CN102600434B - Compound mixture for curing cervical vertigo - Google Patents

Abstract

The invention relates to a compound mixture for curing cervical vertigo, which is characterized in that the compound mixture is prepared by the following raw materials in percent by weight through a method which comprises the following steps of: cleaning 14-22 percent of teasel root, 12-18 percent of fossil bone, 8-10 percent of Fructus ligustri Lucidi, 6-10 percent of mother of pearl, 8-10 percent of Tribulus terrestris L., 3-4 percent of Ligusticum wallichii, 6-8 percent of lobed kudzuvine root, 6-10 percent of Salvia miltiorrhiza, 5-7 percent of Chinese flowering quince, 3-6 percent of Rhizoma anemarrhenae, 4-6 percent of moutan bark, 3-5 percent of Rhizoma acori Talarinowii, 3-6 percent of Radix curcumae and 3-6 percent of licorice root, soaking the raw materials in water, boiling, removing residues to obtain filtrate, sterilizing and refining to obtain the mixture. The compound mixture for curing cervical vertigo has the efficacies of nourishing liver and kidney, calming liver wind, removing heat to cool blood, promoting blood circulation to remove meridian obstruction, activating spleen qi, resolving dampness, activating yang and promoting resuscitation, can effectively cure cervical spondylosis of vertebral artery type and does not have any adverse effect.

Description

The dizzy neck complexing agent of a kind of Compound Resisting

Technical field

The present invention relates to the pharmaceutical formulation field, specifically a kind of dizzy neck complexing agent of Compound Resisting that is used for the treatment of vertebral artery type of cervical spondylosis.

Background technology

Vertebral artery type of cervical spondylosis is to stimulate or the compressing vertebral artery causes the cerebral tissue blood supply insufficiency because of cervical spine disk pathological change, hyperosteogeny of cervical vertebra, due to cerebral hypoxia ischemia.They are many causes the cervical vertebra degeneration due to long-time incorrect with neck, thereupon degeneration of cervical intervertebral disc, cervical vertebrae physiological flexibility change, hyperosteogeny of cervical vertebra, stimulate and compressing neck soft, vertebral artery and a kind of comprehensive syndrome of complicated symptoms of causing.The age of onset of vertebral artery type of cervical spondylosis is high than other myelopathys, and sickness rate has parallel ascendant trend with the increase at age, and symptom also increases and day by day increases the weight of with the age.Existing vertebral artery type of cervical spondylosis is subject to the attention of domestic and international medical circle day by day, and unified be called " cervical vertigo " in the world also goed deep in pathogenetic research increasingly.Noticed that at present blood supply of vertebral artery is not enough in close relations with this myelopathy, it is the main cause of primary disease morbidity, abroad someone adds up, approximately 70% cervical spondylosis with vertebral artery get involved, blood supply insufficiency, growth with the age increases, cervical spine degeneration increases the weight of day by day, and hyperosteogeny also progressively increases, to vertebral artery or vertebra week nerve compression, stimulate day by day serious and morbidity or make symptom more obvious.Along with modern life level improves, lifestyle change, rhythm of life is accelerated, operating pressure strengthens, long-time operation computer, mobile phone and the factor such as lack exercise all can cause cervical spondylosis, cervical spondylosis is not the patent of middle-aged and elderly people now, and many young, even pediatric population also begins to have the tendency of cervical spondylosis.Primary disease has the trend of rejuvenation, and it treats slowlyer, and relapse rate is high, severe patient can cause cerebrovascular, there is no at present thorough radical cure method, is mainly doctor trained in Western medicine symptomatic treatment and rehabilitation, to improve symptom as main, curative effect is unsatisfactory, also can't stop disease progression.Bring serious harm for patient's health, patients ' life quality is descended comprehensively, and increase the financial burden of family, society.Chinese medicine has shown at the treatment vertebral artery type of cervical spondylosis advantage and the characteristic that it is unique in recent years, and is evident in efficacy.

Summary of the invention

Purpose of the present invention is exactly in order to overcome above-mentioned deficiency, Chinese medicine preparation of the treatment vertebral artery type of cervical spondylosis that provide a kind of and have no side effect, clinical effectiveness is good and preparation method thereof.

For achieving the above object, the present invention can be achieved by the following measures:

The technical solution used in the present invention is: adopting Radix Dipsaci, Os Draconis, Fructus Ligustri Lucidi, Concha Margaritifera, Fructus Atriplicis Sibiricae, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae, Radix Glycyrrhizae is that raw material is prepared from, its available following method obtains: after Radix Dipsaci, Os Draconis, Fructus Ligustri Lucidi, Concha Margaritifera, Fructus Atriplicis Sibiricae, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae, Radix Glycyrrhizae are cleaned, be soaked in water, then decoct, the filtrate of removing slag to get, sterilization makes mixture after refining.

Its technical characterictic is, it is Radix Dipsaci 14-22%, Os Draconis 12-18%, Fructus Ligustri Lucidi 8-10%, Concha Margaritifera 6-10%, Fructus Atriplicis Sibiricae 8-10%, Rhizoma Chuanxiong 3-4%, Radix Puerariae 6-8%, Radix Salviae Miltiorrhizae 6-10%, Fructus Chaenomelis 5-7%, Rhizoma Anemarrhenae 3-6%, Cortex Moutan 4-6%, Rhizoma Acori Graminei 3-5%, Radix Curcumae 3-6%, Radix Glycyrrhizae 3-6% that raw material forms (weight), and each raw material components percentage ratio sum equals absolutely.

Each cost of material of the present invention is low, and compliance is good, has no side effect, and has the principle for the treatment of of nourishing the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome, clearing away heat and cooling blood, the clear sharp head, promoting blood circulation to remove obstruction in the collateral, waking up the patient from unconsciousness by dissipating phlegm.

Therapeutic Principle of the present invention: cervical spondylosis be the most commonly encountered diseases that causes the blood supply of vertebral artery deficiency because of, vertebral artery type of cervical spondylosis belongs to motherland's medical science " dizzy " category, how because of caused by liver and kidney deficiency, muscles and bones mistake are supported, due to excessive rising of liver-YANG, wind-yang and up-boring, stasis blocking meridians.As far back as " Plain Questions. the most pure virginity will be discussed greatly " think " all wind trembling and dizziness all belong to liver ", bright. anxiety Fu proposes the argument of " blood stasis causes dizzy ".Multilist shows deficiency in origin and excess in superficiality clinically, and empty person is take the hepatic and renal YIN deficiency as this, and real person is take wind, fire, expectorant, the stasis of blood as mark, though dizzy sick position is closely related with the dirty malfunction of liver,spleen,kidney three at clear key, and deficiecny of liver-YIN, pathogenic fire derived from stagnation of liver-QI can cause excessive rising of liver-YANG; Dysfunction of the spleen in transportation, stagnation of phlegm-damp in middle-JIAO is hoodwinked key clearly; Deficiency of kidney-essence, illness of the mother organ affecting the child one, deficiency and exhaustion of liver-YIN also can cause excessive rising of liver-YANG.Therefore drafted the principle for the treatment of of nourishing the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome, clearing away heat and cooling blood, promoting blood circulation to remove obstruction in the collateral, waking up the patient from unconsciousness by dissipating phlegm.The hot tepor of Radix Dipsaci nature and flavor sweetness and bitterness in the side in the present invention, has invigorating the liver and kidney, the promoting the circulation of blood arteries and veins, the merit of reuniting the fractured tendons and bones, this product can invigorating the liver and kidney, again can the promoting the circulation of blood arteries and veins, the advantage that tonify without causing stagnation is arranged has again the merit of detumescence, pain relieving, granulation promoting, " book on Chinese herbal medicine converge speech ": " Radix Dipsaci; mend the medicine of continuous blood vessels also, non-this of the blood vessels that on the whole broken does not continue; Non-this of the muscles and bones of being hindered is not supported ", modern pharmacological research Radix Dipsaci root contains carotene, cupreol, triterpenoid saponin etc., and the cervical vertebra of releasing muscle group spasm is arranged, and recovers the ligament function, improves cervical curvature, recovers cervical stability; The Os Draconis sweet-puckery flavor is slightly cold, the GUIXIN Liver Channel, have suppressing the hyperactive liver and subsiding YANG, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., the merit of tranquillizing and allaying excitement, this product can suppressing the hyperactive liver and dive and hold back floating sun, the modern pharmacological research Os Draconis mainly contain calcium carbonate, calcium phosphate etc., after the contained calcium salt of Os Draconis absorbs, the permeability that promotes blood coagulation, reduces blood vessel wall is arranged and suppress the effect such as skeletal muscle excitement; Be both the principal agent liver and kidney tonifying altogether, suppressing the hyperactive liver and subsiding YANG.Fructus Ligustri Lucidi nature and flavor sweetness and bitterness is cool, returns the Liver and kidney warp, has the merit of liver and kidney tonifying, clearing away heat to improve acuity of vision, and this product can liver and kidney tonifying, is the product of clear benefits simply, can be apt to clearind deficient heat again, and Fructus Ligustri Lucidi has the effects such as the immunologic function of enhancing, raising peripheral leukocytes; Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, the clear sharp head, and have suppress Skeletal Muscle Contraction, in and the gastric acid effect; The Fructus Atriplicis Sibiricae suppressing the hyperactive liver is soothing the liver, dispelling pathogenic wind for improving eyesight; The Rhizoma Chuanxiong blood-activating and qi-promoting contains ligustrazine, promotes microcirculation, and the Rhizoma Chuanxiong lactone also has obvious spasmolysis.Radix Puerariae spasmolytic, yang invigorating, blood circulation promoting and blood stasis dispelling are removed the cervical vertebra muscle group and are shunk, and increase muscle fiber elasticity, softening ligament can effectively stop intervertebral disc fibrosis and intervertebral disc degeneration, has antiplatelet aggregation, reducing the blood viscosity effect, can effectively stop the cervical spine degeneration process, is ministerial drug altogether.Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, collateral dredging improve blood circulation, remove or alleviate the cervical vertebra degeneration to vertebrarterial pressure symptom, improve blood circulation; The Fructus Chaenomelis relaxing muscles and tendons and activating QI and blood in the collateral can be removed cervical region muscular contracture stiffness of the nape, unable to move around; The relieving restlessness of Rhizoma Anemarrhenae clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; The removing dampness of being amusing of Rhizoma Acori Graminei, Radix Curcumae, activating YANG to wake up the patient from unconciousness is adjuvant drug altogether.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription can relax medicine strong and alleviate poisonous side effect of medicine, can be in harmonious proportion again taste, and invigorating the spleen and benefiting QI with solid the foundation of acquired constitution, can the winter protection medicine of a cold nature thing impairment of the spleen be upset one's stomach as making medicine.Prescription of the present invention, giving consideration to both the incidental and fundamental can be removed cervical vertebra muscle group spasm, recovers the ligament function, improves cervical curvature, recovers cervical stability.Change the cervical vertebra vascular permeability, effectively reduce blood viscosity, promote blood circulation, improve the vertebra basilar arterial blood supply.Have nourishing the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome, clearing away heat and cooling blood, promoting blood circulation to remove obstruction in the collateral, the removing dampness of being amusing, the merit of activating YANG to wake up the patient from unconciousness is effectively treated vertebral artery type of cervical spondylosis.

The specific embodiment

The invention will be further described below in conjunction with embodiment:

embodiment: the dizzy neck complexing agent of the present embodiment Compound Resisting adopts Radix Dipsaci, Os Draconis, Fructus Ligustri Lucidi, Concha Margaritifera, Fructus Atriplicis Sibiricae, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae, Radix Glycyrrhizae is that raw material is prepared from, its component (% by weight) is Radix Dipsaci 18%, Os Draconis 18%, Fructus Ligustri Lucidi 10%, Concha Margaritifera 9%, Fructus Atriplicis Sibiricae 8%, Rhizoma Chuanxiong 3%, Radix Puerariae 6%, Radix Salviae Miltiorrhizae 6%, Fructus Chaenomelis 4%, the Rhizoma Anemarrhenae 5%, Cortex Moutan 3%, Rhizoma Acori Graminei 3%, Radix Curcumae 3%, Radix Glycyrrhizae 4%, get 56 kilograms of above-mentioned 14 kinds of raw material gross weights, use the 20000ml water soaking about 30 minutes after selected cleaning under greenhouse experiment, then decoct 60 minutes, the routine filtration of removing slag, high pressure, after sterilization process, gained filtrate is 9000ml altogether, the bag packing, sealing, every bag of 150ml.

1, case is selected: the routine patient of clinical random selection 65, male 34 examples, female's 31 examples, age 30-70 year, average 53.2 ± 5.8 years old, the course of disease 2 months 1 years, average 4.7 ± 3.8 years; Cervical X-ray sheet or CT sheet show hyperosteogeny of cervical vertebra, ligament calcification, narrowing of intervertebral space person's 54 examples, be associated with simultaneously physiological bending changer 22 examples, cervical intervertebral disk is outstanding compressing vertebral artery person 11 examples slightly, and all transcranial Doppler sonography (TCD) inspection is shown: vertebro-basilar artery insufficiency or spasm.1. Excluded cases merges serious cardiovascular and cerebrovascular vessel patient, 2. serious hepatic and kidney function obstacle person, 3. gestation or women breast-feeding their children person, 4. those who are allergic to this drug, 5. simple spondylotic radiculopathy, sympathetic type, cervical spondylotic myelopathy person, 6. medication or data are not congruent in accordance with regulations affects the treatment or safety judgement person.

2, diagnostic criteria: the Western medicine diagnose standard, draft with reference to " clinical sacred disease diagnostics ": (1) mostly is greatly middle-aged and elderly people; (2) the cervical vertebra medical history is arranged more; (3) occur suddenly dizzyly, Chang Yutou position, position are relevant; (4) can be with the Sx of neural ischemia during onset of vertigo; (5) Chang Fanfu outbreak; (6) except acute cerebral infarction, cerebral hemorrhage and otological disease.All change in various degree or hyperosteogeny of cervical vertebra through cervical vertebra X sheet prompting cervical curvature.Transcranial Doppler sonography (TCD) inspection is shown: vertebro-basilar artery insufficiency or spasm are clarified a diagnosis, and clinical symptoms and sign all meet the vertebral artery type of cervical spondylosis diagnosis.Syndrome Differentiation of Traditional Chinese Medicine standard: with reference to the diagnostic criteria of dizzy syndrome of upper hyperactivity of liver yang in " traditional Chinese medical science disease Standardization of diagnosis and curative effect ".Primary symptom: dizzy, tinnitus, distending pain in the head is felt sick, nausea general, dry mouth with bitter taste, insomnia and dreamful sleep, forgetful, soreness of waist and knee, red tongue, tongue is few, stringy,thready and rapid pulse.

3, criterion of therapeutical effect: comprise clinical cure, produce effects, effective, invalid, treatment finishes to estimate total effects.Criterion of therapeutical effect is drafted with reference to relevant criterion of therapeutical effect in " new Chinese medicine guideline of clinical investigations ".Clinical cure: dizzy, headache is felt sick, and the symptoms such as nausea and horizontal sample nystagmus, sign disappear, and TCD prompting vertebra basilar arterial blood supply recovers normal; Produce effects: dizzy, headache is felt sick, and the symptoms such as nausea and horizontal sample nystagmus, sign disappear, and TCD prompting vertebra basilar arterial blood supply recovers normal, but sometimes still has recurrence; Effectively: dizzy, headache is felt sick, and symptom, the signs such as nausea and horizontal sample nystagmus obviously alleviate, and TCD prompting vertebra basilar arterial blood supply obviously improves; Invalid: symptom, sign are without obvious improvement, and TCD checks without changing.

4, Therapeutic Method: each serving the dizzy neck complexing agent of use Compound Resisting 150ml, morning every day, late twice one after each meal, 10 days was 1 course for the treatment of, continuously took the present invention and treat three courses for the treatment of every two days each course for the treatment of.

5, therapeutic outcome: the present invention treats 65 examples, cures 16 examples (24.6%), produce effects 21 examples (32.3%), effective 22 examples (33.8%), invalid 6 examples (9.0%), total effective rate 90.7%.

Case 1 Zhang, the man, 67 years old, Mi Shan town, Wendeng City Education Commission did, the retired professor, on 08 09th, 2010 medical in the court, suffered from " cervical spondylosis " more than 1 year, and dizziness is felt sick, sometimes vomiting, vomitus is gastric content, sometimes looks the thing rotation, and no headache, limbs are without numbness, and the extremity activity is good.Cervical vertebra X sheet prompting cervical curvature straightens, hyperosteogeny of cervical vertebra, narrowing of intervertebral space.Transcranial Doppler sonography (TCD) inspection is shown: vertebro-basilar artery insufficiency.Through using Chinese medicine of the present invention, 40 days state of an illness of orally taken for curing are alleviated.

Case 2 Wang, the female, 40 years old, Wendeng City tannery, the workman, on 02 19th, 2011 are medical in the court, suffer from " cervical spondylosis " 5 months, and giddy is felt sick, and ignores the thing rotation, the no headache vomiting, limbs are without numbness, and the extremity activity is good.Cervical vertebra X sheet prompting cervical curvature straightens, the slight hyperosteogeny of cervical vertebra.Transcranial Doppler sonography (TCD) inspection is shown: vertebro-basilar artery insufficiency.Through using Chinese medicine of the present invention, orally taken for curing was recovered in 30 days.

Case 3 Huangs, the female, 49 years old, Wendeng City Construction Bank, the accountant, on November 17th, 2009 is medical in the court, suffers from " cervical spondylosis " more than 7 years, and dizziness is felt sick, and dizziness is felt sick, and sometimes looks the thing rotation, the no headache vomiting, limbs are without numbness, and the extremity activity is good.Cervical vertebra X sheet prompting cervical curvature straightens, hyperosteogeny of cervical vertebra.Transcranial Doppler sonography (TCD) inspection is shown: vertebro-basilar artery insufficiency is looked the thing rotation sometimes, the no headache vomiting, and limbs are without numbness, and the extremity activity is good.Cervical vertebra X sheet prompting cervical curvature straightens, hyperosteogeny of cervical vertebra.Transcranial Doppler sonography (TCD) inspection is shown: vertebro-basilar artery insufficiency.Through using Chinese medicine of the present invention, 40 days state of an illness of orally taken for curing are alleviated.Through using Chinese medicine of the present invention, orally taken for curing was recovered in 40 days.

Claims (1)

1. dizzy neck complexing agent of Compound Resisting, it is characterized in that being made through following methods by the raw material of following weight proportion: after Radix Dipsaci 14-22%, Os Draconis 12-18%, Fructus Ligustri Lucidi 8-10%, Concha Margaritifera 6-10%, Fructus Atriplicis Sibiricae 8-10%, Rhizoma Chuanxiong 3-4%, Radix Puerariae 6-8%, Radix Salviae Miltiorrhizae 6-10%, Fructus Chaenomelis 5-7%, Rhizoma Anemarrhenae 3-6%, Cortex Moutan 4-6%, Rhizoma Acori Graminei 3-5%, Radix Curcumae 3-6%, Radix Glycyrrhizae 3-6% are cleaned, be soaked in water, then decoct, the filtrate of removing slag to get, sterilization makes mixture after refining.