CN103301340B - Drug for treating pregnancy-induced hypertension - Google Patents
Drug for treating pregnancy-induced hypertension Download PDFInfo
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- CN103301340B CN103301340B CN201310271577.1A CN201310271577A CN103301340B CN 103301340 B CN103301340 B CN 103301340B CN 201310271577 A CN201310271577 A CN 201310271577A CN 103301340 B CN103301340 B CN 103301340B
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Abstract
The invention discloses a drug for treating pregnancy-induced hypertension. The drug comprises the following active ingredients by weight: 20g of ganoderma lucidum, 20g of stir-baked cortex eucommia, 20g of herba taxilli, 15g of dipsacus asperoids, 15g of citrus chirocarpus, 15g of rhizoma dioscoreae, 10g of silybum marianum, 10g of radix puerariae, 10g of dogbane leaf, 10g of lotus leaf, 10g of concha haliotidis, 10g of hawthorn, 10g of stigma maydis, 5g of christina loosestrife herb, 5g of Chinese pyrola herb, 5g of radix scutellariae, 5g of radix codonopsis and 5g of radix glycyrrhizae. The traditional Chinese medicine is used for treating pregnancy-induced hypertension, so that the total efficiency can achieve 100%, and the normal growth of fetuses is not influenced.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of hypertensive disorder in pregnancy, belong to technical field of Chinese medicines.
Background technology
Hypertensive disorder in pregnancy is obstetrics' common diseases, and accounting for the 9.4-10.4% of all gestation, is cause one of four of maternal death large reasons, and the maternal death caused accounts for the 10-16% of the relevant death sum of gestation.Its cardinal symptom has hypertension, albuminuria, edema etc.Now introduce respectively:
1, hypertension blood pressure continues the Clinical Manifestations that rising >=140/90mmHg is hypertensive disorder in pregnancy.When blood pressure slightly slowly raises, patient can no conscious sympton, finds that blood pressure increases when health check-up; During the hurried rising of blood pressure, can there is severe headache, dim eyesight, blurred vision in patient, cardiopalmus tachypnea, and cardiovascular and cerebrovascular vessel can be caused unexpected.Serious preeclampsia patients' blood continues to raise, and occurs severe hypertension >=160/110mmHg.
2, albuminuria urine protein can change in every day to some extent along with angiospastic change.Serious preeclampsia Urinary albumen continues to increase, and occurs High-grade Proteinuria, and urine protein is qualitative >=(++), or twenty-four-hour urine protein quantification >=2g.
3, edema can show as frank edema and latent edema.Frank edema is multiple is born in ankle and lower limb, also can show as hydrosarca.Feature does not disappear after having a rest, or occurs suddenly, involves rapidly the dropsy of serous cavity that abdominal cavity, thoracic cavity, pericardial cavity even appear comprising in whole body.Latent edema refers to that fluid retention is in interstice, and main manifestations is that the exception of body weight increases.
Hypertensive disorder in pregnancy therapeutic purposes are generations of prevention serious preeclampsia and eclamposia, reduce female tire perinatal morbidity and mortality rate, improve Maternal-fetal prognosis.At present, western medical treatment method mainly treats hypertensive disorder in pregnancy with spasmolytic, blood pressure lowering, diuresis and calmness etc.The Common drugs for the treatment of gestation hypertension has: magnesium sulfate, beta receptor antagonist, calcium ion channel blocker, diuretic etc.But because Western medicine side effect is large, cause great psychology, mental disorder to patient.
Summary of the invention
The object of this invention is to provide a kind of medicine for the treatment of hypertensive disorder in pregnancy, the selected kinds of traditional Chinese medicines of this medicine carries out prescription, and this medicine effectively can treat hypertensive disorder in pregnancy.
Technical scheme of the present invention is: a kind of medicine for the treatment of hypertensive disorder in pregnancy, it is characterized in that, be made up of the raw material of following weight, Ganoderma 20 grams, Cortex Eucommiae (parched) 20 grams, Herba Taxilli 20 grams, Radix Dipsaci 15 grams, Fructus Citri Sarcodactylis 15 grams, Rhizoma Dioscoreae 15 grams, Herba Silybi mariani 10 grams, 10 grams, Fructus Jujubae, Radix Puerariae 10 grams, Folium Apocyni Veneti 10 grams, 10 grams, Folium Nelumbinis, Concha Haliotidis 10 grams, Fructus Crataegi 10 grams, Stigma Maydis 10 grams, Herba Lysimachiae 5 grams, Semen Euryales 5 grams, Herba Pyrolae 5 grams, Radix Scutellariae 10 grams, Radix Codonopsis 5 grams and 5 grams, Radix Glycyrrhizae.
Preparation and instructions of taking: soak by water, take at twice sooner or later.It within 3 days, is 1 course for the treatment of.Gestation hypertension patient takes 1-3 the course for the treatment of, and preeclampsia (comprising slight, severe) patient takes 3-5 the course for the treatment of.
The pharmacological action of each Chinese medicine:
Ganoderma: property is sweet, taste is put down.GUIXIN, lung, liver, kidney channel.Function with cure mainly: can invigorating QI and tranquilization, relieving cough and asthma.For dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
Cortex Eucommiae (parched): sweet, temperature.Return liver, kidney channel.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension.
Herba Taxilli: bitter, sweet, flat.Return liver, kidney channel.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement, hypertension.
Radix Dipsaci: bitter, pungent, tepor.Return liver, kidney channel.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For deficiency of the liver and kindey, soreness of the waist and knees, rheumatic arthralgia, injury from falling down, the injury of tendon and muscle is fractured, metrorrhagia, vaginal bleeding during pregnancy.
Concha Haliotidis: salty, cold.Return Liver Channel.Function with cure mainly: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.
Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Function with cure mainly: liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.
Rhizoma Dioscoreae: sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Herba Silybi mariani: bitter, cool.Return liver, gallbladder meridian.Function with cure mainly: heat-clearing and toxic substances removing, 'Shugan Lidan '.For dampness-heat in the liver and gallbladder, hypochondriac pain, jaundice.
Fructus Jujubae: sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Radix Puerariae: sweet, pungent, cool.Return spleen, stomach warp.Function with cure mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Folium Apocyni Veneti: sweet, bitter, cold.Return Liver Channel.Function with cure mainly: suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema
Folium Nelumbinis: Folium Nelumbinis is the food of " medicine-food two-purpose ", the Flavonoid substances be rich in Folium Nelumbinis, it is the scavenger of most of oxygen-derived free radicals, SOD(superoxide dismutase can be improved) vigor, reduce MDA(malondialdehyde) and 0X-LDL(OxLDL ELISA) generation, it can increase coronary flow, has antagonism to Myocardial Infarction; Protective effect is had to acute myocardial ischemia; Remarkable result is had to treatment coronary heart disease, hypertension etc.; To reduction diastolic pressure, prevent and treat arrhythmia, cardiovascular diseases etc. and also play an important role.
Fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Effect: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.Cure mainly: for meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.
Herba Lysimachiae: dry, light, flat, returns liver, gallbladder, kidney, urinary bladder channel.Function with cure mainly: dehumidify jaundice eliminating, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling, Herba Lysimachiae, and picric acid is cool, enters liver and gall kidney, bladder footpath, clearing away heat and promoting diuresis, Tonglin Paishi.
Stigma Maydis: sweet is flat.Return bladder, liver, gallbladder meridian.Function with cure mainly: diuresis, expels the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting.Control oedema due to nephritis, beriberi, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis and epistaxis, nasal sinusitis, acute mastitis.
Semen Euryales: there is supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, effect of damp eliminating, leukorrhagia stopping.Cure mainly nocturnal emission, spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.
Herba Pyrolae: sweet, bitter, temperature.Return liver, kidney channel.Function with cure mainly: wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Radix Scutellariae: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.
Radix Codonopsis: return spleen, lung meridian.Function with cure mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function with cure mainly: invigorating the spleen and replenishing QI, grow and cough lung moistening, emergency is detoxified, and is in harmonious proportion hundred medicines.Cure mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.
The traditional Chinese medical science is thought: hypertensive causing is that caused by " excessive rising of liver-YANG ", yang hyperactivity is hyperactivity of fire then, and hyperactivity of fire then mechanism of qi superinverse, pathogenic fire is attacked, and vim and vigour also with on violate and stage an armed rebellion." soothing the liver, nourishing the liver " can not singly set about from liver, from its source kidney, need have only by " supporting kidney to adjust liver ", reaching Liver and kidney with mending, being only the real method of effecting a permanent cure like this.The selected 20 kinds of Chinese prescriptions of the present invention, nourishing liver and kidney, invigorating spleen to remove dampness, invigorating the spleen and replenishing QI, the effect that there is blood pressure lowering simultaneously, eliminate edema, eliminate the symptoms such as albuminuria.Thus both can reach and eliminated symptom fast, Liver and kidney spleen can be nursed one's health again, support sufficient essence and blood, then self with foster whole body to breed fetus.
The invention has the beneficial effects as follows: adopt this treatment by Chinese herbs hypertensive disorder in pregnancy, total effective rate is 100%, and does not affect the normal development of fetus.
Its beneficial effect is further illustrated below in conjunction with clinical data and model case.
One, clinical data
1, physical data: be selected from 25-40 that 2010.5-2012.7 hospital accepts for medical treatment year (31.5 years old mean age) hypertensive disorder in pregnancy patient 321 example, wherein gestation hypertension patient 257 example, preeclampsia patients with mild 48 example, preeclampsia syndrome patient 16 example.
2, diagnostic criteria: occur hypertension, edema, albuminuria after pregnant 20 weeks, can there is stupor and twitch in serious symptom, be divided into that gestation hypertension, preeclampsia are slight, preeclampsia syndrome.
(1): gestation hypertension: blood pressure >=140/90mmHg.Trimester of pregnancy occurs first, can with albuminuria (24h total urinary protein is no more than 0.5g) and/or edema.
(2) preeclampsia is slight: blood pressure >=140/90mmHg, albuminuria+(24h total urinary protein is greater than 0.3g), can with symptoms such as headache, epigastric discomforts.
(3) preeclampsia syndrome: blood pressure >=160/110mmHg, 24h urine protein quantitation >=2g, companion's severe headache, dim eyesight, uncomfortable in chest etc.
Above-mentioned blood pressure standard is as the criterion with diastolic pressure, and as namely 150/110mmHg belongs in severe, albuminuria and diastole are pressed with one when reaching standard, are namely included into such.
3, Therapeutic Method: the medicine taking the embodiment of the present invention 1.It within 3 days, is 1 course for the treatment of.Gestation hypertension patient takes 1-3 the course for the treatment of, and preeclampsia (comprising slight, severe) patient takes 3-5 the course for the treatment of.
4, efficacy assessment standard:
(1) cure: hypertension: high pressure returns to 130mmHg, low pressure returns to 85mmHg; Urine protein: protein negative in urine; Edema, tic, headache, dizziness, dim eyesight, uncomfortable in chest, blurred vision, the symptom of the hypertensive disorder in pregnancy that cardiopalmus tachypnea, eclamposia etc. are all disappears.
(2) effective: hypertension: high pressure returns to 140mmHg, low pressure returns to 90mmHg; Urine protein: one, albumen in urine+; Edema, tic, headache, dizziness, dim eyesight, uncomfortable in chest, blurred vision, the symptom of the hypertensive disorder in pregnancies such as cardiopalmus tachypnea, eclamposia alleviates.
(3) invalid: symptom does not alleviate, the state of an illness continues to worsen.
5, therapeutic outcome: cure 273 examples, effective 48 examples, invalid 0 example, cure rate is 85.0%, and total effective rate is 100%.Carry out follow-up observation to all patients, except 2 examples cause stillborn fetus because being in a bad way, all the other case all neonatal surviveds, to check UP confirmation on all fetuses: this medicine does not affect the growth of fetus completely.
Two, model case
1, Zhang, female, 31 years old.Within pregnant 28 weeks, occur that unrelenting headache, dizziness, blurred vision are admitted to hospital, find blood pressure: 165/112mmHg through examination in hospital, urine protein ++; After 2 days, health check-up finds: urine protein +++, twenty-four-hour urine albumen: 5.2g.Treat 2 courses for the treatment of of medicine of hypertensive disorder in pregnancy through taking the present invention after, symptom obviously alleviates, blood pressure 132/85mmHg, urine protein+.Continue to take 2 courses for the treatment of, blood pressure: 125/80mmHg, urine protein: negative; All symptoms all disappear.Continue to strengthen 1 course for the treatment of of treatment.Follow up a case by regular visits to: the childbirth in 34 weeks of this pregnant women, fetal weight 2.0 kilograms, health check-up indices is all normal.
2, Wang, female, 29 years old.Pregnant 32 weeks, normal producing when examining found: blood pressure 153/101mmHg, ankle and the obvious edema of lower limb, do not disappear after rest.Further urine examination finds: albuminuria+.Patient's readme: even have dizziness, headache syndromes.Treat 2 courses for the treatment of of medicine of hypertensive disorder in pregnancy through taking the present invention after, blood pressure: 130/85mmHg, urine protein: negative; All symptoms all disappear.Follow up a case by regular visits to: this anemia of pregnant woman's After Gravidity 35 Weeks is given a birth, and fetal weight 2.5 kilograms, health check-up indices is all normal.
Detailed description of the invention
Embodiment 1
Formula: Ganoderma 20 grams, Cortex Eucommiae (parched) 20 grams, Herba Taxilli 20 grams, Radix Dipsaci 15 grams, Fructus Citri Sarcodactylis 15 grams, Rhizoma Dioscoreae 15 grams, Herba Silybi mariani 10 grams, 10 grams, Fructus Jujubae, Radix Puerariae 10 grams, Folium Apocyni Veneti 10 grams, 10 grams, Folium Nelumbinis, Concha Haliotidis 10 grams, Fructus Crataegi 10 grams, Stigma Maydis 10 grams, Herba Lysimachiae 5 grams, Semen Euryales 5 grams, Herba Pyrolae 5 grams, Radix Scutellariae 10 grams, Radix Codonopsis 5 grams and 5 grams, Radix Glycyrrhizae.
Preparation and instructions of taking: soak by water, take at twice sooner or later.It within 3 days, is 1 course for the treatment of.
Claims (1)
1. treat the medicine of hypertensive disorder in pregnancy for one kind, it is characterized in that, be made up of the raw material of following weight, Ganoderma 20 grams, Cortex Eucommiae (parched) 20 grams, Herba Taxilli 20 grams, Radix Dipsaci 15 grams, Fructus Citri Sarcodactylis 15 grams, Rhizoma Dioscoreae 15 grams, Herba Silybi mariani 10 grams, 10 grams, Fructus Jujubae, Radix Puerariae 10 grams, Folium Apocyni Veneti 10 grams, 10 grams, Folium Nelumbinis, Concha Haliotidis 10 grams, Fructus Crataegi 10 grams, Stigma Maydis 10 grams, Herba Lysimachiae 5 grams, Semen Euryales 5 grams, Herba Pyrolae 5 grams, Radix Scutellariae 10 grams, Radix Codonopsis 5 grams and 5 grams, Radix Glycyrrhizae.
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| CN103599368B (en) * | 2013-11-05 | 2016-02-17 | 刘京伟 | A kind of Chinese medicine preparation for the treatment of climacteric hypertension |
| CN105030968A (en) * | 2015-07-05 | 2015-11-11 | 吴优 | Liver-kidney yin deficiency hypertension treatment medicine and preparation method thereof |
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| CN101595927A (en) * | 2008-06-06 | 2009-12-09 | 刘泳宏 | A kind of natural lung-nourishing lipopenicillinase, hypoglycemic, blood-pressure decreasing tea and preparation method |
| CN101966271B (en) * | 2010-09-15 | 2012-05-23 | 吴玉平 | Chinese medicinal decoction for treating hypertension |
| CN102423421B (en) * | 2011-12-06 | 2014-06-11 | 陈中元 | Medicine for treating hypertension |
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