CN105233046A - Traditional Chinese medicine for treating pregnancy induced hypertension - Google Patents

Abstract

The invention relates to the field of formulas of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine for treating pregnancy induced hypertension. The traditional Chinese medicine is characterized by comprising the following active pharmaceutical ingredients in parts by weight: 15-20 parts of semen plantaginis, 10-15 parts of lalang grass rhizome, 8-12 parts of spina date seeds, 10-12 parts of Armeniaca mume, 10-15 parts of exocarpium citri rubrum, 6-10 parts of inula flowers, 20-25 parts of lignum dalbergiae odoriferae, 6-8 parts of radix asteris, 10-12 parts of tuber fleeceflower stem, 12-15 parts of herba aristolochiae, 15-20 parts of prince's-feather fruits, 8-10 parts of asarum, 12-16 parts of peucedanum morisonii bess, 6-10 parts of mangnolia officinalis, 15-20 parts of the shell of areca nuts, 16-18 parts of the seeds of Chinese dodder, 12-16 parts of silybum marianum, 3-5 parts of teasel root, and 3-5 parts of calystegia hederacea. The traditional Chinese medicine is prepared from the steps of soaking the above active pharmaceutical ingredients in water, decocting, and removing dregs to obtain filter liquor. The traditional Chinese medicine has the efficacies of inducing diuresis to alleviate edema, promoting blood circulation to remove meridian obstruction, tranquilizing mind and relieving pain, as well as reducing blood pressure and enriching the blood, and is convenient to use, good in absorption effect, free of adverse effect or toxic and side effects, and suitable for clinic treatment for pregnancy induced hypertension.

Description

The Chinese medicine for the treatment of pregnancy induced hypertension syndrome

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine for the treatment of pregnancy induced hypertension syndrome.

Background technology

As everyone knows, pregnancy induced hypertension syndrome and pregnancy induced hypertension syndrome, being also said hypertensive state of pregnancy, preeclampsia etc. in the past, is the distinctive disease of anemia of pregnant woman, and majority occurs in gestation 20 weeks and two weeks puerperal, accounts for all anemia of pregnant woman's 5%.The clinical manifestation of pregnancy induced hypertension syndrome has: occur hypertension, edema, albuminuria after pregnant 20 weeks.The lighter can be asymptomatic or slightly dizzy, and blood pressure slightly raises, companion's edema or mild proteinuria; Severe one headache, dim eyesight, Nausea and vomiting, persistence right hypochondrial region etc., blood pressure raises obviously, and albuminuria increases, and edema is obvious, even goes into a coma, twitches.And after severe PIH is more common in pregnant 7 ~ 8 months late periods, be jeopardize the higher disease of the mortality rate of mother and fetal life.Now because people are to the attention of this disease, take some preventive measures, early prevention, early treatment, mother and sons' mortality rate than greatly reducing in the past, its incidence rate about 4.2%.The cause of disease of severe PIH may with parent resistance to can't stand gestation burden and that various dysfunction occurs is relevant, show as a kind of syndrome, main manifestations is edema, hypertension, albuminuria three symptoms.Normal III trimester women also can edema of lower limbs, but getting up early next day at a night edema of having a rest disappears, and this is normal phenomenon.And the edema of patients with pregnancy does not also disappear through having a rest, and not only lower limbs edema, face, both hands all have edema.Blood pressure increases simultaneously, is greater than 18.6/12kpa, and chemical examination can find there is a large amount of albumen in urine.Because hypertension damages Placenta Hominis blood vessel, placental abruption may be caused.The blood biochemical of Pregnancy is changed into blood urea nitrogen and is raised, and uric acid raises, and CO2 combining power, CO2 CP raises, and plasma protein reduces.

The widespread treatments method taked at present uses magnesium sulfate, the pyridine of the willow amine benzyl heart etc., but circulation is slow, long-term effect is not clearly, this kind of drug price is expensive simultaneously, and it is strong to have toxic and side effects, bring great financial burden not only to patient and family numbers of patients, and have a strong impact on the function such as the intestines and stomach of patient.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, a kind of Chinese medicine for the treatment of pregnancy induced hypertension syndrome is provided, there is inducing diuresis to remove edema, effect that promoting blood circulation to remove obstruction in the collateral, ataralgesia, blood pressure lowering are enriched blood, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, spleen reinforcing diuretic, heart tonifying the kidney invigorating, lung benefiting can regulate the flow of vital energy, improve body internal and external environment, thus treat or alleviate the various symptoms of pregnancy induced hypertension syndrome, be suitable for pregnancy induced hypertension syndrome clinical treatment.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of pregnancy induced hypertension syndrome, it is characterized in that being made up of the crude drug of following weight portion, Semen Plantaginis 15 ~ 20, Rhizoma Imperatae 10 ~ 15, Semen Ziziphi Spinosae 8 ~ 12, FLOS MUME 10 ~ 12, Exocarpium Citri Rubrum 10 ~ 15, Flos Inulae 6 ~ 10, Lignum Dalbergiae Odoriferae 20 ~ 25, Radix Asteris 6 ~ 8, Caulis Polygoni Multiflori 10 ~ 12, Herba Aristolochiae 12 ~ 15, water Polygonum 15 ~ 20, Herba Asari 8 ~ 10, cold syndrome of the stomach grass 12 ~ 16, Cortex Magnoliae Officinalis 6 ~ 10, Pericarpium Arecae 15 ~ 20, Semen Cuscutae 16 ~ 18, Herba Silybi mariani 12 ~ 16, Radix Dipsaci 3 ~ 5, DAWANHUA 3 ~ 5, by medicinal for above-mentioned raw materials water soaking, to remove slag after decocting to obtain filtrate.

The invention has the beneficial effects as follows, there is inducing diuresis to remove edema, effect that promoting blood circulation to remove obstruction in the collateral, ataralgesia, blood pressure lowering are enriched blood, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, can spleen reinforcing diuretic, heart tonifying the kidney invigorating, lung benefiting regulate the flow of vital energy, improve body internal and external environment, thus treat or alleviate the various symptoms of pregnancy induced hypertension syndrome, be suitable for pregnancy induced hypertension syndrome clinical treatment.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Semen Plantaginis, Rhizoma Imperatae, Semen Ziziphi Spinosae, FLOS MUME, Exocarpium Citri Rubrum, Flos Inulae, Lignum Dalbergiae Odoriferae, Radix Asteris, Caulis Polygoni Multiflori, Herba Aristolochiae, water Polygonum, Herba Asari, cold syndrome of the stomach grass, Cortex Magnoliae Officinalis, Pericarpium Arecae, Semen Cuscutae, Herba Silybi mariani, Radix Dipsaci, DAWANHUA is adopted to be that crude drug is prepared from.The every auxiliary medicine of its component (weight portion) is Semen Plantaginis 18, Rhizoma Imperatae 13, Semen Ziziphi Spinosae 10, FLOS MUME 11, Exocarpium Citri Rubrum 12, Flos Inulae 8, Lignum Dalbergiae Odoriferae 22, Radix Asteris 7, Caulis Polygoni Multiflori 11, Herba Aristolochiae 13, water Polygonum 17, Herba Asari 9, cold syndrome of the stomach grass 14, Cortex Magnoliae Officinalis 8, Pericarpium Arecae 17, Semen Cuscutae 17, Herba Silybi mariani 14, Radix Dipsaci 4, DAWANHUA 4.Get above-mentioned 19 kinds of crude drug, gross mass is 250g, at room temperature crude drug is added water to 900-1000ml, soak 4 hours, then boil slow fire with high heat and decoct to about 100-120 minute, remove slag to obtain filtrate about 200ml, medicinal residues add water 300-400ml again, decoct 30-40 minute, remove slag to obtain filtrate about 100ml, decocts medicine soup about 300ml for twice altogether.Every day, potion was oral at twice, each (medicine) being taken before meal about 150ml.

Semen Plantaginis relieving stranguria by diuresis of the present invention, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, removing heat-phlegm; Rhizoma Imperatae is used for heat in blood and spits blood, epistaxis, hematuria, calentura excessive thirst, cough due to lung-heat, gastropyretic vomiting, jaundice due to damp-heat, edema oliguria, the puckery pain of pyretic stranguria; Semen Ziziphi Spinosae suppressing the hyperactive liver is regulated the flow of vital energy, nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, and beneficial will is breathed out surely, hearing-improing and eyesight improving; FLOS MUME soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizzy, scrofula; Exocarpium Citri Rubrum regulating the flow of QI to ease the stomach, drying dampness to eliminate phlegm.For cough with copious phlegm, vomiting and nausea painful abdominal mass is vexed; Flos Inulae sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.For cough due to wind and cold, phlegm retention stores knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomiting eructation, epigastric oppression and rigidity; Lignum Dalbergiae Odoriferae promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge; Radix Asteris warming the lung, the therapeutic method to keep the adverse QI flowing downwards, expectorant, cough-relieving.Control cough due to wind and cold's asthma, asthenia coughs vomiting bloody pus, sore throat, dysuria; Caulis Polygoni Multiflori controls insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies; Herba Aristolochiae has promoting flow of QI and blood, the effect of removing obstruction in the collateral to relieve pain; Water Polygonum falls apart blood eliminating mass, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, goiter swells and ache, and food stagnation does not disappear, epigastric distending pain; Herba Asari induces sweat cold expelling, and wind-expelling pain-stopping is sensible, warming the lung to resolve fluid-retention; Cold syndrome of the stomach grass expelling wind and cold, regulating QI to relieve pain.Cure mainly: cold flu, cough, cold syndrome of the stomach distending pain; Cortex Magnoliae Officinalis has effect of circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma; Pericarpium Arecae is used for retention of damp leading to blockage of QI, and gastral cavity abdominal distention is vexed, defecates not well, edema distension, beriberi edema, dysuria; Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Suffer from a deficiency of the kidney rush down for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen kidney vaginal bleeding during pregnancy, frequent fetal movement, spleen; Herba Silybi mariani heat-clearing and toxic substances removing, protects the liver, function of gallbladder promoting, protects brain.Good efficacy is all had to liver, the scorching diseases of gallbladder such as inflammation around acute or chronic hepatitis, liver cirrhosis, cholangitis and hepatic duct; Radix Dipsaci tonifying liver, bone and muscle strengthening, determines meridians, only through in (muscles and bones) ache, antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine; DAWANHUA controls heating, fracture, frequent micturition, hematoma.

The each raw material of the present invention also can the embodiment that mixes of ratio (weight portion) listed by according to the form below realize, and its processing method is identical with embodiment one.

Clinical data

1, case selection:

Select my institute to make a definite diagnosis the routine clinical observation of patients with pregnancy 300, patient is divided into two groups at random, treatment group 150 example, 21 years old ~ 38 years old age, 27 years old mean age, the course of disease 1 month ~ 3 months, average 1.5 months.Matched group 150 example, 22 years old ~ 45 years old age, 28 years old mean age, course of disease two weeks ~ 2 month, average 1 month.The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.

2, medicament selection:

Treatment group takes the embodiment of the present invention one Chinese medicine preparation, and every day, potion was oral at twice, each (medicine) being taken before meal about 150ml; Within 7 days, be 1 course for the treatment of, 1 ~ 2 course for the treatment of of the lighter, 3 ~ 4 courses for the treatment of of severe one.

Matched group takes dexamethasone tablet, oral, one time 1 ~ 4,2 ~ 4 times on the one, sooner or later take after the meal; Maintenance dose one time 1,1 time on the one, the course for the treatment of is depending on the state of an illness.

3, efficacy determination:

(1) cure: the transference cures such as hypertension, dizzy edema, nausea and vomiting.

(2) effective: above-mentioned symptom is alleviated to some extent, physical recovery is healthy.

(3) invalid: disease is unchanged.

4, result:

Take in the treatment group of medicine of the present invention, cure 104 examples, effective 28 examples, invalid 18 examples, cure rate 69.3%, total effective rate 88%.

86 examples are cured, effective 29 examples, invalid 35 examples, cure rate 57.3%, total effective rate 76.7% in matched group.

Above result display, treatment group cure rate and total effective rate are apparently higher than matched group.

Model case is illustrated:

1, paddy, female, 28 years old.Suffer from entire patient's edema, headache, feeling of fullness in the head, blurred vision, carrys out my institute's department of obstetrics and gynecology inspection, be diagnosed as preeclampsia, recommend through doctor, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention, symptom obviously alleviates to some extent, after taking 2 courses for the treatment of, transference cure, physical recovery is normal, recovery from illness.

2, Ma, female, 26 years old.There is the symptoms such as headache, blurred vision, upper abdominal pain in patient, body weight rapid drawdown in the recent period, and with nausea and vomiting, the phenomenons such as blood pressure rising.Pregnancy induced hypertension syndrome is diagnosed as by my institute; After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, in high spirits, have rosy cheeks, health is fully recovered, and does not recur again.

Claims (1)

1. treat the Chinese medicine of pregnancy induced hypertension syndrome for one kind, it is characterized in that being made up of the crude drug of following weight portion: Semen Plantaginis 15 ~ 20, Rhizoma Imperatae 10 ~ 15, Semen Ziziphi Spinosae 8 ~ 12, FLOS MUME 10 ~ 12, Exocarpium Citri Rubrum 10 ~ 15, Flos Inulae 6 ~ 10, Lignum Dalbergiae Odoriferae 20 ~ 25, Radix Asteris 6 ~ 8, Caulis Polygoni Multiflori 10 ~ 12, Herba Aristolochiae 12 ~ 15, water Polygonum 15 ~ 20, Herba Asari 8 ~ 10, cold syndrome of the stomach grass 12 ~ 16, Cortex Magnoliae Officinalis 6 ~ 10, Pericarpium Arecae 15 ~ 20, Semen Cuscutae 16 ~ 18, Herba Silybi mariani 12 ~ 16, Radix Dipsaci 3 ~ 5, DAWANHUA 3 ~ 5, by medicinal for above-mentioned raw materials water soaking, filtrate of removing slag after decocting to obtain.