CN102600434A

CN102600434A - Compound mixture for curing cervical vertigo

Info

Publication number: CN102600434A
Application number: CN2012101050653A
Authority: CN
Inventors: 徐东强; 刘硕; 王永尼
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-04-02
Filing date: 2012-04-02
Publication date: 2012-07-25
Anticipated expiration: 2032-04-02
Also published as: CN102600434B

Abstract

The invention relates to a compound mixture for curing cervical vertigo, which is characterized in that the compound mixture is prepared by the following raw materials in percent by weight through a method which comprises the following steps of: cleaning 14-22 percent of teasel root, 12-18 percent of fossil bone, 8-10 percent of Fructus ligustri Lucidi, 6-10 percent of mother of pearl, 8-10 percent of Tribulus terrestris L., 3-4 percent of Ligusticum wallichii, 6-8 percent of lobed kudzuvine root, 6-10 percent of Salvia miltiorrhiza, 5-7 percent of Chinese flowering quince, 3-6 percent of Rhizoma anemarrhenae, 4-6 percent of moutan bark, 3-5 percent of Rhizoma acori Talarinowii, 3-6 percent of Radix curcumae and 3-6 percent of licorice root, soaking the raw materials in water, boiling, removing residues to obtain filtrate, sterilizing and refining to obtain the mixture. The compound mixture for curing cervical vertigo has the efficacies of nourishing liver and kidney, calming liver wind, removing heat to cool blood, promoting blood circulation to remove meridian obstruction, activating spleen qi, resolving dampness, activating yang and promoting resuscitation, can effectively cure cervical spondylosis of vertebral artery type and does not have any adverse effect.

Description

A kind of compound recipe resists dizzy neck complexing agent

Technical field

The present invention relates to the pharmaceutical formulation field, specifically a kind of anti-dizzy neck complexing agent of compound recipe that is used to treat vertebral artery type of cervical spondylosis.

Background technology

Vertebral artery type of cervical spondylosis is to stimulate or the compressing vertebral artery causes the cerebral tissue blood supply insufficiency because of cervical spine disk pathological change, hyperosteogeny of cervical vertebra, due to the cerebral hypoxia ischemia.They are many owing to long-time incorrectly cause the cervical vertebra degeneration with neck, thereupon degeneration of cervical intervertebral disc, cervical vertebrae physiological flexibility change, hyperosteogeny of cervical vertebra, stimulate and compressing neck soft, vertebral artery and cause the comprehensive syndrome that a kind of symptom is complicated.The age of onset of vertebral artery type of cervical spondylosis is high than other myelopathys, and sickness rate has parallel ascendant trend with the increase at age, and symptom also increases with the age and increases the weight of day by day.Existing vertebral artery type of cervical spondylosis receives the attention of domestic and international medical circle day by day, also deeply unified in the world day by day be called " cervical vertigo " of Study on Pathogenesis.Noticed that at present blood supply of vertebral artery is not enough in close relations with this myelopathy; Be the main cause of primary disease morbidity, abroad the someone adds up, about 70% cervical spondylosis with vertebral artery get involved, blood supply insufficiency; Growth with the age increases; The cervical vertebra regression increases the weight of day by day, and hyperosteogeny also progressively increases, to vertebral artery or vertebra week nerve compression, stimulate serious day by day and morbidity or make symptom more obvious.Along with modern life level improves; Life style changes, and rhythm of life is accelerated, and operating pressure strengthens; Long-time operation computer, mobile phone and factor such as lack exercise all can cause cervical spondylosis; Cervical spondylosis is not the patent of middle-aged and elderly people now, and is many young, even child crowd also begins to have the tendency of cervical spondylosis.Primary disease has the trend of rejuvenation, and it treats slowlyer, and relapse rate is high; Severe patient can cause cerebrovascular, does not still have thorough radical cure method at present, mainly is doctor trained in Western medicine symptomatic treatment and rehabilitation; To improve symptom is main, and curative effect is unsatisfactory, also can't stop disease progression.Bring serious harm for patient's health, patients ' life quality is descended comprehensively, and increase the financial burden of family, society.Chinese medicine has shown its special advantages and characteristic at the treatment vertebral artery type of cervical spondylosis in recent years, and is evident in efficacy.

Summary of the invention

The object of the invention is exactly in order to overcome above-mentioned deficiency, Chinese medicine preparation of the treatment vertebral artery type of cervical spondylosis that provide a kind of and have no side effect, clinical effectiveness is good and preparation method thereof.

For achieving the above object, the present invention can realize through following measure:

The technical scheme that the present invention adopts is: adopting Radix Dipsaci, Os Draconis, Fructus Ligustri Lucidi, Concha Margaritifera, Fructus Atriplicis Sibiricae, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae, Radix Glycyrrhizae is that feedstock production forms; Its available following method obtains: after Radix Dipsaci, Os Draconis, Fructus Ligustri Lucidi, Concha Margaritifera, Fructus Atriplicis Sibiricae, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae, Radix Glycyrrhizae are cleaned; Be soaked in water; Decoct then; Remove slag to such an extent that filtrate, sterilization makes mixture after refining.

Its technical characterictic is; It is Radix Dipsaci 14-22%, Os Draconis 12-18%, Fructus Ligustri Lucidi 8-10%, Concha Margaritifera 6-10%, Fructus Atriplicis Sibiricae 8-10%, Rhizoma Chuanxiong 3-4%, Radix Puerariae 6-8%, Radix Salviae Miltiorrhizae 6-10%, Fructus Chaenomelis 5-7%, Rhizoma Anemarrhenae 3-6%, Cortex Moutan 4-6%, Rhizoma Acori Graminei 3-5%, Radix Curcumae 3-6%, Radix Glycyrrhizae 3-6% that raw material is formed (weight), and each raw material components percentage ratio sum equals absolutely.

Each cost of material of the present invention is low, and compliance is good, has no side effect, and has the principle of treatment of nourishing the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome, clearing away heat and cooling blood, the clear sharp head, promoting blood circulation to remove obstruction in the collateral, waking up the patient from unconsciousness by dissipating phlegm.

Therapeutic Principle of the present invention: cervical spondylosis be cause the insufficient most commonly encountered diseases of blood supply of vertebral artery because of, vertebral artery type of cervical spondylosis belongs to motherland's medical science " dizzy " category, how because of caused by liver and kidney deficiency, muscles and bones mistake are supported, due to the excessive rising of liver-YANG, wind-yang and up-boring, stasis of blood resistance meridians.As far back as " element is asked. the most pure virginity will be discussed greatly " think " all wind trembling and dizziness, all belong to liver ", bright. anxiety Fu proposes the argument of " blood stasis causes dizzy ".Multilist shows deficiency in origin and excess in superficiality clinically, and empty person is this with the hepatic and renal YIN deficiency, and real person is a mark with wind, fire, expectorant, the stasis of blood, though dizzy sick position is closely related with liver,spleen,kidney three dirty malfunctions at clear key, and deficiecny of liver-YIN, pathogenic fire derived from stagnation of liver-QI can cause excessive rising of liver-YANG; Dysfunction of the spleen in transportation, stagnation of phlegm-damp in middle-JIAO is hoodwinked key clearly; Deficiency of kidney-essence, illness of the mother organ affecting the child one, deficiency and exhaustion of liver-YIN also can cause excessive rising of liver-YANG.So drafted the principle of treatment of nourishing the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome, clearing away heat and cooling blood, promoting blood circulation to remove obstruction in the collateral, waking up the patient from unconsciousness by dissipating phlegm.The hot tepor of Radix Dipsaci nature and flavor sweetness and bitterness in the side has invigorating the liver and kidney, the promoting the circulation of blood arteries and veins among the present invention; The merit of reuniting the fractured tendons and bones, these article can invigorating the liver and kidney, again can the promoting the circulation of blood arteries and veins; The advantage that tonify without causing stagnation is arranged has the merit of detumescence, pain relieving, granulation promoting again, " book on Chinese herbal medicine converge speech ": " Radix Dipsaci; the medicine of mending continuous blood vessels also, non-this of the blood vessels that on the whole broken does not continue; Non-this of the muscles and bones of being hindered is not supported ", modern pharmacological research Radix Dipsaci root contains carotene, cupreol, triterpenoid saponin etc., and the cervical vertebra of releasing muscle group spasm is arranged, and recovers the ligament function, improves cervical curvature, recovers cervical stability; Os Draconis property sweet-puckery flavor is slightly cold; The GUIXIN Liver Channel; Have suppressing the hyperactive liver and subsiding YANG, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., the merit of tranquillizing and allaying excitement, these article can suppressing the hyperactive liver and dive and hold back floating sun, the main carbonated calcium of modern pharmacological research Os Draconis, calcium phosphate etc.; After the contained calcium salt of Os Draconis absorbs, the permeability that promotes blood coagulation, reduces blood vessel wall is arranged and suppress effect such as skeletal muscle excitement; The two is the principal agent liver and kidney tonifying altogether, suppressing the hyperactive liver and subsiding YANG.Fructus Ligustri Lucidi nature and flavor sweetness and bitterness is cool, returns the Liver and kidney warp, has the merit of liver and kidney tonifying, clearing away heat to improve acuity of vision, and these article can liver and kidney tonifying, is the article of clear benefits simply, can be apt to clearind deficient heat again, and Fructus Ligustri Lucidi has effects such as raise immunity, raising peripheral leukocytes; Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, the clear sharp head, and have suppress Skeletal Muscle Contraction, in and the gastric acid effect; The Fructus Atriplicis Sibiricae suppressing the hyperactive liver is soothing the liver, dispelling pathogenic wind for improving eyesight; The Rhizoma Chuanxiong blood-activating and qi-promoting contains ligustrazine, promotes microcirculation, and the Rhizoma Chuanxiong lactone also has tangible spasmolysis.Radix Puerariae spasmolytic, yang invigorating, blood circulation promoting and blood stasis dispelling are removed the cervical vertebra muscle group and are shunk, and increase muscle fiber elasticity; Softening ligament can effectively stop intervertebral disc fibrosis and intervertebral disc degeneration, has antiplatelet aggregation; Reducing the blood viscosity effect, can effectively stop cervical vertebra regression process, is ministerial drug altogether.Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, collateral dredging improve blood circulation, remove or alleviate the cervical vertebra degeneration to vertebrarterial pressure symptom, improve local blood circulation; The Fructus Chaenomelis relaxing muscles and tendons and activating QI and blood in the collateral can be removed cervical region muscular contracture stiffness of the nape, unable to move around; The relieving restlessness of Rhizoma Anemarrhenae clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; The removing dampness of being amusing of Rhizoma Acori Graminei, Radix Curcumae, activating YANG to wake up the patient from unconciousness is adjuvant drug altogether.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, it is strong and alleviate poisonous side effect of medicine to relax medicine, can be in harmonious proportion taste again, invigorating the spleen and benefiting QI, with solid the foundation of acquired constitution, can the winter protection medicine of a cold nature thing impairment of the spleen upseting one's stomach is messenger drug.Prescription of the present invention, giving consideration to both the incidental and fundamental can be removed cervical vertebra muscle group spasm, recovers the ligament function, improves cervical curvature, recovers cervical stability.Change the cervical vertebra vascular permeability, effectively blood viscosity lowering promotes blood circulation, improves the vertebra basilar arterial blood supply.Have nourishing the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome, clearing away heat and cooling blood, promoting blood circulation to remove obstruction in the collateral, the removing dampness of being amusing, the merit of activating YANG to wake up the patient from unconciousness is effectively treated vertebral artery type of cervical spondylosis.

The specific embodiment

Below in conjunction with embodiment the present invention is done further description:

Embodiment: it is that feedstock production forms that the anti-dizzy neck complexing agent of present embodiment compound recipe adopts Radix Dipsaci, Os Draconis, Fructus Ligustri Lucidi, Concha Margaritifera, Fructus Atriplicis Sibiricae, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae, Radix Glycyrrhizae; Its component (weight %) is Radix Dipsaci 18%, Os Draconis 18%, Fructus Ligustri Lucidi 10%, Concha Margaritifera 9%, Fructus Atriplicis Sibiricae 8%, Rhizoma Chuanxiong 3%, Radix Puerariae 6%, Radix Salviae Miltiorrhizae 6%, Fructus Chaenomelis 4%, the Rhizoma Anemarrhenae 5%, Cortex Moutan 3%, Rhizoma Acori Graminei 3%, Radix Curcumae 3%, Radix Glycyrrhizae 4%; Get 56 kilograms of above-mentioned 14 kinds of raw material gross weights, selected clean back with 20000ml water logging bubble about 30 minutes, decocts 60 minutes then under greenhouse experiment; The routine filtration of removing slag; Behind high pressure, the sterilization process, gained filtrating is 9000ml altogether, the bag packing; Sealing, every bag of 150ml.

1, case is selected: clinically select 65 routine patients at random, male 34 examples, women 31 examples, age 30-70 year, average 53.2 ± 5.8 years old, the course of disease 2 months 1 years, average 4.7 ± 3.8 years; Cervical vertebra X-ray film or CT sheet show hyperosteogeny of cervical vertebra, ligament calcification, narrowing of intervertebral space person's 54 examples; Be associated with physiological bending changer 22 examples simultaneously; The slightly outstanding compressing vertebral artery of cervical intervertebral disk person 11 examples, all TCD (TCD) inspection is shown: vertebro-basilar artery insufficiency or spasm.Get rid of case and 1. merge serious cardiovascular and cerebrovascular vessel patient; 2. severe hepatic renal insufficiency person, 3. gestation or women breast-feeding their children person are 4. to this medicine allergy sufferers; 5. simple spondylotic radiculopathy, sympathetic type, cervical spondylotic myelopathy person be not 6. by the regulation medication or data is not congruent affects the treatment or safety judgement person.

2, diagnostic criteria: the Western medicine diagnose standard, draft with reference to " clinical sacred disease diagnostics ": (1) is middle-aged and elderly people mostly; (2) the cervical vertebra medical history is arranged more; (3) occur dizzyly suddenly, Chang Yutou position, position are relevant; (4) can be during dizzy outbreak with the Sx of neural ischemia; (5) Chang Fanfu outbreak; (6) except acute cerebral infarction, cerebral hemorrhage and the otological disease.All change in various degree or hyperosteogeny of cervical vertebra through cervical vertebra X sheet prompting cervical curvature.TCD (TCD) inspection is shown: vertebro-basilar artery insufficiency or spasm are clarified a diagnosis, and clinical symptoms and sign all meet the vertebral artery type of cervical spondylosis diagnosis.Chinese medical discrimination typing standard: with reference to the diagnostic criteria of dizzy syndrome of upper hyperactivity of liver yang in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ".Primary symptom: dizzy, tinnitus, distending pain in the head is felt sick, nausea general, dry mouth with bitter taste, insomnia and dreamful sleep, forgetful, soreness of waist and knee, red tongue, tongue is few, stringy,thready and rapid pulse.

3, criterion of therapeutical effect: comprise clinical cure, produce effects, effective, invalid, treatment finishes to estimate total effects.Criterion of therapeutical effect is drafted with reference to relevant criterion of therapeutical effect in " new Chinese medicine clinical research guideline ".Clinical cure: dizzy, headache is felt sick, and symptoms such as nausea and level appearance nystagmus, sign disappear, and TCD prompting vertebra basilar arterial blood supply recovers normal; Produce effects: dizzy, headache is felt sick, and symptoms such as nausea and level appearance nystagmus, sign disappear, and TCD prompting vertebra basilar arterial blood supply recovers normal, but still has recurrence sometimes; Effectively: dizzy, headache is felt sick, and symptom, signs such as nausea and level appearance nystagmus obviously alleviate, and TCD prompting vertebra basilar arterial blood supply obviously improves; Invalid: symptom, sign do not have obvious improvement, and the TCD inspection does not have change.

4, Therapeutic Method: take the anti-dizzy neck complexing agent 150ml of compound recipe at every turn, morning every day, late twice one after each meal, 10 days was 1 course of treatment, continuously took the present invention and treat three courses of treatment at a distance from two days each course of treatment.

5, therapeutic outcome: the present invention treats 65 examples, cures 16 examples (24.6%), produce effects 21 examples (32.3%), effective 22 examples (33.8%), invalid 6 examples (9.0%), total effective rate 90.7%.

Case 1 Zhang, the man, 67 years old, the Mi Shan of Wendeng City town Education Commission did the retired professor; Went to a doctor in the court on 08 09th, 2010, it is surplus to suffer from " cervical spondylosis " 1 year, and dizziness is felt sick, sometimes vomiting; Vomitus is a gastric content, looks the thing rotation sometimes, no headache, and limbs do not have numbness, and the extremity activity is good.Cervical vertebra X sheet prompting cervical curvature becomes straight, hyperosteogeny of cervical vertebra, narrowing of intervertebral space.TCD (TCD) inspection is shown: vertebro-basilar artery insufficiency.Through using Chinese medicine of the present invention, 40 days state of an illness of orally taken for curing are alleviated.

Case 2 Wang, the woman, 40 years old, Wendeng City tannery, the workman, the prescription on individual diagnosis in the court on 02 19th, 2011 was suffered from " cervical spondylosis " 5 months, and giddy is felt sick, and ignores the thing rotation, the no headache vomiting, limbs do not have numbness, and the extremity activity is good.Cervical vertebra X sheet prompting cervical curvature becomes straight, the slight hyperosteogeny of cervical vertebra.TCD (TCD) inspection is shown: vertebro-basilar artery insufficiency.Through using Chinese medicine of the present invention, orally taken for curing was recovered in 30 days.

Case 3 Huangs, the woman, 49 years old, Wendeng City Construction Bank, the accountant, on November 17th, 2009 went to a doctor in the court, and it is surplus to suffer from " cervical spondylosis " 7 years, and dizziness is felt sick, and dizziness is felt sick, and looks the thing rotation sometimes, the no headache vomiting, limbs do not have numbness, and the extremity activity is good.Cervical vertebra X sheet prompting cervical curvature becomes straight, hyperosteogeny of cervical vertebra.TCD (TCD) inspection is shown: vertebro-basilar artery insufficiency is looked the thing rotation sometimes, the no headache vomiting, and limbs do not have numbness, and the extremity activity is good.Cervical vertebra X sheet prompting cervical curvature becomes straight, hyperosteogeny of cervical vertebra.TCD (TCD) inspection is shown: vertebro-basilar artery insufficiency.Through using Chinese medicine of the present invention, 40 days state of an illness of orally taken for curing are alleviated.Through using Chinese medicine of the present invention, orally taken for curing was recovered in 40 days.

Claims

1. a compound recipe resists dizzy neck complexing agent; It is characterized in that making through following method: after Radix Dipsaci 14-22%, Os Draconis 12-18%, Fructus Ligustri Lucidi 8-10%, Concha Margaritifera 6-10%, Fructus Atriplicis Sibiricae 8-10%, Rhizoma Chuanxiong 3-4%, Radix Puerariae 6-8%, Radix Salviae Miltiorrhizae 6-10%, Fructus Chaenomelis 5-7%, Rhizoma Anemarrhenae 3-6%, Cortex Moutan 4-6%, Rhizoma Acori Graminei 3-5%, Radix Curcumae 3-6%, Radix Glycyrrhizae 3-6% are cleaned by following materials of weight proportions; Be soaked in water; Decoct then; Remove slag to such an extent that filtrate, sterilization makes mixture after refining.