CN104208474B - Traditional Chinese medicine composition for treating acute urinary tract infection and application thereof - Google Patents
Traditional Chinese medicine composition for treating acute urinary tract infection and application thereof Download PDFInfo
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- CN104208474B CN104208474B CN201410444530.5A CN201410444530A CN104208474B CN 104208474 B CN104208474 B CN 104208474B CN 201410444530 A CN201410444530 A CN 201410444530A CN 104208474 B CN104208474 B CN 104208474B
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Abstract
The invention relates to a traditional Chinese medicine composition for treating acute urinary tract infection. The traditional Chinese medicine composition is prepared from the following raw pharmaceutical materials: oldenlandia diffusa, herba leonuri, herba plantaginis, common knotgrass, raw liquorice, cogon grass rhizome, raw milkvetch root, fried atractylodes macrocephala, ledebouriella root, malva seed, anemarrhena rhizome and phellodendron bark. The invention further provides application of the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the effects of clearing away heat and toxic materials and relieving stranguria by diuresis through combining monarch, ministerial, adjuvant and guide drugs. Shown by clinical trials, the traditional Chinese medicine composition has a remarkable treatment effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically, be a kind of Chinese medicine composition for treating acute urinary tract infection and
Its application.
Background technology
Urinary tract infection (Urinary Tract Infection, UTI) referred to as urine sense, refers to that pathogen invades urinary tract mucosa
Or the urinary tract inflammation disease that tissue is caused.Urinary tract infection can occur from baby to old all age group, common
In women, domestic census statistics incidence of urinary infections about 0.91%.Relevant document shows that the U.S. is used to treat urinary tract infection
Medical expense is just up to 1,000,000,000 dollars/year.Therefore the study on prevention of urinary tract infection has been become the important topic for currently facing it
One.
Modern medicine thinks that multiple pathogens such as antibacterial, funguses, mycoplasma, chlamydia, virus, parasite etc. can cause
Urinary tract infection.Clinically common with gram negative bacilli, wherein escherichia coli are most commonly seen, constitute about the 80%- of acute urine sense
90%, next to that paracolon, Bacillus proteuss, klebsiella bacillus, Pseudomonas aeruginosa etc..The treatment of clinical urinary tract infection with
Based on antibiotic, due to the abuse of antibiotic, the situation for causing Resistant strain insensitive is increasing, and curative effect is not good enough, while depositing
In the hidden danger such as anaphylaxiss and toxic and side effects, and considerably increase medical expense.
Urinary tract infection belongs to motherland's medical science " stranguria " category, stranguria（Pyretic stranguria）It is that kidney deficiency, damp and hot heresy are reluctant to leave lower Jiao, bladder gas
Caused by changing mistake department.Pyretic stranguria major lesions are in kidney and vesicourethral.The interior-excess heat syndrome that pathogenic heat causes mostly is from differential diagnosis in terms of eight principles.By because of sense
By exopathogen it is different, the difference of body constitution, divide again accumulate in pyretic toxicity, damp invasion of lower energizer, the hot and suffocating stagnation of QI, have table disease the exterior and interior syndromes appearing simultaneously etc. concurrently.But
Cardinal symptom frequent micturition odynuria, few abdomen are ached.According to above-mentioned theory using heat-clearing and toxic substances removing, relieving stranguria by diuresis, based on eliminating evil
Basic therapy.
Chinese patent literature CN100372554C discloses a kind of medicine for treating acute urinary tract infection and its preparation
Method, the invention is directed to acute urinary tract infection, proposes pathogenic characteristic burnt under Liver Channel depression and stagnation of QI, the damp-heat accumulation of stranguria, with
It is therapeutic rules to discongest the Liver Channel stagnation of QI, Qinghua damp-heat in lower-JIAO, is developed with reference to clinical experience for many years.The medicine is by raw material bavin
Recklessly, Radix Scutellariae, Herba Polygoni Avicularis, etc. medical material be prepared from, have the effect that：The gram negative bacteria common to urinary tract infection has anti-
Bacterium acts on；The renal inflammation that experimental urinary tract infection models mice can be made reacts significantly mitigation；E. coli adhesion can be prevented
To mouse bladder epithelium；There is significant inhibitory action to general inflammation；Mouse peritoneal pain caused by chemical factor is had
Significant analgesic activity；Urine volume after rat Water l oad can be dramatically increased；To the cytophagous phagocytic function of mouse peritoneal without obvious
Affect.The present invention provides a kind of Chinese medicine composition for the treatment of acute urinary tract infection for having not yet to see report and its application.
The content of the invention
The purpose of the present invention is for deficiency of the prior art, there is provided a kind of Chinese medicine composition for treating acute urinary tract infection
Thing.
Another purpose of the present invention is to provide a kind of application of the Chinese medicine composition for treating acute urinary tract infection.
For achieving the above object, the present invention is adopted the technical scheme that：A kind of Chinese medicine composition for treating acute urinary tract infection
Thing, described Chinese medicine composition is made up of the crude drug of following weight portion：Herba Hedyotidis Diffusae 25-35 parts, Herba Leonuri 12-18 parts,
Herba Plantaginiss 12-18 parts, common knotgrass 12-18 parts, Radix Glycyrrhizae 4-8 parts, Rhizoma Imperatae 25-35 parts, Radix Astragali 12-18 parts, Rhizoma Atractylodis Macrocephalae (parched) 7-
13 parts, Radix Saposhnikoviae 4-8 parts, Semen Abutili 7-13 parts, Rhizoma Anemarrhenae 7-13 parts, Cortex Phellodendri 7-13 parts.
Described Chinese medicine composition is made up of the crude drug of following weight portion：Herba Hedyotidis Diffusae 28-32 parts, Herba Leonuri 13-
17 parts, Herba Plantaginiss 13-17 parts, common knotgrass 13-17 parts, Radix Glycyrrhizae 5-7 parts, Rhizoma Imperatae 28-32 parts, Radix Astragali 13-17 parts, fry white
Art 9-11 part, Radix Saposhnikoviae 5-7 parts, Semen Abutili 9-11 parts, Rhizoma Anemarrhenae 9-11 parts, Cortex Phellodendri 9-11 parts.
Described Chinese medicine composition is made up of the crude drug of following weight portion：30 parts of Herba Hedyotidis Diffusae, 15 parts of Herba Leonuri, car
First careless 15 parts, 15 parts of common knotgrass, 6 parts of Radix Glycyrrhizae, 30 parts of Rhizoma Imperatae, 15 parts of Radix Astragali, 10 parts of Rhizoma Atractylodis Macrocephalae (parched), 6 parts of Radix Saposhnikoviae, Semen Abutili
10 parts, 10 parts of the Rhizoma Anemarrhenae, 10 parts of Cortex Phellodendri.
To realize above-mentioned second purpose, the present invention is adopted the technical scheme that：Described Chinese medicine composition is controlled in preparation
Treat the application in the medicine of acute urinary tract infection.
The invention has the advantages that：
The Chinese medicine composition of the present invention cures mainly pyretic stranguria（Acute urinary tract infection）, clinical testing data shows to have significantly to be treated
Effect.Relative to the antibiotic therapy acute urinary tract infection of current main flow, treatment by Chinese herbs stable curative effect, to conventional antibiotic therapy without
The patient of effect is still effective, the anti-infectious function with wide spectrum, and untoward reaction is few, to anemia of pregnant woman and the Small side effects of fetus, tool
Have broad application prospects.
Specific embodiment
The specific embodiment that the present invention is provided is elaborated with reference to embodiment.
A kind of Chinese medicine composition for treating acute urinary tract infection, is made up of the crude drug of following weight portion：
Herba Hedyotidis Diffusae 25-35 parts, Herba Leonuri 12-18 parts, Herba Plantaginiss 12-18 parts, common knotgrass 12-18 parts, Radix Glycyrrhizae 4-8
Part, Rhizoma Imperatae 25-35 parts, Radix Astragali 12-18 parts, Rhizoma Atractylodis Macrocephalae (parched) 7-13 parts, Radix Saposhnikoviae 4-8 parts, Semen Abutili 7-13 parts, Rhizoma Anemarrhenae 7-13
Part, Cortex Phellodendri 7-13 parts.
Fang Zhong, Herba Hedyotidis Diffusae, Herba Polygoni Avicularis, Herba Plantaginiss, Semen Abutili heat-clearing and toxic substances removing, relieving stranguria by diuresis, are monarch drug；The Rhizoma Anemarrhenae, Cortex Phellodendri
Clearing away heat-damp and promoting diuresis, cure mainly damp-heat in lower-JIAO, and Herba Leonuri activating blood and promoting diuresis, Rhizoma Imperatae cooling blood for hemostasis assist monarch drug clearing away heat-damp and promoting diuresis treating stranguria, are minister
Medicine；The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae harmonizing yingfen and weifen, strengthening vital QI to eliminate pathogenic factors is improved immune function, is assistant the effect of strengthen anti-infectious immunity power
Medicine；Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, to make medicine.All medicine phases are closed, and the effect of heat-clearing and toxic substances removing, relieving stranguria by diuresis is played altogether.
The Chinese medicine composition of embodiment 1
30 parts of Herba Hedyotidis Diffusae, 15 parts of Herba Leonuri, 15 parts of Herba Plantaginiss, 15 parts of common knotgrass, 6 parts of Radix Glycyrrhizae, 30 parts of Rhizoma Imperatae,
15 parts of Radix Astragali, 10 parts of Rhizoma Atractylodis Macrocephalae (parched), 6 parts of Radix Saposhnikoviae, 10 parts of Semen Abutili, 10 parts of the Rhizoma Anemarrhenae, 10 parts of Cortex Phellodendri.
The Chinese medicine composition of embodiment 2
28 parts of Herba Hedyotidis Diffusae, 17 parts of Herba Leonuri, 13 parts of Herba Plantaginiss, 17 parts of common knotgrass, 5 parts of Radix Glycyrrhizae, 32 parts of Rhizoma Imperatae,
13 parts of Radix Astragali, 11 parts of Rhizoma Atractylodis Macrocephalae (parched), 5 parts of Radix Saposhnikoviae, 11 parts of Semen Abutili, 9 parts of the Rhizoma Anemarrhenae, 11 parts of Cortex Phellodendri.
The Chinese medicine composition of embodiment 3
32 parts of Herba Hedyotidis Diffusae, 13 parts of Herba Leonuri, 17 parts of Herba Plantaginiss, 13 parts of common knotgrass, 7 parts of Radix Glycyrrhizae, 28 parts of Rhizoma Imperatae,
17 parts of Radix Astragali, 9 parts of Rhizoma Atractylodis Macrocephalae (parched), 7 parts of Radix Saposhnikoviae, 9 parts of Semen Abutili, 11 parts of the Rhizoma Anemarrhenae, 9 parts of Cortex Phellodendri.
The Chinese medicine composition of embodiment 4
25 parts of Herba Hedyotidis Diffusae, 18 parts of Herba Leonuri, 12 parts of Herba Plantaginiss, 18 parts of common knotgrass, 4 parts of Radix Glycyrrhizae, 35 parts of Rhizoma Imperatae,
12 parts of Radix Astragali, 13 parts of Rhizoma Atractylodis Macrocephalae (parched), 4 parts of Radix Saposhnikoviae, 13 parts of Semen Abutili, 7 parts of the Rhizoma Anemarrhenae, 13 parts of Cortex Phellodendri.
The Chinese medicine composition of embodiment 5
35 parts of Herba Hedyotidis Diffusae, 12 parts of Herba Leonuri, 18 parts of Herba Plantaginiss, 12 parts of common knotgrass, 8 parts of Radix Glycyrrhizae, 25 parts of Rhizoma Imperatae,
18 parts of Radix Astragali, 7 parts of Rhizoma Atractylodis Macrocephalae (parched), 8 parts of Radix Saposhnikoviae, 7 parts of Semen Abutili, 13 parts of the Rhizoma Anemarrhenae, 7 parts of Cortex Phellodendri.
The preparation of the Chinese medicine composition of embodiment 6
The arbitrary described Chinese medicine composition of embodiment 1-5, with water 1000ml decoctions, boils and takes 400ml, point sooner or later 2 times it is oral,
Decoction being taken warmly after meal.
The preparation of the Chinese medicine composition of embodiment 7
The arbitrary described Chinese medicine composition of embodiment 1-5 prepares any agent for pharmaceutically allowing by conventional formulation means
Type, such as granule, capsule, tablet, pill, oral liquid etc..
The clinical trial of embodiment 8
1. physical data
100 patients of this group, derive from our hospital 2012-2013 out-patients, meet Second China National nephropathy
The diagnostic criteria of the urinary tract infection that academic conference is drafted.Divide treatment group（Embodiment 1）With matched group（Levofloxacin）.Wherein,
Treatment group 50, man 6, female 44；32 years old mean age.Matched group 50, man 7, female 43；34 years old mean age.2 groups
Sex and between the age without significant difference, 2 groups of patient's hepatic and renal functions are normal, without Other diseases.
2. diagnostic criteria
A. Chinese medical discrimination diagnosing acute urinary tract infection, is ached with frequent micturition, odynuria, few abdomen, fever with chills, body of the tongue
Red, yellow fur, rapid pulse is main clinical manifestation.
B. Western medicine diagnostic criteria：Cleaning centrifugation stage casing uropsammus examination：, there is urinary tract infection symptom leukocyte >=10/HP
Person, or CCMS bacteria quantified culture：Clump count >=105ml.
3. Therapeutic Method
Treatment group：The Chinese medicine composition of embodiment 1, with water 1000ml decoctions, boils and takes 400ml, 2 oral, meals of point morning and evening
Decoction being taken warmly afterwards.Continuously take two weeks, observe 6 weeks.
Matched group：SANJIN PIAN, orally, 3 times/day, 5 pieces/times, continuously takes 2 weeks, observes 6 weeks.
4. criterion of therapeutical effect
Promulgate according to Ministry of Health of the People's Republic of China《New Chinese medicine guideline of clinical investigations》Relevant standard.Control
More：Clinical symptom disappearance, tests antibacterial culturing bacterium colony ＜ 105ml, and routine urinalysis are normal；Take a turn for the better：Symptom mitigation, urine bacterium colony substantially subtracts
Few, routine urinalysis improve；Do not heal：Symptom and lab testing are not improved.
5. therapeutic outcome
Treatment group's total effective rate 96%, matched group effective percentage 80%, comparing 2 groups has significant difference, P ＜ 0.05.As a result such as
Shown in table 1：
1 two groups of comparitive studies of table
Routine blood test, stool routine examination, liver function (ALT, AST) in this test before and after all subjects, renal function
(BUN, Scr), Electrocardiographic testing result do not find obvious abnormal change.During test, experimenter does not occur and medicine phase
The malaise symptoms and sign of pass, have no adverse reaction.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of without departing from the inventive method, can also make some improvement and supplement, and these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (4)
1. a kind of Chinese medicine composition for treating acute urinary tract infection, it is characterised in that described Chinese medicine composition is by following weight
The crude drug of part is made：Herba Hedyotidis Diffusae 25-35 parts, Herba Leonuri 12-18 parts, Herba Plantaginiss 12-18 parts, common knotgrass 12-18 parts, life
Radix Glycyrrhizae 4-8 parts, Rhizoma Imperatae 25-35 parts, Radix Astragali 12-18 parts, Rhizoma Atractylodis Macrocephalae (parched) 7-13 parts, Radix Saposhnikoviae 4-8 parts, Semen Abutili 7-13 parts, know
Female 7-13 parts, Cortex Phellodendri 7-13 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that described Chinese medicine composition is by following weight portion
Crude drug is made：Herba Hedyotidis Diffusae 28-32 parts, Herba Leonuri 13-17 parts, Herba Plantaginiss 13-17 parts, common knotgrass 13-17 parts, Radix Glycyrrhizae
5-7 parts, Rhizoma Imperatae 28-32 parts, Radix Astragali 13-17 parts, Rhizoma Atractylodis Macrocephalae (parched) 9-11 parts, Radix Saposhnikoviae 5-7 parts, Semen Abutili 9-11 parts, Rhizoma Anemarrhenae 9-
11 parts, Cortex Phellodendri 9-11 parts.
3. Chinese medicine composition according to claim 1, it is characterised in that described Chinese medicine composition is by following weight portion
Crude drug is made：30 parts of Herba Hedyotidis Diffusae, 15 parts of Herba Leonuri, 15 parts of Herba Plantaginiss, 15 parts of common knotgrass, 6 parts of Radix Glycyrrhizae, Rhizoma Imperatae 30
Part, 15 parts of Radix Astragali, 10 parts of Rhizoma Atractylodis Macrocephalae (parched), 6 parts of Radix Saposhnikoviae, 10 parts of Semen Abutili, 10 parts of the Rhizoma Anemarrhenae, 10 parts of Cortex Phellodendri.
4. according to claim 1-3 arbitrary described Chinese medicine composition answering in the medicine for preparing treatment acute urinary tract infection
With.
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