CN102283947A - Application of medicinal composition to preparation of medicaments for treating postoperative adhesion - Google Patents
Application of medicinal composition to preparation of medicaments for treating postoperative adhesion Download PDFInfo
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- CN102283947A CN102283947A CN2011102110587A CN201110211058A CN102283947A CN 102283947 A CN102283947 A CN 102283947A CN 2011102110587 A CN2011102110587 A CN 2011102110587A CN 201110211058 A CN201110211058 A CN 201110211058A CN 102283947 A CN102283947 A CN 102283947A
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Abstract
The invention relates to application of a medicinal composition to the preparation of medicaments for treating postoperative adhesion. In the medicinal composition, a nakedflower beautyberry leaf extract is used as an active ingredient, and the nakedflower beautyberry leaf extract has a good effect on the postoperative adhesion and has the characteristics of low cost, high safety and the like.
Description
Technical field
The present invention the present invention relates to a kind of application of pharmaceutical composition, relates in particular to its application in preparation iatrotechnics posterior synechiae medicine.
Background technology
Tissue adhesion is still a still unsolved clinically surgery difficult problem so far.Adhesion is often followed behind common abdominal cavity, gynecological, orthopedics and operation on vessels of heart.Prevent and treat the generation of adhesion by improving operation and auxiliary treatment clinically.Auxiliary treatment mainly contains medicine and physical barriers dual mode.The medicine of Western medicine control is mainly nonsteroidal antiinflammatory drug, corticosteroid, anticoagulant, enzyme, phosphatidylcholine and other classes.The blood circulation promoting regulates qi medicine is mainly used in the Chinese herb prevention adhesion, as: Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Hirudo, the Radix Aucklandiae, Fructus Aurantii, Cortex Magnoliae Officinalis, Flos Carthami etc.; Stimulate purgatives medicine, the qi-activating drug of enterokinesia, as: Radix Et Rhizoma Rhei, Semen Persicae, the Radix Aucklandiae, Fructus Aurantii, Cortex Magnoliae Officinalis etc.; Qi-tonifying drug, as: the Radix Astragali, Radix Codonopsis etc.The biophysics barrier is mainly macromolecular solution barrier (as hyaluronic acid (HA) and derivant thereof) and mechanical barrier (can absorb mechanical barrier and expanded polytetrafluoroethylsealing etc. as oxidized regenerated cellulose, biological absorbent antiseize film etc. and can not absorb mechanical barrier).Research finds that physical barriers relates to the evaluation to operation again, operative doctor is difficult to accept, its curative effect also remains further to be proved conclusively, Western medicine untoward reaction big (as postponing wound healing etc.), and Chinese medicine is used for the existing certain basis of tissue adhesion, as CN200910229786 Chinese medicine preparation for the treatment of surgical intestinal adhesions, Chinese medicine preparation and the method for making and the application thereof of CN200610161271 prevention and treatment intestinal adhesion after abdominal cavity operation.But still there is not the correlational study of making that any entity or individual are applied to Callicarpa nudiflora tissue adhesion at present.
Summary of the invention
[0003] the object of the present invention is to provide the application of a kind of pharmaceutical composition in preparation iatrotechnics posterior synechiae medicine, this pharmaceutical composition is active component with the Callicarpa nudiflora extract.
Callicarpa nudiflora extract is by one or more preparations in the following method among the present invention:
(1) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract A that gets;
(2) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, the ethanol elution of reuse 10%～90%, eluent filters, concentrate the dry Callicarpa nudiflora extract B that gets;
(3) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and pressed liquor filters, and filtrate concentrates, the dry Callicarpa nudiflora extract C that gets, press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract D that gets;
(4) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution and pressed liquor merge, and filter, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, the ethanol elution of reuse 10%～90%, eluent filters, concentrate the dry Callicarpa nudiflora extract E that gets;
(5) adopt fresh or exsiccant Callicarpa nudiflora raw material, add water or rare alcohol or rare ketone solvent and decoct secondary, collecting decoction filters, concentrate, carry out membrane filtration, use earlier ultrafiltration, nanofiltration again, membrane material concentrates with ceramic composite membrane and poly tetrafluoroethylene, the dry Callicarpa nudiflora F that gets.
Pharmaceutical composition of the present invention can be supplied with the medicine form: oral agents, spray, injectable powder, injection.For increasing curative effect, can use two or more administering mode combined treatments wherein.
Callicarpa nudiflora extract of the present invention has good effect to tissue adhesion, has characteristics such as inexpensive, that safety is good.
Specific embodiment
Embodiment 1
The preparation of Callicarpa nudiflora extract
By following any method preparation, get one or more mixing of a-f kind:
(1) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract a that gets;
(2) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, reuse 10%～90% ethanol elution, eluent filters, concentrate the dry Callicarpa nudiflora extract b that gets;
(3) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and pressed liquor filters, and filtrate concentrates, the dry Callicarpa nudiflora extract c that gets, press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract d that gets;
(4) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution and pressed liquor merge, and filter, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, the ethanol elution of reuse 10%～90%, eluent filters, concentrate the dry Callicarpa nudiflora extract e that gets;
(5) adopt fresh or exsiccant Callicarpa nudiflora raw material, add water or rare alcohol or rare ketone and decoct secondary, collecting decoction filters, concentrate, carry out membrane filtration, use earlier ultrafiltration, nanofiltration again, membrane material concentrates with ceramic composite membrane and poly tetrafluoroethylene, the dry Callicarpa nudiflora f that gets.
Embodiment 2
Get Callicarpa nudiflora leaf and twig 2.0kg(dry product), decoct with water secondary, 10 times of amounts decocted 2 hours for the first time, 8 times of amounts decocted collecting decoction 1 hour for the second time, filter, be concentrated into 2000ml, carry out membrane filtration, earlier use ultrafiltration, nanofiltration again, membrane material ceramic composite membrane and poly tetrafluoroethylene, concentrate, drying gets the 285.0g Callicarpa nudiflora extract, it is 14.25% that Callicarpa nudiflora extracts yield, and recording general flavone content is 113.7mg/g, and content of luteolin is that 1.27mg/g(is by dry product).
Embodiment 3
Get the bright product of Callicarpa nudiflora leaf and twig 2.0kg(), add rare ketone and decoct secondary, each 10 times of amounts, decocted 2 hours, collecting decoction filters, be concentrated into 2000ml, carry out membrane filtration, use earlier ultrafiltration, nanofiltration again, membrane material concentrates with ceramic composite membrane and poly tetrafluoroethylene, drying gets the 129.2g Callicarpa nudiflora extract, and it is 6.46% that Callicarpa nudiflora extracts yield, recording general flavone content is 51.8mg/g, and content of luteolin is that 0.68mg/g(is by the aquatic foods product).
Embodiment 4
Get the fresh Callicarpa nudiflora leaf 1kg that gathers October, add 2kg water and be broken into homogenate, squeezing, press residue adds the rare ketone heating extraction of 3kg, extracting solution and pressed liquor merge, filter, concentrate, the dry 120.4g extract that gets, it is 12.04% that Callicarpa nudiflora extracts yield, recording general flavone content is 56.9mg/g, and content of luteolin is 0.69mg/g, and total tannin content 14.22mg/g(is by fresh medical material).
Embodiment 5
Get the fresh Callicarpa nudiflora leaf 1kg that JIUYUE is gathered, add 2kg water and be broken into homogenate, squeezing, press residue adds the rare pure heating extraction of 3kg, and extracting solution and pressed liquor merge, and filters, filtrate washes cylinder with water by macroporous adsorbent resin column chromatography, discards water lotion, the ethanol elution of reuse 70% takes off liquid and filters, and concentrates, the dry 95.2g extract that gets, it is 9.52% that Callicarpa nudiflora extracts yield, and recording general flavone content is 59.8mg/g, and content of luteolin is that 0.78mg/g(is by fresh medical material).
Embodiment 6
Get the fresh Callicarpa nudiflora leaf 1kg that JIUYUE is gathered, heating extraction twice adds rare pure 8kg at every turn, extracts 2 hours, merging filtrate, filter, concentrate, the dry 91.8g extract that gets, it is 9.18% that Callicarpa nudiflora extracts yield, recording general flavone content is 48.7mg/g, and content of luteolin is 0.69mg/g, and total tannin content 13.55 mg/g(are by fresh medical material).
Embodiment 7
Get Callicarpa nudiflora leaf and twig 2.0kg(dry product), heating extraction twice adds water 10kg at every turn, extracts 2 hours, merging filtrate, filter, concentrate, the dry 491.3g extract that gets, it is 24.56% that Callicarpa nudiflora extracts yield, recording general flavone content is 108.3mg/g, and content of luteolin is 1.35 mg/g, and total tannin content 41.7 mg/g(are by dry product).
Embodiment 8
The inhibition experiment of postoperative intestinal adhesion
If low high two dosage groups, be respectively 0.05g/kg and 0.5g/kg, by oral form of medication administration, other establishes positive drug group (sodium hyaluronate injection, Shandong Bausch ﹠ Lomb Freda Pharmaceutical Co., Ltd. produces) and normal blank group, about 10 of every group of SD rat male, body weight 250-300g, totally 43 rats.
(1) experimental technique:
The rats underwent abdominal operation, and the part serous coat of wearing and tearing ileocecus ileum (0.3 * 8cm), cause rat abdominal cavity intestinal adhesion.Wherein the positive drug group is smeared an amount of sodium hyaluronate injection in the serous coat place with cotton swab behind the wearing and tearing serous coat, and postoperative is sewed up to steam again and raised.After all operation finishes with the rat random packet, every group about 10.Behind the successive administration 14 days, open the abdominal cavity, the adhesion degree is graded, estimate intestinal adhesion with reference to the Nair standard, divide 5 grades according to the quantity of adhesive band, specific as follows: 0: as not have adhesion fully, 1: adhesive band between internal organs or between internal organs and stomach wall, 2: two adhesive bands between internal organs or between internal organs and stomach wall, 3: more than two adhesive bands, and internal organs directly do not adhere to stomach wall, and 4: internal organs directly adhere to stomach wall, and no matter adhesive band what.
Get portion of tissue simultaneously and do pathology observation assessment.Date processing adopts X 2 test.
(2) experimental result:
Each treated animal non-incision of postoperative infects, administration group and matched group comparison, control animals all sticks together, administration group part animal do not stick together or the adhesion degree lighter.Compare with the blank group, low dose group difference has the significance meaning, and high dose group and positive drug group difference have the highly significant meaning.It is apparent in view to show that medicine high dose group of the present invention is improved rat tissue adhesion effect.
Histological observation: between the medication group pathologic finding adhesion degree difference not obvious, but all obviously be lighter than blank group, serous coat is partly or entirely repaired, as seen fibrocyte, arrangement of collagen fibers is loose irregular, and blood capillary proliferation is not obvious, sees a small amount of granulocyte and macrophage.The blank adhesion organization's fibroblast proliferation of organizing enlivens, and collagen fiber are fine and close to be arranged, and blood capillary proliferation is obvious, and granulocyte and macrophage are more, peel off serous coat and do not see reparation.
Table 2: extract of the present invention is to the inhibitory action of rat postoperative intestinal adhesion (X ± SD)
Compare with matched group: * P＜0.05; * p＜0.01
Embodiment 9
The tissue adhesion medication preparation
1, preparation tablets
(extract a) among the embodiment 1 with Callicarpa nudiflora extract 100g of the present invention, starch 50g, microcrystalline Cellulose (lactose) 35g, carboxymethyl starch sodium 3g mix homogeneously, add 3% an amount of hypromellose alcoholic solution system soft material, granulate 60～70 ℃ of dryings, 18 mesh sieve granulate with 18 mesh sieves, add magnesium stearate 1.5g, mixing is pressed into 1000, and coating promptly.
, capsule preparation
With Callicarpa nudiflora extract 100g of the present invention (extract among the embodiment 5), microcrystalline Cellulose 78g adds 3% an amount of hypromellose alcoholic solution system soft material, granulate 60～70 ℃ of dryings, 18 mesh sieve granulate with 18 mesh sieves, magnesium stearate 1.5g mixing is filled to 1000.
, oral liquid preparation
With Callicarpa nudiflora extract 20g of the present invention (extract c among the embodiment 1), sucrose 200g, sodium benzoate 1.5g and distilled water 500ml dissolving, thin up filters to 1000ml, fill (10 milliliters every), sterilization is promptly.
, granule preparation
It is an amount of to get Callicarpa nudiflora extract 100g of the present invention (extract among the embodiment 6), sucrose 120g and 50% ethanol, mixes, granulate, and drying, granulate, packing is promptly.
, spray preparation
Get Callicarpa nudiflora extract 50g of the present invention (extract among the embodiment 2), nipalgin 0.3g, adding distil water dissolves in right amount, filters, and adding distil water is to 1000ml again, and fill is sterilized promptly.
, injection preparation
Get Callicarpa nudiflora extract 10g of the present invention (embodiment 3 is extract obtained), add 100ml ethanol again after adding the 50ml water dissolution, stir, cold preservation, precipitation filters and reclaims ethanol, be concentrated into 25-30ml, add ethanol again and reach 80% to containing the alcohol amount, cold preservation filters, filtrate recycling ethanol adds benzyl alcohol 0.2g, sodium chloride 9g to there not being the alcohol flavor, stirring and dissolving, add the injection water to 1000ml, filter with the G3 sintered glass funnel, fill, sterilization are promptly.
, injectable powder preparation
Get Callicarpa nudiflora extract 100g of the present invention (embodiment 4 is extract obtained), add 200ml ethanol again after adding the 150ml water dissolution, stir, cold preservation, precipitation filters and reclaims ethanol, be concentrated into 80-100ml, add ethanol again and reach 80% to containing the alcohol amount, cold preservation filters, filtrate recycling ethanol adds the injection water to 150ml to there not being the alcohol flavor, filters with the G3 sintered glass funnel, fill, sterilization are sub-packed in the cillin bottle lyophilization, tamponade, gland promptly gets injectable powder.
Claims (4)
1. the application of pharmaceutical composition in preparation iatrotechnics posterior synechiae medicine is characterized in that this pharmaceutical composition is an active component with the Callicarpa nudiflora extract of effective dose.
2. application according to claim 1 is characterized in that described Callicarpa nudiflora extract is by one or more preparations in the following method:
(1) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract A that gets;
(2) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, the ethanol elution of reuse 10%～90%, eluent filters, concentrate the dry Callicarpa nudiflora extract B that gets;
(3) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and pressed liquor filters, and filtrate concentrates, the dry Callicarpa nudiflora extract C that gets, press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract D that gets;
(4) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution and pressed liquor merge, and filter, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, the ethanol elution of reuse 10%～90%, eluent filters, concentrate the dry Callicarpa nudiflora extract E that gets;
(5) adopt fresh or exsiccant Callicarpa nudiflora raw material, add water or rare alcohol or rare ketone and decoct secondary, collecting decoction filters, concentrate, carry out membrane filtration, use earlier ultrafiltration, nanofiltration again, membrane material concentrates with ceramic composite membrane and poly tetrafluoroethylene, the dry Callicarpa nudiflora F that gets.
3. application according to claim 1 is characterized in that described pharmaceutical composition can supply with the medicine form and be: oral agents, spray, injectable powder, injection.
4. pharmaceutical composition according to claim 3 is characterized in that, described is that the dosage form dosage made of the pharmaceutical composition of active component is for containing Callicarpa nudiflora total flavones 0.5-2 gram/sky with the Callicarpa nudiflora extract.
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Cited By (3)
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| WO2014075570A1 (en) * | 2012-11-19 | 2014-05-22 | 苏州润新生物科技有限公司 | Beautyberry total glycosides extract and preparation method and use thereof |
| CN113252496A (en) * | 2021-04-22 | 2021-08-13 | 西安近代化学研究所 | Method for measuring content of binder in PBX explosive |
| CN113827649A (en) * | 2021-11-11 | 2021-12-24 | 海南康盾生物制药有限公司 | Medicament for brain glioma postoperative rehabilitation and preparation method thereof |
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2011
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014075570A1 (en) * | 2012-11-19 | 2014-05-22 | 苏州润新生物科技有限公司 | Beautyberry total glycosides extract and preparation method and use thereof |
| CN103816296A (en) * | 2012-11-19 | 2014-05-28 | 苏州润新生物科技有限公司 | Callicarpa bodinieri total glycosides extract as well as preparation method and application thereof |
| CN103816296B (en) * | 2012-11-19 | 2020-03-31 | 苏州润新生物科技有限公司 | Callicarpa total glycoside extract and preparation method and application thereof |
| US10758585B2 (en) | 2012-11-19 | 2020-09-01 | Suzhou Neupharma Co., Ltd. | Beautyberry total glycosides extract and preparation method and use thereof |
| CN113252496A (en) * | 2021-04-22 | 2021-08-13 | 西安近代化学研究所 | Method for measuring content of binder in PBX explosive |
| CN113252496B (en) * | 2021-04-22 | 2023-03-21 | 西安近代化学研究所 | Method for measuring content of binder in PBX explosive |
| CN113827649A (en) * | 2021-11-11 | 2021-12-24 | 海南康盾生物制药有限公司 | Medicament for brain glioma postoperative rehabilitation and preparation method thereof |
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