CN105324395A - 治疗急性肾损伤的方法 - Google Patents

治疗急性肾损伤的方法 Download PDF

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Publication number
CN105324395A
CN105324395A CN201480011012.2A CN201480011012A CN105324395A CN 105324395 A CN105324395 A CN 105324395A CN 201480011012 A CN201480011012 A CN 201480011012A CN 105324395 A CN105324395 A CN 105324395A
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CN
China
Prior art keywords
kidney
injury
experimenter
acute
renal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480011012.2A
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English (en)
Chinese (zh)
Inventor
R.A.扎格
D.安德烈斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Fred Hutchinson Cancer Center
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AbbVie Inc
Fred Hutchinson Cancer Center
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Application filed by AbbVie Inc, Fred Hutchinson Cancer Center filed Critical AbbVie Inc
Publication of CN105324395A publication Critical patent/CN105324395A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7019—Ischaemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7038—Hypoxia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480011012.2A 2013-03-08 2014-03-10 治疗急性肾损伤的方法 Pending CN105324395A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361775174P 2013-03-08 2013-03-08
US61/775174 2013-03-08
PCT/US2014/022688 WO2014138738A1 (en) 2013-03-08 2014-03-10 Methods of treating acute kidney injury

Publications (1)

Publication Number Publication Date
CN105324395A true CN105324395A (zh) 2016-02-10

Family

ID=51492045

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480011012.2A Pending CN105324395A (zh) 2013-03-08 2014-03-10 治疗急性肾损伤的方法

Country Status (10)

Country Link
US (1) US20160015701A1 (cg-RX-API-DMAC7.html)
EP (1) EP2964671A4 (cg-RX-API-DMAC7.html)
JP (1) JP2016512201A (cg-RX-API-DMAC7.html)
CN (1) CN105324395A (cg-RX-API-DMAC7.html)
AU (1) AU2014225320A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015020788A2 (cg-RX-API-DMAC7.html)
CA (1) CA2901922A1 (cg-RX-API-DMAC7.html)
HK (1) HK1220209A1 (cg-RX-API-DMAC7.html)
MX (1) MX2015011730A (cg-RX-API-DMAC7.html)
WO (1) WO2014138738A1 (cg-RX-API-DMAC7.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109789117A (zh) * 2016-10-05 2019-05-21 米托布里奇公司 治疗急性肾损伤的方法
CN113272013A (zh) * 2019-12-17 2021-08-17 奇努克医疗公司 用阿曲生坦治疗IgA肾病的方法
CN115005157A (zh) * 2022-06-02 2022-09-06 上海交通大学医学院附属新华医院 一种低氧致急性肾损伤动物模型的构建方法
CN115279402A (zh) * 2019-11-06 2022-11-01 西北大学 对ve-ptp磷酸酶的抑制保护肾免于缺血-再灌注损伤

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Publication number Priority date Publication date Assignee Title
US9855245B2 (en) 2013-04-30 2018-01-02 Abbvie Inc. Methods for improving lipid profiles using atrasentan
WO2016073846A1 (en) * 2014-11-07 2016-05-12 Abbvie Inc. Methods of treating ckd using predictors of fluid retention
EP3235496A1 (en) * 2016-04-19 2017-10-25 Noorik Biopharmaceuticals AG Treatment of acute renal failure
KR102177349B1 (ko) * 2018-02-13 2020-11-12 서울대학교병원 체세포 복제 효율 증진용 조성물
WO2020006571A1 (en) * 2018-06-29 2020-01-02 pulseData Inc. Machine learning systems and methods for predicting risk of renal function decline
US20220304979A1 (en) * 2019-12-17 2022-09-29 Chinook Therapeutics, Inc. Methods of reducing disease flares
US20230270718A1 (en) * 2020-04-10 2023-08-31 Chinook Therapeutics, Inc. Methods of treating diabetic kidney disease
CN113209111A (zh) * 2021-05-14 2021-08-06 上海海糖生物医药科技有限公司 一种褐藻寡糖的应用
CN116731117B (zh) * 2023-06-19 2024-05-10 武汉大学 Kim-1靶向性多肽及其在急性肾损伤中肾靶向性的应用

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US20060100743A1 (en) * 2004-04-23 2006-05-11 Renal Diagnostic Inc. Automated non-invasive real-time acute renal failure detection system
US20060205733A1 (en) * 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
US20110319333A1 (en) * 2010-06-24 2011-12-29 Morehouse School Of Medicine Method and compositions for the treatment and detection of endothelin-1 related kidney diseases

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US5273961A (en) * 1992-09-22 1993-12-28 Genentech, Inc. Method of prophylaxis of acute renal failure

Patent Citations (3)

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US20060100743A1 (en) * 2004-04-23 2006-05-11 Renal Diagnostic Inc. Automated non-invasive real-time acute renal failure detection system
US20060205733A1 (en) * 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
US20110319333A1 (en) * 2010-06-24 2011-12-29 Morehouse School Of Medicine Method and compositions for the treatment and detection of endothelin-1 related kidney diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
S GULMEN等: "Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats", 《JOURNAL OF SUGRICAL RESEARCH》 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109789117A (zh) * 2016-10-05 2019-05-21 米托布里奇公司 治疗急性肾损伤的方法
CN109789117B (zh) * 2016-10-05 2022-08-23 米托布里奇公司 治疗急性肾损伤的方法
CN115279402A (zh) * 2019-11-06 2022-11-01 西北大学 对ve-ptp磷酸酶的抑制保护肾免于缺血-再灌注损伤
US12121509B2 (en) 2019-12-17 2024-10-22 Chinook Therapeutics, Inc. Methods of improving renal function
US11491137B2 (en) 2019-12-17 2022-11-08 Chinook Therapeutics, Inc. Methods of improving renal function
CN116327758A (zh) * 2019-12-17 2023-06-27 奇努克医疗公司 用阿曲生坦治疗IgA肾病的方法
US11998526B2 (en) 2019-12-17 2024-06-04 Chinook Therapeutics, Inc. Methods of improving renal function
CN113272013A (zh) * 2019-12-17 2021-08-17 奇努克医疗公司 用阿曲生坦治疗IgA肾病的方法
US12370174B2 (en) 2019-12-17 2025-07-29 Chinook Therapeutics, Inc. Methods of improving renal function
US12521369B2 (en) 2019-12-17 2026-01-13 Chinook Therapeutics, Inc. Methods of improving renal function
US12582631B2 (en) 2019-12-17 2026-03-24 Chinook Therapeutics, Inc. Methods of improving renal function
CN115005157A (zh) * 2022-06-02 2022-09-06 上海交通大学医学院附属新华医院 一种低氧致急性肾损伤动物模型的构建方法
CN115005157B (zh) * 2022-06-02 2023-12-26 上海交通大学医学院附属新华医院 一种低氧致急性肾损伤动物模型的构建方法

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CA2901922A1 (en) 2014-09-12
EP2964671A1 (en) 2016-01-13
WO2014138738A8 (en) 2015-12-30
AU2014225320A1 (en) 2015-08-06
EP2964671A4 (en) 2016-08-31
HK1220209A1 (zh) 2017-04-28
US20160015701A1 (en) 2016-01-21
JP2016512201A (ja) 2016-04-25
MX2015011730A (es) 2016-04-04
BR112015020788A2 (pt) 2017-10-10
WO2014138738A1 (en) 2014-09-12

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Application publication date: 20160210