stability and low toxic and side effects, has the functions of hair care, hair nourishing and easy carding, and simultaneously fully plays the treatment roles of the selenium sulfide medicine in removing dandruff, resisting fungi and resisting scalp seborrheic dermatitis.
Description
Technical Field
The invention relates to the technical field of medicines for preventing or treating skin seborrheic dermatitis, in particular to a selenium disulfide lotion composition and a preparation method thereof.
Background
Seborrheic dermatitis is a skin disease which is common in clinic and is easy to repeatedly attack, the incidence rate is about 2% -5%, the abnormal sebum component and excessive sebum secretion are the basis of the incidence, the number of malassezia is increased, local inflammation is promoted, the dermatitis is especially easy to occur on scalp, and the local external medicine is widely applied clinically with safe and convenient use, reliable curative effect and the like.
The selenium disulfide lotion is used as a dermatological medicine, has the function of resisting seborrhea, has a certain antifungal function, is used for removing dandruff and scalp seborrheic dermatitis, is in a suspension state in an external lotion product because the selenium disulfide is almost insoluble in water and organic solvents, and is used for solving the problems that local medicine aggregation, adhesion, difficult cleaning and the like occur in the use process of the product, propylene glycol is basically used as a wetting agent for preparing selenium disulfide superfine powder in the market, and the dosage of the propylene glycol is relatively high in order to achieve the state of finer particle size, and the skin, the mucous membrane and the skin can be red, erythra, itching and roughness are possibly caused due to the fact that the propylene glycol has irritation to the skin and the mucous membrane and the irritation is large when the concentration is large. The long-term use of large amounts of propylene glycol can affect the epidermis and sebum structures of the skin. The product itself can increase the stimulus to the seborrheic dermatitis during the use process of the product, and the treatment effect can not be achieved. Therefore, developing a selenium sulphide lotion which is less irritating, easy to clean and easy to comb is a technical problem which one skilled in the art wants to solve.
Disclosure of Invention
In order to overcome the defects of the technology, the invention provides the selenium sulfide lotion composition and the preparation method thereof, and the composition has the advantages of small irritation, good stability, convenient cleaning, easy carding and the like.
The invention is realized by the following technical scheme:
in one aspect, the invention provides a selenium sulfide lotion composition, which is characterized by comprising the following components in percentage by mass: 5-12% of selenium sulfide superfine powder, 1-5% of bentonite, 8-15% of alkyl ether sulfate, 2-8% of N-acyl amino acid salt, 0.1-1% of phosphonated polysaccharide and the balance of water and pH regulator; according to the scheme, selenium disulfide superfine powder with the particle size of 1-20 mu m is used as a main medicine, the defects of greasiness and large irritation of a surfactant or an additive in the traditional formula lotion are abandoned, the treatment of seborrheic dermatitis accompanied by obvious oily dandruff is improved by adding a mild amino acid surfactant, the use compliance of selenium disulfide is improved, and the wet comb property and dry comb property of hair are improved by adding cationic hydroxyethyl guar gum, so that the dispersion uniformity and suspension stability of main medicine selenium disulfide powder in an auxiliary material matrix are achieved, the drug effect function of a product is improved, and the side effect of hair damage caused by uneven medicine and local aggregation of the medicine is reduced; the anti-dandruff lotion has the advantages of reducing the toxic and side effects of selenium disulfide while playing the anti-dandruff effect, caring hair, and solving the defects of adhesion and difficult combing of the hair of the lotion of the original product.
Further, according to mass percentage, 6-10% of selenium sulfide superfine powder, 2-5% of bentonite, 8-12% of alkyl ether sulfate, 2-5% of N-acyl amino acid salt, 0.1-0.5% of phosphonated polysaccharide, and the balance of water and pH regulator. Wherein the pH regulator can be sodium dihydrogen phosphate, citric acid, or other pH value of the acid-base substance regulating system, and will not be described herein.
Further, the alkyl ether sulfate salt is selected from one of triethanolamine lauryl sulfate, sodium lauryl sulfate, and monoethanolamine lauryl sulfate salt or a combination thereof.
Further, the alkyl ether sulfate salt is selected from lauryl sulfate monoethanolamine salt.
Further, the N-acyl amino acid salt is selected from one of cocoyl sarcosinate, cocoyl sarcosinate TEA salt, lauroyl sarcosinate, myristoyl sarcosinate, palmitoyl sarcosinate or a combination thereof.
Further, the N-acyl amino acid salt is selected from cocoyl sarcosinate. Sodium cocoyl sarcosinate belongs to a mild anionic surfactant, has good foaming and wetting and decontamination performances, can reduce the irritation of other surfactants, can effectively prevent desquamation, and helps skin maintain moisture.
Further, the phosphonated polysaccharide is selected from one of cationic carboxymethyl guar, cationic hydroxyethyl guar, cationic hydroxypropyl guar, cationic carboxymethyl hydroxypropyl guar, cationic hydrophobically modified hydroxypropyl guar, hydrophobically modified cationic guar, or a combination thereof.
Further, the phosphonated polysaccharide is selected from cationic hydroxyethyl guar. The cationic hydroxyethyl guar gum has satisfactory foaming and stabilizing effects in the hair products, antistatic effects, and has the advantages of improving the wet comb property and the dry comb property of hair, and enabling the hair to maintain luster, softness and elasticity for a long time.
In another aspect, the invention provides a selenium sulfide lotion composition, which is characterized in that: the method comprises the following steps:
s1, heating a proper amount of purified water to 70-80 ℃, adding alkyl ether sulfate and N-acyl amino acid salt, and stirring until the mixture is completely dissolved;
s2, adding the phosphonated polysaccharide into a proper amount of purified water, stirring and dispersing uniformly to obtain gel, adding the gel into the emulsifier prepared in the S1, mixing, stirring and heating at 70-80 ℃ for 10-15min;
s3, cooling to 50-60 ℃, adding selenium sulfide superfine powder and bentonite, and homogenizing for 10-15min;
s4, cooling to below 40 ℃, adding a pH regulator, stirring uniformly, and regulating the pH to 4.0-5.0 to obtain the selenium sulfide lotion. Essence with mass fraction of 0.5% -1.0% can be added according to special conditions of the product, and fragrance can be customized.
Further, the selenium sulfide superfine powder is prepared by the following method: adding selenium sulfide, titanium dioxide, purified water and glyceryl monolinoleate into an IKA colloid mill, grinding at a rotating speed of 8000-10000rpm for homogenizing and dispersing for 5-10min, wherein the mass ratio of the selenium sulfide, the titanium dioxide, the purified water and the glyceryl monolinoleate is 2.5:3:1:2. the proposal adopts the existing wet grinding method, adopts the glyceryl monolinoleate as an emulsifier, ensures that the selenium disulfide powder is dispersed uniformly and suspended stably in an auxiliary material matrix, improves the drug effect function of the product, reduces the side effect of hair injury caused by uneven medicine and local aggregation of the medicine, adopts soybean oil as a raw material, is prepared by biocatalysis refining, does not contain trans fatty acid, has good compatibility with skin and does not generate irritation and sensitization.
The beneficial effects are that: the selenium sulfide lotion composition prepared by the invention solves the defects that the selenium sulfide lotion is not easy to clean and damage hair after use, and the hair is not easy to comb after use, has fine paste, strong stability and low toxic and side effects of selenium sulfide, has the functions of hair care, hair nourishing and easy carding, and simultaneously fully plays the treatment roles of the selenium sulfide medicine in removing dandruff, resisting fungi and resisting scalp seborrheic dermatitis.
Detailed Description
The present invention will be described in detail with reference to specific embodiments thereof, so that those skilled in the art can better understand the technical solutions of the present invention. The experimental procedures, which do not address the specific conditions in the examples below, are generally carried out under conventional conditions or under conditions recommended by the manufacturer. The test materials used in the examples described below, unless otherwise specified, were purchased from conventional biochemical reagent stores. Percentages and parts are by weight unless otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any methods and materials similar or equivalent to those described herein can be used in the present invention. The preferred methods and materials described herein are presented for illustrative purposes only.
Example 1
Adding selenium sulfide, titanium dioxide, glyceryl monolinoleate and purified water into an IKA colloid mill, grinding at a rotating speed of 8000-10000rpm for homogenizing and dispersing for 5-10min to obtain selenium sulfide superfine powder with a particle size of 5-10 mu m, wherein the mass ratio of the selenium sulfide to the titanium dioxide to the glyceryl monolinoleate is 2.5:3:1:2; heating purified water to 70-80deg.C, adding sodium dodecyl sulfate and sodium cocoyl sarcosinate, and stirring to dissolve completely to obtain emulsifier; adding cationic carboxymethyl guar gum into a proper amount of purified water, stirring and dispersing uniformly to obtain gel, adding the gel into an emulsifier, mixing, stirring and heating at 70-80 ℃ for 10-15min; cooling to 50-60deg.C, adding selenium sulfide superfine powder and bentonite, and homogenizing for 10-15min; cooling to below 40deg.C, adding sodium dihydrogen phosphate, citric acid and essence, stirring to uniformity, and adjusting pH to 4.0-5.0 to obtain selenium sulfide lotion; according to the mass percentage, 5% of selenium sulfide superfine powder, 3% of bentonite, 8% of sodium dodecyl sulfate, 5% of cocoyl sarcosine sodium, 0.3% of cationic carboxymethyl guar gum, 0.05% of sodium dihydrogen phosphate, 0.06% of citric acid and 78.59% of water.
Example 2
The preparation method is the same as in example 1, except that the mass percentage of selenium disulfide superfine powder is 5%, bentonite is 3%, lauryl sulfate triethanolamine is 5%, cocoyl sarcosine TEA salt is 6%, cationic carboxymethyl guar gum is 0.1%, sodium dihydrogen phosphate is 0.04%, citric acid is 0.05%, and water is 80.81%.
Example 3
The preparation method is the same as in example 1, except that the mass percentage of selenium disulfide superfine powder is 10%, bentonite is 5%, lauryl sulfate monoethanolamine salt is 12%, palmitoyl sarcosinate is 8%, cationic hydrophobically modified hydroxypropyl guar is 0.7%, sodium dihydrogen phosphate is 0.05%, citric acid is 0.06%, and water is 64.19%.
Example 4
The preparation method is the same as in example 1, except that the mass percentage of selenium disulfide superfine powder is 12%, bentonite is 5%, sodium dodecyl sulfate is 15%, cocoyl sarcosine sodium is 5%, cationic hydroxyethyl guar gum is 1%, sodium dihydrogen phosphate is 0.05%, citric acid is 0.07%, and water is 61.88%.
Example 5
The preparation method is the same as in example 1, except that the mass percentage of selenium disulfide superfine powder is 7.5%, bentonite is 2%, lauryl sulfate monoethanolamine salt is 10%, cocoyl sarcosine sodium is 5%, cationic hydroxyethyl guar gum is 0.5%, sodium dihydrogen phosphate is 0.04%, citric acid is 0.06%, and water is 74.9%.
Example 6
The preparation method is the same as in example 1, except that the mass percentage of selenium disulfide superfine powder is 3%, bentonite is 1%, lauryl sulfate monoethanolamine salt is 8%, myristoyl sarcosinate is 2%, cationic hydroxyethyl guar gum is 0.3%, sodium dihydrogen phosphate is 0.03%, citric acid is 0.03%, and water is 85.64%.
Performance test of inventive examples and comparative examples
(1) Stability test: placing the sample at 40 ℃ for 48 hours, and observing whether layering occurs in the product after recovering the sample at 25 ℃; the test pieces were left at-8℃for 48h, and after recovery at 25℃the products were observed for delamination and the results are shown in Table 1.
TABLE 1
| Group of | High temperature stability | Low temperature stability |
| Example 1 | Qualified product | Qualified product |
| Example 2 | Qualified product | Qualified product |
| Example 3 | Qualified product | Qualified product |
| Example 4 | Qualified product | Qualified product |
| Example 5 | Qualified product | Qualified product |
| Example 6 | Qualified product | Qualified product |
(2) Antibacterial and anti-dandruff test: 300 volunteers with dandruff were divided into 6 groups of 50 persons each, shampoo of test sample was used 2 times per week, safety and anti-dandruff efficacy were evaluated by the use feeling of volunteers, and the results are shown in table 2.
Criteria for anti-dandruff efficacy: is very effective: the anti-dandruff effect is very good, the foam is fine and smooth and full, and the hair is fresh and not tight after washing; the method is effective: the hair conditioner has a certain anti-dandruff effect, foam is easy to rinse, and hair is not dried after washing; invalidation: no change is caused before and after the use.
TABLE 2
(3) Skin irritation test: taking forearm of the subject as the tested part, taking 2mL of sample, and applying the sample to the tested part. After 24 hours of observation, the skin reaction was changed. The results of 30 human volunteers in each group were evaluated by the degree of erythema and edema on the skin, and are shown in Table 3.
The scoring criteria were: negative response (0 score), mild erythema (1 score), moderate erythema/edema/papule (2 score), moderate erythema/edema/papule, and out of the test zone (3 score), severe erythema/edema/papule, and out of the test zone (4 score).
TABLE 3 Table 3
From the above table, the selenium sulfide lotion composition provided by the invention has no irritation to skin basically, and shows that the selenium sulfide superfine powder is adopted as a main body, and mild amino acid surfactant and cationic hydroxyethyl guar gum are matched, so that the anti-dandruff efficacy is exerted, the toxic and side effects of selenium sulfide are reduced, and the irritation caused by direct contact with skin is reduced.
Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and that many similar changes can be made by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. A selenium sulphide lotion composition, characterized by comprising the following components in mass percent: 5-12% of selenium sulfide superfine powder, 1-5% of bentonite, 8-15% of alkyl ether sulfate, 2-8% of N-acyl amino acid salt, 0.1-1% of phosphonated polysaccharide and the balance of water and pH regulator.
2. A selenium sulphide lotion composition according to claim 1, wherein: according to the mass percentage, 5-10% of selenium sulfide superfine powder, 2-5% of bentonite, 8-12% of alkyl ether sulfate, 2-5% of N-acyl amino acid salt, 0.1-0.5% of phosphonated polysaccharide and the balance of water and pH regulator.
3. A selenium sulphide lotion composition according to claim 1, wherein: the alkyl ether sulfate salt is selected from one or a combination of triethanolamine lauryl sulfate, sodium dodecyl sulfate and monoethanolamine lauryl sulfate.
4. A selenium sulphide lotion composition according to claim 2, characterized in that: the alkyl ether sulfate salt is selected from lauryl sulfate monoethanolamine salt.
5. A selenium sulphide lotion composition according to claim 1, wherein: the N-acyl amino acid salt is selected from one or a combination of cocoyl sarcosinate, cocoyl sarcosinate TEA salt, lauroyl sarcosinate, myristoyl sarcosinate and palmitoyl sarcosinate.
6. A selenium sulphide lotion composition according to claim 5, wherein: the N-acyl amino acid salt is selected from cocoyl sarcosinate sodium.
7. A selenium sulphide lotion composition according to claim 1, wherein: the phosphonated polysaccharide is selected from one or a combination of cationic carboxymethyl guar, cationic hydroxyethyl guar, cationic hydroxypropyl guar, cationic carboxymethyl hydroxypropyl guar, cationic hydrophobically modified hydroxypropyl guar, hydrophobically modified cationic guar.
8. A selenium sulphide lotion composition according to claim 7, wherein: the phosphonated polysaccharide is selected from cationic hydroxyethyl guar.
9. A method for preparing a selenium sulfide lotion composition, which is characterized by comprising the following steps:
s1, heating a proper amount of purified water to 70-80 ℃, adding alkyl ether sulfate and N-acyl amino acid salt, and stirring until the mixture is completely dissolved;
s2, adding the phosphonated polysaccharide into a proper amount of purified water, stirring and dispersing uniformly to obtain gel, adding the gel into the emulsifier prepared in the S1, mixing, stirring and heating at 70-80 ℃ for 10-15min;
s3, cooling to 50-60 ℃, adding selenium sulfide superfine powder and bentonite, and homogenizing for 10-15min;
s4, cooling to below 40 ℃, adding a pH regulator and essence, stirring uniformly, and regulating the pH to 4.0-5.0 to obtain the selenium sulfide lotion.
10. The method of manufacturing according to claim 9, wherein: the selenium sulfide superfine powder is prepared by the following method: adding selenium sulfide, titanium dioxide, purified water and glyceryl monolinoleate into an IKA colloid mill, grinding at a rotating speed of 8000-10000rpm, and homogenizing and dispersing for 5-10min, wherein the mass ratio of the selenium sulfide, the titanium dioxide, the purified water and the glyceryl monolinoleate is 2.5:3:1:2.
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