CN104689258A - Traditional Chinese medicine for treating phlegm-blood stasis syndrome type mammary gland adenosis - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicine recipes, in particular to traditional Chinese medicine for treating the phlegm-blood stasis syndrome type mammary gland adenosis. The traditional Chinese medicine is characterized in that the traditional Chinese medicine comprises, 18 g of snake gourd, 15 g of fritillaria thunbergii, 9 g of radix bupleuri, 15 g of roots of common peony, 12 g of tangerine leaves, 12 g of rhizoma cyperi, 12 g of rhizoma atractylodis macrocephalae, 15 g of rhizoma sparganii, 15 g of curcuma zedoary, 12 g of loofah sponge, 10 g of semen brassicae, 15 g of radix curcumae, 12 g of radix angelicae dahuricae and 12 g of ligusticum wallichii. The raw materials are soaked with water and decocted, and filter liquid is obtained after deslagging.

Description

The Chinese medicine for the treatment of intermingled phlegm and blood stasis type adenosis of breast

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine for the treatment of intermingled phlegm and blood stasis type adenosis of breast.

Background technology

As everyone knows, adenosis of breast belongs to a kind of common type of mammary dysplasia, and main change is the focal hypertrophy of mammary gland alveolus and conduit, can with corresponding connective tissue proliferation, and leaflet structure is not normal.Be the comparatively common disease of hyperplasia of mammary glands glands of women, be apt to occur in Women of Childbearing Age, main manifestations is periodic mastalgia and lump, can accompany menoxenia, and severe patient can affect orthobiosis.Treatment at present for adenosis of breast mainly relies on vitamins, hormones or operative treatment, and effect is undesirable.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, provides a kind of Chinese medicine for the treatment of intermingled phlegm and blood stasis type adenosis of breast, cost is low, evident in efficacy, has no side effect.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of intermingled phlegm and blood stasis type adenosis of breast, it is characterized in that being made up of following crude drug, Fructus Trichosanthis 18 grams, Bulbus Fritillariae Thunbergii 15 grams, Radix Bupleuri 9 grams, above-mentioned 14 taste crude drug are soaked in water by Radix Paeoniae Rubra 15 grams, Folium Citri tangerinae 12 grams, Rhizoma Cyperi 12 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, Rhizoma Sparganii 15 grams, Rhizoma Curcumae 15 grams, Retinervus Luffae Fructus 12 grams, Semen Sinapis Albae 10 grams, Radix Curcumae 15 grams, the Radix Angelicae Dahuricae 12 grams, Rhizoma Chuanxiong 12 grams, filtrate of removing slag after decocting to obtain.

The invention has the beneficial effects as follows, cost is low, evident in efficacy, have no side effect.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment:

Every auxiliary medicine is Fructus Trichosanthis 18 grams, Bulbus Fritillariae Thunbergii 15 grams, Radix Bupleuri 9 grams, Radix Paeoniae Rubra 15 grams, Folium Citri tangerinae 12 grams, Rhizoma Cyperi 12 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, Rhizoma Sparganii 15 grams, Rhizoma Curcumae 15 grams, Retinervus Luffae Fructus 12 grams, Semen Sinapis Albae 10 grams, Radix Curcumae 15 grams, the Radix Angelicae Dahuricae 12 grams, Rhizoma Chuanxiong 12 grams, add water above-mentioned raw materials medicine 1100-1200ml, soak 4-5 hour, then boiling slow fire with high heat decocts to about 60 minutes, remove slag to obtain filtrate about 200ml, medicinal residues add water about 300-400ml again, decoct about 30 minutes, remove slag to obtain filtrate about 100ml, be total to obtain about 300ml medicine juice, i.e. obtained decoction of the present invention, every day 1 dose point sooner or later 2 times oral.

1 clinical data and method

1.1 adenosis of breast diagnostic criterias

Diagnostic criteria with reference to China Association of Traditional Chinese Medicine surgery breast disease Professional Committee is formulated.

1.1.1 symptom and sign

1) breast has distending pain in various degree, twinge or dull pain, can be radiated to oxter, shoulder back, can have dependency with menstruation, emotion changes. and continuous 3 months or be interrupted pain and do not alleviate for 3-6 months.

2) one or both sides breast occur single or multiplely to differ in size, the lump of form of diverse, lump dispersibles in whole breast, unclear with surrounding tissue boundary, with skin or deep tissue adhesion. push away movable. can tenderness be had. can the growth and decline with the change of emotion and menstrual cycle.Some patients's nipple can have discharge or pruritus.

1.1.2 exclusion standard

Get rid of the front children's's Gynecomastia of menophania, gynecomastia and breast innocent and malignant tumour.

1.1.3 auxiliary examination

Aluminum target x line takes the photograph sheet, B ultrasonic, mammary gland fiber duct mirror, Puncture cytology or histological examination.

It is more than all tools that one+" exclusion standard " person in " symptom+sign ", should diagnose in conjunction with " auxiliary examination " according to clinical condition.

1.2 cyclomastopathy tcm syndrome differentiation and typing standard

Breast disease Professional Committee of surgery of Chinese medicine association of cyclomastopathy syndrome of intermin-gled phlegm and blood stasis Syndrome Differentiation of Traditional Chinese Medicine canonical reference China passes through standard.

1.2.1 caused by hepatic stagnation qi stagnation

1) main symptom: a, distending pain of the breast, alter pain; B, mastalgia and (or) lump and menstruation, emotion changes are relevant: c, irritable; D, two side of body distensions.

2) secondary card: a, lump are single lamellar, and matter is soft, touch a tender spot obviously: b, young women; C, menoxenia, or dysmenorrhea; D, body of the tongue.

Tool 3 main symptoms or 2 main symptoms+2 cards can be diagnosed as caused by hepatic stagnation qi stagnation.

1.2.2 intermingled phlegm and blood stasis type

1) main symptom: a, breast twinge; B, lump are multiformity, obscure boundary, and matter is more tough: dark red or the livid purple or tongue limit point of c, tongue has ecchymosis, or Sublingual venation is slightly swollen, livid purple.

2) secondary card: a, breast twinge and (or) lump and menstruation, emotion are very not relevant; B, menstruation are spread out the phase, pass through smooth or with stasis of blood block; C, greasy fur on tongue, hesitant pulse, string or cunning.

Tool 3 main symptoms or 2 main symptoms+2 cards can be diagnosed as intermingled phlegm and blood stasis type.

1.2.3 Chong and Ren channel disorder type

1) main symptom: a, mastalgia symptom are comparatively light, or without pain; B, soreness of the waist and knees or companion's heel pain; C, the confusion of the menstrual cycle, amount less or natural law of passing through of short duration or not to the utmost dripping, or amenorrhea.

2) secondary card; A, middle age with ± women: b, dizziness and tinnitus; C, pale tongue, thin white fur of tongue, thready pulse.

1.3 inclusive criterias:

1. the adenosis of breast diagnostic criteria that surgery's breast disease Professional Committee of China Association of Traditional Chinese Medicine formulates is met.

2. meet syndrome of intermin-gled phlegm and blood stasis Syndrome Differentiation of Traditional Chinese Medicine standard 3. 20 years old that breast disease Professional Committee of Chinese surgery of Chinese medicine association formulates≤age≤the 50 years old 4. course of disease >=January.

1.4 exclusion standards:

1. breast red and swollen heat pain, occur together the acute inflammatory condition such as heat; 2. lump in breast, hard fixing, increase fast, change with the breast carcinoma such as skin adhesion; 3. internal organs serious condition and the psychotics such as cardiovascular, liver, kidney and hemopoietic system is merged; 4. age < 20 years old or > 55 years old, and gestation, women breast-feeding their children; 5. do not press predetermined treatment, cannot judge that curative effect or data are not congruent; recent hormone takes history and radiotherapy history [3]; simple mastalgia is children's's Gynecomastia, gynecomastia 8..

1.5 physical data:

120 routine adenosis of breast patients are in January, 2011 to 2013 year institute of traditional Chinese medicine of December Weihai City surgery and outpatients of gynecology.Adopt random digits table to be divided into treatment group, matched group, often organize 60 examples.In treatment group, 23 ~ 55 years old age, year mean age (31 ± 4); The course of disease is the shortest 4 months, the longest 10 years, individual month of average course of disease (22.11 ± 9.07).In matched group, 26 ~ 54 years old age, year mean age (33 ± 5); The course of disease is the shortest 6 months, the longest 12 years, individual month of average course of disease (24.68 ± 10.67).

Above-mentioned general clinical data is through statistical procedures, and between group, parameters is harmonious good, has comparability.

1.6 case-data analyses

Table 1, two groups of patient ages compare

Group	N	Man	Female	20－	30－	40－	50-(year)	Mean age X ± S
									Treatment group	60	0	60	7	22	28	3	31.23±4.17
Matched group	60	0	60	9	23	26	2	33.50±5.44

Note: two groups of patient ages compare, through statistical disposition, there was no significant difference (P > 0.05), has comparability.

Table 2, two groups of patient's courses of disease compare

Group	N	0－	5－	10－	Average course of disease X ± S
						Treatment group	60	29	23	8	22.11±9.07
Matched group	60	24	27	9	24.68±10.67

Note: two groups of patient's courses of disease compare, through statistical disposition, there was no significant difference (P > 0.05), has comparability.

Before table 3, two groups of treatments, traditional Chinese medical science individual event symptom compares

Note: before two groups of treatments, traditional Chinese medical science individual event symptom compares, and through statistical disposition, there was no significant difference (P > 0.05), has comparability.

Before table 4, two groups of patient treatments, B ultrasonic diagnosis is compared

Group	N	Body of gland is disorderly, thicken, Echo heterogenicity	Low echo nodules
				Treatment group	60	60	57
Matched group	60	60	58

Note: two groups of patient's ultrasonic experiments compare, through statistical disposition, there was no significant difference (P > 0.05), has comparability.

2 treatment and observational techniques

2.1 Therapeutic Method

2.1.1 treatment group: basic side composition: Chinese juniper beach wormwood 18 grams, Bulbus Fritillariae Thunbergii 15 grams, Radix Bupleuri 9 grams, Radix Paeoniae Rubra 15 grams, Folium Citri tangerinae 12 grams, Rhizoma Cyperi 12 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, Rhizoma Sparganii 15 grams, Rhizoma Curcumae 15 grams, Retinervus Luffae Fructus 12 grams, Semen Sinapis Albae 10 grams, Radix Curcumae 15 grams, the Radix Angelicae Dahuricae 12 grams, Rhizoma Chuanxiong 12 grams.Decocting 300ml, every day 1 dose, divide and take for 2 times, 10 days is a course for the treatment of, has three days off between the course for the treatment of, and treatment time is 2 months.If menorrhagia, menstrual period can withdraw.

2.1.2 matched group: adopt oral Chinese patent medicine RUPIXIAO, each 3, every day 3 times, treatment time is 2 months.All other medicines are not used during medicine.

2.2 observation of curative effect

2.2.1 observation index

(1) clinical efficacy evaluation criteria: the criterion of therapeutical effect formulated according to the second time breast disease academic conference of national surgery of Chinese medicine association, after treatment, row high-frequency color doppler ultrasound checks to judge curative effect.Cure: lump in breast and pain disappear completely; Effective: the maximum lump reduced more than 1/2 of breast, mastalgia disappears substantially; Effective: the maximum lump reduced of breast is less than 1/2, or lump deliquescing, pain relief; Invalid: lump in breast is unchanged or increase, and pain does not subtract or increases the weight of.

(2) visual analogue scales (Visual Analogue Scale/Score is called for short VAS): specific practice is: the horizontal line of standardized bar 10 cm on paper, and one end of horizontal line is 0, represents painless; The other end is 10, represents severe pain; Mid portion represents pain in various degree.Allowing patient according to feeling standardized mark on horizontal line, representing the degree of pain.

2.2.2 safety observations index lab index: liver function, renal function, electrocardiogram, routine blood test, routine urinalysis, just routine, each inspection 1 time before and after medication; Untoward reaction: follow up a case by regular visits at every turn or medical time itemized record.

2.2.2 safety observations project and method

(1) respectively check once before and after blood, urine, stool routine examination treatment.

(2) serum alanine aminotransferase (ALT), serum AST (AST), serum creatinine (Scr), before and after carbamide ammonia (BUN) treatment, each inspection once.

(3) untoward reaction or side effect during itemized record medication, and note anaphylaxis.

2.3.2 health giving quality observation item and method

(1) Clinical symptom and sign: the Clinical symptom and sign such as record treatment Patients Before And After mastalgia, lump, menoxenia.By symptom and sign performance light (+), in (++), heavy (+++) be designated as 2 respectively, 4,6 points.

(2) B ultrasonic performance sign, observes the forward and backward mammary gland structure for the treatment of and Tumor size change, by mild degree (+), in (++), heavy (+++) charge to 2 respectively, 4,6 points.

3 efficacy assessment standards

3.1 total effects evaluation criterias

(1) effective: clinical symptom disappearance, integration is 0 or treats rear total mark minimizing >=2/3.

(2) effective: clinical symptoms obviously alleviates or treats rear symptom total mark minimizing >=1/2 < 2/3.

(3) invalid: clinical symptoms is not improved or treats rear symptom total mark and reduces > 0 < 1/3 or increase the weight of, and after treatment, total mark increases

3.2 tcm syndrome evaluation criterias

(1) analyze scoring system

For objective evaluation curative effect, take sxemiquantitative to score to cardinal symptom, by symptom and sign performance without (one), light (+), in (++), heavy (+++), remember 0 respectively, 2,4,6 points.(see table 5)

Table 5 tcm syndrome sxemiquantitative standards of grading table

Syndrome	Without (one)	Gently (+)	In (++)	Heavy (+++)
					Mastalgia	0	2	4	6
Lump in breast	0	2	4	6

(2) efficacy evaluation method

Curative effect is evaluated with the ratio of integration difference compared with the integration before treatment before and after treating.Effective: > 60-95%, effectively: 30-60%, invalid < 30%.

3.3 B ultrasonic efficacy evaluations:

(1) effective: mammary gland structure is smooth or slightly disorderly, and body of gland thickens < 0.5cm, and tuberosity disappears or reduces more than 1/2.

(2) effective: mammary gland structure disturbance, body of gland thickens < 1.0cm, and tuberosity reduces less than 1/2.

(3) invalid: mammary gland structure disturbance, Echo heterogenicity, low echo nodules size and number is unchanged, or tuberosity increases increase, occurs blood flow or pernicious sign.

4.1 statistical procedures:

Adopt SPSS17.0 statistical software to carry out statistical analysis, enumeration data chi-square butter, measurement data represents with mean ± standard deviation, compares with t inspection, represent that difference has statistical significance with P < 0.05 between group

5.1 therapeutic effect

5.1 tcm symptom comparitive study

5.1.1 two groups of tcm symptom total effectses are than effect, in table 6

Table 6 liang group tcm symptom total effects is than effect

Group	N	Clinical recovery	Effective	Effectively	Invalid	Total effective rate (100%)
							Treatment group	60	2	21	26	11	81.7
Matched group	60	0	20	22	18	70.0

Note: two groups of tcm symptom total effectses compare, has significant difference (P < 0.01).Treatment group total effective rate is 81.7%, matched group total effective rate is 70.0%, through X 2 test, treatment group and matched group comparing difference have statistical significance (P < 0.05), and result prompting treatment group clinical efficacy is better than matched group.

5.1.2 traditional Chinese medical science individual event symptom comparitive study after two groups of treatments, in table 7

Traditional Chinese medical science individual event symptom comparitive study after table 7 liang group treatment

P=0.035

Note: two groups for the treatment of rear udder attachment pain symptoms compare, and have statistical significance (P < 0.05), and prompting treatment group is alleviated mastalgia symptom effect and is better than matched group.

Note: two groups for the treatment of rear udder attachment lump symptoms compare, and have statistical significance (P < 0.05), prompting treatment group reduces lump in breast effect and is better than matched group.

5.1.3 before and after two groups of treatments, the change of TCM syndrome integration compares (X ± S) in table 8

Before and after table 8 liang group treatment, the change of TCM syndrome integration is compared (X ± S)

Group	N	Before treatment	After treatment
				Treatment group	60	6.11±1.74	3.15±1.26
Matched group	60	6.23±1.68	5.39±1.41

Note: treat front and back disease integration change separately for two groups and compare, have statistical significance (P < 0.05), more also have statistical significance between group, both promptings all can reduce disease integration, but treatment group effect is better than matched group.

5.1.4 before and after two groups of treatments, the change of individual event symptom integral is compared, in table 9

Before and after table 9 liang group patient treatment, the change of individual event symptom integral is compared (X ± S)

Note: treat the change of front and back individual event symptom integral separately for two groups and compare, have statistical significance (P < 0.05), more also have statistical significance between group, both promptings all can reduce individual event disease integration, but treatment group effect is better than matched group.

5.1.5 two groups of B ultrasonic comparitive study, in table 10

Table 10 liang group B ultrasonic comparitive study

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate %
						Treatment group	60	18	30	12	80.0
Matched group	60	13	24	23	61.7

P=0.039

Note: two groups of ultrasonic comparitive study, has statistical significance (P < 0.05), and the ultrasonic curative effect of prompting treatment group is better than matched group.

5.1.6 before and after two groups of patient treatments, VAS scoring is compared in table 11

Before and after table 11 liang group patient treatment, VAS scoring is compared (mean ± standard deviation is divided)

Group

Number of cases

Before treatment

After treatment

Treatment group

60

5.52±1.48

2.42±0.81

Matched group

60

5.42±1.46

4.95±1.10

Note: compare before two groups of patient treatments, P>0.05; Compare after treatment, P < 0.05.

From table 11, compare in two groups of groups, before and after treatment group treatment, difference has statistical significance (P < 0.01), and before and after treatment of control group, difference has statistical significance (P < 0.05), illustrates that two groups all can be improved patient pain's symptom; Between group, comparing difference all has statistical significance (P < 0.05), and result prompting treatment group therapeutic effect is better than matched group.

5.4 safety observation and untoward reaction

Routine blood test and the change of hepatic and renal function index before and after treatment, in table 12

Table 12 treats front and back routine blood test and the change of hepatic and renal function index

Note: treat forward and backward each Indexes Comparison there was no significant difference, (P > 0.05), safety is compared: two group of 120 routine patient does not all occur obvious adverse reaction.

4 discuss

Adenosis of breast doctor trained in Western medicine thinks that its generation is out of proportion relevant with estrogen and progestogen in body, clinical manifestation mainly contain 1. periodically pain present be that before menstruation, distending pain of the breast increases the weight of, lump increases; Pain relief or alleviation after passing through, lump diminishes.Pain is often distending pain, prickling-like pain or dull pain, can to Ipsilateral axillary fossa, shoulder radiation.2. lump in breast is often multiple, can involve both sides mammary gland.But also can single-shot, lump is generally less, and diameter is many at more than 2cm.Lump shape differs, nodositas block in sheet and streak etc., and edge is very unclear.Lump hardness differs with the degree of proliferation of fibrous tissue.Mammary gland tumor and pain often because uncomfortable in chestly not relax, the emotion changes such as irascible temperament and changing, especially with cyclomastopathy type patient, when pain after anxious state of mind anger increases the weight of, lump increases hardening.3. menoxenia cyclomastopathy type patient menstrual is often irregular, and menstrual period are short, Hypomenorrhea.Belong to Chinese medicine " nodules of the breast " category, describe in " Yangke Xinde Ji, Experience Gained in Treating External Diseases " " good in depression of liver-QI, smoulder and form ... depression of liver-QI; and swollen hard formation ", so primary disease etiology and pathogenesis to be mainly feelings will unsuccessful, depressed rage impairing the liver, depression of liver-QI, stagnation of QI due to depression of the liver, QI and blood is condensed newborn network; Worry impairing spleen, dysfunction of the spleen in transportation, in phlegm-damp, life causes stagnation of QI expectorant blood coagulation stasis combinate form to become lump.Or making stagnation of QI-blood because of Chong and Ren channel disorder, meridian and vessels obstruction causes lump in breast, pain and menoxenia.Liver spleen be disease send out dirty, qi and blood stagnation is that disease is by place.The stasis of blood, expectorant are pathological product, and newborn network is not freely pathological change, and the main manifestations of primary disease is pain, lump, and changes with menstrual cycle, and the course of disease is long, and partial breast pain and mental status have close contacting.We in conjunction with motherland's medical science and modern medicine to the understanding of this disease, with the method for dialectical differential diagnosis of diseases, think intermingled phlegm and blood stasis type adenopathy mainly with resolving depression of regulating the flow of vital energy, dissipating phlegm and resolving masses, unimpeded newborn network for principle for the treatment of, make irritability fluent, the strong fortune of temper, blood circulation depending on qi flow, the expectorant knot that disappears is loose.My seminar is according to clinical empirical summary we for many years, in side, Radix Bupleuri, Rhizoma Cyperi, Radix Curcumae are regulated the flow of vital energy with soothing liver-QI for relieving depression, Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying and expectorant painful abdominal mass, Chinese juniper beach wormwood, Bulbus Fritillariae Thunbergii, Semen Sinapis Albae dissipating phlegm and resolving masses, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizoma Sparganii, Rhizoma Curcumae promoting blood circulation and breaking stagnation and easing pain, Folium Citri tangerinae, Retinervus Luffae Fructus relax newborn dredging collateral.Chinese juniper beach wormwood master quenches one's thirst, fever of the body stuffy sensation with restlessness, hot greatly, tonify deficiency regulating the spleen and stomach, continuous wound absolutely, except hot eight subcutaneous ulcers chronic in the intestines and stomach, and body yellowish complexion, one's lips are dry and one's mouth parched, lose heart, Tong Yueshui, only normal urination; Bulbus Fritillariae Thunbergii removing heat-phlegm, dissipating depression of QI eliminating stagnation; Radix Bupleuri has reconciling superficies and interior, effect of soothing the liver yang invigorating; Radix Paeoniae Rubra has clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling; Folium Citri tangerinae controls hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness; Rhizoma Cyperi dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving; The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect; Rhizoma Sparganii is used for lump in the abdomen mass in the abdomen, dysmenorrhea, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain; Rhizoma Curcumae is used for abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gathers; Retinervus Luffae Fructus has dredge the meridian passage, effect of removing toxic substances and promoting subsidence of swelling; Semen Sinapis Albae warming spleen and stomach for dispelling cold, promoting the circulation of QI eliminating phlegm, the meridian dredging, detumescence poison; Radix Curcumae promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice; The Radix Angelicae Dahuricae gets rid of illness the functions such as dehumidifying, evacuation of pus granulation promoting, promoting blood circulation and stopping pain; Rhizoma Chuanxiong activating QI to alleviate the depression, method wind-dryness is wet, and only invigorates blood circulation.Originally can make mechanism of qi must logical, blood stasis must be alive, expectorant is turbid must be changed, logical QI and blood regulating, promotes that endocrine is normal.

Claims (1)

1. treat the Chinese medicine of intermingled phlegm and blood stasis type adenosis of breast for one kind, it is characterized in that being made up of following crude drug: Fructus Trichosanthis 18 grams, Bulbus Fritillariae Thunbergii 15 grams, Radix Bupleuri 9 grams, Radix Paeoniae Rubra 15 grams, Folium Citri tangerinae 12 grams, Rhizoma Cyperi 12 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, Rhizoma Sparganii 15 grams, Rhizoma Curcumae 15 grams, Retinervus Luffae Fructus 12 grams, Semen Sinapis Albae 10 grams, Radix Curcumae 15 grams, the Radix Angelicae Dahuricae 12 grams, Rhizoma Chuanxiong 12 grams, above-mentioned 14 taste crude drug are soaked in water, filtrate of removing slag after decocting to obtain.