CN103599558B - A kind of quick hemostatic dressing and preparation method thereof - Google Patents
A kind of quick hemostatic dressing and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of quick hemostatic dressing, comprise the raw material components of following weight portion: chitosan 30-100 part, heparin sodium 2-30 part, collagen protein 10-80 part, aloin 10-80 part.Quick hemostatic dressing of the present invention, the requirement that can realize fast, stop blooding in a large number, its anthemorrhagic speed is better than existing bleeding-stopping dressing.Present invention also offers the preparation method of described quick hemostatic dressing, adopt the quick hemostatic dressing of the present invention that the method for foaming process is produced, its anthemorrhagic speed can be more rapid.
Description
Technical field
The present invention relates to a kind of quick hemostatic dressing and preparation method thereof, belong to medical dressing Material Field.
Background technology
Clinical medicine is pointed out, human body does not take effective emergency treatment because of acute hemorrhage, then patient will be dead in 6-20 minute.If human body is lost blood, the 20%(that exceedes whole body blood volume is grown up about 800cc) namely suffer a shock; The 40%(exceeding whole body blood volume if lose blood is grown up about 1600cc) be namely at death's door.According to statistics, died of wounds number accounts for 10% of total death toll, and the 30%-40% causing death and account for wherein that wherein bleeds profusely, therefore, early stage Bleeding control is the main method reducing mortality rate.
At present, various in style for the dressing stopped blooding, this novel biomaterial of bleeding-stopping dressing many uses chitosan of latest development is hemostasis main body.Chitosan, not only has biocompatibility and biodegradability, and aboundresources, is easy to obtain, and is applied in bleeding-stopping dressing, has the functions such as antibacterial, antiinflammatory, hemostasis, analgesia, promotion wound healing.For strengthening the performance of chitosan as bleeding-stopping dressing further, have in prior art and adopt chitosan and the mixing of other materials, and then make bleeding-stopping dressing.Such as, quick-hemagglutination hemostasis sponge disclosed in Chinese patent literature CN1387922A, comprises collagen protein and chitosan.Because chitosan has the effect promoting blood coagulation, collagen protein biocompatibility is better, and the sthptic sponge made has good haemostatic effect, and side effect is less.Chinese patent literature CN102600495A discloses a kind of absorbable hemostatic composition and preparation method thereof, on the basis of above-mentioned collagen protein and chitosan, with the addition of hyaluronic acid again, hyaluronic acid has good biocompatibility equally, be cross-linked with each other with collagen protein, chitosan and mix, further enhance haemostatic effect.Chinese patent literature CN101450223A discloses a kind of hemostatic material based on chitosan, collagen protein and sodium carboxymethyl cellulose, wherein, the effect that sodium carboxymethyl cellulose alleviates postoperative peritoneal adhesions degree is obviously better than hyaluronate sodium, can control wound tissue liquid and ooze out, promotes wound surface quickly-healing.
But the hemostatic material related in above-mentioned patent documentation all as in prior art hemostatic material the same, good haemostatic effect can be played to generality is hemorrhage, there is good biocompatibility, when using during wound healing to human body produce side effect less.But, when facing the situation of acute hemorrhage or operative hemorrhage, its anthemorrhagic speed and hemostasis amount still cannot meet a large amount of quick hemorrhage time emergent management requirement.
Summary of the invention
The problem of quick-acting haemostatic powder requirement when technical problem to be solved by this invention is that bleeding-stopping dressing of the prior art is not suitable for acute bleeding profusely, so provide a kind of and realize fast, bleeding-stopping dressing that a large amount of hemostasis requires.
The present invention still further provides the preparation method of above-mentioned quick hemostatic dressing.
For this reason, the invention provides a kind of quick hemostatic dressing, comprise the raw material components of following weight portion: chitosan 30-100 part, heparin sodium 2-30 part, collagen protein 10-80 part, aloin 10-80 part.
Further, described quick hemostatic dressing, comprises the raw material components of following weight portion: chitosan 40-70 part, heparin sodium 3-10 part, collagen protein 10-30 part, aloin 10-30 part.
Most preferred, described quick hemostatic dressing, comprises the raw material of following weight portion: chitosan 60 parts, heparin sodium 5 parts, collagen protein 20 parts, aloin 18 parts.
Hemostasis adjuvant of the present invention can also to add in prior art conventional use other be applicable to wound healing and hemostasis nutritional labeling, as the conventional nutrients such as hyaluronic acid or sodium carboxymethyl cellulose.
Described aloin be aloe leaf under the vacuum of-50 DEG C, pulverize the nano-particle obtained after lyophilization.
The particle diameter of described aloin granule is 100-1000nm.
Preferably, described bleeding-stopping dressing be by described each raw material components is mixed be incorporated in 100-200 DEG C of vacuum condition under carry out the foaming mode of process obtained.
The invention still further relates to a kind of preparation method of quick hemostatic dressing, comprise the following steps:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: by above-mentioned raw materials mixture under vacuo, control temperature 100-200 DEG C is carried out foamable process 1-3h;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
Preferred further, under described foaming is treated to the vacuum of 150 DEG C, heating 1h.
Described sterilization steps is uniform irradiation 36-72 hour under gamma-rays.
The invention also discloses a kind of quick hemostatic dressing prepared through said method.
Quick hemostatic dressing of the present invention has the following advantages:
(1) quick hemostatic dressing of the present invention, adopts chitosan, heparin sodium, collagen protein, aloin to make bleeding-stopping dressing.Because chitosan itself has with carbonium, electronegative hemagglutination can be promoted, and then make blood rapid solidification, meanwhile, also can secrete thrombin by stimulating platelet, jointly play the effect of blood coagulation.Collagen protein is the Main Ingredients and Appearance of human body ligament and flesh key, is also the main composition of extracellular matrix, also has and can promote blood accumulation with Platelet, thus realize the effect of rapid blood coagulation.Collagen protein makes an addition in bleeding-stopping dressing, not only can play Blood clotting, also can be used as cytoskeleton wound healing.Aloin has the effect of sterilization, eliminating inflammation and expelling toxin, promotion wound healing.Above-mentioned three kinds of materials mixing, rapid blood coagulation, support wound surface place cell, wound healing, the combined effect of anti-inflammation and sterilization multiple effect, can realize quick-acting haemostatic powder.Especially also added in prior art in quick hemostatic dressing of the present invention be usually used in anticoagulation heparin sodium, although heparin sodium is unfavorable for the use of hemostasis in the prior art as common anticoagulant, but in bleeding-stopping dressing of the present invention, the heparin sodium added utilizes its anticoagulant property to serve to prevent wound between post-hemorrhagic period and bleeding-stopping dressing adhesion on the contrary, or the problem of wound adhesion when using described quick hemostatic dressing between healing stage, utilize simultaneously stop the mode of the blood coagulation flowed out accelerate blood fast adsorb by bleeding-stopping dressing.The results showed, adopt quick hemostatic dressing of the present invention to be 10ml/cm to bleeding capacity in 10-15s
2wound carry out hemostasis, be greatly better than the anthemorrhagic speed of existing bleeding-stopping dressing;
(2) quick hemostatic dressing of the present invention, the chitosan, collagen protein, the biological macromolecule of heparin sodium obtained by natural materials that adopt, all there is good biocompatibility with human body, aloin is also the granule adopting aloe leaf crushed after being dried, above-mentioned constituent does not have toxicity, little to human body side effect;
(3) preparation method of the quick hemostatic dressing described in, have employed foaming process, said components is heated at suitable temperature, do not destroying under the bioactive condition of each component, form loose structure, make described quick hemostatic dressing have excellent adsorption function, when acute bleeding profusely, realize quick-acting haemostatic powder.
Detailed description of the invention
In the following each embodiment of the present invention, described chitosan, heparin sodium, collagen protein, aloin can select the conventional product adopted in prior art to carry out the preparation of bleeding-stopping dressing, below the product only providing wherein a kind of model is set forth effect of the present invention, effect between the product of commercially available each model zero difference.Wherein:
The medicinal chitosan of food grade that the deacetylation that chitosan selects carapace Products Co., Ltd of Jinhu County of Huantai County to produce is greater than 93%;
Heparin sodium is the heparin sodium that Wuhan that CAS is numbered 9041-8-1 far becomes science and technology to create company limited to produce;
Collagen protein is the model that bio tech ltd of Xu Er U.S., Shijiazhuang produces is the collagen protein raw material of aaa.
embodiment 1
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 30 parts, heparin sodium 16 parts, collagen protein 10 parts, aloin 45 parts.
Its preparation method is:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 3h under above-mentioned raw materials mixture being placed in the vacuum of temperature 100 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
embodiment 2
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 100 parts, heparin sodium 30 parts, collagen protein 80 parts, aloin 10 parts.
Its preparation method is:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 1h under above-mentioned raw materials mixture being placed in the vacuum of temperature 200 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
embodiment 3
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 65 parts, heparin sodium 2 parts, collagen protein 45 parts, aloin 80 parts.
Its preparation method is:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 1h under above-mentioned raw materials mixture being placed in the vacuum of temperature 150 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
embodiment 4
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 40 parts, heparin sodium 10 parts, collagen protein 20 parts, aloin 10 parts.
Its preparation method is:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 2h under above-mentioned raw materials mixture being placed in the vacuum of temperature 120 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
embodiment 5
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 55 parts, heparin sodium 3 parts, collagen protein 10 parts, aloin 30 parts.
Its preparation method is:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 1h under above-mentioned raw materials mixture being placed in the vacuum of temperature 150 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
embodiment 6
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 70 parts, heparin sodium 6 parts, collagen protein 30 parts, aloin 20 parts.
Its preparation method is:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 3h under above-mentioned raw materials mixture being placed in the vacuum of temperature 180 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
embodiment 7
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 60 parts, heparin sodium 5 parts, collagen protein 20 parts, aloin 18 parts.
Its preparation method is:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 1h under above-mentioned raw materials mixture being placed in the vacuum of temperature 200 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
embodiment 8
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 60 parts, heparin sodium 5 parts, collagen protein 20 parts, aloin 18 parts.
The preparation of aloin: aloe leaf, under the vacuum of-50 DEG C, is pulverized after lyophilization and obtained the nano-particle that particle diameter is 550nm.
The preparation of quick hemostatic dressing:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 2h under above-mentioned raw materials mixture being placed in the vacuum of temperature 100 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product.
embodiment 9
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 60 parts, heparin sodium 5 parts, collagen protein 20 parts, aloin 18 parts.
The preparation of aloin: aloe leaf, under the vacuum of-50 DEG C, is pulverized after lyophilization and obtained the nano-particle that particle diameter is 100nm.
The preparation of quick hemostatic dressing:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 1h under above-mentioned raw materials mixture being placed in the vacuum of temperature 150 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, dry after being processed into required form, be placed in gamma-rays under uniform irradiation within 36 hours, carry out sterilizing, to obtain final product.
embodiment 10
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 120 parts, heparin sodium 5 parts, collagen protein 20 parts, aloin 18 parts, R-polysaccharide 5 parts.
The preparation of aloin: aloe leaf, under the vacuum of-50 DEG C, is pulverized after lyophilization and obtained the nano-particle that particle diameter is 1000nm.
The preparation of quick hemostatic dressing:
(1) batch mixing: get chitosan, heparin sodium, collagen protein, aloin, the mixing of R-polysaccharide according to selected parts by weight;
(2) foaming process: carry out foamable process 1h under above-mentioned raw materials mixture being placed in the vacuum of temperature 150 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, dry after being processed into required form, be placed in gamma-rays under uniform irradiation within 36 hours, carry out sterilizing, to obtain final product.
embodiment 11
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 80 parts, heparin sodium 5 parts, collagen protein 5 parts, aloin 40 parts.
The preparation of aloin: aloe leaf, under the vacuum of-50 DEG C, is pulverized after lyophilization and obtained the nano-particle that particle diameter is 500nm.
The preparation of quick hemostatic dressing:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: carry out foamable process 1h under above-mentioned raw materials mixture being placed in the vacuum of temperature 150 DEG C;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, dry after being processed into required form, be placed in gamma-rays under uniform irradiation within 36 hours, carry out sterilizing, to obtain final product.
embodiment 12
The bleeding-stopping dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 30 parts, collagen protein 10 parts.
The preparation of bleeding-stopping dressing:
(1) batch mixing: get chitosan, collagen protein mixing according to selected parts by weight;
(2) lyophilization: lower freezing 12 hours of the temperature mixture that step (1) obtains being placed in-20 DEG C, at re-using freezer dryer-40 DEG C freezing 12 hours, evacuation 24 hours at-60 DEG C.
embodiment 13
The bleeding-stopping dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 30 parts, collagen protein 10 parts, hyaluronic acid 10 parts.
The preparation of bleeding-stopping dressing:
(1) batch mixing: get chitosan, collagen protein, hyaluronic acid mixing according to selected parts by weight;
(2) lyophilization: lower freezing 12 hours of the temperature mixture that step (1) obtains being placed in-20 DEG C, at re-using freezer dryer-40 DEG C freezing 12 hours, evacuation 24 hours at-60 DEG C.
embodiment 14
The bleeding-stopping dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 30 parts, collagen protein 10 parts, sodium carboxymethyl cellulose 10 parts.
The preparation of bleeding-stopping dressing:
(1) batch mixing: get chitosan, collagen protein, sodium carboxymethyl cellulose mixing according to selected parts by weight;
(2) lyophilization: lower freezing 12 hours of the temperature mixture that step (1) obtains being placed in-20 DEG C, at re-using freezer dryer-40 DEG C freezing 12 hours, evacuation 24 hours at-60 DEG C.
embodiment 15
The quick hemostatic dressing of the present embodiment comprises the raw material components of following weight portion: chitosan 30 parts, heparin sodium 16 parts, collagen protein 10 parts, aloin 45 parts.
Its preparation method is:
(1) batch mixing: get chitosan, collagen protein, sodium carboxymethyl cellulose mixing according to selected parts by weight;
(2) lyophilization: lower freezing 12 hours of the temperature mixture that step (1) obtains being placed in-20 DEG C, at re-using freezer dryer-40 DEG C freezing 12 hours, evacuation 24 hours at-60 DEG C.
experimental example
experiment one, blood flow volume adsorbs
(1) experimental procedure: get 10ml blood, be placed in 50ml beaker, the bleeding-stopping dressing prepared in Example 1-15 respectively again, the unified cuboid bulk cutting out length × wide × height=1cm × 1cm × 0.5cm, be placed in beaker under room temperature and carry out Blood index experimental test, and the time of record absorption needed for whole blood, the record maximum adsorption time that cannot all adsorb.
(2) experimental result:
| Numbering | Whether all adsorb | (all/maximum) adsorption time |
| Embodiment 1 | Be | 15s |
| Embodiment 2 | Be | 14s |
| Embodiment 3 | Be | 14s |
| Embodiment 4 | Be | 14s |
| Embodiment 5 | Be | 13s |
| Embodiment 6 | Be | 12s |
| Embodiment 7 | Be | 12s |
| Embodiment 8 | Be | 13s |
| Embodiment 9 | Be | 13s |
| Embodiment 10 | Be | 17s |
| Embodiment 11 | Be | 18s |
| Embodiment 12 | No | 29s |
| Embodiment 13 | No | 27s |
| Embodiment 14 | No | 28s |
| Embodiment 15 | Be | 16s |
From upper table data, adopt the embodiment 1-11 and 15 of quick hemostatic dressing scheme of the present invention group can reach whole absorption, and embodiment 12-14 group does not reach whole absorption, and the absorption maximum time of embodiment 1-11 group is all apparently higher than the effect of each experimental group of this programme.Illustrate that, in the bleeding-stopping dressing of same volume, quick hemostatic dressing of the present invention has larger adsorbance.
The embodiment 1-9 group absorption time used, all in 15s, the scheme especially described in embodiment 7-9 group, its absorption is more rapid obviously, and does not use the embodiment 15 groups of foaming technique, although the time realizing all absorption is slightly long, still achieves whole absorption.Scheme in embodiment 10,11 groups, though adsorption time declines to some extent, but still can all adsorb.And only adopt the embodiment 12 groups of the obtained bleeding-stopping dressing of chitosan, collagen protein, adopt chitosan, collagen protein, hyaluronic embodiment group 13, adopt the adsorption time needed for embodiment 14 groups of chitosan, collagen protein, sodium carboxymethyl cellulose longer, all be greater than 25s, and whole absorption cannot be realized.Therefore, quick hemostatic dressing absorption blood of the present invention is rapid, and adsorption effect is more excellent.
experiment two, quick-acting haemostatic powder experiment
(1) experimental procedure:
Choose the Belgian rabbit that 150 body weight are 6.0 ~ 6.3kg, be divided into 15 groups at random, often organize 10, be labeled as embodiment 1-15 group respectively, every rabbit cuts off 2/3rds of left ear auricular vein, auris dextra ear edge tremulous pulse and left hind femoral artery, respectively with different bleeding-stopping dressing pressure dressing wounds after free hemorrhage 5s, 5s.Wherein, the bleeding-stopping dressing that each group experiment is used all unification cuts the cuboid bulk of growth × wide × height=5cm × 5cm × 2cm.
(2) experimental result
| Group | The average bleeding stopping period (s) of left ear auricular vein | The average bleeding stopping period (s) of auris dextra ear edge tremulous pulse | The average bleeding stopping period (s) of left hind femoral artery |
| Embodiment 1 group | 6 | 10 | 18 |
| Embodiment 2 groups | 5 | 9 | 17 |
| Embodiment 3 groups | 5 | 9 | 17 |
| Embodiment 4 groups | 6 | 9 | 17 |
| Embodiment 5 groups | 5 | 9 | 17 |
| Embodiment 6 groups | 5 | 9 | 17 |
| Embodiment 7 groups | 5 | 8 | 16 |
| Embodiment 8 groups | 5 | 8 | 15 |
| Embodiment 9 groups | 5 | 8 | 15 |
| Embodiment 10 groups | 9 | 12 | 27 |
| Embodiment 11 groups | 9 | 15 | 31 |
| Embodiment 12 groups | 13 | 25 | 92 |
| Embodiment 13 groups | 15 | 28 | 103 |
| Embodiment 14 groups | 12 | 22 | 85 |
| Embodiment 15 groups | 7 | 13 | 25 |
From upper table data, adopt the embodiment 1-9 group of quick hemostatic dressing of the present invention, haemostatic effect is best.Especially when measuring the bleeding stopping period of the larger hind leg femoral artery of bleeding capacity, quick hemostatic dressing of the present invention has good haemostatic effect, hemostasis can be realized within a short period of time, its anthemorrhagic speed is better than hemostatic material of the prior art greatly, be applicable to acute emergent management of bleeding profusely, and the bleeding-stopping dressing anthemorrhagic speed adopting foaming technique to obtain is more rapid.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still within protection scope of the present invention.
Claims (4)
1. a quick hemostatic dressing, is characterized in that, is made up of the raw material components of following weight portion: chitosan 30-100 part, heparin sodium 2-30 part, collagen protein 10-80 part, aloin 10-80 part; Described bleeding-stopping dressing be by described each raw material components is mixed be incorporated in 100-200 DEG C of vacuum condition under carry out the foaming mode of process obtained;
Its preparation method is:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: by above-mentioned raw materials mixture under vacuo, control temperature 100-200 DEG C is carried out foamable process 1-3h;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product;
Wherein, the particle diameter of described aloin granule is 100-1000nm;
Described aloin be aloe leaf under the vacuum of-50 DEG C, pulverize the nano-particle obtained after lyophilization;
Under described foaming is treated to the vacuum of 150 DEG C, heating 1h;
Described sterilization steps is uniform irradiation 36-72 hour under gamma-rays.
2. quick hemostatic dressing according to claim 1, is characterized in that, is made up of the raw material components of following weight portion: chitosan 40-70 part, heparin sodium 3-10 part, collagen protein 10-30 part, aloin 10-30 part.
3. quick hemostatic dressing according to claim 1 and 2, is characterized in that, is made up of the raw material of following weight portion: chitosan 60 parts, heparin sodium 5 parts, collagen protein 20 parts, aloin 18 parts.
4. the preparation method of the quick hemostatic dressing according to any one of claim 1-3, is characterized in that, has following steps:
(1) batch mixing: get the mixing of chitosan, heparin sodium, collagen protein and aloin according to selected parts by weight;
(2) foaming process: by above-mentioned raw materials mixture under vacuo, control temperature 100-200 DEG C is carried out foamable process 1-3h;
(3) maturation: raw material step (2) obtained, cools under being placed in room temperature, obtains cotton piece of stopping blooding;
(4) the hemostasis cotton piece distilled water that step (3) obtains is cleaned, be processed into dry, sterilizing after required form, obtain final product; Under described foaming is treated to the vacuum of 150 DEG C, heating 1h; Described sterilization steps is uniform irradiation 36-72 hour under gamma-rays.
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| CN108553681A (en) * | 2018-04-24 | 2018-09-21 | 江西省科学院应用化学研究所 | A kind of hemostasis medical dressing and preparation method thereof |
| CN109045345A (en) * | 2018-08-29 | 2018-12-21 | 佛山市森昂生物科技有限公司 | A kind of biological hemostatic powder and preparation method thereof |
| CN112535761A (en) * | 2020-12-28 | 2021-03-23 | 苏州举健生物科技有限公司 | Antibacterial hemostatic healing-promoting gel, preparation method and application thereof |
| CN114848886A (en) * | 2022-06-08 | 2022-08-05 | 扬州卓和医用材料有限公司 | Absorbable hemostatic dressing |
| CN114949327A (en) * | 2022-06-15 | 2022-08-30 | 扬州卓和医用材料有限公司 | Bactericidal rapid hemostatic dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1119133C (en) * | 2001-12-27 | 2003-08-27 | 唐宝辉 | Process for producing absorption styptic sponge used in operation |
| CN1425471A (en) * | 2003-01-10 | 2003-06-25 | 青岛海大吉秀生物制品有限公司 | Medical dressing for wound heeling sponge of biological compound formulation and its preparing method |
| RU2254145C1 (en) * | 2003-10-14 | 2005-06-20 | "Красноярская государственная медицинская академия Министерства здравоохранения Российской Федерации" (ГОУ ВПО КРАСГМА МИНЗДРАВА РОССИИ) | Wound coat based on collagen-chitosan complex |
| CN100387308C (en) * | 2005-11-30 | 2008-05-14 | 合肥恒星医疗用品有限公司 | Wet wound dressing containing plant effective ingredient |
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Effective date of registration: 20160912 Address after: 433000 No. 27 textile Avenue, Xiantao Industrial Park, Hubei Province Patentee after: Hubei Xianming Medical Devices Co., Ltd. Address before: 518104, No. 267-269, Wan An Road, Wan Feng Village, manholes Town, Guangdong, Shenzhen Patentee before: Wang Xianzong |