CN100387308C - Wet wound dressing containing plant effective ingredient - Google Patents
Wet wound dressing containing plant effective ingredient Download PDFInfo
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- CN100387308C CN100387308C CNB2005101228232A CN200510122823A CN100387308C CN 100387308 C CN100387308 C CN 100387308C CN B2005101228232 A CNB2005101228232 A CN B2005101228232A CN 200510122823 A CN200510122823 A CN 200510122823A CN 100387308 C CN100387308 C CN 100387308C
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Abstract
The present invention relates to a wet wound dressing which contains plant effective components. The present invention comprises a non-woven fabric lining and a sticking material, wherein the sticking material is prepared from 1 to 10 portions of hydrocotyle asiatica extract, 3 to 12 portions of aloe gel extract, 7 to 15 portions of thickening agent, 2 to 4 portions of dispersing agent and water as the rest. The dressing is used for covering operative incisions of surgery and gynecopathy and the wound surfaces of various traumas, burns and scalds. The dressing prevents the intrusion and infection of external bacteria, keeps a wet environment for the incisions and the wound surfaces, and has the efficiency of resisting bacteria, relieving inflammation, stopping pain, relieving itching, promoting wound healing, inhibiting the formation of abnormal scars. The dressing adheres to the incisions or the wound surfaces but does not stick to, so that patients do not feel painful in changing the dressing.
Description
One, technical field
The present invention relates to a kind of dressing of clinical practice, particularly a kind of functional moist dressing exactly is a kind of wet wound dressing that contains effective ingredients in plant.
Two, background technology
Clinical skin wound is handled of doctor trained in Western medicine mainly covers with dressing.Understanding to dressing plays buffer action on the one hand in early days, protects from infection, and plays absorption on the other hand, gets rid of the wound exudate effect, keeps the wound surface drying.This class dressing makes wound surface drying, dehydration and incrustation.Many histiocytes at wound surface place have been lost in incrustation on the one hand, on the other hand the wound surface epithelization are had obvious obstacle.It is found that afterwards to keep the wound surface energy of wetting to quicken its healing, along with the progress of science and technology, various novel Wound dressings constantly come out and use simultaneously, so the brand-new theory of wound healing is just arisen at the historic moment and widely accepted for medical and health sector under a kind of moistening environment.So-called moistening environment is the wet union environment in other words, be meant by cover sealing at the wound surface place or semi-enclosed dressing or cover the cover layer that can form gel at the wound surface place and the wound surface place is formed and keep the moistening environment, this class dressing claims that this is moist dressing or closed dressing.This dressing is made of the wadding and the stickup material of semipermeable membrane or non-woven fabrics and so on usually.Protect subsides (French yogurt company outlet) and have inside and outside two-layer as appropriate, skin is a polyurethane semi permeability non-woven fabrics, internal layer is and the bonded synthetic rubber class of a small amount of carboxymethyl cellulose material, can the absorption portion sepage keep moistening, promote the wound surface epithelial hyperplasia, quicken wound healing, non-woven fabrics wadding impermeability stops bacterial invasion, prevents external infection, the adhesiveness good with normal skin makes wound surface form a sealing, moistening environment.On the basis of moist dressing, people add other active component again in pasting material, be used for antibiotic, reduce or avoid functional moist dressing such as cicatrization.As create the skin spirit, collection sterilization, film forming and promotion healing are one, solve the dressing field and use antibiotic easily to produce the difficult problem of Resistant strain; Also have chitosan dressing, the anti-stick dressing of CAD, CAD chitosan dressing, the dressing of CAD lipid hydro colloid, nano silver antibiotic dressing, medical silicon gel dressing, permanent magnetism healing accelerating dressing or the like in addition.
The Herba Centellae beginning is stated from Shennong's Herbal, and existing is the " conventional Chinese medicine that Chinese pharmacopoeia is recorded.Be the dry herb of Umbelliferae Centella plant Herba Centellae.Chemical constituent and the pharmacological action of Herba Centellae is widely studied (" Chinese Chinese medicine information magazine " Vol.9, No.8, in August, 2002, Zhao Yuxin etc. " progress of Herba Centellae ").The asiaticoside that extracts in the self asiatic, the oral asiaticoside sheet of processing is arranged, be used for keloid and scleroderma, processing external asiaticoside frost ointment, asiaticoside fat ointment are arranged, the effect that clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling are arranged is used for jaundice due to damp-heat, heatstroke diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down etc.
Aloe is a Liliaceae, perennial evergreen meat herbaceous plant.Aloetic medical treatment, beauty treatment, health care, edible and multiple function such as view and admire and early generally acknowledged by common people.Its pharmacological action is first-elected to be bacteriostasis, medicinal ingredient aloe-emodin, tinctura aloes and Aloin A etc. all have direct bactericidal action, and antibacterial does not develop immunity to drugs, can remove simultaneously the harmful metabolite and the residual endotoxin (" Nanjing Normal University's journal " (natural science edition) Vol.27, No.1.2004, Hua Chun " Aloe vulgaris bacteriostasis ") of killed bacterial that produce when infecting.Aloe has the physiologically active of hemostasis, antiinflammatory and healing to skin trauma, and curative effect is obvious.Its synergism (" Beijing Union University's journal " Vol.5.No.2,, Jia Ji Cheng etc.: " bioactive substance one aloetic antiinflammatory, healing activity " in 1991) because of bradykinin enzyme, magnesium lactate, Aloin A and lectin etc.
Three, summary of the invention
On the basis of the physiologically active further investigation of the present invention's effective ingredient in to Herba Centellae and Aloe, with its integrated application in moist dressing, solve the processing problems of pasting material simultaneously, being intended to provides a kind of functional wet wound dressing for clinical operation otch, various wound, empyrosis wound surface.
This wet wound dressing is made up of non-woven fabrics wadding and stickup material institute, is to paste to expect to have following component and parts by weight with the fundamental difference that has various moist dressings now:
Herba Centellae extract 1～10 minute
3～12 parts of Aloe gel juices
7～15 parts of thickening agents
2～4 parts of dispersants
Water complements to 100 parts.
Preferably
Herba Centellae extract 2～7 minutes
5～10 parts of Aloe gel juices
8～12 parts of thickening agents
2～4 parts of dispersants
Water complements to 100 parts.
Described Herba Centellae extract is a Herba Centellae herb elder generation ethanol extraction, and the extractum after the dealcoholysis adds water to be stirred, separate, and aqueous solution is through macroporous resin adsorption and eluting, and what the collection eluent obtained behind precipitation is the solid extract of main component with the Herba Centellae total glycosides.
Described Aloe gel juice by aloe juice after filtration, concentrate, sterilization treatment obtains.Aloe juice by aloe leaf clean, airing is after the juice that fragmentation, squeezing obtain, perhaps usefulness refiner homogenate homogenizing after fragmentation is got the juice that its supernatant obtains behind the high speed centrifugation.Can directly use juice, but the convenient storing of its gel juice.
Described thickening agent makes to be pasted material and has certain viscosity and moisture retention, as carboxymethyl cellulose (CMC), hydroxyethyl-cellulose, sodium alginate, xanthan gum, carrageenan, glycerol etc., preferred CMC or/and glycerol or/and sodium alginate.
Described dispersant is a surfactant, guarantees that various effective ingredient are uniformly dispersed in pasting material.Preferred tween series is as Tween 80 etc.
Make wadding with non-woven fabrics, drop into and paste moistening in the material, cover then on wound or the wound surface and fix with medical air-permeable adhesive tape.
Active substance in this stickup material in Herba Centellae and the Aloe has collaborative mutually synergy, activate epithelial hyperplasia on the one hand, promote that normal granulation tissue generates, the formation of the normal collagen fiber of guiding, the normal healing of accelerated in wounds or wound surface, suppress fibrocellular propagation on the other hand, prevent its hyperplasia and unordered diffusion, thereby prevent the formation of abnormal scars.Have anti-inflammation, analgesia itching relieving function simultaneously, be applicable to that surgery, obstetrics and gynecology operation otch and various skin trauma, empyrosis wound surface use.
The existing buffer action of this wet wound dressing prevents outside bacterial invasion, infection, can make otch or wound surface keep the moistening environment simultaneously again.This stickup material adheres to tightly otch or wound surface, but also inadhesion, patient's no pain when change dressings.
The applicant has carried out clinical experiment with this wet wound dressing (the grand wet wound dressing that inspires confidence in of trade name), and compares with traditional dressing, and the result is as follows:
One, wound pain degree
Total routine number-+++ +++
Experimental group 30 22 620
Matched group 30 15 10 32
Annotate: "-" do not have obvious pain; "+" mild pain; " ++ " pain but can stand; " +++" pain is impatient at, and needs the medicine pain relieving;
Two, wound local inflammation response situation
Total routine number-++ ++ ++
Experimental group 30 21 810
Matched group 30 10 16 31
Annotate: "-" antiinflammatory is fine, NIP; "+" has certain inflammatory reaction, but very slight; " ++ " inflammatory reaction moderate; " +++" inflammatory reaction severe (infection).
Three, the shallow II degree of wound wound healing time
Total routine number The average healing (my god)
Experimental group 30 8.5 ± 1.6
Matched group 30 12.5 ± 3.8
Four, the dark II degree of wound wound healing time
Total routine number The average healing (my god)
Experimental group 30 11.8 ± 3.2
Matched group 30 15.7 ± 6.6
Clinical trial certificate, the without any side effects and untoward reaction of this wet wound dressing, and obvious analgesia is arranged and reduce the effect of wound infection, transudate is few, can effectively promote the healing of wound, desalination wound cicatrix.
Four, the specific embodiment
1, the preparation of Herba Centellae extract
Getting exsiccant Herba Centellae herb pulverizes, use alcohol reflux, extracting solution concentrates behind activated carbon decolorizing and obtains extractum, adding distil water stirs, and filters, and aqueous solution is through macroporous resin adsorption, water, Diluted Alcohol eluant solution successively, collect Diluted Alcohol eluant solution liquid and concentrated, use recrystallizing methanol, obtaining with the Herba Centellae total glycosides is the solid extract (calling A in the following text) of main component.
2, the preparation of Aloe gel juice
Get the Aloe vulgaris blade and clean the back airing, juice is collected in the squeezing of broken back.Perhaps use refiner homogenate, homogenizing after the vanes fragmentation behind the airing, high speed centrifugation is got its supernatant and is promptly got juice then.Juice negative pressure dehydration is after filtering concentrated, and 10 portions of juice concentrate and obtain 1 part of gel juice, standby after sterilizing (calling B in the following text).
3, get 1 part of A, 3 parts of B, 7 parts of CMC, 2 parts of sodium lauryl sulphates, adding distil water stirs, and transfers pH6.5～7.5, and distilled water complements to 100 parts.
4, get 10 parts of A, 12 parts of B, 15 parts of glycerol, 4 parts of Tween 80s, adding distil water stirs, and transfers pH6.5～7.5, and distilled water complements to 100 parts.
5, get 2 parts of A, 10 parts of B, 12 parts of CMC, 8 04 parts of tweens, adding distil water stirs, and transfers pH6.5～7.5, and distilled water complements to 100 parts.
6, get 7 parts of A, 5 parts of B, 8 parts of glycerol, 2 parts of sodium lauryl sulphates, adding distil water stirs, and transfers pH6.5～7.5, and distilled water complements to 100 parts.
7, get 3.5 parts of A, 6 parts of B, 10 parts of glycerol, 3 parts of Tween 80s, adding distil water stirs, and transfers pH6.5～7.5, and distilled water complements to 100 parts.
8, get in the stickup material of non-woven fabrics input embodiment 3～7 and soak, take out the back and packs and seal with aluminium plastic packaging bag.
Claims (2)
1. a wet wound dressing that contains effective ingredients in plant is made up of non-woven fabrics wadding and stickup material institute, and it is characterized in that: pasting material has following component and parts by weight:
1～10 part of Herba Centellae extract
3～12 parts of Aloe gel juices
7～15 parts of thickening agents
2～4 parts of dispersants
Water complements to 100 parts.
2. dressing according to claim 1 is characterized in that:
2～7 parts of Herba Centellae extracts
5～10 parts of Aloe gel juices
8～12 parts of thickening agents
2～4 parts of dispersants
Water complements to 100 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101228232A CN100387308C (en) | 2005-11-30 | 2005-11-30 | Wet wound dressing containing plant effective ingredient |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101228232A CN100387308C (en) | 2005-11-30 | 2005-11-30 | Wet wound dressing containing plant effective ingredient |
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| CN1806855A CN1806855A (en) | 2006-07-26 |
| CN100387308C true CN100387308C (en) | 2008-05-14 |
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| CNB2005101228232A Expired - Fee Related CN100387308C (en) | 2005-11-30 | 2005-11-30 | Wet wound dressing containing plant effective ingredient |
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| CN103599558B (en) * | 2013-07-16 | 2015-08-12 | 汪贤宗 | A kind of quick hemostatic dressing and preparation method thereof |
| CN104083590B (en) * | 2014-07-22 | 2017-12-05 | 四川省乐至贵均卫生材料有限公司 | Aloe barbadensis Miller composition gels freeze-dried powder external use plaster and preparation method thereof |
| CN104623719B (en) * | 2015-02-03 | 2016-09-28 | 广东泰宝医疗科技股份有限公司 | A kind of aquagel dressing and preparation method thereof |
| CN105363064B (en) * | 2015-11-02 | 2018-06-05 | 石森林 | A kind of compound aloe barbadensis Miller polysaccharide gel antiseptic dressing for treatment burn |
| CN105535679B (en) * | 2015-12-30 | 2018-08-21 | 胡广 | A kind of probiotics ferment restoration of the ecosystem composition |
| CN105726399A (en) * | 2016-03-14 | 2016-07-06 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressings for repairing scars |
| CN107998441A (en) * | 2017-11-10 | 2018-05-08 | 牛云飞 | One kind prevents adhesion antibacterial burn and scald dressing and preparation method thereof |
| CN111166929A (en) * | 2018-11-09 | 2020-05-19 | 上海弗霓生物科技有限公司 | Wet wound dressing and preparation method thereof |
| CN109646378B (en) * | 2019-01-30 | 2020-12-15 | 佛山市百分之秀化妆品有限公司 | Whitening and moisturizing freckle-removing emulsion and preparation method thereof |
| CN110711263A (en) * | 2019-12-03 | 2020-01-21 | 河南汇博医疗股份有限公司 | Functional dressing with functions of preventing, repairing and modifying scars and preparation method thereof |
| CN111035800A (en) * | 2020-01-13 | 2020-04-21 | 昆明丰钰商贸有限责任公司 | Liquid band-aid containing aloe extract |
| CN114504620A (en) * | 2022-03-11 | 2022-05-17 | 上海医妃医药科技有限公司 | Wound is applied ointment or plaster behind medical and artistic |
| CN114732937B (en) * | 2022-05-20 | 2022-09-09 | 斯贝福（北京）生物技术有限公司 | Dressing for animal ear cartilage supporting material and preparation method and application thereof |
| CN114984301B (en) * | 2022-05-30 | 2023-03-17 | 浙江大学 | Antibacterial dressing for promoting wound surface to heal without scars and preparation method thereof |
| CN114984294A (en) * | 2022-06-07 | 2022-09-02 | 山东万容生物科技有限公司 | Dressing and preparation method thereof |
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| KR20030095483A (en) * | 2002-06-10 | 2003-12-24 | 박명수 | Single-use diaper haning functions of sudaming precaution and antivirus |
| CN1607011A (en) * | 2003-10-13 | 2005-04-20 | 汕头市美佳源实业有限公司 | Method for preparing aloe dressing preparation by letting prop absorbing aloe liquid and its application |
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2005
- 2005-11-30 CN CNB2005101228232A patent/CN100387308C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030095483A (en) * | 2002-06-10 | 2003-12-24 | 박명수 | Single-use diaper haning functions of sudaming precaution and antivirus |
| CN1607011A (en) * | 2003-10-13 | 2005-04-20 | 汕头市美佳源实业有限公司 | Method for preparing aloe dressing preparation by letting prop absorbing aloe liquid and its application |
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| CN1806855A (en) | 2006-07-26 |
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