BR112015020054A2 - Método de detectar resistência aos efeitos terapêuticos de um inibidor de akt em uma célula cancerosa - Google Patents
Método de detectar resistência aos efeitos terapêuticos de um inibidor de akt em uma célula cancerosaInfo
- Publication number
- BR112015020054A2 BR112015020054A2 BR112015020054A BR112015020054A BR112015020054A2 BR 112015020054 A2 BR112015020054 A2 BR 112015020054A2 BR 112015020054 A BR112015020054 A BR 112015020054A BR 112015020054 A BR112015020054 A BR 112015020054A BR 112015020054 A2 BR112015020054 A2 BR 112015020054A2
- Authority
- BR
- Brazil
- Prior art keywords
- akt inhibitor
- cancer cell
- therapeutic effects
- detecting resistance
- methods
- Prior art date
Links
- 229940126638 Akt inhibitor Drugs 0.000 title abstract 3
- 239000003197 protein kinase B inhibitor Substances 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361769108P | 2013-02-25 | 2013-02-25 | |
| PCT/US2014/017948 WO2014130923A2 (en) | 2013-02-25 | 2014-02-24 | Methods and compositions for detecting and treating drug resistant akt mutant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015020054A2 true BR112015020054A2 (pt) | 2017-08-29 |
Family
ID=50290260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015020054A BR112015020054A2 (pt) | 2013-02-25 | 2014-02-24 | Método de detectar resistência aos efeitos terapêuticos de um inibidor de akt em uma célula cancerosa |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9994913B2 (enExample) |
| EP (1) | EP2959014B1 (enExample) |
| JP (2) | JP6669500B2 (enExample) |
| KR (1) | KR102182488B1 (enExample) |
| CN (1) | CN105247072B (enExample) |
| AR (1) | AR094873A1 (enExample) |
| BR (1) | BR112015020054A2 (enExample) |
| CA (1) | CA2901126C (enExample) |
| MX (1) | MX369175B (enExample) |
| RU (1) | RU2015140573A (enExample) |
| WO (1) | WO2014130923A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2901126C (en) | 2013-02-25 | 2022-01-25 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
| EP3162156B1 (en) | 2014-06-27 | 2020-04-22 | Techflux Inc. | Method and device for transmitting data unit |
| US20180256557A1 (en) * | 2015-08-28 | 2018-09-13 | Giordano Caponigro | Pharmaceutical combination comprising (a) the alpha-isoform specific pi3k inhibitor alpelisib (byl719) and (b) an akt inhibitor, preferably mk-2206, afuresertib or uprosertib, and the use thereof in the treatment/prevention of cancer |
| US20180325902A1 (en) * | 2015-11-06 | 2018-11-15 | The Penn State Research Foundation | Compositions and methods relating to cancer |
| US11626275B2 (en) * | 2018-08-13 | 2023-04-11 | Thermo Fisher Scientific (Bremen) Gmbh | Isotopic mass spectrometer |
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| BE759493A (fr) | 1969-11-26 | 1971-05-25 | Thomae Gmbh Dr K | Nouvelles 2-(5-nitro-2-furyl)-thieno(3,2-d) pyrimidines et procedes pour les fabriquer |
| US3763156A (en) | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
| RO62428A (fr) | 1971-05-04 | 1978-01-15 | Thomae Gmbh Dr K | Procede pour la preparation des thyeno-(3,2-d)-pyrimidines |
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| WO2008049022A2 (en) * | 2006-10-18 | 2008-04-24 | Translational Genomics Research Institute | Methods for detection of cancer |
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| EP2247756A2 (en) * | 2008-02-21 | 2010-11-10 | Université Libre de Bruxelles | Method and kit for the detection of genes associated with pik3ca mutation and involved in pi3k/akt pathway activation in the er-positive and her2-positive subtypes with clinical implications |
| CA2831932A1 (en) * | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt and mek inhibitor compounds, and methods of use |
| RU2635193C2 (ru) * | 2011-04-01 | 2017-11-09 | Дженентек, Инк. | Биомаркеры для прогнозирования чувствительности к противоопухолевой терапии |
| KR20150092760A (ko) * | 2012-12-07 | 2015-08-13 | 더 제너럴 하스피탈 코포레이션 | Pi3k/akt 저해제 화합물과 her3/egfr 저해제 화합물의 조합 및 과다증식성 장애의 치료에 있어서의 이의 용도 |
| CA2901126C (en) | 2013-02-25 | 2022-01-25 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
-
2014
- 2014-02-24 CA CA2901126A patent/CA2901126C/en active Active
- 2014-02-24 CN CN201480023235.0A patent/CN105247072B/zh active Active
- 2014-02-24 JP JP2015559038A patent/JP6669500B2/ja not_active Expired - Fee Related
- 2014-02-24 BR BR112015020054A patent/BR112015020054A2/pt not_active Application Discontinuation
- 2014-02-24 RU RU2015140573A patent/RU2015140573A/ru not_active Application Discontinuation
- 2014-02-24 WO PCT/US2014/017948 patent/WO2014130923A2/en not_active Ceased
- 2014-02-24 KR KR1020157026097A patent/KR102182488B1/ko not_active Expired - Fee Related
- 2014-02-24 EP EP14711045.6A patent/EP2959014B1/en active Active
- 2014-02-24 MX MX2015010776A patent/MX369175B/es active IP Right Grant
- 2014-02-24 AR ARP140100577A patent/AR094873A1/es active IP Right Grant
-
2015
- 2015-08-21 US US14/832,594 patent/US9994913B2/en active Active
-
2018
- 2018-05-08 US US15/974,533 patent/US10612100B2/en active Active
-
2019
- 2019-05-08 JP JP2019088252A patent/JP2019176858A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10612100B2 (en) | 2020-04-07 |
| CN105247072B (zh) | 2019-10-15 |
| RU2015140573A (ru) | 2017-03-30 |
| EP2959014B1 (en) | 2019-11-13 |
| MX2015010776A (es) | 2015-11-26 |
| AR094873A1 (es) | 2015-09-02 |
| JP6669500B2 (ja) | 2020-03-18 |
| WO2014130923A3 (en) | 2015-04-23 |
| WO2014130923A2 (en) | 2014-08-28 |
| JP2016510591A (ja) | 2016-04-11 |
| CN105247072A (zh) | 2016-01-13 |
| US9994913B2 (en) | 2018-06-12 |
| KR20150122198A (ko) | 2015-10-30 |
| CA2901126C (en) | 2022-01-25 |
| JP2019176858A (ja) | 2019-10-17 |
| US20180327860A1 (en) | 2018-11-15 |
| MX369175B (es) | 2019-10-30 |
| US20160153049A1 (en) | 2016-06-02 |
| EP2959014A2 (en) | 2015-12-30 |
| KR102182488B1 (ko) | 2020-11-24 |
| CA2901126A1 (en) | 2014-08-28 |
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