CN104147108B - Bacteriostatic gel containing brown alga oligose - Google Patents
Bacteriostatic gel containing brown alga oligose Download PDFInfo
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- CN104147108B CN104147108B CN201310173408.4A CN201310173408A CN104147108B CN 104147108 B CN104147108 B CN 104147108B CN 201310173408 A CN201310173408 A CN 201310173408A CN 104147108 B CN104147108 B CN 104147108B
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- alga oligose
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Abstract
The invention discloses a kind of bacteriostatic gel containing brown alga oligose, it is characterised in that the gel includes the active component of following weight proportion：The parts by weight of brown alga oligose 6 10, waste tender 0.3 0.7 parts by weight, the parts by weight of frutus cnidii 0.1 0.3, the parts by weight of kuh-seng 0.3 0.7.The present invention gel is rapid-action, good effect, easy to use, body-sensing is comfortable and has no toxic side effect, be that the gynaecology of a new generation prevents the biological agent product of vaginitis, cervicitis.Start the anti-infective beginning that traditional Chinese medicine and brown alga oligose combine.
Description
Technical field
The invention belongs to field of medicaments, in particular to a kind of bacteriostatic gel containing brown alga oligose and its application.
Background technology
Brown alga oligose is the oligomer of algin, is a kind of functional oligosaccharide.Brown alga oligose is by β-D mannuronic acids
(ManA) it is formed by connecting with its C-5 epimer α-L guluronic acid (GulA) by 1-4 glycosidic bonds.Brown alga oligose molecule
Low, not only water-soluble strong, stability height is measured, and there is many bioactivity, such as antitumor, anti-oxidant, antibacterial, growth promotion
Brown alga is a higher monoid in algae, rich in chlorophyll a and c, carrotene and several lutein,
Its photosynthate is essential oil, laminaran and mannitol, sea-plant iodine, substantial amounts of vitamin and inorganic salts, is often considered as
The good merchantable brand of extra-nutrition, utilization pharmaceutically more have history of more than one thousand years, early had on ancient medical book " Compendium of Materia Medica ", " Bencao Jingshu "
The function such as record tang and have treatment goitre, goiter and tumor knot gas and water swollen, diuresis, go, modern medicine study, be also proved
A little brown algas have hypotensive and antitumaous effect, and anti-coagulants, styptic, alternative blood plasma, hemostatic gauze, hemostasis is made even with brown alga
Sponge, medical stamp, cream base etc., there is high medical economic value.It is ocean human body bodyguard by good reputation, the soft Huang of ocean human body
Gold.However, individually the therapeutic effect of brown alga oligose is unstable, therefore how to provide a kind of stable medicine of therapeutic effect is this
Field technical problem urgently to be resolved hurrily.
The content of the invention
A kind of the defects of it is an object of the invention to overcome prior art, there is provided the stable medicine of curative effect.
Waste tender (dai medicine name)：Alias be numb chapter that, there is Qinghuo Jiedu, desinsection is antipruritic, anti-inflammatory, and relieve the pain itching-relieving action；
Frutus cnidii：The effect of with removing toxic substances desinsection eliminating dampness wind-dispelling；
Kuh-seng：It is usually used in gynaecology with lower itch, damp-heat dysentery, jaundice and various diseases of having blood in stool；
One aspect of the present invention is related to a kind of bacteriostatic gel containing brown alga oligose, it is characterised in that the gel includes as follows
The active component of weight proportion：The waste tender 0.3-0.7 parts by weight frutus cnidii 0.1-0.3 parts by weight of brown alga oligose 6-10 parts by weight
Kuh-seng 0.3-0.7 parts by weight.
In a preferred embodiment of the present invention, described active component proportioning is tender for the parts by weight famine of brown alga oligose 8
The parts by weight of 0.5 parts by weight frutus cnidii, 0.2 parts by weight kuh-seng 0.5.
In another preferred embodiment of the present invention, described gel auxiliary material includes carbomer 8-12 parts by weight, glue
Former albumen 2-4 parts by weight and sodium cellulose glycolate 6-10 parts by weight.
In another preferred embodiment of the present invention, described gel process for preparing comprises the following steps：
（1）Chinese medicine is traditionally（Water extraction）Deduct a percentage and be mixed into A liquid for liquid；
（2）Carbomer and sodium cellulose glycolate add A liquid and purified water, foaming and intumescing after agitation；Entered with 100 eye mesh screens
Row filtering, obtains B liquid
（3）Brown alga oligose adds purified water, obtains C liquid.
（4）Collagen dissolves, and obtains D liquid.
（5）C liquid is added in B liquid, agitation（Agitation is carried out in a direction）It is well mixed, it is put into and vacuumizes biological respinse
In kettle, 60 degree of constant temperature one hour adds D liquid after mixing, 40 degree constant temperature 2 hours, is cooled to 20 degree, the addition g of glycerine 100, then
Agitation is mixed, and then cooling vacuumizes, and checks pH value, and pH value is adjusted with 1% glacial acetic acid or 10% sodium hydroxide；Then sterilizing packing.
Another aspect of the present invention further relates to above-mentioned bacteriostatic gel in treatment cervical erosion postoperative wound medicine is prepared
Application, it is preferred that described medicine coordinates micro-wave therapeutic to use.
Another aspect of the present invention further relates to above-mentioned bacteriostatic gel answering in treatment cervicitis and/or colpitis medicine is prepared
With.
The present invention gel is rapid-action, good effect, easy to use, body-sensing is comfortable and has no toxic side effect, be the woman of a new generation
Section prevents the biological agent product of vaginitis, cervicitis.Start the anti-infective beginning that traditional Chinese medicine and brown alga oligose combine.
Embodiment
Describe the technology contents of the present invention in detail below by embodiment：
Brown alga oligose gynaecology bacteriostatic gel preparation method
Brown alga oligose gynaecology bacteriostatic gel prescription 1000ml total amounts
Carbomer 10g, sodium cellulose glycolate 8g, collagen 3g, brown alga oligose 8g,
Waste tender 0.5g, frutus cnidii 0.2g, kuh-seng 0.5g；
1：Chinese medicine is traditionally（Water extraction）Deduct a percentage and be mixed into A liquid for liquid
1 carbomer 10g, the g of sodium cellulose glycolate 8 add A liquid and purified water, foaming and intumescing after agitation；With 100 mesh
Screen cloth is filtered, and obtains B liquid
2 brown alga oligose 8g add purified water, obtain C liquid.
The g of 3 collagen 3 dissolves, and obtains D liquid.
4 add C liquid in B liquid, agitation（Agitation is carried out in a direction）It is well mixed, it is put into and vacuumizes biological respinse kettle
In, 60 degree of constant temperature one hour adds D liquid after mixing, 40 degree constant temperature 2 hours, be cooled to 20 degree, the addition g of glycerine 100, then stir
Dynamic to mix, then cooling is vacuumized, and checks pH value, and pH value is adjusted with 1% glacial acetic acid or 10% sodium hydroxide.Then sterilizing packing
Clinical data
Cervical erosion postoperative wound treatment data
Method：Patient menstrual totally after start within 3-7 days to treat, after routine microwave treatment of cervical erosion, use physiology salt
This gel overlay is advised into patient's further consultation behind cervical erosion surface, treatment after the water cotton balls wiping surface of a wound.
As a result：In 89 patients, micro-wave therapeutic is intended for single use in 6 slight erosions.In erosion patients in 37,15
Micro-wave therapeutic is intended for single use, as a control group, 22 micro-wave therapeutic is intended for single use after coordinate this gel for treating again.46 severe gruels
In rotten patient, 20 are intended for single use micro-wave therapeutic, and as a control group, 26 are intended for single use after micro-wave therapeutic and coordinate fast first to relax gel
Treatment.1 and table 2 are the results are shown in Table using group and treatment group.
All healed after micro-wave therapeutic is intended for single use in 6 slight erosion patients.In the patient that 48 coordinate this gel for treating
In, more than more than 60%, vaginal fluid significantly reduces wound healing compared with control group during further consultation in the 7th day, 46 during further consultation in the 15th day
Example patient heals completely, and absence of vagina secretion.2 patient's cervical surfaces only have small part and not healed, and the surface of a wound is less than original
1/4, healed completely when further consultation in the 30th day.No case was recurrence during further consultation after 2 months.
Table 1:Micro-wave therapeutic result is intended for single use in 35 control groups
| Indexing | Number of cases（n） | Cure rate（%） | Obvious effective rate（%） | Inefficiency（%） | Total effective rate（%） |
| Moderate | 15 | 11(78.6) | 2(14.3) | 1(7.1) | 100 |
| Severe | 20 | 15(71.4) | 4(19.0) | 2(9.5) | 100 |
| Altogether | 35 | 26(74.3) | 3(17.1) | 3(8.6) | 100 |
Table 2:48 are intended for single use microwave using group and coordinate this product treatment results
| Indexing | Number of cases（n） | Cure rate（%） | Obvious effective rate（%） | Inefficiency（%） | Total effective rate（%） |
| Moderate | 22 | 21(95.5) | 2(4.5) | 0 | 100 |
| Severe | 26 | 24(92.4) | 4(7.7) | 0 | 100 |
| Altogether | 48 | 45(93.8) | 3(6.2) | 0 | 100 |
Colpitis therapeutic effect
Age bracket 17-53；- 18 months 15 days patients of the course of disease；6 courses for the treatment of of pipe one
Criterion：
Recurrence：Drug withdrawal is recurred after the latter moon；
Effectively：Got nowhere with two course for the treatment of symptom mitigations, then with a course for the treatment of；
It is effective：Journey symptom disappears；
Recovery from illness：2 to 6 courses for the treatment of of medication recover normal condition
Data show this product in gynecological disease, and curative effect is protruded substantially, better than like product.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
The change or replacement expected without creative work, it should all be included within the scope of the present invention.Therefore, it is of the invention
Protection domain should be determined by the scope of protection defined in the claims.
Claims (5)
1. a kind of preparation method of bacteriostatic gel, is made up of following steps：
The bacteriostatic gel prescription of 1000ml total amounts includes：
Carbomer 10g, sodium cellulose glycolate 8g, collagen 3g, brown alga oligose 8g, waste tender 0.5g, frutus cnidii 0.2g, kuh-seng
0.5g；
(1) Chinese medicine water extraction deduction is mixed into A liquid for liquid；
(2) carbomer and sodium cellulose glycolate add A liquid and purified water, foaming and intumescing after agitation；Carried out with 100 eye mesh screens
Filter, obtains B liquid；
(3) brown alga oligose adds purified water, obtains C liquid；
(4) collagen dissolves, and obtains D liquid；
(5) C liquid is added in B liquid, agitation is well mixed, is put into and vacuumizes in biological respinse kettle, 60 degree constant temperature one hour, mixing
D liquid is added afterwards, 40 degree constant temperature 2 hours, is cooled to 20 degree, adds glycerine 100g, then stirs mixings, is then cooled down and is vacuumized, inspection
PH value is looked into, pH value is adjusted with 1% glacial acetic acid or 10% sodium hydroxide；Then sterilizing packing.
A kind of 2. bacteriostatic gel that preparation method as described in claim 1 obtains.
3. the bacteriostatic gel described in claim 2 is preparing the application in treating cervical erosion postoperative wound medicine.
4. bacteriostatic gel according to claim 3 is preparing the application in treating cervical erosion postoperative wound medicine,
Characterized in that, described medicine coordinates micro-wave therapeutic to use.
5. application of the bacteriostatic gel in treatment cervicitis and/or colpitis medicine is prepared described in claim 2.
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| CN201310173408.4A CN104147108B (en) | 2013-05-13 | 2013-05-13 | Bacteriostatic gel containing brown alga oligose |
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| CN201310173408.4A CN104147108B (en) | 2013-05-13 | 2013-05-13 | Bacteriostatic gel containing brown alga oligose |
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| CN104147108B true CN104147108B (en) | 2018-01-19 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581172B (en) * | 2017-02-13 | 2020-09-04 | 湖北精耕生物工程有限公司 | Medicine for preventing and treating mycotic vaginitis, trichomonas vaginitis and senile vaginitis and preparation method thereof |
| CN112245332A (en) * | 2020-12-02 | 2021-01-22 | 青岛博智汇力生物科技有限公司 | Eczema gel containing marine oligosaccharide |
| CN114366848A (en) * | 2022-02-14 | 2022-04-19 | 杭州仁世医疗器械有限公司 | Liquid sterilization dressing beneficial to wound surface repair |
| CN114832139A (en) * | 2022-05-17 | 2022-08-02 | 江西昂生生物科技有限公司 | Wound repair functional dressing and preparation method and application thereof |
| CN114957511B (en) * | 2022-05-19 | 2024-01-05 | 青岛海洋生物医药研究院股份有限公司 | Algin oligosaccharide zinc and preparation method and application thereof |
| CN117618328A (en) * | 2023-08-21 | 2024-03-01 | 西安惠普生物科技有限公司 | Sodium alginate-containing HPV-resistant gel and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101791425A (en) * | 2010-03-30 | 2010-08-04 | 赵雪林 | Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100543028C (en) * | 2006-09-21 | 2009-09-23 | 寻山集团有限公司 | A kind of preparation method of algin oligosaccharide |
| CN103041367B (en) * | 2013-01-10 | 2014-03-12 | 泰山医学院 | Traditional Chinese medicine compound preparation for preventing and treating vaginitis and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101791425A (en) * | 2010-03-30 | 2010-08-04 | 赵雪林 | Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 苦参碱、氧化苦参碱与蛇床子提取物联合抗菌作用研究;郭晓蕾等;《中华中医药学刊》;20110630;第29卷(第6期);第1399页左栏第1段 * |
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