CN105296656A - 一种诊治鼻咽癌的分子标志物 - Google Patents
一种诊治鼻咽癌的分子标志物 Download PDFInfo
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- CN105296656A CN105296656A CN201510849579.3A CN201510849579A CN105296656A CN 105296656 A CN105296656 A CN 105296656A CN 201510849579 A CN201510849579 A CN 201510849579A CN 105296656 A CN105296656 A CN 105296656A
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- nasopharyngeal carcinoma
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- Immunology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
试剂 | 体积 |
正向引物 | 1μl |
反向引物 | 1μl |
SYBR Green聚合酶链式反应体系 | 12.5μl |
模板 | 2μl |
去离子水 | 补足25μl |
组别 | G1期 | G2期 | S期 |
转染pcDNA3.1空载体组 | 31.02±1.15 | 15.21±0.42 | 53.77±0.59 |
转染pcDNA3.1-CALN1 | 69.01±1.34* | 13.26±1.28 | 17.73±1.05* |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510849579.3A CN105296656B (zh) | 2015-11-27 | 2015-11-27 | 一种诊治鼻咽癌的分子标志物 |
Applications Claiming Priority (1)
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CN201510849579.3A CN105296656B (zh) | 2015-11-27 | 2015-11-27 | 一种诊治鼻咽癌的分子标志物 |
Publications (2)
Publication Number | Publication Date |
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CN105296656A true CN105296656A (zh) | 2016-02-03 |
CN105296656B CN105296656B (zh) | 2018-06-12 |
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CN201510849579.3A Active CN105296656B (zh) | 2015-11-27 | 2015-11-27 | 一种诊治鼻咽癌的分子标志物 |
Country Status (1)
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CN (1) | CN105296656B (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105886625A (zh) * | 2016-04-28 | 2016-08-24 | 北京泱深生物信息技术有限公司 | Chka基因在制备食管癌诊治产品中的应用 |
CN105886629A (zh) * | 2016-04-29 | 2016-08-24 | 北京泱深生物信息技术有限公司 | 分子标志物在诊治食管鳞癌中的应用 |
CN105950721A (zh) * | 2016-04-28 | 2016-09-21 | 北京泱深生物信息技术有限公司 | Itm2a基因作为食管癌诊治标志物的用途 |
CN108707665A (zh) * | 2018-05-07 | 2018-10-26 | 佛山市第人民医院(中山大学附属佛山医院) | 用于鼻咽癌诊断的标志物 |
CN110004227A (zh) * | 2019-03-05 | 2019-07-12 | 江苏省肿瘤医院 | 一种鼻咽癌诊断和/或预后评估的生物标记物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104884637A (zh) * | 2012-11-05 | 2015-09-02 | 普隆奈治疗公司 | 利用生物标志物通过bcl2表达的调节治疗癌症的方法 |
-
2015
- 2015-11-27 CN CN201510849579.3A patent/CN105296656B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104884637A (zh) * | 2012-11-05 | 2015-09-02 | 普隆奈治疗公司 | 利用生物标志物通过bcl2表达的调节治疗癌症的方法 |
Non-Patent Citations (3)
Title |
---|
ITO H 等: ""Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line,MCF-7,induced by the anti-cancer drug,daunorubicin"", 《BIOCHIMICA ET BIOPHYSICA ACTA》 * |
WU B X等: ""Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses"", 《NEUROMOLECULAR MEDICINE》 * |
朱孝峰等: ""神经酰胺诱导鼻咽癌细胞凋亡"", 《中国药理学通报》 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105886625A (zh) * | 2016-04-28 | 2016-08-24 | 北京泱深生物信息技术有限公司 | Chka基因在制备食管癌诊治产品中的应用 |
CN105950721A (zh) * | 2016-04-28 | 2016-09-21 | 北京泱深生物信息技术有限公司 | Itm2a基因作为食管癌诊治标志物的用途 |
CN105950721B (zh) * | 2016-04-28 | 2019-08-13 | 北京泱深生物信息技术有限公司 | Itm2a基因作为食管癌诊治标志物的用途 |
CN105886629A (zh) * | 2016-04-29 | 2016-08-24 | 北京泱深生物信息技术有限公司 | 分子标志物在诊治食管鳞癌中的应用 |
CN105886629B (zh) * | 2016-04-29 | 2019-09-27 | 北京泱深生物信息技术有限公司 | 分子标志物在诊治食管鳞癌中的应用 |
CN108707665A (zh) * | 2018-05-07 | 2018-10-26 | 佛山市第人民医院(中山大学附属佛山医院) | 用于鼻咽癌诊断的标志物 |
CN108707665B (zh) * | 2018-05-07 | 2022-03-22 | 佛山市第一人民医院(中山大学附属佛山医院) | 用于鼻咽癌诊断的标志物 |
CN110004227A (zh) * | 2019-03-05 | 2019-07-12 | 江苏省肿瘤医院 | 一种鼻咽癌诊断和/或预后评估的生物标记物 |
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CN105296656B (zh) | 2018-06-12 |
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Denomination of invention: Molecular marker for nasopharynx cancer diagnosis and treatment Effective date of registration: 20181225 Granted publication date: 20180612 Pledgee: Huaxia Bank Beijing branch Wanliu Limited by Share Ltd Pledgor: Beijing Yang Shen biology information technology company limited Registration number: 2018990001252 |
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Effective date of registration: 20210402 Address after: 266000 room 2503, Qianshan building, D2, Qingdao International Innovation Park Phase II, No.1 Keyuan Weiyi Road, Laoshan District, Qingdao City, Shandong Province Patentee after: Qingdao Yangshen biomedical Co.,Ltd. Address before: 100080 room 3103, cube court building, 1 good luck street, Haidian District, Beijing. Patentee before: BEIJING MEDINTELL BIOMED INFORMATION TECHNOLOGY Co.,Ltd. |
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