CN114699549A - Chitin antibacterial hemostatic material film and preparation method thereof - Google Patents
Chitin antibacterial hemostatic material film and preparation method thereof Download PDFInfo
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- CN114699549A CN114699549A CN202210229688.5A CN202210229688A CN114699549A CN 114699549 A CN114699549 A CN 114699549A CN 202210229688 A CN202210229688 A CN 202210229688A CN 114699549 A CN114699549 A CN 114699549A
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- 229920002101 Chitin Polymers 0.000 title claims abstract description 85
- 239000000463 material Substances 0.000 title claims abstract description 53
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 29
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000004814 polyurethane Substances 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000000835 fiber Substances 0.000 claims description 8
- 239000007863 gel particle Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 3
- 229920006264 polyurethane film Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 238000013329 compounding Methods 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 25
- 208000027418 Wounds and injury Diseases 0.000 abstract description 25
- 230000029663 wound healing Effects 0.000 abstract description 8
- 206010048038 Wound infection Diseases 0.000 abstract description 3
- 229920001661 Chitosan Polymers 0.000 description 13
- 230000001737 promoting effect Effects 0.000 description 7
- 230000035876 healing Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 229920000297 Rayon Polymers 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 239000002313 adhesive film Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 210000002640 perineum Anatomy 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
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- 206010061218 Inflammation Diseases 0.000 description 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
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- 230000000202 analgesic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 210000001124 body fluid Anatomy 0.000 description 1
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- 239000012876 carrier material Substances 0.000 description 1
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- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
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- 230000004069 differentiation Effects 0.000 description 1
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- 239000003792 electrolyte Substances 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 231100000456 subacute toxicity Toxicity 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/023—Adhesive plasters or dressings wound covering film layers without a fluid handling layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a chitin antibacterial hemostatic material film, which comprises: the invention discloses a chitin dressing block and a PU film material compounded with the chitin dressing block, wherein the thickness of the chitin dressing block is 0.1-0.5nm, the thickness of the PU film material is 0-0.2nm, and the invention also discloses a preparation method of a chitin antibacterial hemostatic material film. The problem of clinical lateral perineotomy wound is difficult to care is solved, lateral perineotomy wound infection is prevented, and wound healing is promoted.
Description
Technical Field
The invention belongs to the technical field of medical treatment, and particularly relates to a chitin antibacterial hemostatic material film and a preparation method thereof.
Background
An important function of modern wound dressings is to effectively restore important functions of damaged skin and to act all the way to wound healing and skin lesion healing. It can resist mechanical factors (such as dirt, collision, inflammation, etc.), resist pollution and chemical stimulation, prevent second-degree infection, prevent dryness and body fluid loss (electrolyte loss), prevent heat loss, and actively influence the wound healing process through debridement in addition to comprehensively protecting the wound, thereby creating a microenvironment for promoting wound healing.
Chitin is the only natural high molecular material with positive charge in nature, is a natural basic polysaccharide, the chemical structure of Chitin (Chitin) is very similar to that of cellulose, the difference is that the C-2 hydroxyl of each glucose unit is replaced, and in Chitin, acetylamino (-NHCOCH2) is contained, and the Chitin is divided into three crystals of alpha, beta and gamma according to the crystal structure, wherein the Chitin existing in nature is mostly alpha-type Chitin, the content of which is the most, the most stable, and the Chitin widely exists in cell walls of crustaceans, insects and parts of microorganisms. The yield of the natural product can reach 10-100 tons every year, and the natural product is the second most polysaccharide next to cellulose, and the resource is very rich. The material contains-NH 2 group and-OH group, is easy to modify and can generate various derivatives with different properties, and the most important derivative after chitin deacetylation is chitosan.
The chitin has excellent biological activity and biocompatibility, can be absorbed by human bodies and has no toxic and side effects; has wound protecting, antibacterial, hemostatic, analgesic, exudation reducing, cell growth promoting, wound healing promoting, air permeable, and moisture keeping effects; also has humoral immunity promoting and ecological regulating effects (reducing cholesterol, softening blood vessel, promoting heart function, etc.); has strong affinity to various proteins, and can be used as excellent physiologically active substances and excellent carrier materials of enzyme, antigen and antibody, and impurity separation and purification materials of natural traditional Chinese medicines; can be made into artificial skin, permeable membrane for hemodialysis; can be used as medicinal carrier and sustained release agent; has a weave structure, and can be used for the growth and regulation of cells and tissues and the induction of cell differentiation and tissue differentiation and growth, such as skin, cartilage and blood vessel reconstruction, and the like. The test results of acute toxicity, subacute toxicity, endothelial reaction, pyrogen, transplantation test, cytotoxicity, hemolysis, allergy, antigen and the like are negative, and the safety is high.
The medical dressing at present uses medical dressing directly to paste on the wound face and has partial viscose layer to paste and be used for fixed wound dressing in the aspect of handling the wound, and the dressing is by can simply prevent infection, simple hemostasis and slow accelerating wound healing's effect, but traditional medical dressing can only play the effect of handling general body part wound, can't solve the needs of the special position wound of health, if the perineum side is cut, if use improperly, cause secondary damage to the wound very easily. And traditional medical dressing does not have the wound exudate that can in time absorb, causes the healing of wound to slow down, and the medicine direct contact wound on traditional medical dressing has the side effect to human tissue how much, and the use amount is less moreover, and the drug effect is lower.
Therefore, the development of a wound care material for treating a special part of a body in a medical treatment process is urgently needed, and the medical dressing of the chitin (chitosan) antibacterial hemostatic material adhesive film for medical treatment, which uses a novel material chitin (chitosan) antibacterial hemostatic material adhesive film for medical treatment, has the advantages of fast healing effect on a wound, capability of isolating the wound from the outside and avoiding secondary damage, and overcomes the defects that the existing medical dressing has a special part wound which is not easy to be adhered by a viscose material, very slow healing effect on the wound, and incapability of isolating the wound from the outside and easily causing secondary damage.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a chitin antibacterial hemostatic material film and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, a chitin antibacterial hemostatic material film and a preparation method thereof comprise: the chitin dressing block comprises a chitin dressing block and a PU (polyurethane) film material compounded with the chitin dressing block, wherein the thickness of the chitin dressing block is 0.1-0.5nm, and the thickness of the PU film material is 0-0.2 nm.
Preferably, the chitin dressing block comprises: 1-5 parts of chitin fiber and 0.1-1 part of solid gel particles.
In a second aspect, a preparation method of the chitin antibacterial hemostatic material film comprises the following steps:
preparing a chitin dressing block;
the chitin dressing block is compounded with the PU film material.
Preferably, the chitin dressing block is prepared by:
mixing the chitin fiber and the solid gel particles according to the formula amount, heating for dissolving, fully stirring, and then needling to obtain the chitin dressing block.
Preferably, the chitin dressing block is compounded with the PU film material, and the method comprises the following steps:
and uniformly covering the chitin dressing block on the surface of the PU film material, and heating to obtain the chitin antibacterial hemostatic material film.
Preferably, the heating temperature is 45-55 ℃.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
in the invention, the chitin (chitosan) dressing block has viscosity when meeting liquid, can be adhered to a wound without using viscose, has the functions of stopping bleeding, resisting bacteria and promoting healing, is used for a special part which cannot be adhered by an adhesive, such as a lateral perineal cutting part, and has water resistance and high air permeability by a PU film compounded with the chitin (chitosan) dressing block by a special process, so that the wound can be effectively prevented from being invaded by postpartum lochia to cause infection. The problem of clinical lateral perineotomy wound is difficult to care is solved, lateral perineotomy wound infection is prevented, and wound healing is promoted.
Detailed Description
The following examples are combined to further illustrate specific embodiments of the chitosan antibacterial hemostatic material film and the preparation method thereof. The chitin antibacterial hemostatic material film and the preparation method thereof are not limited to the description of the following examples.
Example 1:
this embodiment provides a specific implementation of a chitosan hemostatic material film, including: the chitin dressing block is 0.1nm thick, and the PU film material is 0nm thick.
Further, the chitin dressing block comprises: 1 mass part of chitin fiber and 0.1 mass part of solid gel particles.
Example 2:
this embodiment provides a specific implementation of a chitosan hemostatic material film, including: the chitin dressing block is 0.3nm thick, and the PU film material is 0.1nm thick.
Further, the chitin dressing block comprises: 3 parts of chitin fiber and 0.5 part of solid gel particles.
Example 3:
this embodiment provides a specific implementation of a chitosan hemostatic material film, including: the chitin dressing block is 0.5nm thick, and the PU film material compounded with the chitin dressing block is 0.2nm thick.
Further, the chitin dressing block comprises: 5 parts of chitin fiber and 1 part of solid gel particles.
Example 4:
the embodiment provides a specific implementation method of a preparation method of a chitin antibacterial hemostatic material film, which comprises the following steps:
preparing a chitin dressing block;
the chitin dressing block is compounded with the PU film material.
Further, the preparation of the chitin dressing block comprises the following steps:
mixing the chitin fiber and the solid gel particles according to the formula amount, heating to dissolve, fully stirring, and then needling to obtain the chitin dressing block.
Further, chitin dressing piece and PU membrane material are compound, include:
and uniformly covering the chitin dressing block on the surface of the PU film material, and heating to obtain the chitin antibacterial hemostatic material film.
Further, the heating temperature was 45 ℃.
Example 5:
the embodiment provides a specific implementation manner of a preparation method of a chitin antibacterial hemostatic material film, other steps are the same as those in embodiment 4, and further, the heating temperature is 50 ℃.
Example 6:
the embodiment provides a specific implementation manner of a preparation method of a chitin antibacterial hemostatic material film, other steps are the same as those in embodiment 4, and further, the heating temperature is 55 ℃.
By adopting the technical scheme:
the chitin (chitosan) antibacterial hemostatic material adhesive film comprises a chitin (chitosan) dressing block and a composite PU film. The prepared chitin (chitosan) dressing block has viscosity when meeting liquid, can be adhered on a wound without using viscose, and has the functions of stopping bleeding, resisting bacteria and promoting healing. The product is used for special parts which can not be adhered by the adhesive, such as perineum lateral cutting parts, and the PU film compounded with the chitin (chitosan) dressing block has water resistance and high air permeability, and can effectively prevent postpartum lochiorrhea from invading wounds to cause infection. The problem of clinical lateral perineotomy wound is difficult to care is solved, lateral perineotomy wound infection is prevented, and wound healing is promoted.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.
Claims (6)
1. The chitin antibiotic hemostatic material pad pasting, its characterized in that includes: the chitin dressing block comprises a chitin dressing block and a PU (polyurethane) film material compounded with the chitin dressing block, wherein the thickness of the chitin dressing block is 0.1-0.5nm, and the thickness of the PU film material is 0-0.2 nm.
2. The chitin antimicrobial hemostatic material patch according to claim 1, wherein the chitin dressing block material comprises: 1-5 parts of chitin fiber and 0.1-1 part of solid gel particles.
3. The preparation method of the chitin antibacterial hemostatic material film is characterized by comprising the following steps:
preparing a chitin dressing block;
the chitin dressing block is compounded with the PU film material.
4. The method for preparing the chitin antibacterial hemostatic material film of claim 3, wherein the preparation of the chitin dressing block comprises:
mixing the chitin fiber and the solid gel particles according to the formula amount, heating for dissolving, fully stirring, and then needling to obtain the chitin dressing block.
5. The method for preparing the chitin antibacterial hemostatic material film as claimed in claim 3, wherein the compounding of the chitin dressing block and the PU film material comprises:
uniformly covering the chitin dressing block on the surface of a PU (polyurethane) film material, and heating to obtain the chitin antibacterial hemostatic material film.
6. The method for preparing the chitin antibacterial hemostatic material film according to claim 5, characterized in that: the heating temperature is 45-55 ℃.
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| CN202210229688.5A CN114699549A (en) | 2022-03-09 | 2022-03-09 | Chitin antibacterial hemostatic material film and preparation method thereof |
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| CN101284145A (en) * | 2008-04-21 | 2008-10-15 | 武汉锐尔生物科技有限公司 | Medical dressing and its preparation method and application |
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| CN103007337A (en) * | 2012-12-31 | 2013-04-03 | 凌峰 | Polymer dressing and dressing patch |
| WO2016042471A1 (en) * | 2014-09-15 | 2016-03-24 | Mavi Sud S.R.L. | Composition and material comprising chitin nanofibrils, lignin and a co-polymer and their uses |
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
| CN106806063A (en) * | 2017-01-20 | 2017-06-09 | 湖北华来生物科技有限公司 | A kind of medical dressing and its preparation technology containing nano-chitosan |
-
2022
- 2022-03-09 CN CN202210229688.5A patent/CN114699549A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284145A (en) * | 2008-04-21 | 2008-10-15 | 武汉锐尔生物科技有限公司 | Medical dressing and its preparation method and application |
| CN201220003Y (en) * | 2008-06-25 | 2009-04-15 | 唐忠 | Sterilized application |
| CN103007337A (en) * | 2012-12-31 | 2013-04-03 | 凌峰 | Polymer dressing and dressing patch |
| WO2016042471A1 (en) * | 2014-09-15 | 2016-03-24 | Mavi Sud S.R.L. | Composition and material comprising chitin nanofibrils, lignin and a co-polymer and their uses |
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
| CN106806063A (en) * | 2017-01-20 | 2017-06-09 | 湖北华来生物科技有限公司 | A kind of medical dressing and its preparation technology containing nano-chitosan |
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