CN103301340A - Drug for treating pregnancy-induced hypertension - Google Patents

Drug for treating pregnancy-induced hypertension Download PDF

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CN103301340A
CN103301340A CN2013102715771A CN201310271577A CN103301340A CN 103301340 A CN103301340 A CN 103301340A CN 2013102715771 A CN2013102715771 A CN 2013102715771A CN 201310271577 A CN201310271577 A CN 201310271577A CN 103301340 A CN103301340 A CN 103301340A
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radix
pregnancy
liver
herba
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牛余霞
蒋秀芳
王学玲
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牛余霞
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Abstract

The invention discloses a drug for treating pregnancy-induced hypertension. The drug comprises the following active ingredients by weight: 20g of ganoderma lucidum, 20g of stir-baked cortex eucommia, 20g of herba taxilli, 15g of dipsacus asperoids, 15g of citrus chirocarpus, 15g of rhizoma dioscoreae, 10g of silybum marianum, 10g of radix puerariae, 10g of dogbane leaf, 10g of lotus leaf, 10g of concha haliotidis, 10g of hawthorn, 10g of stigma maydis, 5g of christina loosestrife herb, 5g of Chinese pyrola herb, 5g of radix scutellariae, 5g of radix codonopsis and 5g of radix glycyrrhizae. The traditional Chinese medicine is used for treating pregnancy-induced hypertension, so that the total efficiency can achieve 100%, and the normal growth of fetuses is not influenced.

Description

A kind of medicine for the treatment of hypertensive disorder in pregnancy
Technical field
The present invention relates to a kind of medicine for the treatment of hypertensive disorder in pregnancy, belong to technical field of Chinese medicines.
Background technology
Hypertensive disorder in pregnancy is obstetrics' common diseases, accounts for the 9.4-10.4% of whole gestation, is one of four large reasons that cause maternal death, and the maternal death that causes accounts for the 10-16% of the relevant dead sum of gestation.Its cardinal symptom has hypertension, albuminuria, edema etc.Now introduce respectively:
1, the lasting rising 〉=140/90mmHg of hypertension blood pressure is the Clinical Manifestations of hypertensive disorder in pregnancy.But patient's no conscious sympton during the slight slow rising of blood pressure finds that when health check-up blood pressure increases; During the hurried rising of blood pressure, severe headache, dim eyesight, blurred vision can appear in the patient, and the cardiopalmus tachypnea can cause cordis and cerebral accident.Serious preeclampsia patient blood pressure continues to raise, and serious hypertension 〉=160/110mmHg occurs.
2, the albuminuria urine protein can change in every day to some extent along with angiospastic variation.Serious preeclampsia Urinary albumen continue to increase, and High-grade Proteinuria occurs, and urine protein is qualitative 〉=(++), or twenty-four-hour urine protein quantification 〉=2g.
3, edema can show as frank edema and latent edema.Multiple ankle and the lower limb be born in of frank edema also can show as hydrosarca.Characteristics do not disappear for after having a rest, or occur suddenly, involve rapidly whole body even the dropsy of serous cavity of abdominal cavity, thoracic cavity, pericardial cavity occurs comprising.Latent edema refers to fluid retention in interstice, and main manifestations is the unusual increase of body weight.
The hypertensive disorder in pregnancy therapeutic purposes are generations of prevention serious preeclampsia and eclamposia, reduce female tire perinatal morbidity and mortality rate, improve mother and baby's prognosis.At present, the western medical treatment method is mainly treated hypertensive disorder in pregnancy with spasmolytic, blood pressure lowering, diuresis and calmness etc.The Common drugs for the treatment of gestation hypertension has: magnesium sulfate, beta receptor antagonist, calcium ion channel blocker, diuretic etc.But because the Western medicine side effect is large, cause great psychology, mental disorder to the patient.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of hypertensive disorder in pregnancy, the selected kinds of traditional Chinese medicines of this medicine is carried out prescription, and this medicine can effectively be treated hypertensive disorder in pregnancy.
Technical scheme of the present invention is: a kind of medicine for the treatment of hypertensive disorder in pregnancy, it is characterized in that, raw material by following weight is made, Ganoderma 20 grams, Cortex Eucommiae (parched) 20 grams, Herba Taxilli 20 grams, Radix Dipsaci 15 grams, Fructus Citri Sarcodactylis 15 grams, Rhizoma Dioscoreae 15 grams, Herba Silybi mariani 10 grams, Fructus Jujubae 10 grams, Radix Puerariae 10 grams, Folium Apocyni Veneti 10 grams, Folium Nelumbinis 10 grams, Concha Haliotidis 10 grams, Fructus Crataegi 10 grams, Stigma Maydis 10 grams, Herba Lysimachiae 5 grams, Semen Euryales 5 grams, Herba Pyrolae 5 grams, Radix Scutellariae 10 grams, Radix Codonopsis 5 grams and Radix Glycyrrhizae 5 grams.
Preparation and instructions of taking: decocting boils, and sooner or later takes at twice.3 days is 1 course for the treatment of.Gestation hypertension patient takes 1-3 the course for the treatment of, and preeclampsia (comprising slight, severe) patient takes 3-5 the course for the treatment of.
The pharmacological action of each Chinese medicine:
Ganoderma: property is sweet, and flavor is flat.GUIXIN, lung, liver, kidney channel.Function with cure mainly: can invigorating QI and tranquilization, relieving cough and asthma.Be used for dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
Cortex Eucommiae (parched): sweet, temperature.Return liver, kidney channel.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension.
Herba Taxilli: bitter, sweet, flat.Return liver, kidney channel.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.Be used for rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and the metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement, hypertension.
Radix Dipsaci: bitter, hot, tepor.Return liver, kidney channel.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia.Be used for deficiency of the liver and kindey, soreness of the waist and knees, rheumatic arthralgia, injury from falling down, injury of tendon and muscle fracture, metrorrhagia, vaginal bleeding during pregnancy.
Concha Haliotidis: salty, cold.Return Liver Channel.Function with cure mainly: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Be used for having a headache dizzy conjunctival congestion cataracta, blurring of vision, optic atrohic blindness nyctalopia.
Fructus Citri Sarcodactylis: hot, bitter, sour, temperature.Return liver, spleen, lung meridian.Function with cure mainly: liver-smoothing, qi-regulating, and stomach and alleviating pain.Be used for stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite vomiting.
Rhizoma Dioscoreae: sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.Be used for insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.
Herba Silybi mariani: hardship, cold.Return liver, gallbladder meridian.Function with cure mainly: heat-clearing and toxic substances removing, 'Shugan Lidan '.Be used for dampness-heat in the liver and gallbladder, hypochondriac pain, jaundice.
Fructus Jujubae: sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be used for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Radix Puerariae: sweet, hot, cold.Return spleen, stomach warp.Function with cure mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea is had loose bowels; The hypertension neck pain.
Folium Apocyni Veneti: sweet, bitter, cold.Return Liver Channel.Function with cure mainly: suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.Be used for dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema
Folium Nelumbinis: Folium Nelumbinis is the food of " medicine-food two-purpose ", the Flavonoid substances that is rich in the Folium Nelumbinis, it is the scavenger of most of oxygen-derived free radicals, can improve the SOD(superoxide dismutase) vigor, reduce the MDA(malondialdehyde) and the 0X-LDL(OxLDL ELISA) generation, it can increase coronary flow, and Myocardial Infarction is had antagonism; Acute myocardial ischemia there is protective effect; Treatment coronary heart disease, hypertension etc. there is remarkable result; To reducing diastolic pressure, prevent and treat arrhythmia, cardiovascular diseases etc. and also play an important role.
Fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Effect: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.Cure mainly: be used for meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.
Herba Lysimachiae: dried, light, flat, return liver, gallbladder, kidney, urinary bladder channel.Function with cure mainly: dehumidifying jaundice eliminating, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling, Herba Lysimachiae, picric acid is cool, enters the liver and gall kidney, bladder footpath, clearing away heat and promoting diuresis, Tonglin Paishi.
Stigma Maydis: sweet, flat.Return bladder, liver, gallbladder meridian.Function with cure mainly: diuresis expels the heat-evil suppressing the hyperactive liver, function of gallbladder promoting.Control oedema due to nephritis, beriberi, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis and epistaxis, nasal sinusitis, acute mastitis.
Semen Euryales: have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the effect of damp eliminating, leukorrhagia stopping.Cure mainly nocturnal emission, spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.
Herba Pyrolae: sweet, bitter, temperature.Return liver, kidney channel.Function with cure mainly: wind-damp dispelling, bone and muscle strengthening, the hemostasis.Be used for rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Radix Scutellariae: hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication, the hemostasis, antiabortive.
Radix Codonopsis: return spleen, lung meridian.Function with cure mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function with cure mainly: invigorating the spleen and replenishing QI, grow and to cough lung moistening, the emergency detoxifcation is in harmonious proportion hundred medicines.Cure mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.
The traditional Chinese medical science is thought: hypertensive causing is due to " excessive rising of liver-YANG ", and yang hyperactivity is hyperactivity of fire then, and hyperactivity of fire is then attacked on mechanism of qi superinverse, the pathogenic fire, and vim and vigour also with on violate and stage an armed rebellion." soothing the liver, nourishing the liver " can not singly set about from liver, needs from its source kidney, has only by " supporting kidney to transfer liver ", reaches Liver and kidney with mending, and is only so the real method of effecting a permanent cure.The selected 20 kinds of Chinese prescriptions of the present invention, nourishing liver and kidney, invigorating spleen to remove dampness, invigorating the spleen and replenishing QI, the effect that has simultaneously the symptoms such as blood pressure lowering, elimination edema, elimination albuminuria.Eliminated fast symptom thereby both can reach, and can nurse one's health the Liver and kidney spleen again, and supported sufficient essence and blood, then self is to support whole body to breed fetus.
The invention has the beneficial effects as follows: adopt this treatment by Chinese herbs hypertensive disorder in pregnancy, total effective rate is 100%, and does not affect the normal development of fetus.
Further specify its beneficial effect below in conjunction with clinical data and model case.
One, clinical data
1, physical data: hypertensive disorder in pregnancy patient 321 examples that are selected from the 25-40 year (31.5 years old mean age) that 2010.5-2012.7 hospital accepts for medical treatment, gestation hypertension patient 257 examples wherein, preeclampsia patients with mild 48 examples, preeclampsia severe patient 16 examples.
2, diagnostic criteria: hypertension, edema, albuminuria occur after pregnant 20 weeks, serious symptom stupor can occur and twitch, and is divided into gestation hypertension, preeclampsia is slight, preeclampsia severe.
(1): gestation hypertension: blood pressure 〉=140/90mmHg.Trimester of pregnancy occurs first, can be with albuminuria (the 24h total urinary protein is no more than 0.5g) and/or edema.
(2) preeclampsia is slight: blood pressure 〉=140/90mmHg, albuminuria+(the 24h total urinary protein is greater than 0.3g) can be with symptoms such as headache, epigastric discomforts.
(3) preeclampsia severe: blood pressure 〉=160/110mmHg, 24h urine protein quantitation 〉=2g, companion severe headache, dim eyesight, uncomfortable in chest etc.
Above-mentioned blood pressure standard is as the criterion with diastolic pressure, namely belongs in severe such as 150/110mmHg, and albuminuria and diastole are pressed with one when reaching standard, namely are included into such.
3, Therapeutic Method: the medicine of taking the embodiment of the invention 1.3 days is 1 course for the treatment of.Gestation hypertension patient takes 1-3 the course for the treatment of, and preeclampsia (comprising slight, severe) patient takes 3-5 the course for the treatment of.
4, efficacy assessment standard:
(1) cure: hypertension: high pressure returns to 130mmHg, and low pressure returns to 85mmHg; Urine protein: albumen is negative in the urine; Edema, tic, headache, dizziness, dim eyesight, uncomfortable in chest, blurred vision, the symptom of the hypertensive disorder in pregnancy that cardiopalmus tachypnea, eclamposia etc. are all disappears.
(2) effective: hypertension: high pressure returns to 140mmHg, and low pressure returns to 90mmHg; Urine protein: one in albumen in the urine+; Edema, tic, headache, dizziness, dim eyesight, uncomfortable in chest, blurred vision, the sx↓ of the hypertensive disorder in pregnancies such as cardiopalmus tachypnea, eclamposia.
(3) invalid: symptom does not alleviate, and the state of an illness continues to worsen.
5, therapeutic outcome: cure 273 examples, effective 48 examples, invalid 0 example, cure rate is 85.0%, total effective rate is 100%.All patients are carried out follow-up observation, except 2 examples due to illness feelings seriously cause the stillborn fetus, all the other case all neonatal surviveds, on the confirmation that checks UP of all fetuses: this medicine does not affect fetal development fully.
Two, model case
1, Zhang, woman, 31 years old.Pregnant 28 weeks occur unrelenting headache, dizziness, blurred vision and be admitted to hospital, find blood pressure: 165/112mmHg through examination in hospital, urine protein ++; Health check-up is found after 2 days: urine protein +++, twenty-four-hour urine albumen: 5.2g.Through taking medicine that the present invention treats hypertensive disorder in pregnancy after 2 courses for the treatment of, symptom obviously alleviates, blood pressure 132/85mmHg, and urine protein+.Continue to take 2 courses for the treatment of, blood pressure: 125/80mmHg, urine protein: feminine gender; All symptoms all disappear.Continue to strengthen and treat 1 course for the treatment of.Follow up a case by regular visits to: this pregnant women 34 week childbirth, 2.0 kilograms of fetal weights, the health check-up indices is all normal.
2, Wang, woman, 29 years old.In pregnant 32 weeks, normal producing when examining found: blood pressure 153/101mmHg, the obvious edema of ankle and lower limb does not disappear after the rest.Further urine examination is found: albuminuria+.Patient's readme: idol has dizziness, headache symptom.Through taking medicine that the present invention treats hypertensive disorder in pregnancy after 2 courses for the treatment of, blood pressure: 130/85mmHg, urine protein: feminine gender; All symptoms all disappear.Follow up a case by regular visits to: this anemia of pregnant woman's After Gravidity 35 Weeks childbirth, 2.5 kilograms of fetal weights, the health check-up indices is all normal.
The specific embodiment
Embodiment 1
Prescription: Ganoderma 20 grams, Cortex Eucommiae (parched) 20 grams, Herba Taxilli 20 grams, Radix Dipsaci 15 grams, Fructus Citri Sarcodactylis 15 grams, Rhizoma Dioscoreae 15 grams, Herba Silybi mariani 10 grams, Fructus Jujubae 10 grams, Radix Puerariae 10 grams, Folium Apocyni Veneti 10 grams, Folium Nelumbinis 10 grams, Concha Haliotidis 10 grams, Fructus Crataegi 10 grams, Stigma Maydis 10 grams, Herba Lysimachiae 5 grams, Semen Euryales 5 grams, Herba Pyrolae 5 grams, Radix Scutellariae 10 grams, Radix Codonopsis 5 grams and Radix Glycyrrhizae 5 grams.
Preparation and instructions of taking: decocting boils, and sooner or later takes at twice.3 days is 1 course for the treatment of.

Claims (1)

1. medicine for the treatment of hypertensive disorder in pregnancy, it is characterized in that, raw material by following weight is made, Ganoderma 20 grams, Cortex Eucommiae (parched) 20 grams, Herba Taxilli 20 grams, Radix Dipsaci 15 grams, Fructus Citri Sarcodactylis 15 grams, Rhizoma Dioscoreae 15 grams, Herba Silybi mariani 10 grams, Fructus Jujubae 10 grams, Radix Puerariae 10 grams, Folium Apocyni Veneti 10 grams, Folium Nelumbinis 10 grams, Concha Haliotidis 10 grams, Fructus Crataegi 10 grams, Stigma Maydis 10 grams, Herba Lysimachiae 5 grams, Semen Euryales 5 grams, Herba Pyrolae 5 grams, Radix Scutellariae 10 grams, Radix Codonopsis 5 grams and Radix Glycyrrhizae 5 grams.
CN201310271577.1A 2013-06-28 2013-06-28 Drug for treating pregnancy-induced hypertension Expired - Fee Related CN103301340B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103599368A (en) * 2013-11-05 2014-02-26 刘京伟 Traditional Chinese medicinal preparation for treating menopause hypertension
CN105030968A (en) * 2015-07-05 2015-11-11 吴优 Liver-kidney yin deficiency hypertension treatment medicine and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101595927A (en) * 2008-06-06 2009-12-09 刘泳宏 A kind of natural lung-nourishing lipopenicillinase, hypoglycemic, blood-pressure decreasing tea and preparation method
CN101966271A (en) * 2010-09-15 2011-02-09 吴清玲 Chinese medicinal decoction for treating hypertension
CN102423421A (en) * 2011-12-06 2012-04-25 陈中元 Medicine for treating hypertension

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101595927A (en) * 2008-06-06 2009-12-09 刘泳宏 A kind of natural lung-nourishing lipopenicillinase, hypoglycemic, blood-pressure decreasing tea and preparation method
CN101966271A (en) * 2010-09-15 2011-02-09 吴清玲 Chinese medicinal decoction for treating hypertension
CN102423421A (en) * 2011-12-06 2012-04-25 陈中元 Medicine for treating hypertension

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103599368A (en) * 2013-11-05 2014-02-26 刘京伟 Traditional Chinese medicinal preparation for treating menopause hypertension
CN103599368B (en) * 2013-11-05 2016-02-17 刘京伟 A kind of Chinese medicine preparation for the treatment of climacteric hypertension
CN105030968A (en) * 2015-07-05 2015-11-11 吴优 Liver-kidney yin deficiency hypertension treatment medicine and preparation method thereof

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