CN111603603A - Gynecological rapid hemostatic dressing and preparation method thereof - Google Patents
Gynecological rapid hemostatic dressing and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention discloses a gynecological rapid hemostatic dressing and a preparation method thereof, belonging to the technical field of medical materials, compared with the prior art, the invention provides a gynecological rapid hemostatic dressing and a preparation method thereof, the operation method is simple, scientific and reasonable, rapid hemostasis and bacteriostasis can be realized, the effect is obvious, bletilla striata and pseudo-ginseng traditional Chinese medicine have the effects of promoting blood circulation and removing blood stasis, and the dressing has good curative effect on traumatic hemorrhage, the added collagen, carboxymethyl chitosan, sodium carboxymethyl cellulose, thrombin, heparin sodium and sodium alginate have wide application range in the prior art, the curative effect of the medicine is improved after the preparation operation, meanwhile, an antiphlogistic is used for auxiliary sterilization treatment, the hemostatic effect is further improved, the dressing has no toxicity in clinical use, has small side effect on human body, not only can play a blood coagulation role, but also can promote wound healing, and can realize hemostasis in a short time, can be suitable for emergency treatment of acute massive hemorrhage in obstetrics and gynecology department.
Description
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a gynecological rapid hemostatic dressing and a preparation method thereof.
Background
The key to the treatment is timely hemostasis, and the effective circulation amount is rapidly supplemented in a sufficient amount, so that the blood pressure is rapidly raised in a short time, and the patient can be turned to safe.
Modern wound dressings include interactive wound dressings, calcium alginate dressings, silver dressings, foam dressings, hydrocolloid dressings and hydrogel dressings, can basically satisfy the condition of general operation acute hemorrhage or operation hemorrhage, but, to the needs of quick, a large amount of hemostasis of gynaecology's operation acute hemorrhage, it still can't satisfy the requirement of urgent treatment, consequently needs a gynaecology and uses quick hemostasis dressing and preparation method to solve above-mentioned problem.
Disclosure of Invention
Technical problem to be solved
In order to overcome the defects of the prior art, the invention provides a rapid hemostatic dressing for gynecology and a preparation method thereof, which solve the problems mentioned in the background technology.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: the rapid hemostatic dressing for gynecology consists of the following raw materials: bletilla striata, pseudo-ginseng, dextrin, gelatin, starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, an anti-inflammatory agent, carboxymethyl chitosan and sodium carboxymethyl cellulose, wherein the raw materials comprise the following components in parts by weight: 4-6 parts of bletilla striata, 6-10 parts of pseudo-ginseng, 4-6 parts of dextrin, 6-9 parts of gelatin, 20-30 parts of starch, 8-10 parts of polyvinyl alcohol, 4-6 parts of thrombin, 4-6 parts of heparin sodium, 8-12 parts of collagen, 7-10 parts of sodium alginate, 4-8 parts of an anti-inflammatory agent, 4-8 parts of carboxymethyl chitosan and 6-8 parts of sodium carboxymethyl cellulose.
A preparation method of a gynecological rapid hemostatic dressing comprises the following steps:
s1, firstly, cutting pseudo-ginseng and bletilla striata into blocks, cleaning to remove impurities, adding cleaned dextrin and gelatin, mixing, grinding into powder, adding water, boiling, extracting, and concentrating the water extract into extract for later use;
s2, mixing starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, antiinflammatory agent, carboxymethyl chitosan, and sodium carboxymethyl cellulose;
s3, placing the mixture obtained in S1 and S2 into a container, adding water and stirring until the mixture is fully dissolved to obtain a mixed solution;
s4, performing vacuum deaeration on the mixed solution, performing freeze drying treatment under vacuum condition, controlling the temperature to be minus 40 to minus 50 ℃ for 1 to 2 hours, then controlling the temperature to be minus 20 to minus 30 ℃ for 1 to 2 hours, and then controlling the temperature to be minus 10 ℃ for 1 to 2 hours; taking the freeze drying process as a cycle, and carrying out freeze drying treatment for 2-4 cycles;
s5, washing the obtained hemostatic material with water, drying and sterilizing to obtain the hemostatic material.
As a further scheme of the invention: the preparation steps of the extract in the S1 are that 100 parts of drinking water is added for the first time of decoction, the time is counted after the boiling, the decoction is extracted for 1 hour, and the liquid medicine is filtered; adding 80 parts of drinking water into the second decoction dregs, boiling, timing, decocting for 1 hour, and filtering the liquid medicine; mixing the two filtrates, and concentrating to obtain extract.
As a further scheme of the invention: the anti-inflammatory agent is ciprofloxacin or metronidazole.
(III) advantageous effects
Compared with the prior art, the invention provides the gynecological rapid hemostatic dressing and the preparation method thereof, the operation method is simple, scientific and reasonable, the dressing can rapidly stop bleeding and inhibit bacteria, the effect is obvious, bletilla striata and pseudo-ginseng traditional Chinese medicines have the effects of promoting blood circulation and removing blood stasis, the dressing has a good curative effect on traumatic bleeding, the added collagen, carboxymethyl chitosan, sodium carboxymethyl cellulose, thrombin, heparin sodium and sodium alginate have wide application range in the prior art, the curative effect of the medicines is improved after preparation and operation, meanwhile, the antiphlogistic is used for auxiliary sterilization treatment, the hemostatic effect is further improved, the dressing has no toxicity in clinical use, has small side effect on human body, can play a blood coagulation role, can promote wound healing, can realize hemostasis in a short time, and is suitable for emergency treatment of a large amount of gynecological acute bleeding.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
Example 1:
the invention provides a technical scheme that: the rapid hemostatic dressing for gynecology consists of the following raw materials: bletilla striata, pseudo-ginseng, dextrin, gelatin, starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, an anti-inflammatory agent, carboxymethyl chitosan and sodium carboxymethyl cellulose, wherein the raw materials comprise the following components in parts by weight: 4 parts of bletilla striata, 6 parts of pseudo-ginseng, 4 parts of dextrin, 6 parts of gelatin, 20 parts of starch, 8 parts of polyvinyl alcohol, 4 parts of thrombin, 4 parts of heparin sodium, 8 parts of collagen, 7 parts of sodium alginate, 4 parts of an anti-inflammatory agent, 4 parts of carboxymethyl chitosan and 6 parts of sodium carboxymethyl cellulose.
A preparation method of a gynecological rapid hemostatic dressing comprises the following steps:
s1, firstly, cutting pseudo-ginseng and bletilla striata into blocks, cleaning to remove impurities, adding cleaned dextrin and gelatin, mixing, grinding into powder, adding water, boiling, extracting, and concentrating the water extract into extract for later use;
s2, mixing starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, antiinflammatory agent, carboxymethyl chitosan, and sodium carboxymethyl cellulose;
s3, placing the mixture obtained in S1 and S2 into a container, adding water and stirring until the mixture is fully dissolved to obtain a mixed solution;
s4, performing vacuum defoaming on the mixed solution, performing freeze drying treatment under vacuum conditions, controlling the temperature to be 40 ℃ below zero for 1 hour, controlling the temperature to be 20 ℃ below zero for 1 hour, and controlling the temperature to be 10 ℃ below zero for 1 hour; taking the freeze drying process as a cycle, and carrying out freeze drying treatment for 2 cycles;
s5, washing the obtained hemostatic material with water, drying and sterilizing to obtain the hemostatic material.
As a further scheme of the invention: the preparation steps of the extract in the S1 are that 100 parts of drinking water is added for the first time of decoction, the time is counted after the boiling, the decoction is extracted for 1 hour, and the liquid medicine is filtered; adding 80 parts of drinking water into the second decoction dregs, boiling, timing, decocting for 1 hour, and filtering the liquid medicine; mixing the two filtrates, and concentrating to obtain extract.
The anti-inflammatory agent is ciprofloxacin.
Example 2:
the invention provides a technical scheme that: the rapid hemostatic dressing for gynecology consists of the following raw materials: bletilla striata, pseudo-ginseng, dextrin, gelatin, starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, an anti-inflammatory agent, carboxymethyl chitosan and sodium carboxymethyl cellulose, wherein the raw materials comprise the following components in parts by weight: 6 parts of bletilla striata, 10 parts of pseudo-ginseng, 6 parts of dextrin, 9 parts of gelatin, 30 parts of starch, 10 parts of polyvinyl alcohol, 6 parts of thrombin, 6 parts of heparin sodium, 12 parts of collagen, 10 parts of sodium alginate, 8 parts of an anti-inflammatory agent, 8 parts of carboxymethyl chitosan and 8 parts of sodium carboxymethyl cellulose.
A preparation method of a gynecological rapid hemostatic dressing comprises the following steps:
s1, firstly, cutting pseudo-ginseng and bletilla striata into blocks, cleaning to remove impurities, adding cleaned dextrin and gelatin, mixing, grinding into powder, adding water, boiling, extracting, and concentrating the water extract into extract for later use;
s2, mixing starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, antiinflammatory agent, carboxymethyl chitosan, and sodium carboxymethyl cellulose;
s3, placing the mixture obtained in S1 and S2 into a container, adding water and stirring until the mixture is fully dissolved to obtain a mixed solution;
s4, performing vacuum deaeration on the mixed solution, performing freeze drying treatment under vacuum condition, controlling the temperature to be 50 ℃ below zero for 2h, controlling the temperature to be 30 ℃ below zero for 2h, and controlling the temperature to be 10 ℃ below zero for 2 h; taking the freeze drying process as one cycle, and carrying out freeze drying treatment for 4 cycles;
s5, washing the obtained hemostatic material with water, drying and sterilizing to obtain the hemostatic material.
As a further scheme of the invention: the preparation steps of the extract in the S1 are that 100 parts of drinking water is added for the first time of decoction, the time is counted after the boiling, the decoction is extracted for 1 hour, and the liquid medicine is filtered; adding 80 parts of drinking water into the second decoction dregs, boiling, timing, decocting for 1 hour, and filtering the liquid medicine; mixing the two filtrates, and concentrating to obtain extract.
The anti-inflammatory agent is metronidazole.
Example 3
The invention provides a technical scheme that: the rapid hemostatic dressing for gynecology consists of the following raw materials: bletilla striata, pseudo-ginseng, dextrin, gelatin, starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, an anti-inflammatory agent, carboxymethyl chitosan and sodium carboxymethyl cellulose, wherein the raw materials comprise the following components in parts by weight: 5 parts of bletilla striata, 7 parts of pseudo-ginseng, 5 parts of dextrin, 8 parts of gelatin, 25 parts of starch, 8 parts of polyvinyl alcohol, 5 parts of thrombin, 5 parts of heparin sodium, 10 parts of collagen, 8 parts of sodium alginate, 5 parts of an anti-inflammatory agent, 5 parts of carboxymethyl chitosan and 6 parts of sodium carboxymethyl cellulose.
A preparation method of a gynecological rapid hemostatic dressing comprises the following steps:
s1, firstly, cutting pseudo-ginseng and bletilla striata into blocks, cleaning to remove impurities, adding cleaned dextrin and gelatin, mixing, grinding into powder, adding water, boiling, extracting, and concentrating the water extract into extract for later use;
s2, mixing starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, antiinflammatory agent, carboxymethyl chitosan, and sodium carboxymethyl cellulose;
s3, placing the mixture obtained in S1 and S2 into a container, adding water and stirring until the mixture is fully dissolved to obtain a mixed solution;
s4, performing vacuum defoaming on the mixed solution, performing freeze drying treatment under vacuum conditions, controlling the temperature to be 40 ℃ below zero for 1 hour, controlling the temperature to be 25 ℃ below zero for 1 hour, and controlling the temperature to be 10 ℃ below zero for 2 hours; taking the freeze drying process as a cycle, and carrying out freeze drying treatment for 3 cycles;
s5, washing the obtained hemostatic material with water, drying and sterilizing to obtain the hemostatic material.
As a further scheme of the invention: the preparation steps of the extract in the S1 are that 100 parts of drinking water is added for the first time of decoction, the time is counted after the boiling, the decoction is extracted for 1 hour, and the liquid medicine is filtered; adding 80 parts of drinking water into the second decoction dregs, boiling, timing, decocting for 1 hour, and filtering the liquid medicine; mixing the two filtrates, and concentrating to obtain extract.
The anti-inflammatory agent is ciprofloxacin.
The gynecological rapid hemostatic dressing and the preparation method thereof have the advantages that the operation method is simple, scientific and reasonable, rapid hemostasis and bacteriostasis can be realized, the effect is obvious, bletilla striata and pseudo-ginseng traditional Chinese medicines have the effects of promoting blood circulation and removing blood stasis and have a good curative effect on traumatic hemorrhage, the added collagen, carboxymethyl chitosan, sodium carboxymethyl cellulose, thrombin, heparin sodium and sodium alginate are wide in application range in the prior art, the medicinal curative effect is improved after preparation and operation, meanwhile, an anti-inflammatory agent is used for auxiliary sterilization treatment, the hemostatic effect is further improved, the clinical use is free from toxicity, the side effect on a human body is small, the hemostatic dressing not only can play a blood coagulation role, but also can promote wound healing, hemostasis can be realized in a short time, and the dressing can be suitable for emergency treatment of acute massive hemorrhage in obstetric.
Although the preferred embodiments of the present patent have been described in detail, the present patent is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present patent within the knowledge of those skilled in the art.
Claims (4)
1. The utility model provides a gynaecology is with quick hemostatic dressing which characterized in that: the hemostatic dressing consists of the following raw materials: bletilla striata, pseudo-ginseng, dextrin, gelatin, starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, an anti-inflammatory agent, carboxymethyl chitosan and sodium carboxymethyl cellulose, wherein the raw materials comprise the following components in parts by weight: 4-6 parts of bletilla striata, 6-10 parts of pseudo-ginseng, 4-6 parts of dextrin, 6-9 parts of gelatin, 20-30 parts of starch, 8-10 parts of polyvinyl alcohol, 4-6 parts of thrombin, 4-6 parts of heparin sodium, 8-12 parts of collagen, 7-10 parts of sodium alginate, 4-8 parts of an anti-inflammatory agent, 4-8 parts of carboxymethyl chitosan and 6-8 parts of sodium carboxymethyl cellulose.
2. A preparation method of a gynecological rapid hemostatic dressing is characterized by comprising the following steps: the method comprises the following steps:
s1, firstly, cutting pseudo-ginseng and bletilla striata into blocks, cleaning to remove impurities, adding cleaned dextrin and gelatin, mixing, grinding into powder, adding water, boiling, extracting, and concentrating the water extract into extract for later use;
s2, mixing starch, polyvinyl alcohol, thrombin, heparin sodium, collagen, sodium alginate, antiinflammatory agent, carboxymethyl chitosan, and sodium carboxymethyl cellulose;
s3, placing the mixture obtained in S1 and S2 into a container, adding water and stirring until the mixture is fully dissolved to obtain a mixed solution;
s4, performing vacuum deaeration on the mixed solution, performing freeze drying treatment under vacuum condition, controlling the temperature to be minus 40 to minus 50 ℃ for 1 to 2 hours, then controlling the temperature to be minus 20 to minus 30 ℃ for 1 to 2 hours, and then controlling the temperature to be minus 10 ℃ for 1 to 2 hours; taking the freeze drying process as a cycle, and carrying out freeze drying treatment for 2-4 cycles;
s5, washing the obtained hemostatic material with water, drying and sterilizing to obtain the hemostatic material.
3. The preparation method of the gynecological rapid hemostatic dressing according to claim 2, wherein the preparation method comprises the following steps: the preparation steps of the extract in the S1 are that 100 parts of drinking water is added for the first time of decoction, the time is counted after the boiling, the decoction is extracted for 1 hour, and the liquid medicine is filtered; adding 80 parts of drinking water into the second decoction dregs, boiling, timing, decocting for 1 hour, and filtering the liquid medicine; mixing the two filtrates, and concentrating to obtain extract.
4. The preparation method of the gynecological rapid hemostatic dressing according to claim 2, wherein the preparation method comprises the following steps: the anti-inflammatory agent is ciprofloxacin or metronidazole.
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