CN101284145A - Medical dressing and its preparation method and application - Google Patents
Medical dressing and its preparation method and application Download PDFInfo
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- CN101284145A CN101284145A CNA2008100474002A CN200810047400A CN101284145A CN 101284145 A CN101284145 A CN 101284145A CN A2008100474002 A CNA2008100474002 A CN A2008100474002A CN 200810047400 A CN200810047400 A CN 200810047400A CN 101284145 A CN101284145 A CN 101284145A
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Abstract
The invention discloses a dressing for medical use, a preparation method and an application thereof. The dressing comprises one or more of chitin derivative, chitosan derivative or water soluble chitin 1-100 wt%, water 0-99 wt%, and filler 0-60 wt%. The preparation method comprises respectively dissolving one or more of the chitin derivative, chitosan derivative or water soluble chitin into water to obtain 0.5-10 wt% aqueous solution, mixing intensively, adding 0-15 wt% filler, mixing intensively, vacuum de-bubbling to obtain hydrocolloid dressing, and subsequently obtaining filmy dressing, spongeous dressing or non-woven fabric dressing. The preparation method has simple process, and can be used for restoring skin wound such as operative incision in clinic, skin graft region, burn, scald, ulcer or bedsore.
Description
Technical field
The present invention relates to a kind of medical dressing and its production and use, belong to field of medical products, also belong to technical field of biological material.
Background technology
Medical dressing is the material that is used for covering wound.Their topmost functions are the transudates of control wound and protect wound to avoid the pollution of antibacterial and grit.Before the better document record of healing effect can be traced back to 4500 after wound surface covered, the development through several thousand a large amount of dissimilar dressing occurred to today, but for a long time, the wound dressing design is a prerequisite based on the drying that keeps wound all.This idea obtains the transformation of essence after the sixties in last century.British Winter in 1962 find wound under dampness than healing soon under the drying regime, henceforth " wet method therapy " becomes the main theoretical basis of new medical dressing design gradually.Begin western developed country from the eighties in last century and developed commodity Versiva by name and bearing hydrocolloid dressing, the commodity Aquacel by name of Granuflex and the dressing of Kaltostat that the ConvaTec company of novel wound dressing of a series of high-tech based on the wet method therapy such as Britain produces, the dressing of the commodity that Courtaulds company produces Sorbsan by name, Smith; The dressing of the commodity that Nephew company produces Algisite by name, the gauze dressing of the commodity that Minnesota Mining and Manufacturing Company produces Tegagen by name, the sheet-like hydrous gel of the commodity that U.S. Bard company produces Vigilon by name etc., these dressing have mainly used water miscible polysaccharide or derivatives thereof such as carboxymethyl cellulose, sodium alginate, pectin, protein such as gelatin, collagen protein and fibrin, and synthetic high polymer such as polyurethane and crosslinked poly(ethylene oxide) etc.Although these dressing effects are better, all there is deficiency, low as the alginate dressing strength, the sodium ion of wound and Dressing Room and calcium ion-exchanged easily cause the dressing dissolving and the anti-microbial property of not having; Protein such as gelatin reach except intensity is relatively poor not to have the defective of antibacterial activity, makes it also have the certain immunogenicity and the danger of transmitted virus owing to it comes from the xenogenesis mammal.
Chitin (chitin) is 1, and 2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-callose that 4-connects extensively is present in insecticide, Crustaceans and the fungal cell wall, and about 10,000,000,000 tons of year biosynthesis amount is that occurring in nature content is only second to cellulosic natural polysaccharide.Chitosan (chitosan) is the derivant of de-acetyl chitin; generally be used for the polysaccharide of medical dressing such as cellulose, starch and sodium alginate etc. with other and be not both 2 of its saccharide residues for amino; the structure of this unique molecular is given its impayable peculiar biological activity.The performances such as to studies show that chitin and chitosan in a large number both at home and abroad nontoxic except having, excellent biological compatibility and biological degradability, also have hemostasis, analgesia, short through wound healing, suppress cicatrix and property such as antibiotic.In recent years, to chitin and chitosan in the research Showed Very Brisk aspect the wound covering.Up to the present, the patent application aspect, about nearly 200 of the patent of the wound dressing of using chitosan and chitin, it mainly is to adopt chitin and chitosan material powder or make non-woven fabrics, sponge, film, hydrogel and liquid dressing etc. over past ten years.The product aspect, it is the dried small shrimps binder with quick-acting haemostatic powder effect of raw material that the U.S. " Hai Mukang " company has succeeded in developing with the chitosan, equips our troops in the Gulf War and gets most of the attention; At Japan's five kinds of novel wound dressings that make by chitin and chitosan that gone on the market: Beschitin W, Beschitin F, Chitipack C, Chitipack S and ChitipackP.The product of China's listing mainly contains the road An Pushu of the biomaterial Science and Technology Ltd. carboxymethyl chitosan repair membrane (CN1500525A) that Mengcheng County, Anhui Lutao company is health skin peace Shenzhen sunlight of manufacture of materials with the chitin.Yet these patents and the product overwhelming majority use chitin and chitosan raw material itself and simple modified product to prepare wound dressing, and dressing constituent is single, thereby performance is also single.As because chitosan and chitin are water insoluble, thereby and wound location interact and relatively lowly can not fully realize its short more effect and anti-microbial property.Therefore chitosan dressing generally all is to make after chitosan is dissolved in diluted acid at present.Although it has antibiotic resistance performance, too high acidity (pH 3-5) causes serious stimulation to wound and causes patient's discomfort and influence wound healing; Chitosan and the chitin imbibition ability of preserving moisture is also limited in addition, is difficult to satisfy the requirement of " wet method therapy ".Wu Yiguang (CN 1500525A) makes the ionic chitin derivativ in Zhunyang although introduce carboxymethyl in chitosan, because its carboxy methylation degree is low thereby still can only be dissolved in the acid solution, has zest greatly with its made dressing.People (CN1813786A such as Liu Wan Shun in recent years, CN101049513A, CN101053669A, CN1887358A), people such as Wu Qingji (CN1833731A, CN1833732A) also adopt carboxymethyl chitosan or carapace usually to prepare hydrogel, fiber, type dressing such as sponge, but all not to the structure such as the molecular weight of carboxymethyl chitin or chitosan material, deacetylation and carboxy methylation degree are controlled, the Acidity of Aikalinity that does not also have control material, thereby all can not reach comparatively ideal effect, too much amino can make wound location inflammatory reaction aggravation in the dressing, too high or too low acidity produces wound to stimulate, and molecular weight and substitution value can have a strong impact on the maintenance and the healing rate generation of the moistening degree of wound location.Thereby these technology have all limited chitin and the application of chitosan in wound repair.
Summary of the invention
Purpose of the present invention just provides a kind of preparation method of medical dressing, preparation has the medical dressing of ad hoc structure and pH, this dressing and skin-friendliness are good, skin is had no stimulation, energy efficient absorption wound fluid, keep the wound surface moist environment, and have analgesia, promote wound healing, suppress cicatrization and function such as antibiotic, can perfect reparation wound.
Realize that the technical scheme that the object of the invention adopts is: medical dressing of the present invention comprises one or more of the chitin derivativ, chitosan derivatives or the water-soluble chitosan that account for gross mass 5%～100%, the quality percentage composition is 1%～99% water, and the quality percentage composition is 0～60% filler.
Described dressing is hydrocolloid shape, membranaceous, spongy or for adhesive-bonded fabric dressing, when containing chitin derivativ in the dressing, the mass percent concentration of chitin derivativ is 5～10% in membranaceous dressing, spongy dressing or the adhesive-bonded fabric dressing.
Described filler is a kind or 2 kinds or 3 kinds or 4 kinds among glycerol, propylene glycol, butanediol and the PEG400.
At least contain a kind of molecular weight in the described medical dressing greater than 200,000 chitin derivativ, chitosan derivatives or water-soluble chitosan, wherein used chitin derivativ is carboxymethyl chitin, ethoxyl chitin and Chitofilmer, chitosan derivatives is carboxymethyl chitosan, hydroxyethyl chitosan or hydroxypropyl chitosan, wherein the carboxymethyl chitosan molecular weight is 1000～2000,000, deacetylation is 70%～99%, the carboxy methylation degree is that the substitution value of 0.5～1.5,6 hydroxyls is greater than 0.5; The carboxymethyl chitin molecular weight is 1000～3000,000, and deacetylation is 5%～60%, and the carboxy methylation degree is being that the substitution value of 0.5～1.2,6 hydroxyls is greater than 0.5; Hydroxyethyl chitosan, hydroxypropyl chitosan, ethoxyl chitin or Chitofilmer molecular weight are 1000～2000, and between 000, the substitution value substitution value of 6 hydroxyls is 0.4～1.0; The water-soluble chitosan molecular weight is 1000～2000,000, and deacetylation is 40%-60%.
Above-mentioned medical dressing prepares by following steps: with the water-soluble respectively mass percent concentration that is made into of one or more of chitin derivativ, chitosan derivatives or water-soluble chitosan is 0.5～10% aqueous solution, with a kind of solution stirring of obtaining evenly or several aqueous solution that obtain respectively even, be 0～15% adding filler by the quality percentage composition again, filler is a kind or 2 kinds or 3 kinds or 4 kinds among glycerol, propylene glycol, butanediol and the PEG400, abundant mix homogeneously, vacuum deaerator obtains bearing hydrocolloid dressing.With bearing hydrocolloid dressing curtain coating or coating film forming in rustless steel or mould of plastics, oven dry or shady and cool natural drying make membranaceous dressing under temperature is lower than 80 ℃; Perhaps bearing hydrocolloid dressing is loaded in rustless steel or the mould of plastics, in-10 ℃～-60 ℃ freezing, place the vacuum freeze drier lyophilization to obtain spongy dressing then; To be the aqueous solution of 30%～100% ethanol, acetone or ether mixed liquor or to contain mass percent be 1～10%CaCl in percent by volume under the bearing hydrocolloid dressing room temperature perhaps
2Or Ca (HCO
3)
2Adopt solution spinning to prepare fiber in the solidification liquid of the mixed liquor of the ethanol of aqueous solution, acetone or ether, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls dozen sheet again and makes adhesive-bonded fabric dressing.
Medical dressing pH value of the present invention is between 6～7.5, and the pH value of human body fluid is about 7.2-7.4, the pH value of this dressing is near the pH value of human body fluid, can reduce stimulation on the one hand to wound, well compatible with wound, cytokine is in this pH value and also can keeps maximum vigor on the other hand, and the repair ability of cell is also the strongest, so the dressing that pH is between the 6-7.5 is more suitable for using in the reparation of skin wound.
The present invention adopts one or more of carboxymethyl chitin/chitosan, ethoxyl chitin/chitosan, Chitofilmer/chitosan and water-soluble chitosan kind of ad hoc structure.The carboxymethyl chitosan molecular weight is 1000～2000,000, and deacetylation is 70%～99%, and the carboxy methylation degree is that the substitution value of 0.5～1.5,6 hydroxyls is greater than 0.5; The carboxymethyl chitin molecular weight is 1000～3000,000, and deacetylation is 5%～60%, and the carboxy methylation degree is being that the substitution value of 0.5～1.2,6 hydroxyls is greater than 0.5; Hydroxyethyl chitosan, hydroxypropyl chitosan, ethoxyl chitin or Chitofilmer molecular weight are 1000～2000, and between 000, the substitution value substitution value of 6 hydroxyls is 0.4～1.0; The water-soluble chitosan molecular weight is 1000～2000,000, and deacetylation is 40%-60%.Adopt the feedstock production wound dressing of these ad hoc structures, can make dressing have best suction and blend the moistening ability of wound that keeps, make cytokine that wound location oozes out, enzyme, protein etc. be in activated state, thereby better promote wound healing, and the very big macromolecule component of the molecular weight that contains in the dressing, make dressing also have excellent intensity and elasticity, so applicable to each position of health at hygrometric state; Contain oligomer in addition in the dressing and be easier to absorb, control then antibiotic property, short and analgesic effect, inhibition cicatrix ability and the balance inflammatory reaction of scalable dressing of content of free amino group by the proportioning of optimizing the dressing composition.So the medical dressing that the present invention makes is used for the reparation of skin traumas such as operative incision, bark fetching district, burn, scald, ulcer, decubital ulcer clinically.
Advantage of the present invention is: optimization and control dressing constituent structure and prescription make dressing have the pH value suitable with human body fluid, minimum zest, the moisture-absorbing moisture-keeping performance of excellence, higher intensity and elasticity, has better antibiotic property, and can balance inflammatory reaction, short and analgesia and suppress cicatrization, be applicable to the reparation of the skin traumas such as operative incision, bark fetching district, burn, scald, ulcer, decubital ulcer at outside each position of health.
The specific embodiment
Embodiment 1:
Get molecular weight 2,860,000, deacetylation 15%, carboxy methylation degree are that the carboxymethyl chitin 25g of the substitution value 0.6 of 0.7,6 hydroxyl is dissolved in that to obtain mass percent in the 4975ml distilled water be 0.5% solution; Getting molecular weight is 480,000, and deacetylation is 15%, and substitution value is 0.5 ethoxyl chitin, 100 grams, is dissolved in that to obtain mass percent in the 3900ml distilled water be 4% solution; Getting molecular weight is 1500, and deacetylation is 98%, and the carboxy methylation degree is carboxymethyl chitosan 50 gram of the substitution value 0.97 of 1.45,6 hydroxyls, is dissolved in that to obtain mass percent in the 450ml distilled water be 10% solution.Behind three solution chamber's relaxing the bowels with purgatives of warm nature mix homogeneously, add glycerol 160ml, isopropyl alcohol 100ml continues the mix homogeneously vacuum deaerator and gets bearing hydrocolloid dressing, pH value 7.2.
With above-mentioned hydrocolloid curtain coating or coating film forming in rustless steel or mould of plastics, make membranaceous dressing at 70 ℃ of baking 6h.
Above-mentioned hydrocolloid is loaded in rustless steel or the mould of plastics, in-20 ℃ freezing, make porous spongy dressing in the vacuum freeze drier lyophilization then.
To be 1～10%CaCl containing mass percent concentration under the above-mentioned hydrocolloid room temperature
2Or Ca (HCO
3)
2Percent by volume be to adopt solution spinning to prepare fiber in the solidification liquid of 50% ethanol water, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls to beat sheet and make adhesive-bonded fabric dressing again.
Embodiment 2:
Get molecular weight 1,890,000, deacetylation 70%, carboxy methylation degree are the carboxymethyl chitosan 50g of the substitution value 0.6 of 0.65,6 hydroxyl, are dissolved in that to obtain mass percent in the 4950ml distilled water be 1% solution; Getting molecular weight is 450,000, substitution value is 0.8, deacetylation is that 15% Chitofilmer, 100 grams and molecular weight are 30,000, deacetylation is 5%, the carboxy methylation degree is that the substitution value of 1.45,6 hydroxyls is that 0.95 carboxymethyl chitin 50g is dissolved in that to obtain mass percent in the 2350ml distilled water be 6% solution.Behind the above solution chamber relaxing the bowels with purgatives of warm nature mix homogeneously, add glycerol 200ml, PEG400100g continues mix homogeneously, gets bearing hydrocolloid dressing, pH value 6.8.
With above-mentioned bearing hydrocolloid dressing curtain coating or coating film forming in rustless steel or mould of plastics, dry in room temperature and to make membranaceous dressing.
Above-mentioned bearing hydrocolloid dressing is loaded in rustless steel or the mould of plastics, in-10 ℃ freezing, make porous spongy dressing in the vacuum freeze drier lyophilization then.
To be 1～10%CaCl containing mass percent under the above-mentioned bearing hydrocolloid dressing room temperature
2Or Ca (HCO
3)
2Percent by volume be to adopt solution spinning to prepare fiber in the solidification liquid of 50% methanol aqueous solution, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls to beat sheet and make adhesive-bonded fabric dressing again.
Embodiment 3:
Getting molecular weight is 1,920,000, and deacetylation is 52% water-soluble chitosan 50 gram, is dissolved in that to obtain mass percent in the 4950ml distilled water be 1% solution; Get molecular weight 450,000, deacetylation 85%, carboxy methylation degree are that the carboxymethyl chitosan 100g of the substitution value 0.85 of 1.1,6 hydroxyls is dissolved in that to obtain mass percent in the 1900ml distilled water be 5% solution; Get molecular weight 600,000, deacetylation 85%, substitution value are that 0.9 hydroxyethyl chitosan 50g is dissolved in that to obtain mass percent in the 950ml distilled water be 5% solution; Behind the above solution chamber relaxing the bowels with purgatives of warm nature mix homogeneously, add glycerol 600ml, butanediol 100ml continues mix homogeneously and gets bearing hydrocolloid dressing, and pH is 6.2.
With above-mentioned bearing hydrocolloid dressing curtain coating or coating film forming in rustless steel or mould of plastics, make membranaceous dressing at 50 ℃ of baking 8h.
Above-mentioned bearing hydrocolloid dressing is loaded in rustless steel or the mould of plastics, in-40 ℃ freezing, make porous spongy dressing in the vacuum freeze drier lyophilization then.
To be 1～10%CaCl containing mass percent under the above-mentioned bearing hydrocolloid dressing room temperature
2Or Ca (HCO
3)
2Percent by volume be to adopt solution spinning to prepare fiber in 1: 1: 1 the solidification liquid of ethanol-acetone-water mixed solution, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls to beat sheet and make adhesive-bonded fabric dressing again.
Embodiment 4:.
Get molecular weight 650,000, deacetylation 25%, carboxy methylation degree are that the carboxymethyl chitin 50g of the substitution value 0.85 of 1.1,6 hydroxyls is dissolved in that to obtain mass percent in the 950ml distilled water be 5% carboxymethyl chitosan sugar juice; Getting molecular weight is 920,000, and deacetylation is 52% water-soluble chitosan 100 gram, is dissolved in that to obtain mass percent in the 4900ml distilled water be 2% water-soluble chitosan solution.Behind the above solution chamber relaxing the bowels with purgatives of warm nature mix homogeneously, add glycerol 300ml, propylene glycol 200ml continues mix homogeneously and promptly gets bearing hydrocolloid dressing, and pH is 6.5.
With above-mentioned bearing hydrocolloid dressing curtain coating or coating film forming in rustless steel or mould of plastics, make membranaceous dressing at 50 ℃ of baking 8h.
Above-mentioned bearing hydrocolloid dressing is loaded in rustless steel or the mould of plastics, in-20 ℃ freezing, make porous spongy dressing in the vacuum freeze drier lyophilization then.
To be 1～10%CaCl containing mass percent under the above-mentioned bearing hydrocolloid dressing room temperature
2Or Ca (HCO
3)
2Percent by volume be to adopt solution spinning to prepare fiber in the solidification liquid of 50% ethanol water, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls to beat sheet and make adhesive-bonded fabric dressing again.
Embodiment 5:
Get molecular weight 1,750,000, deacetylation 15%, the substitution value degree is that 0.55 Chitofilmer 50g is dissolved in that to obtain mass percent in the 4950ml distilled water be 1% solution, add glycerol 160ml then, isopropyl alcohol 100ml, butanediol 100ml continues the mix homogeneously vacuum deaerator and gets bearing hydrocolloid dressing, pH value 7.0.
With above-mentioned bearing hydrocolloid dressing curtain coating or coating film forming in rustless steel or mould of plastics, make membranaceous dressing at 70 ℃ of baking 6h.
Above-mentioned bearing hydrocolloid dressing is loaded in rustless steel or the mould of plastics, in-60 ℃ freezing, make porous spongy dressing in the vacuum freeze drier lyophilization then.
To be 1～10%CaCl containing mass percent under the above-mentioned bearing hydrocolloid dressing room temperature
2Or Ca (HCO
3)
2Percent by volume be to adopt solution spinning to prepare fiber in the solidification liquid of 50% ethanol water, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls to beat sheet and make adhesive-bonded fabric dressing again.
Embodiment 6:
Get molecular weight 1,890,000, deacetylation 70%, substitution value degree are 0.6 hydroxyethyl chitosan 50g, are dissolved in that to obtain mass percent in the 4950ml distilled water be 1% solution; Getting molecular weight is 50,000, and deacetylation is that 52% water-soluble chitosan, 250 grams are dissolved in and are made into 5% solution in the 5000ml distilled water; Getting molecular weight is 4000, and deacetylation is 98%, and the carboxy methylation degree is that carboxymethyl chitosan 50 gram of the substitution value 0.97 of 1.45,6 hydroxyls is dissolved in and is made into 10% solution in the 450ml distilled water.Behind the above solution chamber relaxing the bowels with purgatives of warm nature mix homogeneously, add glycerol 180ml, isopropyl alcohol 100ml continues the mix homogeneously vacuum deaerator and gets bearing hydrocolloid dressing, pH value 7.2.
With above-mentioned bearing hydrocolloid dressing curtain coating or coating film forming in rustless steel or mould of plastics, make membranaceous dressing at 70 ℃ of baking 6h.
Above-mentioned bearing hydrocolloid dressing is loaded in rustless steel or the mould of plastics, in-20 ℃ freezing, make porous spongy dressing in the vacuum freeze drier lyophilization then.
To in being the solidification liquid of 30% aqueous acetone solution, percent by volume adopt solution spinning to prepare fiber under the above-mentioned bearing hydrocolloid dressing room temperature, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls dozen sheet again and makes adhesive-bonded fabric dressing.
Embodiment 7:
Get molecular weight 450,000, deacetylation 55%, the carboxy methylation degree is 1.25, the carboxymethyl chitin 100g of the substitution value 0.9 of 6 hydroxyls and molecular weight are 40,000, deacetylation is 55%, substitution value is that 0.90 Chitofilmer, 50 grams are dissolved in that to obtain mass percent in the 2850ml distilled water be 5% solution, other gets molecular weight is 3500, deacetylation is 98%, hydroxypropyl chitosan 100 gram of substitution value 0.96 is dissolved in that to obtain mass percent in the 900ml distilled water be 10% hydroxypropyl sugar juice.Behind two solution chamber's relaxing the bowels with purgatives of warm nature mix homogeneously, add glycerol 200ml, isopropyl alcohol 100ml continues the mix homogeneously vacuum deaerator and gets bearing hydrocolloid dressing, pH value 7.1.
With above-mentioned bearing hydrocolloid dressing curtain coating or coating film forming in rustless steel or mould of plastics, make membranaceous dressing at 80 ℃ of baking 5h.
Above-mentioned bearing hydrocolloid dressing is loaded in rustless steel or the mould of plastics, in-20 ℃ freezing, make porous spongy dressing in the vacuum freeze drier lyophilization then.
To be 8:1 in percent by volume under the above-mentioned bearing hydrocolloid dressing room temperature: adopt solution spinning to prepare fiber in the solidification liquid of 1 acetone-ether-water mixed liquid, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls dozen sheet again and makes adhesive-bonded fabric dressing.
The medical dressing that more than makes has good effect in the reparation of the skin traumas such as operative incision, bark fetching district, burn, scald, ulcer or decubital ulcer at outside each position of health.
Claims (10)
1. medical dressing, it is characterized in that: dressing comprises that mass percent concentration is one or more of 1%～100% chitin derivativ, chitosan derivatives or water-soluble chitosan, and mass percent concentration is that 0～99% water and mass percent concentration are 0～60% filler.
2. medical dressing according to claim 1, it is characterized in that: dressing is hydrocolloid shape, membranaceous, spongy or for adhesive-bonded fabric dressing, when containing chitin derivativ in the dressing, the mass percent concentration of chitin derivativ is 5～10% in membranaceous dressing, spongy dressing or the adhesive-bonded fabric dressing.
3. medical dressing according to claim 1, it is characterized in that: contain a kind of molecular weight in the dressing at least greater than 200,000 chitin derivativ, chitosan derivatives or water-soluble chitosan, and chitin derivativ is carboxymethyl chitin, ethoxyl chitin or Chitofilmer, chitosan derivatives is carboxymethyl chitosan, hydroxyethyl chitosan or hydroxypropyl chitosan, wherein the carboxymethyl chitosan molecular weight is 1000～2000,000, deacetylation is 70%～99%, the carboxy methylation degree is that the substitution value of 0.5～1.5,6 hydroxyls is greater than 0.5; The carboxymethyl chitin molecular weight is 1000～3000,000, and deacetylation is 5%～60%, and the carboxy methylation degree is being that the substitution value of 0.5～1.2,6 hydroxyls is greater than 0.5; Hydroxyethyl chitosan, hydroxypropyl chitosan, ethoxyl chitin or Chitofilmer molecular weight are 1000～2000, and between 000, the substitution value substitution value of 6 hydroxyls is 0.4～1.0; The water-soluble chitosan molecular weight is 1000～2000,000, and deacetylation is 40%-60%.
4. medical dressing according to claim 1 is characterized in that: filler is among glycerol, propylene glycol, butanediol or the PEG400 a kind or multiple.
5. medical dressing according to claim 1 is characterized in that: the dressing pH value is 6～7.5.
6. the preparation method of the described medical dressing of claim 1, it is characterized in that may further comprise the steps: with the water-soluble respectively mass percent concentration that is made into of one or more of chitin derivativ, chitosan derivatives or water-soluble chitosan is 0.5～10% aqueous solution, with a kind of solution stirring of obtaining evenly or several aqueous solution that obtain respectively even, be 0～15% adding filler by the quality percentage composition again, abundant mix homogeneously, vacuum deaerator obtains bearing hydrocolloid dressing.
7. according to the preparation method of the described medical dressing of claim 6, it is characterized in that: with bearing hydrocolloid dressing curtain coating or coating film forming in rustless steel or mould of plastics, oven dry or shady and cool natural drying make membranaceous dressing under temperature is lower than 80 ℃; Perhaps bearing hydrocolloid dressing is loaded in rustless steel or the mould of plastics, in-10 ℃～-60 ℃ freezing, place the vacuum freeze drier lyophilization to obtain spongy dressing then; Perhaps will be the aqueous solution of 30%～100% ethanol, acetone or ether mixed liquor or be 1～10%CaCl in percent by volume under the bearing hydrocolloid dressing room temperature containing mass percent
2Or Ca (HCO
3)
2Adopt solution spinning to prepare fiber in the solidification liquid of the mixed liquor of the ethanol of aqueous solution, acetone or ether, the tow that fiber is cut into 3-5cm becomes the flocculence fiber through opening fine combing, rolls dozen sheet again and makes adhesive-bonded fabric dressing.
8. according to the preparation method of the described medical dressing of claim 7, it is characterized in that: contain a kind of molecular weight in the used dressing at least greater than 200,000 chitin derivativ, chitosan derivatives or water-soluble chitosan, and chitin derivativ is a carboxymethyl chitin, ethoxyl chitin or Chitofilmer, chitosan derivatives is a carboxymethyl chitosan, hydroxyethyl chitosan or hydroxypropyl chitosan, wherein the carboxymethyl chitosan molecular weight is 1000～2000,000, deacetylation is 70%～99%, the carboxy methylation degree is that the substitution value of 0.5～1.5,6 hydroxyls is greater than 0.5; The carboxymethyl chitin molecular weight is 1000～3000,000, and deacetylation is 5%～60%, and the carboxy methylation degree is being that the substitution value of 0.5～1.2,6 hydroxyls is greater than 0.5; Hydroxyethyl chitosan, hydroxypropyl chitosan, ethoxyl chitin or Chitofilmer molecular weight are 1000～2000, and between 000, substitution value is 0.4～1.0; The water-soluble chitosan molecular weight is 1000～2000,000, and deacetylation is 40%-60%.
9. according to the preparation method of the described medical dressing of claim 7, it is characterized in that: filler is among glycerol, propylene glycol, butanediol or the PEG400 a kind or multiple.
10. the described medical dressing of claim 1 is used for the reparation of skin traumas such as operative incision, bark fetching district, burn, scald, ulcer or decubital ulcer clinically.
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| CN102198293A (en) * | 2011-05-27 | 2011-09-28 | 缪泽年 | Compound type chitin artificial skin and preparation method thereof |
| CN102218157A (en) * | 2010-04-16 | 2011-10-19 | 浙江医鼎医用敷料有限公司 | Preparation method of chitin functional hydrocolloid medical dressing |
| CN102228715A (en) * | 2011-06-10 | 2011-11-02 | 青岛明药堂医药科技开发有限公司 | Liquid dressing containing chitosan derivative and preparation method thereof |
| CN102302797A (en) * | 2011-09-15 | 2012-01-04 | 德州海利安生物科技股份有限公司 | Medical colloid dressing and application thereof |
| CN102755662A (en) * | 2012-07-25 | 2012-10-31 | 福州乾正药业有限公司 | Medical gel film prepared by compounding chitosan and preparation method of same |
| CN103550816A (en) * | 2013-11-15 | 2014-02-05 | 南通大学 | Preparation method for chitosan-based electrostatic spinning combined wound dressing |
| CN104367623A (en) * | 2014-11-19 | 2015-02-25 | 杨公明 | Biological agent with function of treating skin burn wounds |
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