CN105288161A - Eczema treating external application drug and preparation method thereof - Google Patents
Eczema treating external application drug and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to an eczema treating external application drug, which is prepared from the following raw materials: cortex phellodendri, codonopsis pilosula, sophora flavescens ait, nepeta cataria l, atractylodes lancea, gentiana macrophylla pall, scutellaria baicalensis, rhus chinensis mill, artemisia carvifolia, polygonatum odoratum, agrimonia pilosa ledeb, folium isatidis, gentiana scabra bunge, tree peony bark and fructus kochiae. According to the present invention, the treatment effect of the eczema treating external application drug is significantly superior to the traditional treatment drug, the eczema treating external application drug has advantages of rapid effect, short treatment course, economy, practicality, no side effect, high cure rate, recurrence resistance and the like, and is worthy of promotion and application, the traditional Chinese medicine coating agent has effects of heat clearing, inflammation eliminating, dampness eliminating and bleeding stopping, and the eczema treating external application drug is used for hundreds of eczema patients and the effect is obvious.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, be specifically related to Chinese medicine composition of a kind of eczema and preparation method thereof.
Background technology
Eczema be by heredity or immunity wait internal and external reasons cause a kind of there is pleomorphism skin lesion and easily have ooze out tendency dermal inflammatory reaction.Subjective symptoms acute pruritus.The state of an illness easily repeatedly, can be delayed and not heal for many years.Adopt hormone, antiallergic agent and the calcium that uses in recent years to regulate neural inhibitors of phosphatases clinically, have drug dependence in various degree and least dermatitis side effect, and the problem such as the easy chromogenesis of skin is calm.
The traditional Chinese medical science thinks that eczema morbidity is relevant more than himself body constitution, as intemperance of taking food, and retention of damp-heat in the interior; Or with the passing of time his disease of element trouble causes consumption impairment of YIN blood, and the stimulation of contact foreign objects or affection of exogenous wind-cold etc. bring out morbidity on this basis.Therefore take good care of body constitution by Chinese medicine and have certain curative effect to treatment eczema.
Summary of the invention
The external used medicine of the treatment eczema that the technical problem to be solved in the present invention not easily recurs after being to provide a kind of good effect, healing, this external used medicine has effect of damp eliminating, antiinflammatory, can also play antipruritic, to repair epidermis, protection epidermis effect simultaneously.
For solving the problems of the technologies described above, the external used medicine for the treatment of eczema of the present invention, is made up of following raw material, Cortex Phellodendri, Radix Codonopsis, Radix Sophorae Flavescentis, Herba Schizonepetae, Rhizoma Atractylodis, Radix Gentianae Macrophyllae, Radix Scutellariae, Galla Chinensis, Herba Artemisiae Annuae, Rhizoma Polygonati Odorati, Herba Agrimoniae, Folium Isatidis, Radix Gentianae, Cortex Moutan, the Fructus Kochiae.
Preferably, the weight portion of each raw material is, Cortex Phellodendri 20-25 part, Radix Codonopsis 10-12 part, Radix Sophorae Flavescentis 8-12 part, Herba Schizonepetae 4-8 part, Rhizoma Atractylodis 12-20 part, Radix Gentianae Macrophyllae 1-3 part, Radix Scutellariae 5-8 part, Galla Chinensis 3-7 part, Herba Artemisiae Annuae 10-15 part, Rhizoma Polygonati Odorati 2-5 part, Herba Agrimoniae 1-3 part, Folium Isatidis 4-6 part, Radix Gentianae 7-10 part, Cortex Moutan 7-10 part, Fructus Kochiae 1-4 part.
Preferably, the weight portion of each raw material is, Cortex Phellodendri 22 parts, Radix Codonopsis 11 parts, Radix Sophorae Flavescentis 10 parts, Herba Schizonepetae 6 parts, Rhizoma Atractylodis 15 parts, Radix Gentianae Macrophyllae 2 parts, Radix Scutellariae 6 parts, Galla Chinensis 5 parts, Herba Artemisiae Annuae 12 parts, Rhizoma Polygonati Odorati 4 parts, Herba Agrimoniae 2 parts, Folium Isatidis 5 parts, Radix Gentianae 8 parts, Cortex Moutan 8 parts, the Fructus Kochiae 2 parts.
The invention still further relates to a kind of method manufacturing the medicine of above-mentioned treatment eczema, comprise the following steps,
A. Cortex Phellodendri is taken by weight, Radix Codonopsis, Radix Sophorae Flavescentis, Herba Schizonepetae, Rhizoma Atractylodis, are ground into powder, add soak by water, after water boils, slow fire boils 2 hours, staticly settles 12-24 hour, filter, filtering residue is for subsequent use, and concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block A; Gained filtering residue adds the ethanol of 70% of 5 times of weight, and soak 3 hours, reflux, extract, 20-40 minute, by extracting liquid filtering, concentrated filtrate obtains clear paste, and by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block B;
B. Radix Gentianae Macrophyllae is claimed by weight, Radix Scutellariae, Galla Chinensis, Herba Artemisiae Annuae, Rhizoma Polygonati Odorati, Herba Agrimoniae, Folium Isatidis, Radix Gentianae, Cortex Moutan, the Fructus Kochiae, is ground into powder, and the concentration adding 10 times of raw material weights is the ethanol of 70%, soak 3 hours, utilize Vltrasonic device supersound extraction, supersonic frequency is 10-15kHz, and temperature is 35-40 DEG C, ultrasonic time is 50-60 minute, and filter, concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block C;
C. dry extract block A, B, C are pulverized, mix homogeneously, must treat the medicine of eczema.
The invention still further relates to the method that treatment eczema unguentum prepared by the medicine described in a kind of claim 4, the every weight portion of gained mixed-powder adds 5 parts of isopropyl myristates, ethyl hydroxybenzoate 0.5 part, sodium lauryl sulphate 4 parts, glyceryl monostearate 20 parts, white vaseline 20 parts, liquid paraffin 3 parts, glycerol 3 parts, mix homogeneously.
The external used medicine that the present invention treats eczema is obviously better than traditional treatment medicine, have instant effect, short treating period, economical and practical, have no side effect, the high and not easily advantage such as recurrence of cure rate, clinic promotion and application.This Chinese medicinal pigmentum has heat clearing away, antiinflammatory, dampness, hemostasia effect, for eczema patients hundreds of example, and successful.
Detailed description of the invention
Embodiment 1
Prepare the external used medicine for the treatment of eczema of the present invention, comprise the following steps,
A. medical material is taken by weight: Cortex Phellodendri 20 parts, Radix Codonopsis 10 parts, Radix Sophorae Flavescentis 8 parts, Herba Schizonepetae 4 parts, Rhizoma Atractylodis 12 parts, are ground into powder, add soak by water, after water boils, slow fire boils 2 hours, staticly settles 12-24 hour, filter, filtering residue is for subsequent use, and concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block A; Gained filtering residue adds the ethanol of 70% of 5 times of weight, and soak 3 hours, reflux, extract, 20-40 minute, by extracting liquid filtering, concentrated filtrate obtains clear paste, and by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block B;
B. medical material is taken by weight: Radix Gentianae Macrophyllae 3 parts, Radix Scutellariae 8 parts, Galla Chinensis 7 parts, Herba Artemisiae Annuae 15 parts, Rhizoma Polygonati Odorati 5 parts, Herba Agrimoniae 3 parts, Folium Isatidis 6 parts, Radix Gentianae 10 parts, Cortex Moutan 10 parts, the Fructus Kochiae 4 parts, be ground into powder, the concentration adding 10 times of raw material weights is the ethanol of 70%, soaks 3 hours, utilizes Vltrasonic device supersound extraction, supersonic frequency is 10-15kHz, temperature is 35-40 DEG C, and ultrasonic time is 50-60 minute, filters, concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block C;
C. dry extract block A, B, C are pulverized, mix homogeneously, must treat the medicine of eczema.
Use the method for said medicine powder preparation treatment eczema unguentum, the every weight portion of gained mixed-powder adds 5 parts of isopropyl myristates, ethyl hydroxybenzoate 0.5 part, sodium lauryl sulphate 4 parts, glyceryl monostearate 20 parts, white vaseline 20 parts, liquid paraffin 3 parts, glycerol 3 parts, mix homogeneously.
Embodiment 2
Prepare the external used medicine for the treatment of eczema of the present invention, comprise the following steps,
A. medical material is taken by weight: Cortex Phellodendri 25 parts, Radix Codonopsis 12 parts, Radix Sophorae Flavescentis 12 parts, Herba Schizonepetae 8 parts, Rhizoma Atractylodis 20 parts, are ground into powder, add soak by water, after water boils, slow fire boils 2 hours, staticly settles 12-24 hour, filter, filtering residue is for subsequent use, and concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block A; Gained filtering residue adds the ethanol of 70% of 5 times of weight, and soak 3 hours, reflux, extract, 20-40 minute, by extracting liquid filtering, concentrated filtrate obtains clear paste, and by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block B;
B. medical material is taken by weight: Radix Gentianae Macrophyllae 1 part, Radix Scutellariae 5 parts, Galla Chinensis 3 parts, Herba Artemisiae Annuae 10 parts, Rhizoma Polygonati Odorati 2 parts, Herba Agrimoniae 1 part, Folium Isatidis 4 parts, Radix Gentianae 7 parts, Cortex Moutan 7 parts, the Fructus Kochiae 1 part, be ground into powder, the concentration adding 10 times of raw material weights is the ethanol of 70%, soaks 3 hours, utilizes Vltrasonic device supersound extraction, supersonic frequency is 10-15kHz, temperature is 35-40 DEG C, and ultrasonic time is 50-60 minute, filters, concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block C;
C. dry extract block A, B, C are pulverized, mix homogeneously, must treat the medicine of eczema.
Use the method for said medicine powder preparation treatment eczema unguentum, the every weight portion of gained mixed-powder adds 5 parts of isopropyl myristates, ethyl hydroxybenzoate 0.5 part, sodium lauryl sulphate 4 parts, glyceryl monostearate 20 parts, white vaseline 20 parts, liquid paraffin 3 parts, glycerol 3 parts, mix homogeneously.
Embodiment 3
Prepare the external used medicine for the treatment of eczema of the present invention, comprise the following steps,
A. medical material is taken by weight: Cortex Phellodendri 22 parts, Radix Codonopsis 11 parts, Radix Sophorae Flavescentis 10 parts, Herba Schizonepetae 6 parts, Rhizoma Atractylodis 15 parts, are ground into powder, add soak by water, after water boils, slow fire boils 2 hours, staticly settles 12-24 hour, filter, filtering residue is for subsequent use, and concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block A; Gained filtering residue adds the ethanol of 70% of 5 times of weight, and soak 3 hours, reflux, extract, 20-40 minute, by extracting liquid filtering, concentrated filtrate obtains clear paste, and by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block B;
B. medical material is taken by weight: Radix Gentianae Macrophyllae 2 parts, Radix Scutellariae 6 parts, Galla Chinensis 5 parts, Herba Artemisiae Annuae 12 parts, Rhizoma Polygonati Odorati 4 parts, Herba Agrimoniae 2 parts, Folium Isatidis 5 parts, Radix Gentianae 8 parts, Cortex Moutan 8 parts, the Fructus Kochiae 2 parts, be ground into powder, the concentration adding 10 times of raw material weights is the ethanol of 70%, soaks 3 hours, utilizes Vltrasonic device supersound extraction, supersonic frequency is 10-15kHz, temperature is 35-40 DEG C, and ultrasonic time is 50-60 minute, filters, concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block C;
C. dry extract block A, B, C are pulverized, mix homogeneously, must treat the medicine of eczema.
During use, drug powder is added the ratio mixing of 100 grams of water with every gram of drug powder, use gauze to dip, cleaning affected part.
Embodiment 4
Prepare the external used medicine for the treatment of eczema of the present invention, comprise the following steps,
A. medical material is taken by weight: Cortex Phellodendri 22 parts, Radix Codonopsis 11 parts, Radix Sophorae Flavescentis 10 parts, Herba Schizonepetae 6 parts, Rhizoma Atractylodis 15 parts, are ground into powder, add soak by water, after water boils, slow fire boils 2 hours, staticly settles 12-24 hour, filter, filtering residue is for subsequent use, and concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block A; Gained filtering residue adds the ethanol of 70% of 5 times of weight, and soak 3 hours, reflux, extract, 20-40 minute, by extracting liquid filtering, concentrated filtrate obtains clear paste, and by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block B;
B. medical material is taken by weight: Radix Gentianae Macrophyllae 2 parts, Radix Scutellariae 6 parts, Galla Chinensis 5 parts, Herba Artemisiae Annuae 12 parts, Rhizoma Polygonati Odorati 4 parts, Herba Agrimoniae 2 parts, Folium Isatidis 5 parts, Radix Gentianae 8 parts, Cortex Moutan 8 parts, the Fructus Kochiae 2 parts, be ground into powder, the concentration adding 10 times of raw material weights is the ethanol of 70%, soaks 3 hours, utilizes Vltrasonic device supersound extraction, supersonic frequency is 10-15kHz, temperature is 35-40 DEG C, and ultrasonic time is 50-60 minute, filters, concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block C;
C. dry extract block A, B, C are pulverized, mix homogeneously, must treat the medicine of eczema.
Use the method for said medicine powder preparation treatment eczema unguentum, the every weight portion of gained mixed-powder adds 5 parts of isopropyl myristates, ethyl hydroxybenzoate 0.5 part, sodium lauryl sulphate 4 parts, glyceryl monostearate 20 parts, white vaseline 20 parts, liquid paraffin 3 parts, glycerol 3 parts, mix homogeneously.
The present invention, through clinic trial, achieves satisfied effect, and pertinent clinical data is as follows:
Clinical data:
The diagnostic criteria of chronic eczema is with reference to " clinical dermatology ": repeatedly more can not formed by acute or subacute eczema, also can be chronic inflammatory disease at the beginning; Skin lesion is confined to a place or many places more, and limit office property or general property infiltrate plump, brownish red or band Lycoperdon polymorphum Vitt, pigmentation, rough surface, above covers a small amount of squama or in tongue liquor-saturatedization; The chronic course of disease, but normal acute attack; Also obvious convulsion is had to itch, often in paroxysm.Inclusive criteria: 1. meet diagnostic criteria; 2. 18 ~ 65 years old age, can be First episode or recidivist; 3. signed Informed Consent Form person.Case exclusion standard: 1. age under-18s, over-65s, gestation or women breast-feeding their children; 2. known or suspicious to drugs composition allergy sufferers; 3. orally in nearly 2 weeks cross steroid medicines and/or within 1 week, took antihistaminic medicine orally or corticosteroid hormone is crossed in external; 4. the serious primary disease such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system is associated with, psychiatric patient.5. do not meet inclusive criteria, not by regulation medication, cannot curative effect person be judged.Observe 211 examples altogether, wherein man 110 example, female 101 example; 18 ~ 63 years old age, average 39.1 years old; The course of disease 1 to 15 year.Above-mentioned patient is divided into 4 groups at random, comprises treatment group 1, treatment group 2, treatment group 3, matched group, and between group, the aspect such as case sex, age, course of disease is through statistical procedures no significant difference, has comparability.
Therapeutic Method:
Treatment group 1: the medicine using the method in embodiment 1 to prepare, cleans affected part with warm water, gets 2 grams of drug powders at every turn, add warm water 200 grams, uses gauze to dip, cleaning affected part.Every day 3-5 time one week is a course for the treatment of, continuously two courses for the treatment of of treatment, and treatments period is stopped using other drug.
Treatment group 2: the medicine using the method in embodiment 3 to prepare, cleans affected part with warm water, gets 2 grams of drug powders at every turn, add warm water 200 grams, uses gauze to dip, cleaning affected part.Every day 3-5 time one week is a course for the treatment of, continuously two courses for the treatment of of treatment, and treatments period is stopped using other drug.
Treatment group 3: use medicine prepared by the method in embodiment 4, being cleaned in affected part with warm water, get 3 grams of ointment affected part of exterior coating at every turn, every day 3 times, one week is a course for the treatment of, continuously two courses for the treatment of of treatment, treatments period is stopped using other drug.
Matched group: the happy ointment of the yellow skin of ice, often props up 15 grams, affected part of exterior coating, every day 2 times, smeared for 2 week continuously.
Criterion of therapeutical effect:
Cure: erythra, red pimple, erythema, little water scar, yellow squama and silly skin, ooze out, the clinical symptoms such as rotten to the corn all disappears, physical rehabilitation;
Effective: affected part erythra, red pimple, erythema, little water scar, yellow squama and silly skin, ooze out, clinical symptom relief, the improvement such as rotten to the corn;
Invalid: to compare before symptom and treatment without improving.
Therapeutic effect compares:
Result shows, adopt medicine of the present invention to treat, cure rate is apparently higher than matched group.
Model case: Zhang, man, 44 years old, symptom: erythema, pimple occur little leg outer side symmetry, and pruritus, flows yellow fluid after scratching brokenly.Adopt Drug therapy of the present invention, after the course for the treatment of, pruritus disappears substantially, and lesion does not continue diffusion; After two courses for the treatment of, skin starts to recover normal, and swelling place is disappeared, and the incrustation of the skin place of scratching comes off; After three courses for the treatment of, skin complexion transfers to normally, ruddy glossy, cures.For preventing recurrence, continue to employ a course for the treatment of, thoroughly to detoxify.Pay a return visit after half a year, have no recurrence.
Claims (5)
1. treat an external used medicine for eczema, it is characterized in that: be made up of following raw material, Cortex Phellodendri, Radix Codonopsis, Radix Sophorae Flavescentis, Herba Schizonepetae, Rhizoma Atractylodis, Radix Gentianae Macrophyllae, Radix Scutellariae, Galla Chinensis, Herba Artemisiae Annuae, Rhizoma Polygonati Odorati, Herba Agrimoniae, Folium Isatidis, Radix Gentianae, Cortex Moutan, the Fructus Kochiae.
2. according to the external used medicine for the treatment of eczema according to claim 1, it is characterized in that: the weight portion of each raw material is, Cortex Phellodendri 20-25 part, Radix Codonopsis 10-12 part, Radix Sophorae Flavescentis 8-12 part, Herba Schizonepetae 4-8 part, Rhizoma Atractylodis 12-20 part, Radix Gentianae Macrophyllae 1-3 part, Radix Scutellariae 5-8 part, Galla Chinensis 3-7 part, Herba Artemisiae Annuae 10-15 part, Rhizoma Polygonati Odorati 2-5 part, Herba Agrimoniae 1-3 part, Folium Isatidis 4-6 part, Radix Gentianae 7-10 part, Cortex Moutan 7-10 part, Fructus Kochiae 1-4 part.
3. according to the external used medicine being used for the treatment of eczema according to claim 2, it is characterized in that: the weight portion of each raw material is, Cortex Phellodendri 22 parts, Radix Codonopsis 11 parts, Radix Sophorae Flavescentis 10 parts, Herba Schizonepetae 6 parts, Rhizoma Atractylodis 15 parts, Radix Gentianae Macrophyllae 2 parts, Radix Scutellariae 6 parts, Galla Chinensis 5 parts, Herba Artemisiae Annuae 12 parts, Rhizoma Polygonati Odorati 4 parts, Herba Agrimoniae 2 parts, Folium Isatidis 5 parts, Radix Gentianae 8 parts, Cortex Moutan 8 parts, the Fructus Kochiae 2 parts.
4. a method for the external used medicine of the treatment eczema described in manufacturing claims 1-3, is characterized in that: comprise the following steps,
A. Cortex Phellodendri is taken by weight, Radix Codonopsis, Radix Sophorae Flavescentis, Herba Schizonepetae, Rhizoma Atractylodis, are ground into powder, add soak by water, after water boils, slow fire boils 2 hours, staticly settles 12-24 hour, filter, filtering residue is for subsequent use, and concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block A; Gained filtering residue adds the ethanol of 70% of 5 times of weight, and soak 3 hours, reflux, extract, 20-40 minute, by extracting liquid filtering, concentrated filtrate obtains clear paste, and by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block B;
B. Radix Gentianae Macrophyllae is claimed by weight, Radix Scutellariae, Galla Chinensis, Herba Artemisiae Annuae, Rhizoma Polygonati Odorati, Herba Agrimoniae, Folium Isatidis, Radix Gentianae, Cortex Moutan, the Fructus Kochiae, is ground into powder, and the concentration adding 10 times of raw material weights is the ethanol of 70%, soak 3 hours, utilize Vltrasonic device supersound extraction, supersonic frequency is 10-15kHz, and temperature is 35-40 DEG C, ultrasonic time is 50-60 minute, and filter, concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block C;
C. dry extract block A, B, C are pulverized, mix homogeneously, must treat the external used medicine of eczema.
5. prepare the method for the treatment of eczema unguentum with the medicine described in claim 4 for one kind, it is characterized in that: the every weight portion of gained mixed-powder adds 5 parts of isopropyl myristates, ethyl hydroxybenzoate 0.5 part, sodium lauryl sulphate 4 parts, glyceryl monostearate 20 parts, white vaseline 20 parts, liquid paraffin 3 parts, glycerol 3 parts, potassium sorbate 0.1 part, mix homogeneously.
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