CN105267784A - Traditional Chinese medicine composition for treating ulcerative colitis - Google Patents
Traditional Chinese medicine composition for treating ulcerative colitis Download PDFInfo
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- CN105267784A CN105267784A CN201510821642.2A CN201510821642A CN105267784A CN 105267784 A CN105267784 A CN 105267784A CN 201510821642 A CN201510821642 A CN 201510821642A CN 105267784 A CN105267784 A CN 105267784A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating ulcerative colitis and a preparing method thereof. The traditional Chinese medicine composition is prepared from radix bupleuri, astragalus membranaceus, codonopsis pilosula, scorched hawthorn fruit, semen coicis, poria cocos, myrobalan and portulaca oleracea. The traditional Chinese medicine composition is dosed dialectically, components are simple, combination is reasonable, the remarkable effects of soothing the liver to smooth qi, tonifying spleen and stopping diarrhea, and clearing away heat and toxic materials are realized, ulcerative colitis can be effectively treated, the living quality of patients can be improved, and the traditional Chinese medicine composition is worth of clinical application and popularization.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of ulcerative colitis.
Background technology
Ulcerative colitis is a kind of cause of disease coton and rectal nonspecific inflammatory disease still not fully aware of, and the most common with chronic type, easy recurrent exerbation, prognosis is poor, and the course of disease is very long.Its pathological changes multidigit, in sigmoid colon and rectum, also may extend to descending colon, even whole colon, and bloody diarrhea is its modal early symptom, other symptoms have stomachache successively, have blood in stool, lose weight, tenesmus, vomiting etc.This patient mostly is the Yong adult people of 20 ~ 30 years old, and men and women's sickness rate difference is not obvious, day by day raises at the sickness rate of China.Current doctor trained in Western medicine mainly uses antibiotic to carry out anti-inflammatory analgetic, the treatment such as infection, immunity moderation, and side effect is comparatively large, unsatisfactory curative effect.
Ulcerative colitis belong to the traditional Chinese medical science " have loose bowels " " dysentery " the sick category such as " to have blood in stool ", the therapeutic modalities such as Chinese traditional treatment ulcerative colitis is with a long history, have accumulated abundant clinical experience, mainly contains oral medicinal herb, acupuncture, coloclysis.The traditional Chinese medical science is particular about dialectical treating, and has the advantage of multiple target effect, multipath onset according to the Chinese medicine of disease type reasonable compatibility, by fundamentally improving the repair ability of colon epithelial cell, regulating intestinal canal immunoreation, improve microcirculation, coordinate Zang-Fu relationship, reach the object of thoroughly curing.Therefore the Chinese medicine composition developing the more definite treatment ulcerative colitis of curative effect is necessary.
Summary of the invention
The invention provides a kind of Chinese medicine composition for the treatment of ulcerative colitis, by Radix Bupleuri, the Radix Astragali, Radix Codonopsis, Fructus Crataegi (parched to brown), Semen Coicis, Poria, Fructus Chebulae, Dens Equi is looked for eight taste medical material reasonable compatibilities and is obtained, and can play depressed liver-energy dispersing and QI regulating, invigorating the spleen to arrest diarrhea, the remarkable efficacy of heat-clearing and toxic substances removing, effectively treats ulcerative colitis; Inventor also discloses the Preparation method and use of this Chinese medicine composition on the other hand.
To achieve these goals, and the coordinated increased further between each raw material is to strengthen the effect of nursing ulcerative colitis, preferably, above-mentioned composition is made up of the Chinese crude drug of following weight proportioning: Radix Bupleuri 14-16 part, Radix Astragali 9-11 part, Radix Codonopsis 6-8 part, Fructus Crataegi (parched to brown) 10-14 part, Semen Coicis 10-14 part, Poria 6-8 part, Fructus Chebulae 6-8 part, Dens Equi looks for 9-11 part.
Further preferably, described compositions is made up of the Chinese crude drug of following weight proportioning: Radix Bupleuri 15 parts, the Radix Astragali 10 parts, Radix Codonopsis 7 parts, Fructus Crataegi (parched to brown) 12 parts, Semen Coicis 12 parts, 7 parts, Poria, and Fructus Chebulae 7 parts, Dens Equi looks for 10 parts.
The present invention also asks the purposes protecting this Chinese medicine composition in the medicine of preparation nursing ulcerative colitis.
The function of each component of compositions of the present invention cures mainly as follows:
Radix Bupleuri, bitter, be slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
The Radix Astragali, sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Codonopsis, sweet, flat.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Fructus Crataegi (parched to brown), sour, sweet, tepor.Return spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.
Semen Coicis is sweet, light, cool.Return spleen, stomach, lung meridian.Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Poria, GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Fructus Chebulae, bitter, sour, puckery, flat.Return lung, large intestine channel.Astringing intestine to stop diarrhea is astringed the lung, pathogenic fire reducing sore-throat relieving.For chronic diarrhea chronic dysentery, proctoptosis of having blood in stool, the deficiency of the lung is breathed with cough, and chronic cough is more than, pharyngalgia hoarseness.
Dens Equi is looked for, acid, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
The Chinese medicine composition for the treatment of ulcerative colitis provided by the invention, various dosage form can be made as required, preferably, Chinese medicine composition of the present invention makes oral formulations, such as described oral formulations can be oral liquid, granule or capsule, most preferably, Chinese medicine composition of the present invention makes oral liquid.The present inventor also finds under study for action, by optimized fabrication method, serve the effect of efficacy enhancing and toxicity reducing, reduce the untoward reaction using medicine to produce, make that this Chinese medicine composition is more potent acts on lesion faster, and be prepared into oral formulations, further increase the compliance that patient uses this medicine.Therefore, present invention also offers a kind of method preparing the Chinese medicine composition of above-mentioned nursing ulcerative colitis, the method comprises the following steps: the above-mentioned prescription medical material of recipe quantity is ground into coarse powder respectively, add 5-8 times of water gaging, warm macerating 2 hours, decoct 2 hours, decoct twice, filter, merge twice filtrate, it is 75% that filtrate adds ethanol to alcohol content, with volume percentage, leaves standstill 12 hours, get supernatant, reclaim ethanol to concentrated, add pharmaceutically acceptable carrier, be prepared into clinical acceptable dosage form by conventional method.
Detailed description of the invention
Below the specific embodiment of the present invention is described in detail.Should be understood that, detailed description of the invention described herein, only for instruction and explanation of the present invention, is not limited to the present invention.
Below will be described the present invention by embodiment.
Embodiment 1 capsule
The Chinese medicine composition for the treatment of ulcerative colitis of the present invention is made up of following medical material: Radix Bupleuri 15 parts, the Radix Astragali 10 parts, Radix Codonopsis 7 parts, Fructus Crataegi (parched to brown) 12 parts, Semen Coicis 12 parts, 7 parts, Poria, and Fructus Chebulae 7 parts, Dens Equi looks for 10 parts.
Preparation technology: the above-mentioned prescription medical material of recipe quantity is ground into coarse powder respectively, adds 5-8 times of water gaging, warm macerating 2 hours, decoct 2 hours, decoct twice, filter, merge twice filtrate, it is 75% that filtrate adds ethanol to alcohol content, with volume percentage, leaves standstill 12 hours, get supernatant, reclaim ethanol to concentrated, add pharmaceutically acceptable carrier, be prepared into capsule by conventional method.
When using Chinese medicine preparation of the present invention to nurse ulcerative colitis, take prepared capsule, every contains crude drug amount 0.2g, and every day 3 times, each 2-4 grain, takes after meal half an hour.
Embodiment 2 granule
The Chinese medicine composition for the treatment of ulcerative colitis of the present invention is made up of following medical material: Radix Bupleuri 15 parts, the Radix Astragali 10 parts, Radix Codonopsis 7 parts, Fructus Crataegi (parched to brown) 12 parts, Semen Coicis 12 parts, 7 parts, Poria, and Fructus Chebulae 7 parts, Dens Equi looks for 10 parts.
Preparation technology: the above-mentioned prescription medical material of recipe quantity is ground into coarse powder respectively, adds 5-8 times of water gaging, warm macerating 2 hours, decoct 2 hours, decoct twice, filter, merge twice filtrate, it is 75% that filtrate adds ethanol to alcohol content, with volume percentage, leaves standstill 12 hours, get supernatant, reclaim ethanol to concentrated, add pharmaceutically acceptable carrier, be prepared into granule by conventional method.
When using Chinese medicine preparation of the present invention to nurse ulcerative colitis, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 3 oral liquid
The Chinese medicine composition for the treatment of ulcerative colitis of the present invention is made up of following medical material: Radix Bupleuri 15 parts, the Radix Astragali 10 parts, Radix Codonopsis 7 parts, Fructus Crataegi (parched to brown) 12 parts, Semen Coicis 12 parts, 7 parts, Poria, and Fructus Chebulae 7 parts, Dens Equi looks for 10 parts.
Preparation technology: the above-mentioned prescription medical material of recipe quantity is ground into coarse powder respectively, adds 5-8 times of water gaging, warm macerating 2 hours, decoct 2 hours, decoct twice, filter, merge twice filtrate, it is 75% that filtrate adds ethanol to alcohol content, with volume percentage, leaves standstill 12 hours, get supernatant, reclaim ethanol to concentrated, add pharmaceutically acceptable carrier, be prepared into oral liquid by conventional method.
When using Chinese medicine preparation of the present invention to nurse ulcerative colitis, take prepared oral liquid, containing crude drug amount 0.5g, every day 2 times, each 1 bottle, take half an hour after meal for every bottle.
Embodiment 4 oral liquid
The Chinese medicine composition for the treatment of ulcerative colitis of the present invention is made up of following medical material: Radix Bupleuri 14 parts, the Radix Astragali 9 parts, Radix Codonopsis 6 parts, Fructus Crataegi (parched to brown) 10 parts, Semen Coicis 10 parts, 6 parts, Poria, and Fructus Chebulae 6 parts, Dens Equi looks for 9 parts.
Preparation method is with embodiment 3.
Embodiment 5 oral liquid
The Chinese medicine composition for the treatment of ulcerative colitis of the present invention is made up of following medical material: Radix Bupleuri 16 parts, the Radix Astragali 11 parts, Radix Codonopsis 8 parts, Fructus Crataegi (parched to brown) 14 parts, Semen Coicis 14 parts, 8 parts, Poria, and Fructus Chebulae 8 parts, Dens Equi looks for 11 parts.
Preparation method is with embodiment 3.
Comparative example's oral liquid
A kind of Chinese medicine composition for the treatment of ulcerative colitis is made up of following medical material: Radix Bupleuri 15 parts, the Radix Astragali 10 parts, Radix Sophorae Flavescentis 7 parts, Semen Coicis 12 parts, 7 parts, Poria, and Fructus Chebulae 10 parts, Dens Equi looks for 10 parts.
Preparation method is with embodiment 1.
Chinese medicinal composition capsules agent of the present invention is used for clinical observation test
1, physical data:
Choose liver-depression and spleen-insufficiency type patients of ulcerative colitis 240 example of the outpatient service of Gastroenterology dept. of the court and ward accepting for medical treatment, adopt random number method to be divided into treatment group, matched group 1 group, contrasts 2 groups, often organizes 80 routine patients.Treatment group man 50 example, female 30 example, age 18-60 year, average 45.24 ± 6.25 years old, average course of disease (5.47 ± 3.63) year; Contrast 1 group man 47 example, female 33 example, age 18-64 year, average 46.38 ± 6.75 years old, average course of disease (5.26 ± 3.71) year; Contrast 2 groups man 51 example, female 29 example, age 18-59 year, average 44.62 ± 7.04 years old, average course of disease (5.58 ± 4.16) year.The aspects such as three groups of ages, sex, courses of disease, through statistical procedures, without significant (P > 0.05), have comparability.
2, diagnostic criteria
Western medicine diagnose is according to " peptic ulcer disease Clinics and Practices specifications recommend ".Soft stools or as water sample, increased frequency.The diseases such as abdominal distention stomachache can be accompanied; Chronic chronic diarrhea onset is slow, and the course of disease is longer, recurrent exerbation, time light time heavy; Improper diet, can to bring out by cold and cool or emotion changes; Visible red, the leukocyte a little of stool routine examination, stool cultivates pathogenic bacterium positive or negative.
Tcm diagnosis is according to " Chinese medical disease Standardization of diagnosis and curative effect ".Stagnation of liver-QI with deficiency of the spleen: stomachache increased borborygmus and diarrhea, often send out because feelings will is not smooth, rushing down rear pain delays, red tongue, white and thin fur, stringy pulse; Blood stasis intestinal network: abdominal distention distending pain, defecates smelly as loses ovum, rushing down rear alleviation of pain, indigestion and loss of appetite, belching and acid regurgitation, tongue coating dirt or thick greasy, rolling pulse.
3, exclusion standard:
1. severe complication is had as local stenosis, intestinal obstruction, intestinal perforation, toxic colonic dilatation, massive hemorrhage and colon and rectum carcinoma patient; 2. trimester of pregnancy, women breast-feeding their children; 3. the serious constitutional heart, liver, lung, kidney, disease in the blood system person.
4, Therapeutic Method:
Primary Care: three groups are all given the symptomatic treatments such as antiinflammatory.
Contrasting 1 group gives Mesalazine table oral (accurate word H19980148, the 0.25g/ sheet of traditional Chinese medicines), 4 times/d, 1g/ time.
Oral liquid prepared by the oral embodiment 1 for the treatment of group, every bottle of 10ml, containing crude drug amount 0.5g, every day 2 times, each 1 bottle, takes after meal half an hour.
Contrast oral liquid prepared by 2 groups of oral contrast embodiments, every bottle of 10ml, containing crude drug amount 0.5g, every day 2 times, each 1 bottle, take half an hour after meal.
Two groups of patient procedure are 8 weeks, to stop using other treatment medicine at treatments period, advise that minimal invasive treatment's rule, spirit are optimistic, appropriate level of work and rest, and avoid pungent food greasy plumpness etc.
5, the standard of curative effect evaluation:
The ulcerative colitis curative effect determinate standard formulated for 2003 with reference to Chinese combination of Chinese and Western medicine digestion system disease Professional Committee carries out.
Clinical cure: clinical cardinal symptom disappears, secondary disease disappears or substantially disappears, and square arteries and veins recovers normal substantially; Intestinal mirror check non-cancer lesion recovers normal, or ulcer focus forms cicatrix; Just conventional microscopy 3 is subnormal.
Effective: clinical cardinal symptom disappears substantially, secondary disease is improved degree and is reached more than 2 grades, and square arteries and veins is normal; Intestinal mirror check non-cancer lesion recovery extent reaches more than 2 grades; Just routine examination is normal.
Take a turn for the better: clinical cardinal symptom improvement reaches more than 1 grade; Intestinal mirror check non-cancer lesion recovery extent reaches more than 1 grade; Just red, the leukocyte count 5/HP of conventional microscopy.
Invalid: after treatment, clinical symptoms, endoscopy are without improvement.
6, statistical method
Carry out statistical analysis with statistics software SPSS20.0 to data, enumeration data adopts x
2inspection; Measurement data mean ± standard deviation
represent, carry out t inspection; P < 0.05 represents that between two groups, diversity is remarkable.
7. therapeutic outcome
1. the concrete therapeutic outcome of each group is as shown in table 1.
Table 1: three groups for the treatment of clinical effectiveness
| Group | n | Cure | Effective | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 80 | 38 | 24 | 14 | 4 | 95％* ◎ |
| Contrast 1 group | 80 | 15 | 29 | 15 | 21 | 73.8％ |
| Contrast 2 groups | 80 | 20 | 26 | 17 | 17 | 78.8％ |
Note: treatment group with contrast 1 group and compare, * P < 0.05, and contrast 2 groups and compare,
◎p < 0.05.
As can be seen from table 1 relatively, clinical cure 38 people, total effective rate 95% in treatment group, be all better than contrast 1 or 2 groups, and significant difference or very remarkable, there is statistical significance (P < 0.05).
2. colonic mucosa pathological changes integration situation of change under intestinal mirror: compare in group before and after treatment, under three groups of intestinal mirrors, colonic mucosa pathological changes integration difference all has statistical significance (P < 0.05); Compare after treatment between group, under intestinal mirror, colonic mucosa pathological changes integration difference has statistical significance (P < 0.05), sees the following form 2.
Under three groups of intestinal mirrors, colonic mucosa pathological changes integration situation of change compares
| Group | n | Before treatment | After treatment |
| Treatment group | 80 | 2.62±0.71 | 1.11±0.34* ◎ |
| Contrast 1 group | 80 | 2.59±0.78 | 1.68±0.52 |
| Contrast 2 groups | 80 | 2.66±0.69 | 1.53±0.46 |
Note: treatment group with contrast 1 group and compare, * P < 0.05, and contrast 2 groups and compare,
◎p < 0.05.
Relatively can be found by above data, treatment group therapeutic effect is better than other matched group, and significant difference, there is statistical significance (P < 0.05); The clinical effectiveness for the treatment of group and contrast 2 groups shows, changes prescription and/or proportioning, can not reach the same excellent therapeutic effect of Chinese medicine composition of the present invention.
3. safety: the untoward reaction relevant with medication does not all appear in treatments period three groups, before and after treatment all there is not larger fluctuation in hepatic and renal function indices and electrocardiogram.
To sum up, the invention provides a kind of Chinese medicine composition and preparation method thereof, the dialectical administration of this Chinese medicine composition group, prescription is simplified, and compatibility is reasonable, there is depressed liver-energy dispersing and QI regulating, invigorating the spleen to arrest diarrhea, the remarkable efficacy of heat-clearing and toxic substances removing, effectively can treat ulcerative colitis, improve patients ' life quality, clinic is applied.
Claims (7)
1. treat a Chinese medicine composition for ulcerative colitis, it is characterized in that, described compositions is made up of the Chinese crude drug of following weight proportioning: Radix Bupleuri 14-16 part, Radix Astragali 9-11 part, Radix Codonopsis 6-8 part, Fructus Crataegi (parched to brown) 10-14 part, Semen Coicis 10-14 part, Poria 6-8 part, Fructus Chebulae 6-8 part, Dens Equi looks for 9-11 part.
2. Chinese medicine composition according to claim 1, is characterized in that, described compositions is made up of the Chinese crude drug of following weight proportioning: Radix Bupleuri 15 parts, the Radix Astragali 10 parts, Radix Codonopsis 7 parts, Fructus Crataegi (parched to brown) 12 parts, Semen Coicis 12 parts, 7 parts, Poria, and Fructus Chebulae 7 parts, Dens Equi looks for 10 parts.
3. the Chinese medicine composition according to claim 1,2, is characterized in that, the dosage form of this Chinese medicine composition is oral liquid, granule or capsule.
4. Chinese medicine composition according to claim 3, is characterized in that, the dosage form of this Chinese medicine composition is preferably oral liquid.
5. prepare the method for the Chinese medicine composition described in claim 1 or 2 for one kind, it is characterized in that, the method comprises the following steps: the above-mentioned prescription medical material of recipe quantity is ground into coarse powder respectively, add 5-8 times of water gaging, warm macerating 2 hours, decoct 2 hours, decoct twice, filter, merge twice filtrate, it is 75% that filtrate adds ethanol to alcohol content, with volume percentage, leaves standstill 12 hours, get supernatant, reclaim ethanol to concentrated, add pharmaceutically acceptable carrier, be prepared into clinical acceptable dosage form by conventional method.
6. the purposes of Chinese medicine composition as claimed in claim 1 or 2 in the medicine of preparation treatment ulcerative colitis.
7. the purposes of Chinese medicine composition as claimed in claim 1 or 2 in the medicine of preparation treatment liver-depression and spleen-insufficiency type ulcerative colitis.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027507A (en) * | 2014-05-15 | 2014-09-10 | 当涂县科辉商贸有限公司 | Traditional Chinese medicine decoction for treating ulcerative colitis |
| CN104667243A (en) * | 2014-12-11 | 2015-06-03 | 刘弘强 | Traditional Chinese medicament for treating ulcerative colitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027507A (en) * | 2014-05-15 | 2014-09-10 | 当涂县科辉商贸有限公司 | Traditional Chinese medicine decoction for treating ulcerative colitis |
| CN104667243A (en) * | 2014-12-11 | 2015-06-03 | 刘弘强 | Traditional Chinese medicament for treating ulcerative colitis |
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