CN105288706B - A kind of obstetrics and gynecology department quick hemostatic dressing and preparation method thereof - Google Patents
A kind of obstetrics and gynecology department quick hemostatic dressing and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to Gynecological medical Material Fields, and in particular to a kind of obstetrics and gynecology department quick hemostatic dressing, and preparation method is further disclosed.Quick hemostatic dressing of the present invention, using carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, Notogineng Extract and polyvinyl alcohol as raw material, and it uses first foam again in such a way that gradient profile is freeze-dried during the preparation process, preparation-obtained bleeding-stopping dressing is in absorption and haemostatic effect, the product of the single freeze-drying mode routinely used in compared with the existing technology, the technical effect for absorbing blood are substantially improved；And use quick hemostatic dressing of the present invention best for the haemostatic effect of quick bleeding, hemostasis can be realized within a short period of time, be applicable to the acute emergent management bled profusely of gynemetrics.
Description
Technical field
The invention belongs to Gynecological medical Material Fields, and in particular to a kind of obstetrics and gynecology department quick hemostatic dressing goes forward side by side one
Walk open preparation method.
Background technique
Clinical medicine data show that human body is because acute bleeding is without taking effective emergency treatment, and patient was at 6-20 minutes
It is interior will be dead.If human body blood loss is more than that 20% (adult about 800cc) of whole body blood volume suffers a shock；If blood loss is more than whole body
40% (adult about 1600cc) of blood volume is at death's door.According to statistics, died of wounds number accounts for the 10% of total death toll, and its
In bleed profusely to cause death and account for 30%-40% therein, therefore, it is to reduce the main method of the death rate that early stage, which controls bleeding,.
Gynemetrics's bleeding is even more that clinic leads to the principal element of malpractice, and leads to the main original of haemorrhagic shock
Cause, since capillary groundwater increment sharply declines, effective circulating blood volume falls sharply, and causes important vital organ functional disturbance, organizer
Pathological syndrome with the characteristics of official's anoxic and hypoperfusion, electrolyte disturbance, peripheral circulation failure etc., the key for the treatment of are
Hemostasis in time, and quickly supplements effective internal circulating load enough, so that blood pressure is gone up rapidly in a short time, and patient can just be made to turn to endanger and be
Peace.
Currently, the dressing for the clinical big bleeding of gynemetrics is various in style, the bleeding-stopping dressing of latest development uses chitin more
This novel biomaterial of glycan is hemostasis main body.The bleeding-stopping dressing not only has biocompatibility and biodegradability,
And it is resourceful, it is applied in bleeding-stopping dressing, has the function of antibacterial, anti-inflammatory, hemostasis, analgesia, promotion wound healing etc..For example,
Chinese patent literature CN101450223A discloses a kind of hemostatic material based on chitosan, collagen and sodium carboxymethylcellulose
Material, wherein sodium carboxymethylcellulose has the function of mitigating postoperative peritoneal adhesions degree, can control the exudation of wound tissue liquid, promotees
It quickly heals into the surface of a wound, preferable haemostatic effect can be played to general bleeding, there is good biocompatibility, wound is cured
It is smaller to the side effect of human body generation when being used during conjunction.
Most of quick hemostatic dressing is to be prepared using foaming technique, then pass through freeze-drying to studies have shown that at present
Technology obtains the bleeding-stopping dressing of porous structure, and the anthemorrhagic speed and hemostasis amount of the bleeding-stopping dressing prepared by this method have substantially
The case where being promoted, general operation acute bleeding or operative hemorrhage can be substantially met, it is still, acute for gynaecology and obstetrics operation to go out greatly
When quick, a large amount of hemostasis demand of blood, it is still unable to satisfy the requirement of emergent management.
Summary of the invention
For this purpose, technical problem to be solved by the present invention lies in bleeding-stopping dressings in the prior art to be unable to satisfy gynaecology and obstetrics operation
The problem of hemostasis requires, and then a kind of quick hemostatic dressing used suitable for gynemetrics is provided, and further disclose its preparation
Method.
In order to solve the above technical problems, the method for the present invention for preparing obstetrics and gynecology department quick hemostatic dressing, including such as
Lower step:
(1) mixing: taking smashed Radix Notoginseng that boiling boiling is added to extract, and water extract be concentrated into medicinal extract, obtains Radix Notoginseng extraction
Object, it is spare；
(2) carboxymethyl chitosan 40-120 parts by weight, sodium carboxymethylcellulose 10-25 parts by weight, collagen 20-60 are taken
Parts by weight, Notogineng Extract 30-80 parts by weight, polyvinyl alcohol 10-20 parts by weight, mix well；
(3) under vacuum conditions by above-mentioned raw materials mixture, 150-250 DEG C of temperature progress foamable processing is controlled；
(4) will foaming treated raw material, carry out freeze-drying process under vacuum conditions, control temperature -40~-50 DEG C
Freeze-drying process 1-2h, temperature -20~-30 DEG C freeze-drying process 1-2h is controlled again, controls -10 DEG C of temperature freeze-dryings again
Handle 1-2h；It is a circulation, freeze-drying process 2-4 circulation with above-mentioned freezing dry process；
(5) by obtained hemostatic material wash, sterilizing to get.
Preferably, the carboxymethyl chitosan is 60-100 parts by weight, the sodium carboxymethylcellulose is 15-20 weight
Part, the collagen are 30-50 parts by weight, the Notogineng Extract is 50-60 parts by weight, the polyvinyl alcohol is 12-18
Parts by weight.
Optimal, the carboxymethyl chitosan is 80 parts by weight, the sodium carboxymethylcellulose is 18 parts by weight, the glue
Former albumen is 40 parts by weight, the Notogineng Extract is 55 parts by weight, the polyvinyl alcohol is 15 parts by weight.
In the step (4), the freeze-drying process step is 3 circulations.
In the step (4), each circulation freeze-drying process step specifically: -45 DEG C of temperature freezings of control are dry
Dry processing 1-2h, -25 DEG C of freeze-drying process 1-2h of temperature are controlled again, control -10 DEG C of freeze-drying process 1-2h of temperature again.
In the step (3), the heating temperature of the foaming step is 200 DEG C.
In the step (1), the Notogineng Extract is the water that smashed Radix Notoginseng adds 2-4 times of weight amount, is mentioned through boiling
Take 1-3 gained.
In the step (2), further include the steps that conventional hemostatic compositions, such as hyaluronic acid conventional nutrients are added.
In the step (1), the sterilization steps are through treatment with irradiation under gamma-rays.
The invention also discloses obstetrics and gynecology department quick hemostatic dressings prepared by the above method.
The invention also discloses the applications that above-mentioned bleeding-stopping dressing is used to prepare gynaecology and obstetrics operation hemostatic material.
Quick hemostatic dressing of the present invention, although with conventional use of carboxymethyl chitosan in the prior art, carboxylic first
Base sodium cellulosate, collagen, Notogineng Extract and polyvinyl alcohol are raw material, and each raw material, which all has, to be promoted hemagglutination, makes
The effect that blood quickly solidifies, plays the role of blood coagulation jointly；The collagen of addition can not only play hemoglutination, may be used also
Wound healing is, it can be achieved that quick-acting haemostatic powder.Importantly, bleeding-stopping dressing of the present invention due to using during the preparation process
It first foams again in such a way that gradient profile is freeze-dried, preparation-obtained bleeding-stopping dressing is in absorption and haemostatic effect
On, compared with the existing technology in the product of single freeze-drying mode that routinely uses, absorb the technical effect of blood substantially
It is promoted.As it can be seen that the influence of preparation step difference is significantly larger than its raw material components during preparing the bleeding-stopping dressing
It influences；And use quick hemostatic dressing of the present invention best for the haemostatic effect of quick bleeding, it can be real within a short period of time
Now stop blooding, is applicable to the acute emergent management bled profusely of gynemetrics.
Specific embodiment
In the following each embodiments of the present invention, the carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, poly- second
Enol is the product routinely used in the prior art, effect and indifference between the product of commercially available each model.
Embodiment 1
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment includes the raw material components of following parts by weight: carboxymethyl chitosan
40kg, sodium carboxymethylcellulose 25kg, collagen 20kg, Notogineng Extract 80kg, polyvinyl alcohol 10kg.
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment is prepared by the following method, is included the following steps:
(1) mixing: taking Radix Notoginseng to crush, sieving, and extraction 3 times is boiled in the water heating that the 2 times of weight amount of Radix Notoginseng is added, and will
Water extract is concentrated into medicinal extract, obtains Notogineng Extract, spare；
(2) according to the selected carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, Notogineng Extract, poly- of measuring
Vinyl alcohol mixes well；
(3) under vacuum conditions by above-mentioned raw materials mixture, 150 DEG C of progress foamables of control temperature handle 3h；
(4) will foaming treated raw material, be placed in freeze drier and vacuumize 6h, control -40 DEG C of temperature freeze-dryings
Processing 2h, -20 DEG C of freeze-drying process 2h of temperature are controlled again, control -10 DEG C of freeze-drying process 2h of temperature again；With above-mentioned freezing
Drying process is a circulation, repeats above-mentioned freeze-drying process 4 circulations；
(5) obtained hemostatic material is added into water washing, through under gamma-rays radiation sterilization processing to get.Embodiment 2
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment includes the raw material components of following parts by weight: carboxymethyl chitosan
120kg, sodium carboxymethylcellulose 10kg, collagen 60kg, Notogineng Extract 30kg, polyvinyl alcohol 20kg.
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment is prepared by the following method, is included the following steps:
(1) mixing: taking Radix Notoginseng to crush, sieving, and extraction 1 time is boiled in the water heating that the 4 times of weight amount of Radix Notoginseng is added, and will
Water extract is concentrated into medicinal extract, obtains Notogineng Extract, spare；
(2) according to the selected carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, Notogineng Extract, poly- of measuring
Vinyl alcohol mixes well；
(3) under vacuum conditions by above-mentioned raw materials mixture, 250 DEG C of progress foamables of control temperature handle 2h；
(4) will foaming treated raw material, be placed in freeze drier and vacuumize 6h, control -50 DEG C of temperature freeze-dryings
Processing 1h, -30 DEG C of freeze-drying process 1h of temperature are controlled again, control -10 DEG C of freeze-drying process 1h of temperature again；With above-mentioned freezing
Drying process is a circulation, repeats above-mentioned freeze-drying process 2 circulations；
(5) obtained hemostatic material is added into water washing, through under gamma-rays radiation sterilization processing to get.Embodiment 3
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment includes the raw material components of following parts by weight: carboxymethyl chitosan
60kg, sodium carboxymethylcellulose 20kg, collagen 30kg, Notogineng Extract 60kg, polyvinyl alcohol 12kg.
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment is prepared by the following method, is included the following steps:
(1) mixing: taking Radix Notoginseng to crush, sieving, and extraction 2 times is boiled in the water heating that the 3 times of weight amount of Radix Notoginseng is added, and will
Water extract is concentrated into medicinal extract, obtains Notogineng Extract, spare；
(2) according to the selected carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, Notogineng Extract, poly- of measuring
Vinyl alcohol mixes well；
(3) under vacuum conditions by above-mentioned raw materials mixture, 200 DEG C of progress foamables of control temperature handle 3h；
(4) will foaming treated raw material, be placed in freeze drier and vacuumize 6h, control -35 DEG C of temperature freeze-dryings
Processing 2h, -25 DEG C of freeze-drying process 1h of temperature are controlled again, control -10 DEG C of freeze-drying process 2h of temperature again；With above-mentioned freezing
Drying process is a circulation, repeats above-mentioned freeze-drying process 3 circulations；
(5) obtained hemostatic material is added into water washing, through under gamma-rays radiation sterilization processing to get.Embodiment 4
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment includes the raw material components of following parts by weight: carboxymethyl chitosan
100kg, sodium carboxymethylcellulose 15kg, collagen 50kg, Notogineng Extract 50kg, polyvinyl alcohol 18kg.
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment is prepared by the following method, is included the following steps:
(1) mixing: taking Radix Notoginseng to crush, sieving, and extraction 2 times is boiled in the water heating that the 3 times of weight amount of Radix Notoginseng is added, and will
Water extract is concentrated into medicinal extract, obtains Notogineng Extract, spare；
(2) according to the selected carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, Notogineng Extract, poly- of measuring
Vinyl alcohol mixes well；
(3) under vacuum conditions by above-mentioned raw materials mixture, 200 DEG C of progress foamables of control temperature handle 3h；
(4) will foaming treated raw material, be placed in freeze drier and vacuumize 6h, control -35 DEG C of temperature freeze-dryings
Processing 2h, -25 DEG C of freeze-drying process 1h of temperature are controlled again, control -10 DEG C of freeze-drying process 2h of temperature again；With above-mentioned freezing
Drying process is a circulation, repeats above-mentioned freeze-drying process 3 circulations；
(5) obtained hemostatic material is added into water washing, through under gamma-rays radiation sterilization processing to get.Embodiment 5
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment includes the raw material components of following parts by weight: carboxymethyl chitosan
80kg, sodium carboxymethylcellulose 18kg, collagen 40kg, Notogineng Extract 55kg, polyvinyl alcohol 15kg.
Obstetrics and gynecology department quick hemostatic dressing described in the present embodiment is prepared by the following method, is included the following steps:
(1) mixing: taking Radix Notoginseng to crush, sieving, and extraction 2 times is boiled in the water heating that the 3 times of weight amount of Radix Notoginseng is added, and will
Water extract is concentrated into medicinal extract, obtains Notogineng Extract, spare；
(2) according to the selected carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, Notogineng Extract, poly- of measuring
Vinyl alcohol mixes well；
(3) under vacuum conditions by above-mentioned raw materials mixture, 200 DEG C of progress foamables of control temperature handle 3h；
(4) will foaming treated raw material, be placed in freeze drier and vacuumize 6h, control -35 DEG C of temperature freeze-dryings
Processing 2h, -25 DEG C of freeze-drying process 1h of temperature are controlled again, control -10 DEG C of freeze-drying process 2h of temperature again；With above-mentioned freezing
Drying process is a circulation, repeats above-mentioned freeze-drying process 3 circulations；
(5) obtained hemostatic material is added into water washing, through under gamma-rays radiation sterilization processing to get.
Comparative example 1
Obstetrics and gynecology department quick hemostatic dressing described in this comparative example includes the raw material components of following parts by weight: carboxymethyl chitosan
30kg, sodium carboxymethylcellulose 35kg, collagen 10kg, Notogineng Extract 90kg, polyvinyl alcohol 5kg.The bleeding-stopping dressing
Preparation method with embodiment 5.
Comparative example 2
Obstetrics and gynecology department quick hemostatic dressing described in this comparative example includes the raw material components of following parts by weight: carboxymethyl chitosan
130kg, sodium carboxymethylcellulose 5kg, collagen 70kg, Notogineng Extract 20kg, polyvinyl alcohol 30kg.The bleeding-stopping dressing
Preparation method with embodiment 5.
Comparative example 3
The raw material of the bleeding-stopping dressing of this comparative example preparation is same as Example 5, and difference is only that, the bleeding-stopping dressing
In preparation step (4), the freeze-drying step is to control -35 DEG C of freeze-drying process of temperature under identical vacuum condition
15h。
Comparative example 4
The raw material of the bleeding-stopping dressing of this comparative example preparation is same as Example 5, and difference is only that, the bleeding-stopping dressing
In preparation step (4), the freeze-drying step is to control -25 DEG C of freeze-drying process of temperature under identical vacuum condition
15h。
Comparative example 5
The raw material of the bleeding-stopping dressing of this comparative example preparation is same as Example 5, and difference is only that, the bleeding-stopping dressing
In preparation step (4), the freeze-drying step is to control -10 DEG C of freeze-drying process of temperature under identical vacuum condition
15h。
Comparative example 6
The raw material of the bleeding-stopping dressing of this comparative example preparation is same as Example 5, and difference is only that, the bleeding-stopping dressing
In preparation step, freeze-drying process is no longer carried out after foamable step, but directly cooling treatment at room temperature.
Experimental example
1, blood volume adsorption experiment
The bleeding-stopping dressing being prepared in Example 1-5 and comparative example 1-6 respectively, uniformly cut out length × width × height=
1cm × 1cm × 0.5cm oblong-shaped, it is spare；
50ml blood separately is taken, is all placed in 200ml beaker, carries out Blood index experimental test at normal temperature；
Time needed for recording the bleeding-stopping dressing absorption whole blood, the record that can not all adsorb do not reabsorb blood volume
The final time, experimental result is shown in the following table 1.
1 blood volume Adsorption experimental results of table
| Number | Whether all absorption | (all/maximum) adsorption time |
| Embodiment 1 | It is | 13s |
| Embodiment 2 | It is | 12s |
| Embodiment 3 | It is | 12s |
| Embodiment 4 | It is | 11s |
| Embodiment 5 | It is | 10s |
| Comparative example 1 | It is | 16s |
| Comparative example 2 | It is | 15s |
| Comparative example 3 | It is no | 20s |
| Comparative example 4 | It is no | 19s |
| Comparative example 5 | It is no | 20s |
| Comparative example 6 | It is no | 25s |
By upper table data it is found that quick hemostatic dressing of the invention can in a very short period of time realize 50mL blood volume entirely
Portion absorbs, although and time that comparative example 1-2 group absorbs it is slightly long, still realize whole absorption of big blood volume, and compare
Example 3-6 group then cannot achieve the whole of big blood volume and absorb.As it can be seen that during preparing the bleeding-stopping dressing, preparation step
The influence of rapid difference is significantly larger than the influence of its raw material components；It is also turned out simultaneously using gradient freezing drying mode of the present invention
Compared to the bleeding-stopping dressing of generally conventional freeze-drying process, technical effect is significantly improved bleeding-stopping dressing obtained.
2, quick-acting haemostatic powder is tested
Choose the similar rabbit of 110 weight, be randomly divided into 11 groups, every group 10, every rabbit cut off left ear auricular vein,
2/3rds of auris dextra ear edge artery and left hind femoral artery are right with experimental example 1-5 grades respectively after free bleeding 10s, 10s
Bleeding-stopping dressing pressure dressing wound obtained in ratio 1-6.Wherein, each group experiment bleeding-stopping dressing used uniformly cuts growth × wide
× height=2cm × 2cm × 2cm oblong-shaped records each experimental group bleeding stopping period and is recorded in the following table 2.
Each experimental group quick-acting haemostatic powder time result of table 2
It is by upper table data it is found that best for the haemostatic effect of quick bleeding using quick hemostatic dressing of the present invention,
Hemostasis can be realized within a short period of time, be applicable to the acute emergent management bled profusely of gynemetrics.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (10)
1. a kind of method for preparing obstetrics and gynecology department quick hemostatic dressing, which comprises the steps of:
(1) mixing: taking smashed Radix Notoginseng that boiling boiling is added to extract, and water extract be concentrated into medicinal extract, obtain Notogineng Extract, standby
With；
(2) carboxymethyl chitosan 40-120 parts by weight, sodium carboxymethylcellulose 10-25 parts by weight, collagen 20-60 weight are taken
Part, Notogineng Extract 30-80 parts by weight, polyvinyl alcohol 10-20 parts by weight, mix well；
(3) under vacuum conditions by above-mentioned raw materials mixture, 150-250 DEG C of temperature progress foamable processing is controlled；
(4) will foaming treated raw material, carry out freeze-drying process, the freezing of control temperature -40~-50 DEG C under vacuum conditions
It is dried 1-2h, temperature -20~-30 DEG C freeze-drying process 1-2h is controlled again, controls -10 DEG C of freeze-drying process of temperature again
1-2h；It is a circulation, freeze-drying process 2-4 circulation with above-mentioned freezing dry process；
(5) by obtained hemostatic material wash, sterilizing to get.
2. the method according to claim 1 for preparing obstetrics and gynecology department quick hemostatic dressing, which is characterized in that the carboxymethyl
Chitosan is 60-100 parts by weight, the sodium carboxymethylcellulose is 15-20 parts by weight, the collagen is 30-50 weight
Part, the Notogineng Extract are 50-60 parts by weight, the polyvinyl alcohol is 12-18 parts by weight.
3. the method according to claim 2 for preparing obstetrics and gynecology department quick hemostatic dressing, which is characterized in that the carboxymethyl
Chitosan is 80 parts by weight, the sodium carboxymethylcellulose is 18 parts by weight, the collagen is 40 parts by weight, the Radix Notoginseng
Extract is 55 parts by weight, the polyvinyl alcohol is 15 parts by weight.
4. the method according to claim 3 for preparing obstetrics and gynecology department quick hemostatic dressing, which is characterized in that the step
(4) in, the freeze-drying process step is 3 circulations.
5. the method according to claim 4 for preparing obstetrics and gynecology department quick hemostatic dressing, which is characterized in that the step
(4) in, each circulation freeze-drying process step specifically: control -45 DEG C of freeze-drying process 1-2h of temperature, control again
- 25 DEG C of freeze-drying process 1-2h of temperature, -10 DEG C of freeze-drying process 1-2h of temperature are controlled again.
6. the method according to claim 5 for preparing obstetrics and gynecology department quick hemostatic dressing, which is characterized in that the step
(3) in, the heating temperature of the foaming step is 200 DEG C.
7. -6 any method for preparing obstetrics and gynecology department quick hemostatic dressing according to claim 1, which is characterized in that described
In step (1), the Notogineng Extract is the water that smashed Radix Notoginseng adds 2-4 times of weight amount, is boiled 1-3 gained of extraction.
8. the method according to claim 7 for preparing obstetrics and gynecology department quick hemostatic dressing, which is characterized in that the step
(2) in, further include the steps that conventional hemostatic compositions are added.
9. the obstetrics and gynecology department quick hemostatic dressing being prepared by any the method for claim 1-8.
10. the application that bleeding-stopping dressing described in claim 9 is used to prepare gynaecology and obstetrics operation hemostatic material.
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| CN106581651A (en) * | 2017-02-22 | 2017-04-26 | 青岛市第三人民医院 | Pharmaceutical composition for rapidly stopping bleeding |
| CN107261193B (en) * | 2017-04-20 | 2021-02-09 | 首都医科大学附属北京同仁医院 | Hemostatic material and preparation method thereof |
| CN107233615A (en) * | 2017-08-03 | 2017-10-10 | 苏州凌科特新材料有限公司 | A kind of hemostatic and antibacterial material and preparation method thereof |
| CN108498844A (en) * | 2017-12-18 | 2018-09-07 | 张祖玲 | A kind of obstetrics and gynecology department quick hemostatic dressing and preparation method thereof |
| CN108567459A (en) * | 2018-02-06 | 2018-09-25 | 李红 | A kind of obstetrics and gynecology department hemostasis device |
| CN108014362A (en) * | 2018-02-07 | 2018-05-11 | 苏州元禾医疗器械有限公司 | A kind of preparation method of the wound dressing of dispeling scar |
| CN108653798A (en) * | 2018-06-29 | 2018-10-16 | 中山大学附属第医院 | Composition and hemostatic material in medical use for hemostasis |
| CN110917384A (en) * | 2019-12-14 | 2020-03-27 | 浙江惠龙医疗科技股份有限公司 | Medical dressing with antibacterial and high absorption functions and preparation method thereof |
| CN111603603A (en) * | 2020-06-03 | 2020-09-01 | 韩皓 | Gynecological rapid hemostatic dressing and preparation method thereof |
| CN113577374A (en) * | 2021-07-26 | 2021-11-02 | 哈尔滨贝科德糖生物科技有限公司 | Composite liquid band-aid and preparation method thereof |
| CN114732940B (en) * | 2022-04-24 | 2022-12-06 | 江苏瀚仁生物科技有限公司 | High-elasticity starch cavity hemostatic material and application and preparation method thereof |
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| CN1155411C (en) * | 2001-11-16 | 2004-06-30 | 崔翔 | Freezing absorbant hemostatic cotton and its prepn |
| CN101138648A (en) * | 2006-09-07 | 2008-03-12 | 电子科技大学中山学院 | Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings |
| CN1994481A (en) * | 2006-10-10 | 2007-07-11 | 辽宁师范大学 | Highly effective Chinese medicine-chitosan compound hemostatic material |
| CN101450223A (en) * | 2007-11-30 | 2009-06-10 | 张博 | Hemostasia material based on chitosan, collagen and sodium cellulose glycolate and preparation method and use thereof |
| TWI445555B (en) * | 2011-03-11 | 2014-07-21 | Univ China Medical | Dressing comprising active components of centella asiatica and use of the same |
| CN103599558B (en) * | 2013-07-16 | 2015-08-12 | 汪贤宗 | A kind of quick hemostatic dressing and preparation method thereof |
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