CN103520765B - Method for preparing wound hemostasis dressing - Google Patents
Method for preparing wound hemostasis dressing Download PDFInfo
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- CN103520765B CN103520765B CN201310547279.0A CN201310547279A CN103520765B CN 103520765 B CN103520765 B CN 103520765B CN 201310547279 A CN201310547279 A CN 201310547279A CN 103520765 B CN103520765 B CN 103520765B
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Abstract
The invention provides a method for preparing a wound hemostasis dressing. The method includes the following steps that a chitosan lactate solution is frozen, and then freeze drying is carried out to obtain a chitosan lactate freeze-drying film; compression processing is carried out on the chitosan lactate freeze-drying film under a heating condition to obtain a chitosan lactate film; the chitosan lactate film is attached to a backing material to obtain the wound hemostasis dressing. According to the method, chitosan lactate serves as a raw material, so that the obtained wound hemostasis dressing has no special flavor, and the prepared wound hemostasis dressing has good anti-bacteria performance and a good hemostasis effect. Additionally, in the preparation process of the wound hemostasis dressing, the chitosan lactate film is compact in structure and can still keep a certain state after absorbing blood on a wound, so that the comfortable feeling of the wound is good.
Description
Technical field
The present invention relates to medical accessory technical field of biological materials, particularly relate to a kind of preparation method of wound hemostasis dressing.
Background technology
In war, wound severe loss of blood is one of wounded soldier main causes of death, although surgical operation is one of method of effective Bleeding control, but combat conditions is very severe, very large difficulty is brought to operative treatment, the incidence rate causing war wound to be suffered a shock is higher, and dead incidence rate also increases.The use of bleeding-stopping dressing obviously can reduce amount of bleeding, as long as wounded body just can self rescue in not out of the count situation, for the more time is won in later stage treatment.
Chitosan is the unique cationic polysaccharide of nature, has low-allergen and natural antibacterial, can quick-acting haemostatic powder, is therefore particularly suitable for first aid of battle field; In addition, chitosan also has biocompatibility, can degradation in vivo, absorption, promote wound healing, reduce the generation of cicatrix and antiinflammatory action etc., therefore in the application of bleeding-stopping dressing, antibacterial dressing, repair in trauma dressing, have huge advantage.
Present chitosan hemostasia products, one is dry again after gauze being infiltrated chitosan solution; Chitosan is first dissolved in acetum by one in the preparation, then through following process.If the chitosan dressing that the former prepares bonds with wound in use, secondary injury can be brought when removing, and the chitosan solution of the latter there is dense acetic acid taste, not only has a certain impact to user of service, also brings inconvenience to Producer.The invention provides a kind of chitosan bleeding-stopping dressing without special odor thus.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of chitosan lactate wound hemostasis dressing without special odor, and chitosan lactate bleeding-stopping dressing prepared by the application has good comfort level.
In view of this, this application provides a kind of preparation method of wound hemostasis dressing, comprise the following steps:
Chitosan lactate solution is carried out freezing, then carries out lyophilization, obtain chitosan lactate lyophilizing film;
Described chitosan lactate lyophilizing film is carried out pressurized treatments in a heated condition, obtains chitosan lactate film;
Described chitosan lactate film is adhered to back lining materials, obtains wound hemostasis dressing.
Preferably, the mass concentration of described chitosan lactate solution is 0.5% ~ 3%.
Preferably, in described chitosan lactate solution, the Lactated deacetylation of chitosan is 95% ~ 96%, and viscosity is 30 ~ 510mpa.s.
Preferably, the described freezing time is 12h ~ 48h, and described freezing temperature is-20 ~-100 DEG C.
Preferably, the described cryodesiccated time is 48h ~ 72h.
Preferably, the temperature of described heating is 40 DEG C ~ 80 DEG C.
Preferably, the time of described pressurization is 10min ~ 30min.
Preferably, described back lining materials is other elastomeric nonwoven cloth rubber belt of medical grade or PE film backing adhesive tape.
This application provides a kind of preparation method of wound hemostasis adjuvant, preparation process is specially: first chitosan lactate solution is carried out freezing and lyophilization, obtain chitosan lactate lyophilizing film, then chitosan lactate lyophilizing film is carried out pressurized treatments in a heated condition, obtain chitosan lactate film, finally chitosan lactate film is sticked on back lining materials, namely obtain the dressing of chitosan lactate wound hemostasis.In the process preparing wound hemostasis dressing, the application adopts chitosan lactate to be raw material, preparation method is simple, make the wound hemostasis dressing obtained without special odor, and because chitosan has antibacterial characteristics and haemostatic effect, the wound hemostasis dressing therefore prepared has good antibacterial characteristics and haemostatic effect.On the other hand, preparing in wound hemostasis application procedures, the chitosan lactate lyophilizing membrane structure first prepared is more loose, becomes gel, easily come off after its absorbing blood; Again by fine and close for chitosan lactate membrane structure after the pressurization of lyophilizing film, still can keep certain form at wound after absorbing blood, make the comfort of wound better.
Accompanying drawing explanation
Fig. 1 is the condition of mouse experiment and the bar diagram of result of application the application bleeding-stopping dressing.
Detailed description of the invention
In order to understand the present invention further, below in conjunction with embodiment, the preferred embodiment of the invention is described, but should be appreciated that these describe just for further illustrating the features and advantages of the present invention, instead of limiting to the claimed invention.
The embodiment of the invention discloses a kind of preparation method of wound hemostasis dressing, comprise the following steps:
Chitosan lactate solution is carried out freezing, then carries out lyophilization, obtain chitosan lactate lyophilizing film;
Described chitosan lactate lyophilizing film is carried out pressurized treatments in a heated condition, obtains chitosan lactate film;
Described chitosan lactate film is adhered to back lining materials, obtains wound hemostasis dressing.
This application provides the preparation method of a kind of chitosan wound hemostasis dressing, what wherein said chitosan adopted is chitosan lactate.First the present invention needs to prepare chitosan lactate solution, and chitosan lactate is preferably dissolved in deionized water by the application, obtains chitosan lactate solution.Chitosan lactate described in the application is well known to those skilled in the art, can be prepared according to existing method, also can be buied by market, the application has no particular limits, the deacetylation of described chitosan lactate is preferably 95% ~ 96%, and viscosity is preferably 30 ~ 510mpa.s.The mass concentration of described chitosan lactate solution is preferably 0.5% ~ 3%, is more preferably 0.5% ~ 1%.If the concentration of described chitosan lactate solution is less than 0.5%, then the chitosan lactate film prepared of later stage is too loose soft, and mouldability is bad; If concentration is higher than 3%, then the chitosan lactate film formed is too hard, crisp, cannot fit in wound closely, also can bring sense of discomfort to wound.
In order to obtain the chitosan lactate film of compact structure, the application by before freezing for described chitosan lactate solution preferably by described chitosan lactate solution evacuation bubble removing or standing and defoaming.Freezing by being carried out after the deaeration of chitosan lactate solution, and then carry out lyophilization, obtain chitosan lactate lyophilizing film.Described chitosan lactate solution is after lyophilization, and aqueous solution distillation wherein, therefore obtains the chitosan lactate lyophilizing film of short texture.Described freezing temperature is preferably-20 DEG C ~-100 DEG C, is more preferably-40 DEG C ~-80 DEG C; The described freezing time is preferably 12h ~ 48h, is more preferably 24h ~ 36h.The described cryodesiccated time is preferably 48h ~ 72h.
If directly described chitosan lactate lyophilizing film is applied wound, then can become gel after the structure absorbing blood that described chitosan lactate lyophilizing film is loose, easily come off, and sense of discomfort can be brought to wound.Therefore described chitosan lactate lyophilizing film pressurizes by the application in a heated condition, forms compact structure and smooth chitosan lactate film to make described chitosan lactate lyophilizing film.The temperature of described heating is preferably 40 ~ 80 DEG C, and the time of described pressurization is 10min ~ 30min.The chitosan lactate membrane structure that described chitosan lactate lyophilizing film obtains after heating pressurized treatments is fine and close, still can keep certain form after absorbing blood in wound, and smooth surface, better as the comfort level of wound during wound hemostasis dressing.
Finally described chitosan lactate film is adhered to back lining materials, namely obtain the dressing of chitosan lactate wound hemostasis.Described back lining materials is preferably other elastomeric nonwoven cloth rubber belt of medical grade or PE film back lining materials.
This application provides a kind of preparation method of wound hemostasis adjuvant, preparation process is specially: first chitosan lactate solution is carried out freezing and lyophilization, obtain chitosan lactate lyophilizing film, then chitosan lactate lyophilizing film is carried out pressurized treatments in a heated condition, obtain chitosan lactate film, finally chitosan lactate film is sticked on back lining materials, namely obtain the dressing of chitosan lactate wound hemostasis.In the process preparing wound hemostasis dressing, the application adopts chitosan lactate to be raw material, preparation method is simple, make to obtain wound hemostasis dressing without special odor, and because chitosan has antibacterial characteristics and haemostatic effect, the wound hemostasis dressing therefore prepared has good antibacterial characteristics and haemostatic effect.On the other hand, preparing in wound hemostasis application procedures, the chitosan lactate lyophilizing membrane structure first prepared is more loose, becomes gel, easily come off after its absorbing blood; By fine and close for rear for the pressurization of lyophilizing film chitosan lactate membrane structure, still can keep certain form at wound after absorbing blood, make the comfort of wound better.Therefore the chitosan lactate wound hemostasis dressing that prepared by the application meets blood jelly, easily remove, can not bring secondary injury to wound, and preparation technology is simple, nonpoisonous and tasteless.
In order to understand the present invention further, be described in detail below in conjunction with the preparation method of embodiment to wound hemostasis dressing provided by the invention, protection scope of the present invention is not limited by the following examples.
Embodiment 1
Taking 3.5g deacetylation is 95.9%, viscosity is the chitosan lactate of 36mpa.s, add in 1000ml conical flask, add 700ml deionized water, stirring at room temperature is to all dissolving, be mixed with 0.5%(m/v) chitosan lactate solution, to pour in the mould of 19cm × 19cm × 3cm after above-mentioned solution evacuation bubble removing, put into-20 DEG C of refrigerator and cooled and freeze 12h, then lyophilization 48h, obtain the chitosan lactate lyophilizing film of porous, be the 10min that pressurizes under the condition of 40 DEG C in temperature by the lyophilizing film pressurized equipment obtained, obtain the chitosan lactate film of the compact structure of 1mm thickness, then stick on other elastomeric nonwoven cloth rubber belt of medical grade, fit tightly, obtain the chitosan lactate wound hemostasis dressing without special odor.
Embodiment 2
Taking 3.5g deacetylation is 95.6%, viscosity is the chitosan lactate of 502mpa.s, add in 1000ml conical flask, add 700ml deionized water, stirring at room temperature is to all dissolving, be mixed with 0.5%(m/v) chitosan lactate solution, to pour in the mould of 19cm × 19cm × 3cm after above-mentioned solution evacuation bubble removing, put into-20 DEG C of refrigerator and cooled and freeze 12h, then lyophilization 48h, obtain the chitosan lactate lyophilizing film of porous, be the 20min that pressurizes under the condition of 40 DEG C in temperature by the lyophilizing film pressurized equipment obtained, obtain the chitosan lactate film of the compact structure of 1mm thickness, then stick on other elastomeric nonwoven cloth rubber belt of medical grade, fit tightly, obtain the chitosan lactate wound hemostasis dressing without special odor.
Embodiment 3
Taking 7g deacetylation is 95.6%, viscosity is the chitosan lactate of 502mpa.s, add in 1000ml conical flask, add 700ml deionized water, stirring at room temperature is to all dissolving, be mixed with 1%(m/v) chitosan lactate solution, to pour in the mould of 19cm × 19cm × 3cm after above-mentioned solution evacuation bubble removing, put into-40 DEG C of refrigerator and cooled and freeze 12h, then lyophilization 60h, obtain the chitosan lactate lyophilizing film of porous, be the 30min that pressurizes under the condition of 60 DEG C in temperature by the lyophilizing film pressurized equipment obtained, obtain the chitosan lactate film of the compact structure of 1mm thickness, then stick on other elastomeric nonwoven cloth rubber belt of medical grade, fit tightly, obtain the chitosan lactate wound hemostasis dressing without special odor.
Embodiment 4
Taking 7g deacetylation is 95.6%, viscosity is the chitosan lactate of 502mpa.s, add in 1000ml conical flask, add 700ml deionized water, stirring at room temperature is to all dissolving, be mixed with 1%(m/v) chitosan lactate solution, to pour in the mould of 19cm × 19cm × 3cm after above-mentioned solution evacuation bubble removing, put into-40 DEG C of refrigerator and cooled and freeze 24h, then lyophilization 60h, obtain the chitosan lactate lyophilizing film of porous, be the 10min that pressurizes under the condition of 60 DEG C in temperature by the lyophilizing film pressurized equipment obtained, obtain the chitosan lactate film of the compact structure of 1.5mm thickness, then stick on other elastomeric nonwoven cloth rubber belt of medical grade, fit tightly, obtain the chitosan lactate wound hemostasis dressing without special odor.
Embodiment 5
Taking 14g deacetylation is 95.9%, viscosity is the chitosan lactate of 36mpa.s, add in 1000ml conical flask, add 700ml deionized water, stirring at room temperature is to all dissolving, be mixed with 2%(m/v) chitosan lactate solution, above-mentioned solution is poured in the mould of 19cm × 19cm × 3cm, after discontinuous degassing, put into-60 DEG C of refrigerator and cooled and freeze 24h, then lyophilization 72h, obtain the chitosan lactate lyophilizing film of porous, be the 20min that pressurizes under the condition of 60 DEG C in temperature by the lyophilizing film pressurized equipment obtained, obtain the chitosan lactate film of the compact structure of 1.5mm thickness, then stick on other PE film backing adhesive tape of medical grade, fit tightly, obtain the chitosan lactate wound hemostasis dressing without special odor.
Embodiment 6
Taking 14g deacetylation is 95.9%, viscosity is the chitosan lactate of 36mpa.s, add in 1000ml conical flask, add 700ml deionized water, stirring at room temperature is to all dissolving, be mixed with 2%(m/v) chitosan lactate solution, above-mentioned solution is poured in the mould of 19cm × 19cm × 3cm, after discontinuous degassing, put into-60 DEG C of refrigerator and cooled and freeze 24h, then lyophilization 72h, obtain the chitosan lactate lyophilizing film of porous, be the 20min that pressurizes under the condition of 80 DEG C in temperature by the lyophilizing film pressurized equipment obtained, obtain the chitosan lactate film of the compact structure of 1.5mm thickness, then stick on other PE film backing adhesive tape of medical grade, fit tightly, obtain the chitosan lactate wound hemostasis dressing without special odor.
Embodiment 7
Taking 21g deacetylation is 95.6%, viscosity is the chitosan lactate of 502mpa.s, add in 1000ml conical flask, add 700ml deionized water, stirring at room temperature is to all dissolving, be mixed with 3%(m/v) chitosan lactate solution, above-mentioned solution is poured in the mould of 19cm × 19cm × 3cm, after discontinuous degassing, put into-80 DEG C of refrigerator and cooled and freeze 24h, then lyophilization 60h, obtain the chitosan lactate lyophilizing film of porous, be the 20min that pressurizes under the condition of 80 DEG C in temperature by the lyophilizing film pressurized equipment obtained, obtain the chitosan lactate film of the compact structure of 2mm thickness, then stick on other PE film backing adhesive tape of medical grade, fit tightly, obtain the chitosan lactate wound hemostasis dressing without special odor.
Embodiment 8
Taking 21g deacetylation is 95.6%, viscosity is the chitosan lactate of 502mpa.s, add in 1000ml conical flask, add 700ml deionized water, stirring at room temperature is to all dissolving, be mixed with 3%(m/v) chitosan lactate solution, above-mentioned solution is poured in the mould of 19cm × 19cm × 3cm, after discontinuous degassing, put into-80 DEG C of refrigerator and cooled and freeze 24h, then lyophilization 72h, obtain the chitosan lactate lyophilizing film of porous, be the 30min that pressurizes under the condition of 80 DEG C in temperature by the lyophilizing film pressurized equipment obtained, obtain the chitosan lactate film of the compact structure of 2mm thickness, then stick on other PE film backing adhesive tape of medical grade, fit tightly, obtain the chitosan lactate wound hemostasis dressing without special odor.
The haemostatic effect of embodiment 9 mice docking experiment
Employing Kun Ming mice is laboratory animal, 48, body weight 25 ~ 35g.Experiment point 5 groups: blank group, experimental group A, experimental group B, experimental group C, experimental group D, often organize 8, be fixed on by mice in mouse fixing device, with alcohol swab sterilization mousetail end, cuts and cut off at Mouse Tail-tip 1cm place, have blood flow to go out with sharp shears.Each experimental group carries out lower column processing: (1) blank group otch exposes; (2) the chitosan wound surface bleeding-stopping dressing prepared at the corresponding pressurized conditions that docking place closely sticks 1cm × 1cm of experimental group A, B, C, D.Observe mice docking place bleeding in experiment, every 10s filter paper sucks wound oozing of blood, until stopped bleeding, and record bleeding stopping period.Experiment condition and result as shown in the table:
Table 1 applies condition and the result data table of the mouse experiment of the application's bleeding-stopping dressing
Above experimental result shows, the haemostatic effect without the chitosan Wound dressing of special odor is obviously better than blank group, therefore, without the chitosan Wound dressing of special odor as a kind of novel bleeding-stopping dressing, has a extensive future.
The explanation of above embodiment just understands method of the present invention and core concept thereof for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (17)
1. a preparation method for wound hemostasis dressing, comprises the following steps:
Chitosan lactate solution is carried out freezing, then carries out lyophilization, obtain chitosan lactate lyophilizing film;
The mass concentration of described chitosan lactate solution is 0.5% ~ 3%;
Described chitosan lactate lyophilizing film is carried out pressurized treatments in a heated condition, obtains chitosan lactate film;
Described chitosan lactate film is adhered to back lining materials, obtains wound hemostasis dressing.
2. preparation method according to claim 1, is characterized in that, in described chitosan lactate solution, the Lactated deacetylation of chitosan is 95% ~ 96%, and viscosity is 30 ~ 510mpa.s.
3. the preparation method according to any one of claim 1 ~ 2, is characterized in that, the described freezing time is 12h ~ 48h, and described freezing temperature is-20 ~-100 DEG C.
4. the preparation method according to any one of claim 1 ~ 2, is characterized in that, the described cryodesiccated time is 48h ~ 72h.
5. preparation method according to claim 3, is characterized in that, the described cryodesiccated time is 48h ~ 72h.
6. the preparation method according to any one of claim 1,2,5, is characterized in that, the temperature of described heating is 40 DEG C ~ 80 DEG C.
7. preparation method according to claim 3, is characterized in that, the temperature of described heating is 40 DEG C ~ 80 DEG C.
8. preparation method according to claim 4, is characterized in that, the temperature of described heating is 40 DEG C ~ 80 DEG C.
9. the preparation method according to any one of claim 1,2,5,7,8, is characterized in that, the time of described pressurization is 10min ~ 30min.
10. preparation method according to claim 3, is characterized in that, the time of described pressurization is 10min ~ 30min.
11. preparation methoies according to claim 4, is characterized in that, the time of described pressurization is 10min ~ 30min.
12. preparation methoies according to claim 6, is characterized in that, the time of described pressurization is 10min ~ 30min.
13. according to claim 1 ~ 2,5,7 ~ 8, preparation method described in 10 ~ 12 any one, it is characterized in that, described back lining materials is other elastomeric nonwoven cloth rubber belt of medical grade or PE film backing adhesive tape.
14. preparation methoies according to claim 3, is characterized in that, described back lining materials is other elastomeric nonwoven cloth rubber belt of medical grade or PE film backing adhesive tape.
15. preparation methoies according to claim 4, is characterized in that, described back lining materials is other elastomeric nonwoven cloth rubber belt of medical grade or PE film backing adhesive tape.
16. preparation methoies according to claim 6, is characterized in that, described back lining materials is other elastomeric nonwoven cloth rubber belt of medical grade or PE film backing adhesive tape.
17. preparation methoies according to claim 9, is characterized in that, described back lining materials is other elastomeric nonwoven cloth rubber belt of medical grade or PE film backing adhesive tape.
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| CN201310547279.0A CN103520765B (en) | 2013-11-06 | 2013-11-06 | Method for preparing wound hemostasis dressing |
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| CN109701065B (en) * | 2019-01-03 | 2020-07-17 | 中国人民解放军总医院 | Preparation process of chitosan biological dressing coated with micromolecular lithium chloride |
| CN111375067B (en) * | 2020-03-18 | 2022-02-11 | 四川大学 | Chitosan scaffold and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2001024840A1 (en) * | 1999-10-07 | 2001-04-12 | Coloplast A/S | Wound care device |
| ZA200309861B (en) * | 2001-06-14 | 2004-12-20 | Providence Health Sys Oregon | Wound dressing and method for controlling severe, life-threatening bleeding. |
| DE102004007115A1 (en) * | 2004-02-13 | 2005-08-25 | Cognis Deutschland Gmbh & Co. Kg | Chitosan-containing wound dressings |
| CN101824160A (en) * | 2010-03-30 | 2010-09-08 | 东华大学 | Preparation method of chitosan/polyvinyl alcohol/polylactic acid blended porous membrane |
| CN101798403B (en) * | 2010-03-30 | 2012-02-01 | 东华大学 | Method for preparing chitosan/polyving alcohol/polylactic acid blended dense membrane |
| CN102210885B (en) * | 2011-06-06 | 2013-08-07 | 深港产学研基地 | High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof |
| CN102379773A (en) * | 2011-08-18 | 2012-03-21 | 苏州美迪斯医疗运动用品有限公司 | Self-adhesive elastic bandage capable of being directly used on wound |
| CN103028135B (en) * | 2012-12-14 | 2014-12-24 | 武汉奥绿新生物科技有限公司 | Method for preparing hemostatic sponge for dressing |
| CN102973985B (en) * | 2012-12-26 | 2014-08-13 | 东华大学 | Porous bacterial cellulose skin repair material with density structure and preparation method thereof |
| CN103143053A (en) * | 2013-03-24 | 2013-06-12 | 山东康力医疗器械科技有限公司 | Novel povidone-iodine antibacterial hydrocolloid dressing and preparation method thereof |
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Effective date of registration: 20160602 Address after: 130000, 666A, super street, hi tech Zone, Jilin, Changchun Patentee after: Changchun SinoBiomaterials Co., Ltd. Address before: 130022 Changchun people's street, Jilin, No. 5625 Patentee before: Changchun Institue of Applied Chemistry, Chinese Academy of Sciences |