CN102641358A

CN102641358A - Pharmaceutical composition for treating pregnancy-induced hypertension (PIH)

Info

Publication number: CN102641358A
Application number: CN2012101437100A
Authority: CN
Inventors: 辛崇敏; 卢培玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-05-10
Filing date: 2012-05-10
Publication date: 2012-08-22
Anticipated expiration: 2032-05-10
Also published as: CN102641358B

Abstract

The invention discloses a pharmaceutical composition for treating pregnancy-induced hypertension (PIH) in order to solve the problem of the treatment of PIH. The pharmaceutical composition for treating PIH is characterized in that: the pharmaceutical composition is processed by various traditional Chinese medicines, and comprises the following components by weight ratio: 6 to 10 parts of herb of rose glorybind, 8 to 15 parts of chrysanthemum, 8 to 15 parts of lotus plumule, 6 to 10 parts of tabasheer, 6 to 10 parts of ebony, 8 to 15 parts of semen celosiae, 6 to 10 parts of towel gourd vegetable sponge, 8 to 15 parts of papaya and 3 to 6 parts of madder root. Clinical trials prove that the pharmaceutical composition for treating PIH has the characteristics of good efficacy and higher safety, and is worthy of clinical application and popularization.

Description

A kind of pharmaceutical composition of treating pregnancy induced hypertension syndrome

Technical field

The present invention relates to obstetrics' medical field, be specifically related to treat the pharmaceutical composition of pregnancy induced hypertension syndrome.

Background technology

The increase of pregnancy period body weight and momental minimizing make ready-to-be mother's demand side a series of problems that rising brings to blood pressure in pregnancy of 78%, wherein possibly suffer from pregnancy induced hypertension syndrome for 9.4%, need in time to intervene to guarantee baby's health.So-called pregnancy induced hypertension syndrome is the abbreviation of pregnancy induced hypertension syndrome (pregnancy-induced hypertension syndrome), is the exclusive a kind of disease of anemia of pregnant woman.Generally occur in after 20 weeks of pregnancy period, show as hypertension, albuminuria, edema.Can occur headache, dim eyesight, uncomfortable in chest even tic when serious, baby's health is constituted a serious threat.The cause of disease of pregnancy induced hypertension syndrome is still indeterminate at present, exists three kinds of sayings in modern times in the medical science, i.e. the hypoxic-ischemic theory of uterus and Placenta Hominis; Neuroendocrine theory, immunological theory; Basic pathology is changed to the whole body arteriolospasm, and the placenta uterina blood flow reduces, and causes the fetal placenta hypofunction.In case it is not enough that uterine contraction can increase the weight of Placenta Hominis blood supply oxygen supply, is prone to cause fetal distress in uterus; The severe PIH patient is once making a definite diagnosis, and hospitalization is in time handled immediately, the generation of prevention eclamposia and complication.The Therapeutic Principle of pregnancy induced hypertension syndrome is spasmolytic, blood pressure lowering, calmness, dilatation rationally, diuresis in case of necessity, and magnesium sulfate be in, the first-selected spasmolytic medicine of severe PIH.But because the cause of disease of pregnancy induced hypertension syndrome is not very clear and definite; So not all pregnancy induced hypertension syndrome can relief of symptoms through the magnesium sulfate spasmolytic, take place in order to prevent complication such as cerebrovascular accident, placental abruption this moment, then need use antihypertensive drugs to carry out dilatation; Though but antihypertensive drugs can make blood pressure drops; But reduce the important organ blood flow simultaneously, particularly uteroplacental blood flow has certain harm to fetus.

Summary of the invention

Technical assignment of the present invention is the deficiency to above prior art, and the pharmaceutical composition of a kind of curative effect treatment pregnancy induced hypertension syndrome sure and safe in utilization is provided.

The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition of treating pregnancy induced hypertension syndrome, it is characterized in that processing by plurality of Chinese, and its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Calystegiae Japonicae; 8 ~ 15 parts of Flos Chrysanthemis, 8 ~ 15 parts of Plumula Nelumbiniss, 6 ~ 10 parts of Concretio silicea Bambusae seu schizostachyis; 6 ~ 10 parts of Fructus Mumes, 8 ~ 15 parts of Semen Celosiae, 6 ~ 10 parts of Retinervus Luffae Fructuss; 8 ~ 15 parts of Fructus Chaenomeliss, 3 ~ 6 parts of Radix Rubiae.

Its optimum weight proportioning is: 8 parts of Herba Calystegiae Japonicae, 10 parts of Flos Chrysanthemis, 10 parts of Plumula Nelumbiniss, 8 parts of Concretio silicea Bambusae seu schizostachyis, 8 parts of Fructus Mumes, 10 parts of Semen Celosiae, 8 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Chaenomeliss, 5 parts of Radix Rubiae.

Wherein said:

Herba Calystegiae Japonicae is the root and the herb of convolvulaceous plant Japan day sword.Sweet, cold.Heat clearing away, YIN nourishing, blood pressure lowering, diuresis.

Flos Chrysanthemi is the head inflorescence of feverfew chrysanthemum and mutation thereof.Nature and flavor are sweet, bitter, are slightly cold.Go into lung, Liver Channel.But the merit dispelling wind and heat pathogens makes eye bright, heat-clearing and toxic substances removing, suppressing the hyperactive liver sun.

Plumula Nelumbinis is clear tender plumule in the son reality of nymphaeaceae plant lotus.Nature and flavor are bitter, and are cold.Go into heart channel.The merit heat that can clear away heart-fire.

Concretio silicea Bambusae seu schizostachyi is for Mycophyta Ascomycetes meat seat section Concretio silicea Bambusae seu schizostachyi belongs to fungus Concretio silicea Bambusae seu schizostachyi Stroma.Light, flat.But the merit expelling wind and removing dampness, the easypro warp of invigorating blood circulation, cough-relieving.

Fructus Mume is the dry almost ripe fruit of rose department plant plum.Sour, puckery, flat.Return liver, spleen, lung, large intestine channel.Merit can be astringed the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris peace palace.

Semen Celosiae is the mature seed of amaranthaceous plant Celosia argentea.Nature and flavor are bitter, are slightly cold.Go into Liver Channel.But the merit clearing away liver-fire moves back corneal nebula.

Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae.Sweet, flat.Return lung, stomach, Liver Channel.But the merit collateral dredging is invigorated blood circulation, and dispels the wind.

Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria.Acid, temperature.Return liver, spleen channel.But merit suppressing the hyperactive liver Shujin, the stomach function regulating removing dampness.

Radix Rubiae is the root and rhizome of Maguireothamnus speciosus Radix Rubiae.Nature and flavor are bitter, and are cold.Go into the heart.Liver Channel.But merit promoting the circulation of blood hemostasis, dredge the meridian passage, eliminating phlegm and stopping cough.

Composition principle: the traditional Chinese medical science think the primary disease duty in liver,spleen,kidney three dirty functional disorders.Deficiency of spleen-YANG and kidneyYANG, water-damp not being transformed, general in the flesh table; Or element is how depressed, functional activity of QI being not smooth, and pregnant in addition back carcass is gradually long, hinders ascending or descending movement of vital Qi, and the stagnation of QI wets and stops, and overflows to send out in skin to be edema, and this is the edema during pregnancy.The visceral-qi deficiency in origin gathers to dash under the cloudy blood of pregnant back parent and appoints a fetus nourishing, and cloudy branch must lose, and the moon is YANG hyperactivity suppressing not, and liver-yang is high partially, on disturb key clearly; Or after mid trimester of pregnancy, carcass is gradually big, influences ascending or descending movement of vital Qi, and the stagnation of QI is violated spleen, and insufficiency of the spleen wet gathering, it is turbid to turn to expectorant, and liver-yang is held expectorant under the arm and disturbed clearly on turbid that the vertigo, headache, blurring of vision then appear in key, and this is vertigo in pregnancy.If cloudy blood deficiency very, excessive rising of liver-YANG, liver-wind stirring up internally; Or disturb on the folder phlegm-fire, hoodwink key clearly, be eclamposia and have wind symptom, tic to send out.Primary disease is deficient with internal organs, deficiency of YIN-blood is basis, and wind, fire, expectorant, the stasis of blood are mark.The present invention gets Herba Calystegiae Japonicae heat clearing away YIN nourishing, antihypertensive diuretic to take stopgap measures; The Flos Chrysanthemi dispelling wind and heat pathogens, Concretio silicea Bambusae seu schizostachyi, Retinervus Luffae Fructus dispel the wind, and this three medicine is controlled from wind; Flos Chrysanthemi suppressing liver-YANG, the Plumula Nelumbinis heat that clears away heart-fire, the Semen Celosiae clearing away liver-fire, this three medicine is controlled from fire; The Concretio silicea Bambusae seu schizostachyi dehumidifying, the removing dampness of Fructus Chaenomelis suppressing the hyperactive liver, this two medicine is controlled from phlegm-damp; Retinervus Luffae Fructus is invigorated blood circulation, Radix Rubiae promoting the circulation of blood hemostasis, dredge the meridian passage, and this two medicine is controlled from the stasis of blood; Fructus Mume is sour and astringent, looses with the trip of system gas medicine blood medicine in convergence peace palace.Modern pharmacological research shows: the water decoction of Herba Calystegiae Japonicae can effectively reduce conceived rat periphery blood pressure, but obvious change does not appear in the hemoperfusion of uterus and kidney; And contained alizarin and the quinones of Radix Rubiae can reduce the laboratory animal blood pressure and not influence heart.

The specific embodiment

Below in conjunction with practical situation, specific embodiments of the invention elaborates.

Embodiment 1, the crude drug weight proportion: Herba Calystegiae Japonicae 6g, Flos Chrysanthemi 8g, Plumula Nelumbinis 8g, Concretio silicea Bambusae seu schizostachyi 6g, Fructus Mume 6g, Semen Celosiae 8g, Retinervus Luffae Fructus 6g, Fructus Chaenomelis 8g, Radix Rubiae 3g.

Embodiment 2, the crude drug weight proportion: Herba Calystegiae Japonicae 10g, Flos Chrysanthemi 15g, Plumula Nelumbinis 15g, Concretio silicea Bambusae seu schizostachyi 10g, Fructus Mume 10g, Semen Celosiae 15g, Retinervus Luffae Fructus 10g, Fructus Chaenomelis 15g, Radix Rubiae 6g.

Embodiment 3, the crude drug weight proportion: Herba Calystegiae Japonicae 8g, Flos Chrysanthemi 10g, Plumula Nelumbinis 10g, Concretio silicea Bambusae seu schizostachyi 8g, Fructus Mume 8g, Semen Celosiae 10g, Retinervus Luffae Fructus 8g, Fructus Chaenomelis 10g, Radix Rubiae 5g.

During use, Chinese medicine Herba Calystegiae Japonicae of the present invention, Flos Chrysanthemi, Plumula Nelumbinis, Concretio silicea Bambusae seu schizostachyi, Fructus Mume, Semen Celosiae, Retinervus Luffae Fructus, Fructus Chaenomelis and Radix Rubiae are mixed, decocting 2 times is got decocting liquid, and it is oral to merge the filtration back, and potion divided sooner or later and took for twice every day.

Effective combination of aforementioned pharmaceutical compositions is coordinated mutually, can effectively reach the purpose of treatment pregnancy induced hypertension syndrome, and side effect is less.The above results is that clinical data proves that fully interrelated data is following, wherein studies pharmaceutical composition and is used for the crude drug weight proportion among the embodiment 3.

1 object and method

1.1 the patient that 42 routine pregnancy induced hypertension syndromes that object in January, 2010～2010 year December is accepted for medical treatment in the court and can expecting are treated all meets the diagnostic criteria of the pregnancy induced hypertension syndrome of World Health Organization's regulation; 23～38 years old age, 28 years old mean age.Primipara's 29 examples, multipara's 13 examples, pregnant all 16～36 weeks.The preeclampsia mild PIH (BP >=140/90mmHg); Urine protein >=300mg/24h or (+).

1.2 research method is divided into magnesium sulfate treatment group and treatment by Chinese herbs group of the present invention at random, every group of each 21 example.Between two groups case age, pregnant week, gestational hypertension by stages, aspect the urine protein situation through statistical comparisons no significant difference (P>0.05), two groups have comparability.

1.3 efficacy assessment standard: 1. produce effects: blood pressure drops: systolic pressure≤140～155mmHg; Diastolic pressure≤90～105mmHg; Systolic pressure/diastolic pressure decline 30/15mmHg or reduce to normal; Urine protein descends (++), and clinical symptoms obviously alleviates or disappears, and gestation safety is maintained until 37 all termination of pregnancy.2. effective: blood pressure drops is less than 10mmHg, and urine protein and edema descend (+), but do not reach normal level yet, clinical symptom relief, pregnancy maintenance less than 37 all termination of pregnancy.3. invalid: blood pressure does not have obvious decline or continue to rise, and urine protein, several nothings of edema are improved or increased the weight of, clinical symptoms commentariess on classics of not getting better, and gestation is less than being compelled termination of pregnancy 36 weeks.

1.4 statistical analysis carries out statistical analysis with SPSS 11.0, < 0.05 expression has the significance meaning to P.

2 groups of magnesium sulfate treatment as a result, produce effects 6 examples, effective 12 examples, invalid 3 examples, total effective rate 85.7%; Treatment by Chinese herbs group of the present invention, produce effects example 7 examples, effective 13 examples, invalid 1 example, total effective rate 95.2%.Two groups of difference are through statistical test, and difference has statistical significance (P < 0.05).Do not see that all untoward reaction takes place.

3. conclusion

The prompting of this result of study, the present invention treats pregnancy induced hypertension syndrome and has good effect and the higher characteristics of safety, is worth clinical practice, popularization.

Claims

1. a pharmaceutical composition of treating pregnancy induced hypertension syndrome is characterized in that being processed by plurality of Chinese, and its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Calystegiae Japonicae; 8 ~ 15 parts of Flos Chrysanthemis, 8 ~ 15 parts of Plumula Nelumbiniss, 6 ~ 10 parts of Concretio silicea Bambusae seu schizostachyis; 6 ~ 10 parts of Fructus Mumes, 8 ~ 15 parts of Semen Celosiae, 6 ~ 10 parts of Retinervus Luffae Fructuss; 8 ~ 15 parts of Fructus Chaenomeliss, 3 ~ 6 parts of Radix Rubiae.

2. a kind of pharmaceutical composition of treating pregnancy induced hypertension syndrome according to claim 1 is characterized in that its weight proportion is: 8 parts of Herba Calystegiae Japonicae, 10 parts of Flos Chrysanthemis, 10 parts of Plumula Nelumbiniss, 8 parts of Concretio silicea Bambusae seu schizostachyis, 8 parts of Fructus Mumes, 10 parts of Semen Celosiae, 8 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Chaenomeliss, 5 parts of Radix Rubiae.