CN114949327A - Bactericidal rapid hemostatic dressing and preparation method thereof - Google Patents
Bactericidal rapid hemostatic dressing and preparation method thereof Download PDFInfo
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- CN114949327A CN114949327A CN202210672797.4A CN202210672797A CN114949327A CN 114949327 A CN114949327 A CN 114949327A CN 202210672797 A CN202210672797 A CN 202210672797A CN 114949327 A CN114949327 A CN 114949327A
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- hemostatic dressing
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- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 54
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 42
- 244000089795 Clausena lansium Species 0.000 claims abstract description 29
- 235000008738 Clausena lansium Nutrition 0.000 claims abstract description 29
- 241001265525 Edgeworthia chrysantha Species 0.000 claims abstract description 23
- 230000001954 sterilising effect Effects 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 17
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920002101 Chitin Polymers 0.000 claims abstract description 15
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 10
- 229920000742 Cotton Polymers 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 21
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 12
- 238000001704 evaporation Methods 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000000227 grinding Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 238000000643 oven drying Methods 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 10
- 238000005187 foaming Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 239000012153 distilled water Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 230000023597 hemostasis Effects 0.000 abstract description 6
- 230000008961 swelling Effects 0.000 abstract description 5
- 230000035876 healing Effects 0.000 abstract description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 231100000241 scar Toxicity 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000001678 irradiating effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 241001265524 Edgeworthia Species 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 208000023329 Gun shot wound Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000009306 yunnan baiyao Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a sterilization rapid hemostasis dressing and a preparation method thereof. The material comprises the following raw materials in parts by weight: 50-100 parts of hydroxyethyl chitin, 30-80 parts of ossein, 5-10 parts of a clausena lansium root extract and 5-10 parts of a edgeworthia chrysantha extract. The hemostatic dressing prepared by the invention has good antibacterial performance, can effectively avoid wound swelling and infection after hemostasis, and leaves little scar after healing; the combined use of the clausena lansium root extract and the edgeworthia chrysantha extract improves the hemostasis time, and the combined use has synergistic effect.
Description
Technical Field
The invention belongs to the technical field of preparation of dressing materials, and particularly relates to a sterilization and rapid hemostasis dressing and a preparation method thereof.
Background
The novel healing liquid is suitable for wound surfaces of trauma, ulcer, fistula and the like, can directly soak gauze to cover the skin wound, and can be used after debridement if the wound surface is large. Yunnan Baiyao is suitable for stopping bleeding and relieving swelling of knife wound, gunshot wound and traumatic injury, and can be directly applied to affected parts. The hemostatic dressings in various forms have the problems of long hemostatic time, easy infection and bacterial inflammation, overlong soaking time of wound tissue fluid, swelling, difficult absorption of hemostatic dressing materials, large scars after wound healing and the like.
The radix Clausenae Lansii is root of Clausena lansium of Rutaceae, and has effects of relieving swelling, relieving pain, promoting urination, treating jaundice, malaria, and preventing influenza. The edgeworthia chrysantha is a plant and shrub of edgeworthia of the daphneceae family, is a special famous flower in China, can be used for flower or leaf observation cultivation, is an important economic tree species, has higher economic value for flowers, barks, branches and roots, has higher medicinal value, can be used as a medicine for the whole plant, has the effects of resisting bacteria, inhibiting bacteria, diminishing inflammation and the like, has the effect of dispelling wind and improving eyesight, and can be used for treating rheumatic arthralgia, lumbago, traumatic injury and the like for the roots and the leaves. At present, no report of preparing the hemostatic dressing by compounding the clausena lansium root and the edgeworthia chrysantha exists.
Disclosure of Invention
The invention aims to provide a rapid sterilization hemostatic dressing and a preparation method thereof.
The bactericidal rapid hemostatic dressing comprises the following raw material components in parts by weight: 50-100 parts of hydroxyethyl chitin, 30-80 parts of ossein, 5-10 parts of clausena lansium root extract and 5-10 parts of edgeworthia chrysantha extract.
The preparation method of the clausena lansium root extract comprises the following steps:
(1) oven drying root of Clausena lansium, and grinding into powder;
(2) adding 50-80% ethanol water solution 3-6 times by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dry.
The preparation method of the edgeworthia chrysantha extract comprises the following steps:
(1) oven drying root of lignum Aquilariae Resinatum, and grinding into powder;
(2) adding 50-80% ethanol water solution 3-6 times by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dry.
The preparation method of the absorbable hemostatic dressing comprises the following steps:
(1) according to the weight parts, 50-100 parts of hydroxyethyl chitin, 30-80 parts of ossein, 5-10 parts of a clausena lansium root extract and 5-10 parts of a edgeworthia chrysantha extract are uniformly mixed under the condition of stirring;
(2) heating and foaming the raw material mixture prepared in the step (1) for 1-3h under the vacuum condition at the temperature of 80-150 ℃;
(3) cooling the material prepared in the step (2) at room temperature to obtain hemostatic cotton sheets;
(4) and (4) cleaning the hemostatic cotton sheet prepared in the step (3) with distilled water, processing into a required shape, drying and sterilizing to obtain the hemostatic cotton sheet.
The stirring speed in the step (1) is 400-1000rpm, and the stirring time is 10-30 min.
And (3) heating for 1.5 hours at the foaming treatment of step (2) under the vacuum of 100 ℃.
The sterilization is high-temperature instantaneous sterilization at 121 ℃ for 15 s.
The sterilization is to uniformly irradiate for 36-72h under gamma rays.
The invention has the beneficial effects that: the hemostatic dressing prepared by the invention has good antibacterial performance, can effectively avoid wound swelling and infection after hemostasis, and leaves little scar after healing; the combined use of the clausena lansium root extract and the edgeworthia chrysantha extract improves the hemostasis time, and the combined use has synergistic effect.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Example 1
The bactericidal rapid hemostatic dressing comprises the following raw material components in parts by weight: 80 parts of hydroxyethyl chitin, 60 parts of ossein, 8 parts of a clausena lansium root extract and 8 parts of a edgeworthia chrysantha extract.
The preparation method of the clausena lansium root extract comprises the following steps:
(1) oven drying root of Clausena lansium, and grinding into powder;
(2) adding 4 times of 60% ethanol water solution by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dryness.
The preparation method of the edgeworthia chrysantha extract comprises the following steps:
(1) oven drying root of lignum Aquilariae Resinatum, and grinding into powder;
(2) adding 4 times of 60% ethanol water solution by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dryness.
The preparation method of the absorbable hemostatic dressing comprises the following steps:
(1) according to the weight parts, 80 parts of hydroxyethyl chitin, 60 parts of ossein, 8 parts of clausena lansium extract and 8 parts of edgeworthia chrysantha extract are uniformly mixed under the condition of stirring; the stirring speed is 800rpm, and the stirring time is 20 min;
(2) heating and foaming the raw material mixture prepared in the step (1) for 1.5h under a vacuum condition at a controlled temperature of 100 ℃;
(3) cooling the material prepared in the step (2) at room temperature to obtain hemostatic cotton sheets;
(4) cleaning the hemostatic cotton sheet prepared in the step (3) with distilled water, processing into a required shape, drying and sterilizing to obtain the hemostatic cotton sheet; the sterilization is carried out by uniformly irradiating for 48h under gamma rays.
Example 2
The bactericidal rapid hemostatic dressing comprises the following raw material components in parts by weight: 50 parts of hydroxyethyl chitin, 32 parts of ossein, 6 parts of a clausena lansium root extract and 6 parts of a edgeworthia chrysantha extract.
The preparation method of the clausena lansium root extract comprises the following steps:
(1) oven drying root of Clausena lansium, and grinding into powder;
(2) adding 50% ethanol water solution with 3 times weight parts, reflux extracting for 3 times, mixing filtrates, and evaporating to dryness.
The preparation method of the edgeworthia chrysantha extract comprises the following steps:
(1) oven drying root of lignum Aquilariae Resinatum, and grinding into powder;
(2) adding 50% ethanol water solution with 3 times weight parts, reflux extracting for 3 times, mixing filtrates, and evaporating to dryness.
The preparation method of the absorbable hemostatic dressing comprises the following steps:
(1) according to the weight parts, 50 parts of hydroxyethyl chitin, 32 parts of ossein, 6 parts of a clausena lansium extract and 6 parts of a edgeworthia chrysantha extract are uniformly mixed under the stirring condition; the stirring speed is 400rpm, and the stirring time is 30 min;
(2) heating and foaming the raw material mixture prepared in the step (1) for 3 hours under a vacuum condition at a temperature of 80 ℃;
(3) cooling the material prepared in the step (2) at room temperature to obtain hemostatic cotton sheets;
(4) cleaning the hemostatic cotton sheet prepared in the step (3) with distilled water, processing into a required shape, drying and sterilizing to obtain the hemostatic cotton sheet; the sterilization is high-temperature instantaneous sterilization at 121 ℃ for 15 s.
Example 3
The bactericidal rapid hemostatic dressing comprises the following raw material components in parts by weight: 100 parts of hydroxyethyl chitin, 80 parts of ossein, 10 parts of a clausena lansium root extract and 10 parts of a edgeworthia chrysantha extract.
The preparation method of the clausena lansium root extract comprises the following steps:
(1) oven drying root of Clausena lansium, and grinding into powder;
(2) adding 80% ethanol water solution 5 times the weight of the raw materials, reflux-extracting for 3 times, mixing filtrates, and evaporating to dryness.
The preparation method of the edgeworthia chrysantha extract comprises the following steps:
(1) oven drying root of lignum Aquilariae Resinatum, and grinding into powder;
(2) adding 80% ethanol water solution 5 times the weight of the raw materials, reflux-extracting for 3 times, mixing filtrates, and evaporating to dryness.
The preparation method of the absorbable hemostatic dressing comprises the following steps:
(1) according to the weight parts, 100 parts of hydroxyethyl chitin, 80 parts of ossein, 10 parts of a clausena lansium root extract and 10 parts of a edgeworthia chrysantha extract are uniformly mixed under the stirring condition; the stirring speed is 1000rpm, and the stirring time is 10 min;
(2) heating and foaming the raw material mixture prepared in the step (1) for 1h under the vacuum condition at the temperature of 140 ℃;
(3) cooling the material prepared in the step (2) at room temperature to obtain hemostatic cotton sheets;
(4) cleaning the hemostatic cotton sheet prepared in the step (3) with distilled water, processing into a required shape, drying and sterilizing to obtain the hemostatic cotton sheet; the sterilization is uniform irradiation for 60h under gamma rays.
Comparative example 1
The bactericidal rapid hemostatic dressing comprises the following raw material components in parts by weight: 80 parts of hydroxyethyl chitin, 60 parts of ossein and 16 parts of a clausena lansium root extract.
The preparation method of the clausena lansium root extract comprises the following steps:
(1) oven drying root of Clausena lansium, and grinding into powder;
(2) adding 4 times of 60% ethanol water solution by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dryness.
The preparation method of the absorbable hemostatic dressing comprises the following steps:
(1) according to the weight parts, 80 parts of hydroxyethyl chitin, 60 parts of ossein and 16 parts of clausena lansium extract are taken and mixed evenly under the stirring condition; the stirring speed is 800rpm, and the stirring time is 20 min;
(2) heating and foaming the raw material mixture prepared in the step (1) for 1.5h under a vacuum condition at a controlled temperature of 100 ℃;
(3) cooling the material prepared in the step (2) at room temperature to obtain hemostatic cotton sheets;
(4) cleaning the hemostatic cotton sheet prepared in the step (3) with distilled water, processing into a required shape, drying and sterilizing to obtain the hemostatic cotton sheet; the sterilization is carried out by uniformly irradiating for 48h under gamma rays.
Example 2
The bactericidal rapid hemostatic dressing comprises the following raw material components in parts by weight: 80 parts of hydroxyethyl chitin, 60 parts of ossein and 16 parts of edgeworthia chrysantha extract.
The preparation method of the edgeworthia chrysantha extract comprises the following steps:
(1) oven drying root of lignum Aquilariae Resinatum, and grinding into powder;
(2) adding 4 times of 60% ethanol water solution by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dryness.
The preparation method of the absorbable hemostatic dressing comprises the following steps:
(1) according to the weight parts, 80 parts of hydroxyethyl chitin, 60 parts of ossein and 16 parts of edgeworthia chrysantha extract are taken and mixed evenly under the stirring condition; the stirring speed is 800rpm, and the stirring time is 20 min;
(2) heating and foaming the raw material mixture prepared in the step (1) for 1.5h under a vacuum condition at a controlled temperature of 100 ℃;
(3) cooling the material prepared in the step (2) at room temperature to obtain hemostatic cotton sheets;
(4) cleaning the hemostatic cotton sheet prepared in the step (3) with distilled water, processing into a required shape, drying and sterilizing to obtain the hemostatic cotton sheet; the sterilization is carried out by uniformly irradiating for 48h under gamma rays.
Experimental example:
150 Belgian rabbits with the weight of 6.0-6.3kg are selected and randomly divided into 5 groups, 8 rabbits in each group are marked as examples 1-5 groups respectively, each rabbit cuts two thirds of the veins of the left ear margin and the arteries of the right ear margin, free bleeding is carried out for 5s, and after 5s, different hemostatic dressings are respectively used for compressing wounds. The hemostatic dressings used in the experiments are all cut into cuboid blocks with the length of being multiplied by the width of being multiplied by the height of being multiplied by 5cm multiplied by 2cm, the left ear marginal vein hemostatic time(s) and the right ear marginal artery hemostatic time(s) are recorded, and the experimental results are shown in table 1:
TABLE 1
Note: represents p <0.05 compared to control group
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. The bactericidal rapid hemostatic dressing is characterized by comprising the following raw material components in parts by weight: 50-100 parts of hydroxyethyl chitin, 30-80 parts of ossein, 5-10 parts of a clausena lansium root extract and 5-10 parts of a edgeworthia chrysantha extract.
2. The absorbable hemostatic dressing of claim 1, wherein the clausena lansium root extract is prepared by:
(1) oven drying root of Clausena lansium, and grinding into powder;
(2) adding 50-80% ethanol water solution 3-6 times by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dry.
3. The absorbable hemostatic dressing of claim 1, wherein the edgeworthia chrysantha extract is prepared by:
(1) oven drying root of lignum Aquilariae Resinatum, and grinding into powder;
(2) adding 50-80% ethanol water solution 3-6 times by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dry.
4. The method of making the absorbable hemostatic dressing of claim 1, comprising the steps of:
(1) according to the weight parts, 50-100 parts of hydroxyethyl chitin, 30-80 parts of ossein, 5-10 parts of a clausena lansium root extract and 5-10 parts of a edgeworthia chrysantha extract are uniformly mixed under the condition of stirring;
(2) heating and foaming the raw material mixture prepared in the step (1) for 1-3h under the vacuum condition at the temperature of 80-150 ℃;
(3) cooling the material prepared in the step (2) at room temperature to obtain hemostatic cotton sheets;
(4) and (4) cleaning the hemostatic cotton sheet prepared in the step (3) with distilled water, processing into a required shape, drying and sterilizing to obtain the hemostatic cotton sheet.
5. The method for preparing an absorbable hemostatic dressing according to claim 4, wherein the stirring rate in step (1) is 400-1000rpm and the stirring time is 10-30 min.
6. The method for preparing the absorbable hemostatic dressing of claim 4, wherein the foaming process of step (2) is performed by heating at 100 ℃ for 1.5h under vacuum.
7. The method for preparing the absorbable hemostatic dressing of claim 4, wherein the sterilization is 121 ℃ high temperature transient sterilization for 15 s.
8. The method for preparing the absorbable hemostatic dressing of claim 4, wherein the sterilization is performed by irradiation with gamma rays for 36-72 h.
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