CN105315680A - Drug packaging rubber plug prepared from casein-soybean glue - Google Patents
Drug packaging rubber plug prepared from casein-soybean glue Download PDFInfo
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- CN105315680A CN105315680A CN201510694803.6A CN201510694803A CN105315680A CN 105315680 A CN105315680 A CN 105315680A CN 201510694803 A CN201510694803 A CN 201510694803A CN 105315680 A CN105315680 A CN 105315680A
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Abstract
A drug packaging rubber plug prepared from casein-soybean glue is mainly prepared from auxiliary rubber, casein-soybean glue and a mixed solution which are mixed together, wherein the mixed solution is added into the auxiliary rubber and the casein-soybean glue respectively, and the specific weight of the mixed solution added into the auxiliary rubber and the mixed solution added into the casein-soybean glue is 1: 1.36; the mixtures are stirred for 10 min; 20 percent of a casein-soybean glue and mixed solution mixed glue is taken and added into the auxiliary rubber, stirring is performed, after 3 min, the rest 80 percent of the casein-soybean glue and mixed solution mixed glue is added, and stirring is continually performed for 2 min to obtain a colloid; the colloid is cooled for 1 day in air at 15 DEG C, and slicing is performed to obtain the drug packaging rubber plug. The drug packaging rubber plug has the following beneficial effects: the formula is novel in design, the raw materials can be easily obtained, and a rubber product prepared by the formula is relatively high in chemical stability, nonirritant, high in security, heat-proof, anti-aging and favorable in mechanical property and can be made into drug packaging rubber plugs of different specifications.
Description
Technical field:
The present invention relates to medical grade rubber production technical field, be specifically related to the made drug encapsulation plug of a kind of soybean glue.
Background technology:
Along with the development of society, the rubber item kind being applied to medicine and hygiene fields gets more and more, as various flask for medicinal preparations plug, asepsis injector piston, injection sealant sealing, flexible pipe, conduit, medical air cushion, antiseptic rubber medical gloves, baby nipple, tube for blood transfusion,latex etc.Desirable druggist rubber sundries not only needs to have good physicals, also must ensure nontoxic and have unreactiveness, particularly in body rubber item should have not pathogenic, do not damage adjacent tissue, do not cause the features such as allergy, aging resistance are good.
Traditional druggist rubber sundries is under high temperature, condition of high voltage, and its vulcanization system easily produces and pollutes human body, the exudate of medicament, volatile matter, thus is difficult to prepare the druggist rubber sundries meeting medicine extra best best standard.Existing druggist rubber sundries and preparation method thereof, its complex technical process, the product feature of environmental protection is poor, and safety in utilization is not strong, and work-ing life is lower.
Summary of the invention:
Technical problem to be solved by this invention is to provide that a kind of technique is simple, the drug encapsulation plug of safety and environmental protection, long service life.
Technical problem to be solved by this invention adopts following technical scheme to realize:
The made drug encapsulation plug of a kind of soybean glue, is characterized in that:
Mainly comprise auxiliary glue, soybean glue and mixed solution to be mixed,
Wherein auxiliary glue comprises: deionized water 70-90 part, ethylene vinyl acetate 10-15 part, chitosan 8-12 part, Vltra tears 5-8 part, propolis 2-5 part, kaolin 1-5 part, titanium dioxide 0.8-3 part, nano diatomite 2-3 part, white oil 0.5-2 part, Sorbic Acid 0.5-1.5 part;
Soybean glue comprises: E-44 epoxy resin: 20-30 part, E-51 epoxy resin: 10-15 part, modified amine and polymeric amide mixture 10-15 part, talcum powder: 20-25 part, promotor: 1-2 part, coupling agent: 1-2 part; Soybean 150-200 part, water 20-30 part, essence 5-6 part;
Mixed solution comprises: ginseng 5-10 part, bighead atractylodes rhizome 5-10 part, raw rice sprout 5-10 part, water 50-60 part, Fructus Crataegi (parched to brown) 5-10 part, Divine Comedy 5-10 part, radix polygonati officinalis 5-7 part, Rhizoma Arisaematis 9-12 part, calamus 15-18 part, wood chip 15-18 part, bean curd water 100-120 part.
Its preparation process comprises the following steps:
First deionized water and ethylene vinyl acetate are added in flask, stir, and start heating, when being raised to 90 DEG C to temperature, keep 1 hour;
Then be cooled to 50 DEG C, add chitosan, Vltra tears, uniform dissolution, add propolis, kaolin, titanium dioxide, nano diatomite, white oil, Sorbic Acid successively, intensification flask to 80 DEG C, mixes half an hour, is then cooled to 40 DEG C, preserve, obtain auxiliary glue, stand-by;
E-44 epoxy resin, E-51 epoxy resin Homogeneous phase mixing are obtained component A; All the other components are mixed to get B component, choose component A and mix with B component 1:1, obtain C mixture;
Protein isolate 8%-20%, urea 15%-17%, sodium polyphosphate 1%-10% from soybean, urea is dispersed in water, be mixed and made into urea soln, add albumen, stir 1-2 hour at normal temperatures, add sodium polyphosphate again, continue to stir 2-3 hour, finally essence is added, high-temperature stirring 20 minutes, temperature controls at 90-95 DEG C, obtains D mixture;
After having prepared, by C mixture and the mixing of D mixture, proportion is 100:20-50, adds 5-10 part promotor, is warming up to 90 DEG C, and heating duration can obtain soybean glue in 1 hour, stand-by;
Get ginseng, the bighead atractylodes rhizome, raw rice sprout, pulverize, mixing water, is sprayed on Fructus Crataegi (parched to brown), until Fructus Crataegi (parched to brown) moisture content higher than 50% time, take out Fructus Crataegi (parched to brown) and be placed in sealed can 1-2 hour;
To spray remaining liquid again, wood chip, Divine Comedy, radix polygonati officinalis, Rhizoma Arisaematis smash into powder to pieces with calamus, pour in liquid, stir, take out Fructus Crataegi (parched to brown) simultaneously and be placed in liquid, seal 1 hour, then under being placed in the sun, be exposed to the sun to the complete evaporate to dryness of liquid, take out remaining powder agglomates, smash to pieces, sieve, mix with bean curd water, obtain mixed solution;
In auxiliary glue and soybean glue, add mixed solution respectively, the mixed solution proportion added in both is 1:1.36, stirs 10 minutes, in the epoxy glue first getting 20% soybean glue and mixed solution again and auxiliary glue, stir, after 3 minutes, add remaining 80%, continue stirring 2 minutes, obtain colloid;
Colloid is heavily cooled 1 day, stripping and slicing at the air of 15 DEG C, drug encapsulation plug can be obtained.
The invention has the beneficial effects as follows: formulating of recipe of the present invention is novel, raw material is easy to get, obtained rubber item of filling a prescription thus has higher chemical stability, nonirritant, security are high, heat-resisting, anti-aging, and there is excellent mechanical property, the drug encapsulation plug of different size can be made into.
Embodiment:
The technique means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
The made drug encapsulation plug of a kind of soybean glue, mainly comprises auxiliary glue, soybean glue and mixed solution and is mixed,
Wherein auxiliary glue comprises: deionized water 70 parts, ethylene vinyl acetate 10 parts, chitosan 8 parts, Vltra tears 5 parts, propolis 2 parts, kaolin 1 part, titanium dioxide 0.8 part, nano diatomite 2 parts, white oil 0.5 part, Sorbic Acid 0.5 part;
Soybean glue comprises: E-44 epoxy resin: 20 parts, E-51 epoxy resin: 10 parts, modified amine and polymeric amide mixture 10 parts, talcum powder: 20 parts, promotor: 1 part, coupling agent: 1 part; Soybean 150 parts, 20 parts, water, 5 parts, essence;
Mixed solution comprises: ginseng 5 parts, the bighead atractylodes rhizome 5 parts, raw rice sprout 5 parts, 50 parts, water, Fructus Crataegi (parched to brown) 5 parts, Divine Comedy 5 parts, radix polygonati officinalis 5 parts, Rhizoma Arisaematis 9 parts, calamus 15 parts, wood chip 15 parts, 100 parts, bean curd water.
Embodiment 2
The made drug encapsulation plug of a kind of soybean glue, mainly comprises auxiliary glue, soybean glue and mixed solution and is mixed,
Wherein auxiliary glue comprises: deionized water 90 parts, ethylene vinyl acetate 15 parts, chitosan 12 parts, Vltra tears 8 parts, propolis 5 parts, kaolin 5 parts, titanium dioxide 3 parts, nano diatomite 3 parts, white oil 2 parts, Sorbic Acid 1.5 parts;
Soybean glue comprises: E-44 epoxy resin: 30 parts, E-51 epoxy resin: 15 parts, modified amine and polymeric amide mixture 15 parts, talcum powder: 25 parts, promotor: 2 parts, coupling agent: 2 parts; Soybean 200 parts, 30 parts, water, 6 parts, essence;
Mixed solution comprises: ginseng 10 parts, the bighead atractylodes rhizome 10 parts, raw rice sprout 10 parts, 60 parts, water, Fructus Crataegi (parched to brown) 10 parts, Divine Comedy 10 parts, radix polygonati officinalis 7 parts, Rhizoma Arisaematis 12 parts, calamus 18 parts, wood chip 18 parts, 120 parts, bean curd water.
Its preparation process comprises the following steps:
First deionized water and ethylene vinyl acetate are added in flask, stir, and start heating, when being raised to 90 DEG C to temperature, keep 1 hour;
Then be cooled to 50 DEG C, add chitosan, Vltra tears, uniform dissolution, add propolis, kaolin, titanium dioxide, nano diatomite, white oil, Sorbic Acid successively, intensification flask to 80 DEG C, mixes half an hour, is then cooled to 40 DEG C, preserve, obtain auxiliary glue, stand-by;
E-44 epoxy resin, E-51 epoxy resin Homogeneous phase mixing are obtained component A; All the other components are mixed to get B component, choose component A and mix with B component 1:1, obtain C mixture;
Protein isolate 8%-20%, urea 15%-17%, sodium polyphosphate 1%-10% from soybean, urea is dispersed in water, be mixed and made into urea soln, add albumen, stir 1-2 hour at normal temperatures, add sodium polyphosphate again, continue to stir 2-3 hour, finally essence is added, high-temperature stirring 20 minutes, temperature controls at 90-95 DEG C, obtains D mixture;
After having prepared, by C mixture and the mixing of D mixture, proportion is 100:20-50, adds 5-10 part promotor, is warming up to 90 DEG C, and heating duration can obtain soybean glue in 1 hour, stand-by;
Get ginseng, the bighead atractylodes rhizome, raw rice sprout, pulverize, mixing water, is sprayed on Fructus Crataegi (parched to brown), until Fructus Crataegi (parched to brown) moisture content higher than 50% time, take out Fructus Crataegi (parched to brown) and be placed in sealed can 1-2 hour;
To spray remaining liquid again, wood chip, Divine Comedy, radix polygonati officinalis, Rhizoma Arisaematis smash into powder to pieces with calamus, pour in liquid, stir, take out Fructus Crataegi (parched to brown) simultaneously and be placed in liquid, seal 1 hour, then under being placed in the sun, be exposed to the sun to the complete evaporate to dryness of liquid, take out remaining powder agglomates, smash to pieces, sieve, mix with bean curd water, obtain mixed solution;
In auxiliary glue and soybean glue, add mixed solution respectively, the mixed solution proportion added in both is 1:1.36, stirs 10 minutes, in the epoxy glue first getting 20% soybean glue and mixed solution again and auxiliary glue, stir, after 3 minutes, add remaining 80%, continue stirring 2 minutes, obtain colloid;
Colloid is heavily cooled 1 day, stripping and slicing at the air of 15 DEG C, drug encapsulation plug can be obtained.
Carry out mechanical property and biological property index determining according to China's GB to drug encapsulation plug elastomeric material prepared by embodiment 1-3, result is as shown in table 1,2;
The mechanical performance index of elastomeric material prepared by table 1 the present invention
| Project | Embodiment 1 | Embodiment 2 |
| Shore a hardness/degree | 42 | 52 |
| Tensile strength/MPa | 6.9 | 7.3 |
| Tear strength/kN.m -1 | 45 | 42 |
| Compression set/% | 3.0 | 2.2 |
| Hot air aging coefficient | 0.66 | 0.69 |
The biological property index of elastomeric material prepared by table 2 the present invention
| Project | Embodiment 1 | Embodiment 2 |
| Cell toxicity test | Qualified | Qualified |
| Acute toxicity test | Qualified | Qualified |
| Picosecond laser pulse | Qualified | Qualified |
| Short-term muscle Implant experiment | Qualified | Qualified |
As can be seen from table 1,2, drug encapsulation plug elastomeric material prepared by the present invention not only has good mechanical property, stability, thermotolerance, resistance to deterioration, also there is nontoxic, nonirritant, the feature high to organism security, can be used for the preparation of different size drug encapsulation plug.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and specification sheets just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (2)
1. the made drug encapsulation plug of soybean glue, is characterized in that:
Mainly comprise auxiliary glue, soybean glue and mixed solution to be mixed,
Wherein auxiliary glue comprises: deionized water 70-90 part, ethylene vinyl acetate 10-15 part, chitosan 8-12 part, Vltra tears 5-8 part, propolis 2-5 part, kaolin 1-5 part, titanium dioxide 0.8-3 part, nano diatomite 2-3 part, white oil 0.5-2 part, Sorbic Acid 0.5-1.5 part;
Soybean glue comprises: E-44 epoxy resin: 20-30 part, E-51 epoxy resin: 10-15 part, modified amine and polymeric amide mixture 10-15 part, talcum powder: 20-25 part, promotor: 1-2 part, coupling agent: 1-2 part; Soybean 150-200 part, water 20-30 part, essence 5-6 part;
Mixed solution comprises: ginseng 5-10 part, bighead atractylodes rhizome 5-10 part, raw rice sprout 5-10 part, water 50-60 part, Fructus Crataegi (parched to brown) 5-10 part, Divine Comedy 5-10 part, radix polygonati officinalis 5-7 part, Rhizoma Arisaematis 9-12 part, calamus 15-18 part, wood chip 15-18 part, bean curd water 100-120 part.
2. the made drug encapsulation plug of a kind of soybean glue according to claim 1, is characterized in that: its preparation process comprises the following steps:
First deionized water and ethylene vinyl acetate are added in flask, stir, and start heating, when being raised to 90 DEG C to temperature, keep 1 hour;
Then be cooled to 50 DEG C, add chitosan, Vltra tears, uniform dissolution, add propolis, kaolin, titanium dioxide, nano diatomite, white oil, Sorbic Acid successively, intensification flask to 80 DEG C, mixes half an hour, is then cooled to 40 DEG C, preserve, obtain auxiliary glue, stand-by;
E-44 epoxy resin, E-51 epoxy resin Homogeneous phase mixing are obtained component A; All the other components are mixed to get B component, choose component A and mix with B component 1:1, obtain C mixture;
Protein isolate 8%-20%, urea 15%-17%, sodium polyphosphate 1%-10% from soybean, urea is dispersed in water, be mixed and made into urea soln, add albumen, stir 1-2 hour at normal temperatures, add sodium polyphosphate again, continue to stir 2-3 hour, finally essence is added, high-temperature stirring 20 minutes, temperature controls at 90-95 DEG C, obtains D mixture;
After having prepared, by C mixture and the mixing of D mixture, proportion is 100:20-50, adds 5-10 part promotor, is warming up to 90 DEG C, and heating duration can obtain soybean glue in 1 hour, stand-by;
Get ginseng, the bighead atractylodes rhizome, raw rice sprout, pulverize, mixing water, is sprayed on Fructus Crataegi (parched to brown), until Fructus Crataegi (parched to brown) moisture content higher than 50% time, take out Fructus Crataegi (parched to brown) and be placed in sealed can 1-2 hour;
To spray remaining liquid again, wood chip, Divine Comedy, radix polygonati officinalis, Rhizoma Arisaematis smash into powder to pieces with calamus, pour in liquid, stir, take out Fructus Crataegi (parched to brown) simultaneously and be placed in liquid, seal 1 hour, then under being placed in the sun, be exposed to the sun to the complete evaporate to dryness of liquid, take out remaining powder agglomates, smash to pieces, sieve, mix with bean curd water, obtain mixed solution;
In auxiliary glue and soybean glue, add mixed solution respectively, the mixed solution proportion added in both is 1:1.36, stirs 10 minutes, in the epoxy glue first getting 20% soybean glue and mixed solution again and auxiliary glue, stir, after 3 minutes, add remaining 80%, continue stirring 2 minutes, obtain colloid;
Colloid is heavily cooled 1 day, stripping and slicing at the air of 15 DEG C, drug encapsulation plug can be obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510694803.6A CN105315680A (en) | 2015-10-21 | 2015-10-21 | Drug packaging rubber plug prepared from casein-soybean glue |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510694803.6A CN105315680A (en) | 2015-10-21 | 2015-10-21 | Drug packaging rubber plug prepared from casein-soybean glue |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107216475A (en) * | 2017-07-04 | 2017-09-29 | 五河富强鑫金属制品有限公司 | A kind of preparation method of the double-layer seal cushion rubber of the outer glue of interior metal |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104177715A (en) * | 2014-07-21 | 2014-12-03 | 安徽中马橡塑制品有限公司 | Rubber material formula for medicine packaging rubber plugs |
| CN104194699A (en) * | 2014-08-26 | 2014-12-10 | 安徽神舟飞船胶业有限公司 | Formula and preparation process of epoxy resin-soybean protein glue environment-friendly copolymer adhesive |
| CN104855567A (en) * | 2015-04-27 | 2015-08-26 | 安徽宏云制茶有限公司 | Processing method of yellow transparent tea for relieving hypotension |
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- 2015-10-21 CN CN201510694803.6A patent/CN105315680A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104177715A (en) * | 2014-07-21 | 2014-12-03 | 安徽中马橡塑制品有限公司 | Rubber material formula for medicine packaging rubber plugs |
| CN104194699A (en) * | 2014-08-26 | 2014-12-10 | 安徽神舟飞船胶业有限公司 | Formula and preparation process of epoxy resin-soybean protein glue environment-friendly copolymer adhesive |
| CN104855567A (en) * | 2015-04-27 | 2015-08-26 | 安徽宏云制茶有限公司 | Processing method of yellow transparent tea for relieving hypotension |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107216475A (en) * | 2017-07-04 | 2017-09-29 | 五河富强鑫金属制品有限公司 | A kind of preparation method of the double-layer seal cushion rubber of the outer glue of interior metal |
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Application publication date: 20160210 |