CN105250957A - Drug for treating gonarthrosis and preparation technology thereof - Google Patents
Drug for treating gonarthrosis and preparation technology thereof Download PDFInfo
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- CN105250957A CN105250957A CN201510700662.4A CN201510700662A CN105250957A CN 105250957 A CN105250957 A CN 105250957A CN 201510700662 A CN201510700662 A CN 201510700662A CN 105250957 A CN105250957 A CN 105250957A
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Abstract
The invention discloses a drug for treating gonarthrosis. The drug for treating the gonarthrosis is prepared from, by mass, 5%-6% of radix angelicae pubescentis, 5%-6% of herba taxilli, 9%-10% of rhizoma drynariae, 5%-6% of common club moss herbs, 3%-4% of radix saposhnikoviae, 5%-6% of garden balsam stems, 3%-4% of radix gentianae macrophyllae, 2%-3% of short-pedicel aconite roots, 2%-3% of saffron, 2%-3% of caulis sinomenii, 3%-4% of frankincense, 3%-4% of myrrh, 3%-4% of common burreed rhizome, 3%-4% of rhizoma atractylodis, 2%-3% of radix achyranthis bidentatae, 3%-4% of rhizoma curcumae, 3%-4% of chuanxiong rhizome, 1%-2.5% of aconite roots, 3%-4% of Chinese angelica roots, 4%-5% of herba pyrolae, 0.5%-1.5% of cloves, 10%-12% of dried ginger and 1%-3% of borneol. The invention further discloses a preparation technology of the drug. The drug for treating the gonarthrosis has the functions of promoting blood circulation to remove blood stasis, making blood vessels unblocked and eliminating stasis, the effects of removing swelling and stopping pain are achieved, recovery of soft tissue injuries is accelerated, and spasms of blood vessels and soft tissue are relieved.
Description
Technical field
The present invention relates to medical drugs field, be specifically related to a kind of medicine and the preparation technology thereof that are used for the treatment of gonarthrosis.
Background technology
" knee joint is happy refreshing " spirit is the essential ingredient got of quenching from more than 20 Chinese medicines, make through chelating in conjunction with modern science and technology, the previous generation product of " knee joint is happy refreshing " uses nearly more than 30 years clinically, although effect is rather good at that time, but due to fresh water (FW) adjustment, use and inconvenience, along with the development of science and technology, traditional Chinese medicine combines with modern high technology, create macromolecule new formulation of today, its feature is: easy to use, penetration is strong, curative effect is reliable, instant effect, persistent, simultaneously, this prescription is through in many ways extracting, from the medicines such as Rhizoma Drynariae, decomposable asymmetric choice net goes out the extremely strong material being similar to proteoglycan of a kind of hydrophilic, this material can promote IA hyaluronic generation to a certain extent, the process of inflammation-inhibiting, remove IA harmful substance, lubricating joint, repairing articular cartilage and synovial membrane position together with other drug in formula, make it to recover its original function, " knee joint is happy refreshing " spirit preparation technology is simple, do not need special installation, only affected part is applied to during use, then oneself wraps up with common preservative film or does hot compress in 20 minutes with hot towel, greatly can facilitate hydration with preservative film parcel and dissolve cutin effect, strengthen drug osmotic, make to discharge medicine gradually during drugs through skin horny layer, the better therapeutical effect playing medicine, another can assist medicine " to extract " wind in body exactly, cold, wet, heresy waits harmful substance, add this prescription and contain appropriate ethanol, more can follow footpath by priming, promote the effects such as pathological tissues reparation, and, " knee joint happy refreshing spirit " agents area is special warms, drug effect lasts up to more than 40 minutes, to the infiltration of skin deep until ailing place, " its gas inaccessible, make the property of medicine from its space between skin and muscles of pore people, stimulate the menstrual flow and pass through network, or carry it, or attack and fall apart it, outstanding strong than taking medicine, this to wonderful method also " Chinese medicine circle just payes attention to the approach of TCM in Vitro medication from ancient times, successively formulate out a series of external drug dosage forms, " the happy refreshing spirit of knee joint " is exactly based on the theory of Traditional Chinese medicine blood circulation promoting blood stasis dispelling, with Radix Angelicae Pubescentis, the expelling wind and removing dampness such as Herba Taxilli, nourish blood and seek, active blood stasis dispelling, with Flos Carthami, Radix Angelicae Sinensis, blood circulation strengthened by the medicine of the blood circulation promoting and blood stasis dispelling such as Sanguis Draxonis, Shortstalk Monkshood Root, the Chinese medicine of the muscles and tendons relaxing to alleviate pain such as Lignum Sappan, to be excited nerve tip by the method for Local out dressing, by reflection, blood vessel dilating, promote local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in synovial bursa, make it to return and produce and absorb dynamic equilibrium, reach unobstructed blood vessels, the dissipation stasis of blood is stagnant, the effect of reducing swelling and alleviating pain, utilize in medicine and promote that the perichondrium of damage is usually repaired by the unit of bone cell growth, synovial membrane etc., reach and eliminate synovial membrane inflammation in synovial bursa and the object of fully recovering, the traditional Chinese medical science that Here it is say " Chu is sick in interior, must shape in outer " by modern medicine be exactly: by external said medicine alleviating vascular, the spasm of soft tissue, between conditioner soma and capillary permeability, improve the microcirculation disturbance of different parts, remove the pathological state of the soft tissue such as skin, blood vessel, muscle of patient, recover the physiological property that it is original, gonarthrosis, synovitis are a kind of diseases can suffered from altogether per capita from juvenile pupil to the advanced in years, also a kind of bone degenerative diseases.Along with the development of modern society, society enters senescence, and the chance greatly that people participate in social activity increases, and kneed sickness rate is also in growth at double, and " knee joint is happy refreshing " spirit also just becomes a kind of medicine removing slight illness that extensive patients is badly in need of.
Summary of the invention
Problem to be solved by this invention is to provide the medicine of a kind of blood circulation promoting and blood stasis dispelling, unobstructed blood vessels, the dissipation stasis of blood is stagnant, reducing swelling and alleviating pain effect is fast treatment gonarthrosis.
To achieve these goals, the technical scheme that the present invention takes is: a kind of component proportioning (mass fraction) being used for the treatment of the medicine of gonarthrosis comprises Radix Angelicae Pubescentis (5-6) %, Herba Taxilli (5-6) %, Rhizoma Drynariae (9-10) %, Herba Lycopodii (5-6) %, Radix Saposhnikoviae (3-4) %, Herba speranskiae tuberculatae (5-6) %, Radix Gentianae Macrophyllae (3-4) %, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) (2-3) %, Stigma Croci (2-3) %, Caulis Sinomenii (2-3) %, Olibanum (3-4) %, Myrrha (3-4) %, Rhizoma Sparganii (3-4) %, Rhizoma Atractylodis (3-4) %, Radix Achyranthis Bidentatae (2-3) %, Rhizoma Curcumae (3-4) %, Rhizoma Chuanxiong (3-4) %, Radix Aconiti (1-2.5) %, Radix Angelicae Sinensis (3-4) %, Herba Pyrolae (4-5) %, Flos Caryophylli (0.5-1.5) %, Rhizoma Zingiberis (10-12) %, Borneolum Syntheticum (1-3) %.
Preferably, the component proportioning (mass fraction) being used for the treatment of the medicine of gonarthrosis described in comprises Radix Angelicae Pubescentis 5.6%, Herba Taxilli 5.6%, Rhizoma Drynariae 9.31%, Herba Lycopodii 5.6%, Radix Saposhnikoviae 3.72%, Herba speranskiae tuberculatae 5.6%, Radix Gentianae Macrophyllae 3.72%, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.8%, Stigma Croci 2.8%, Caulis Sinomenii 2.8%, Olibanum 3.7%, Myrrha 3.7%, Rhizoma Sparganii 3.7%, Rhizoma Atractylodis 3.7%, Radix Achyranthis Bidentatae 2.8%, Rhizoma Curcumae 3.7%, Rhizoma Chuanxiong 3.7%, Radix Aconiti 1.9%, Radix Angelicae Sinensis 3.7%, Herba Pyrolae 4.7%, Flos Caryophylli 0.9%, Rhizoma Zingiberis 11.2%, Borneolum Syntheticum 2.2%.
Be used for the treatment of a preparation technology for the medicine of gonarthrosis, described preparation technology carries out according to following steps,
(1) altogether powder: above-mentioned prescription drug being placed in blender, to stir 25-35min powdered, takes out and is placed in the container of drying;
(2) roll: qualification Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) and the croceous true and false, by step (1) described medicine except Borneolum Syntheticum, be all combined into a place, grind coarse powder altogether;
(3) preparation of mixed liquor A: get 75% ethanol 3000 milliliters, all be immersed in wherein by medicine coarse powder, by selected essence, the ratio of (also can) adds upper liquid in 10 ‰, stirs evenly, soak 35-45 days at normal temperatures, obtained described mixed liquor A;
(4) preparation of mixed liquid B: Borneolum Syntheticum is milled into fine powder with appropriate amount of ethanol, closes in mixed liquor A, obtained mixed liquid B;
(5) preparation of mixed liquor C: add in mixed liquid B by being hydrolyzed the ratio of azone in (1-3) %, obtained mixed liquor C;
(6) get liquid: take out mixed liquor C, filter, leave standstill 20-24 hour, refilter, leave standstill 20-24 hour, get supernatant;
(7) finished product: add appropriate amount of purified water, medicinal liquid is adjusted to (65-70) % concentration, pH value is adjusted to 6-7, stirs evenly, and leaves standstill 45-50 hour, bottles and obtains the happy refreshing finished product of described knee joint.
Preferably, the common powder craft of described step (1) is specially, and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Aconiti are first used cold water soak 6-8 days, and every day changes water, soaks after 6-8 days, takes out and dries (outer without moisture, half-dried), be incorporated into other medicine cpc powders.
Preferably, the technique of identifying of the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) of described step (2) is, a, get this product powder and be about 1g, add 10% ammonia solution 1ml, ether 10ml, merceration 24h, filter, filtrate volatilizes, residue dichloromethane washes standardize solution in 1ml volumetric flask, make need testing solution, b, separately get aconitine, mesaconitine, hypaconitine, be made into each 1mg/1ml solution with dichloromethane and compare product solution, at same high-efficient silica gel GF254 plate (10cm × 10cm) upper some sample solution 3 μ l, reference substance solution 3 μ l, launch with thiacyclohexane-ethyl acetate-diethylamine (8:1:1), taking-up is dried, spray and hold mixed liquor colour developing with bismuth potassium iodide iodine test solution etc., c, test liquid chromatograph is showing same color speckle with reference substance chromatograph relevant position.
Preferably, the croceous qualification technique of described step (2), a, get this product 10 milliliters, low temperature evaporates into without alcohol taste, add water to 20 milliliters, with ethyl acetate extraction 2 times (15/10 milliliter), merge ethyl acetate liquid, add anhydrous sodium sulfate 5 grams dehydration, filter, filtrate evaporate to dryness, residue adds ethanol 2 milliliters makes dissolving, make need testing solution, b, separately get Flos Carthami control medicinal material 1 gram, add ethyl acetate 20 milliliters, supersound process 30 minutes, filter, filtrate evaporate to dryness, residue adds ethanol 2 milliliters makes dissolving, medical material solution in contrast, c, test according to thin layer color popularize law (" Chinese Pharmacopoeia " annex), draw each 5 μ I of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with the upper solution of n-butyl alcohol-methanol-water (6:1:5) for developping solution, launch, take out, airing, spray is with anisaldehyde test solution, 105 DEG C to be heated to spot development clear, d, in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, the speckle of aobvious same color.
Adopt technical scheme of the present invention, a kind of medicine major function being used for the treatment of gonarthrosis of the present invention is blood circulation promoting and blood stasis dispelling, unobstructed blood vessels, the dissipation stasis of blood is stagnant, to reach the effect of reducing swelling and alleviating pain, accelerate the recovery of soft group of damage, the spasm of alleviating vascular, soft tissue; Between conditioner soma and capillary permeability; Repair bone perichondrium, improve the microcirculation disturbance of different parts, remove the pathological state of the soft tissue such as joint, blood vessel, muscle of patient, recover the physiological property that it is original, using method is very simple and convenient, whenever where, as long as need, a painting is dealt with problems gently.One deck preservative film can be covered or with hot towel hot compress 20 minutes, fast, half an hour took effect, slow, one to two day, and pain just can significantly be eased or eliminate in place with good conditionsi.
Accompanying drawing explanation
Fig. 1 is a kind of process chart being used for the treatment of the preparation technology of the medicine of gonarthrosis of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail, can be easier to make advantages and features of the invention be readily appreciated by one skilled in the art, thus more explicit defining is made to the protection domain of invention.
Embodiment 1:
A kind of medicine being used for the treatment of gonarthrosis, the described component proportioning (mass fraction) being used for the treatment of the medicine of gonarthrosis comprises Radix Angelicae Pubescentis 5.6%, Herba Taxilli 5.6%, Rhizoma Drynariae 9.31%, Herba Lycopodii 5.6%, Radix Saposhnikoviae 3.72%, Herba speranskiae tuberculatae 5.6%, Radix Gentianae Macrophyllae 3.72%, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.8%, Stigma Croci 2.8%, Caulis Sinomenii 2.8%, Olibanum 3.7%, Myrrha 3.7%, Rhizoma Sparganii 3.7%, Rhizoma Atractylodis 3.7%, Radix Achyranthis Bidentatae 2.8%, Rhizoma Curcumae 3.7%, Rhizoma Chuanxiong 3.7%, Radix Aconiti 1.9%, Radix Angelicae Sinensis 3.7%, Herba Pyrolae 4.7%, Flos Caryophylli 0.9%, Rhizoma Zingiberis 11.2%, Borneolum Syntheticum 2.2%.
Be used for the treatment of a preparation technology for the medicine of gonarthrosis, described preparation technology carries out according to following steps,
(1) powder is total to: Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Aconiti are first used cold water soak 7 days, every day changes water, soaks after 7 days, taking-up is dried (outer without moisture, half-dried), is incorporated in other medicines, being placed in blender, to stir 30min powdered, takes out and be placed in dry container;
(2) roll: qualification Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) and the croceous true and false, by step (1) described medicine except Borneolum Syntheticum, all be combined into a place, grind coarse powder altogether, the technique of identifying of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is, a, get this product powder and be about 1g, add 10% ammonia solution 1ml, ether 10ml, merceration 24h, filter, filtrate volatilizes, residue dichloromethane washes standardize solution in 1ml volumetric flask, make need testing solution, b, separately get aconitine, mesaconitine, hypaconitine, be made into each 1mg/1ml solution with dichloromethane and compare product solution, at same high-efficient silica gel GF254 plate (10cm × 10cm) upper some sample solution 3 μ l, reference substance solution 3 μ l, launch with thiacyclohexane-ethyl acetate-diethylamine (8:1:1), taking-up is dried, spray and hold mixed liquor colour developing with bismuth potassium iodide iodine test solution etc., c, test liquid chromatograph is showing same color speckle with reference substance chromatograph relevant position, croceous qualification technique, a, get this product 10 milliliters, low temperature evaporates into without alcohol taste, add water to 20 milliliters, with ethyl acetate extraction 2 times (15/10 milliliter), merge ethyl acetate liquid, add anhydrous sodium sulfate 5 grams dehydration, filter, filtrate evaporate to dryness, residue adds ethanol 2 milliliters makes dissolving, make need testing solution, b, separately get Flos Carthami control medicinal material 1 gram, add ethyl acetate 20 milliliters, supersound process 30 minutes, filter, filtrate evaporate to dryness, residue adds ethanol 2 milliliters makes dissolving, medical material solution in contrast, c, test according to thin layer color popularize law (" Chinese Pharmacopoeia " annex), draw each 5 μ I of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with the upper solution of n-butyl alcohol-methanol-water (6:1:5) for developping solution, launch, take out, airing, spray is with anisaldehyde test solution, 105 DEG C to be heated to spot development clear, d, in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, the speckle of aobvious same color,
(3) preparation of mixed liquor A: get 75% ethanol 3000 milliliters, all be immersed in wherein by medicine coarse powder, by selected essence, the ratio of (also can) adds upper liquid in 10 ‰, stirs evenly, soak 40 days at normal temperatures, obtained described mixed liquor A;
(4) preparation of mixed liquid B: Borneolum Syntheticum is milled into fine powder with appropriate amount of ethanol, closes in mixed liquor A, obtained mixed liquid B;
(5) preparation of mixed liquor C: add in mixed liquid B by being hydrolyzed the ratio of azone in 2%, obtained mixed liquor C;
(6) get liquid: take out mixed liquor C, filter, leave standstill 24 hours, refilter, leave standstill 24 hours, get supernatant;
(7) finished product: add appropriate amount of purified water, medicinal liquid is adjusted to 65% concentration, pH value is adjusted to 6, stirs evenly, and leaves standstill 45 hours, bottles and is used for the treatment of the pharmaceutical product of gonarthrosis described in obtaining.
Embodiment 2: all the other are identical with embodiment 1, the component proportioning (mass fraction) being used for the treatment of the medicine of gonarthrosis described in difference is comprises Radix Angelicae Pubescentis 5.7%, Herba Taxilli 5.7%, Rhizoma Drynariae 9.4%, Herba Lycopodii 5.8%, Radix Saposhnikoviae 3.8%, Herba speranskiae tuberculatae 5.8%, Radix Gentianae Macrophyllae 3.8%, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.9%, Stigma Croci 2.9%, Caulis Sinomenii 2.9%, Olibanum 3.9%, Myrrha 3.9%, Rhizoma Sparganii 3.9%, Rhizoma Atractylodis 3.9%, Radix Achyranthis Bidentatae 2.8%, Rhizoma Curcumae 3.7%, Rhizoma Chuanxiong 3.7%, Radix Aconiti 1.9%, Radix Angelicae Sinensis 3.7%, Herba Pyrolae 4.8%, Flos Caryophylli 0.9%, Rhizoma Zingiberis 11.7%, Borneolum Syntheticum 2.5%, by Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) in described step (1), Radix Aconiti first uses cold water soak 6 days, every day changes water, soak after 6 days, it is (outer without moisture that taking-up is dried, half-dried), be incorporated in other medicines, being placed in blender, to stir 35min powdered, take out and be placed in dry container.
Embodiment 3: all the other are identical with embodiment 1, the component proportioning (mass fraction) being used for the treatment of the medicine of gonarthrosis described in difference is comprises Radix Angelicae Pubescentis 6.0%, Herba Taxilli 5.9%, Rhizoma Drynariae 9.7%, Herba Lycopodii 5.9%, Radix Saposhnikoviae 3.9%, Herba speranskiae tuberculatae 5.9%, Radix Gentianae Macrophyllae 3.9%, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.9%, Stigma Croci 2.9%, Caulis Sinomenii 2.9%, Olibanum 3.6%, Myrrha 3.5%, Rhizoma Sparganii 3.7%, Rhizoma Atractylodis 3.9%, Radix Achyranthis Bidentatae 2.9%, Rhizoma Curcumae 3.5%, Rhizoma Chuanxiong 3.7%, Radix Aconiti 1.9%, Radix Angelicae Sinensis 3.7%, Herba Pyrolae 4.8%, Flos Caryophylli 0.9%, Rhizoma Zingiberis 11.7%, Borneolum Syntheticum 2.5%, described step (3) is soaked 43 days at normal temperatures, described step (5) adds being hydrolyzed the ratio of azone in 3% in mixed liquid B.
Obvious specific implementation of the present invention is not subject to the restrictions described above; as long as have employed the improvement of the various unsubstantialities that method of the present invention is conceived and technical scheme is carried out; or design of the present invention and technical scheme directly applied to other occasion, all within protection scope of the present invention without to improve.
Claims (6)
1. one kind is used for the treatment of the medicine of gonarthrosis, it is characterized in that: described in be used for the treatment of the medicine of gonarthrosis component proportioning (mass fraction) comprise Radix Angelicae Pubescentis (5-6) %, Herba Taxilli (5-6) %, Rhizoma Drynariae (9-10) %, Herba Lycopodii (5-6) %, Radix Saposhnikoviae (3-4) %, Herba speranskiae tuberculatae (5-6) %, Radix Gentianae Macrophyllae (3-4) %, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) (2-3) %, Stigma Croci (2-3) %, Caulis Sinomenii (2-3) %, Olibanum (3-4) %, Myrrha (3-4) %, Rhizoma Sparganii (3-4) %, Rhizoma Atractylodis (3-4) %, Radix Achyranthis Bidentatae (2-3) %, Rhizoma Curcumae (3-4) %, Rhizoma Chuanxiong (3-4) %, Radix Aconiti (1-2.5) %, Radix Angelicae Sinensis (3-4) %, Herba Pyrolae (4-5) %, Flos Caryophylli (0.5-1.5) %, Rhizoma Zingiberis (10-12) %, Borneolum Syntheticum (1-3) %.
2. a kind of medicine being used for the treatment of gonarthrosis according to claim 1, it is characterized in that: described in be used for the treatment of the medicine of gonarthrosis component proportioning (mass fraction) comprise Radix Angelicae Pubescentis 5.6%, Herba Taxilli 5.6%, Rhizoma Drynariae 9.31%, Herba Lycopodii 5.6%, Radix Saposhnikoviae 3.72%, Herba speranskiae tuberculatae 5.6%, Radix Gentianae Macrophyllae 3.72%, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.8%, Stigma Croci 2.8%, Caulis Sinomenii 2.8%, Olibanum 3.7%, Myrrha 3.7%, Rhizoma Sparganii 3.7%, Rhizoma Atractylodis 3.7%, Radix Achyranthis Bidentatae 2.8%, Rhizoma Curcumae 3.7%, Rhizoma Chuanxiong 3.7%, Radix Aconiti 1.9%, Radix Angelicae Sinensis 3.7%, Herba Pyrolae 4.7%, Flos Caryophylli 0.9%, Rhizoma Zingiberis 11.2%, Borneolum Syntheticum 2.2%.
3. want the preparation technology being used for the treatment of the medicine of gonarthrosis described in 1 according to right, it is characterized in that: described in be used for the treatment of the medicine of gonarthrosis preparation technology carry out according to following steps,
(1) altogether powder: above-mentioned prescription drug being placed in blender, to stir 25-35min powdered, takes out and is placed in the container of drying;
(2) roll: qualification Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) and the croceous true and false, by step (1) described medicine except Borneolum Syntheticum, be all combined into a place, grind coarse powder altogether;
(3) preparation of mixed liquor A: get 75% ethanol 3000 milliliters, all be immersed in wherein by medicine coarse powder, by selected essence, the ratio of (also can) adds upper liquid in 10 ‰, stirs evenly, soak 35-45 days at normal temperatures, obtained described mixed liquor A;
(4) preparation of mixed liquid B: Borneolum Syntheticum is milled into fine powder with appropriate amount of ethanol, closes in mixed liquor A, obtained mixed liquid B;
(5) preparation of mixed liquor C: add in mixed liquid B by being hydrolyzed the ratio of azone in (1-3) %, obtained mixed liquor C;
(6) get liquid: take out mixed liquor C, filter, leave standstill 20-24 hour, refilter, leave standstill 20-24 hour, get supernatant;
(7) finished product: add appropriate amount of purified water, medicinal liquid is adjusted to (65-70) % concentration, pH value is adjusted to 6-7, stirs evenly, and leaves standstill 45-50 hour, bottles and obtains the happy refreshing finished product of described knee joint.
4. want a kind of preparation technology being used for the treatment of the medicine of gonarthrosis described in 3 according to right, it is characterized in that: the common powder craft of described step (1) is specially, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Aconiti are first used cold water soak 6-8 days, every day changes water, soak after 6-8 days, taking-up is dried (outer without moisture, half-dried), is incorporated into other medicine cpc powders.
5. a kind of preparation technology being used for the treatment of the medicine of gonarthrosis according to claim 3, it is characterized in that: the technique of identifying of the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) of described step (2) is, a, get this product powder and be about 1g, add 10% ammonia solution 1ml, ether 10ml, merceration 24h, filter, filtrate volatilizes, residue dichloromethane washes standardize solution in 1ml volumetric flask, make need testing solution, b, separately get aconitine, mesaconitine, hypaconitine, be made into each 1mg/1ml solution with dichloromethane and compare product solution, at same high-efficient silica gel GF254 plate (10cm × 10cm) upper some sample solution 3 μ l, reference substance solution 3 μ l, launch with thiacyclohexane-ethyl acetate-diethylamine (8:1:1), taking-up is dried, spray and hold mixed liquor colour developing with bismuth potassium iodide iodine test solution etc., c, test liquid chromatograph is showing same color speckle with reference substance chromatograph relevant position.
6. the preparation technology being used for the treatment of the medicine of gonarthrosis according to claim 3, it is characterized in that: the croceous qualification technique of described step (2), a, get this product 10 milliliters, low temperature evaporates into without alcohol taste, add water to 20 milliliters, with ethyl acetate extraction 2 times (15/10 milliliter), merge ethyl acetate liquid, add anhydrous sodium sulfate 5 grams dehydration, filter, filtrate evaporate to dryness, residue adds ethanol 2 milliliters makes dissolving, make need testing solution, b, separately get Flos Carthami control medicinal material 1 gram, add ethyl acetate 20 milliliters, supersound process 30 minutes, filter, filtrate evaporate to dryness, residue adds ethanol 2 milliliters makes dissolving, medical material solution in contrast, c, test according to thin layer color popularize law (" Chinese Pharmacopoeia " annex), draw each 5 μ I of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with the upper solution of n-butyl alcohol-methanol-water (6:1:5) for developping solution, launch, take out, airing, spray is with anisaldehyde test solution, 105 DEG C to be heated to spot development clear, d, in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, the speckle of aobvious same color.
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| CN201510700662.4A CN105250957A (en) | 2015-10-26 | 2015-10-26 | Drug for treating gonarthrosis and preparation technology thereof |
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| CN104474517A (en) * | 2014-12-17 | 2015-04-01 | 冯文光 | Chinese patent medicine for treating cervical syndrome and preparation method |
| CN104784318A (en) * | 2015-05-11 | 2015-07-22 | 原所茂 | Orthopedic hot compress medicine and preparation method and using method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101317996A (en) * | 2007-01-20 | 2008-12-10 | 徐长山 | Traditional Chinese medicine emplastrum for rheumatism of muscles and bones |
| CN104474517A (en) * | 2014-12-17 | 2015-04-01 | 冯文光 | Chinese patent medicine for treating cervical syndrome and preparation method |
| CN104784318A (en) * | 2015-05-11 | 2015-07-22 | 原所茂 | Orthopedic hot compress medicine and preparation method and using method thereof |
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Application publication date: 20160120 |
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