CN105247072B - 检测和治疗抗药性akt突变体的方法和组合物 - Google Patents

检测和治疗抗药性akt突变体的方法和组合物 Download PDF

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CN105247072B
CN105247072B CN201480023235.0A CN201480023235A CN105247072B CN 105247072 B CN105247072 B CN 105247072B CN 201480023235 A CN201480023235 A CN 201480023235A CN 105247072 B CN105247072 B CN 105247072B
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dihydro
hydroxy
cyclopenta
pyrimidin
methyl
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CN105247072A (zh
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K·林
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Genetech Inc
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN201480023235.0A 2013-02-25 2014-02-24 检测和治疗抗药性akt突变体的方法和组合物 Active CN105247072B (zh)

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US201361769108P 2013-02-25 2013-02-25
US61/769,108 2013-02-25
PCT/US2014/017948 WO2014130923A2 (en) 2013-02-25 2014-02-24 Methods and compositions for detecting and treating drug resistant akt mutant

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US (2) US9994913B2 (enExample)
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KR (1) KR102182488B1 (enExample)
CN (1) CN105247072B (enExample)
AR (1) AR094873A1 (enExample)
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CA (1) CA2901126C (enExample)
MX (1) MX369175B (enExample)
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CA2901126C (en) 2013-02-25 2022-01-25 Genentech, Inc. Methods and compositions for detecting and treating drug resistant akt mutant
EP3162156B1 (en) 2014-06-27 2020-04-22 Techflux Inc. Method and device for transmitting data unit
US20180256557A1 (en) * 2015-08-28 2018-09-13 Giordano Caponigro Pharmaceutical combination comprising (a) the alpha-isoform specific pi3k inhibitor alpelisib (byl719) and (b) an akt inhibitor, preferably mk-2206, afuresertib or uprosertib, and the use thereof in the treatment/prevention of cancer
US20180325902A1 (en) * 2015-11-06 2018-11-15 The Penn State Research Foundation Compositions and methods relating to cancer
US11626275B2 (en) * 2018-08-13 2023-04-11 Thermo Fisher Scientific (Bremen) Gmbh Isotopic mass spectrometer

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US10612100B2 (en) 2020-04-07
RU2015140573A (ru) 2017-03-30
EP2959014B1 (en) 2019-11-13
MX2015010776A (es) 2015-11-26
AR094873A1 (es) 2015-09-02
JP6669500B2 (ja) 2020-03-18
WO2014130923A3 (en) 2015-04-23
WO2014130923A2 (en) 2014-08-28
JP2016510591A (ja) 2016-04-11
BR112015020054A2 (pt) 2017-08-29
CN105247072A (zh) 2016-01-13
US9994913B2 (en) 2018-06-12
KR20150122198A (ko) 2015-10-30
CA2901126C (en) 2022-01-25
JP2019176858A (ja) 2019-10-17
US20180327860A1 (en) 2018-11-15
MX369175B (es) 2019-10-30
US20160153049A1 (en) 2016-06-02
EP2959014A2 (en) 2015-12-30
KR102182488B1 (ko) 2020-11-24
CA2901126A1 (en) 2014-08-28

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