CN105232989A - Traditional Chinese medicine for treating idiopathic overactive bladder of elderly female - Google Patents

Abstract

The invention belongs to the technical field of medicine and particularly relates to traditional Chinese medicine for treating idiopathic overactive bladder of an elderly female. The traditional Chinese medicine is prepared from, by weight, 4-8 parts of lathyrus davidii, 4-8 parts of dolomiaea berardioidea, 4-8 parts of pedicularis decora franch, 4-8 parts of herminium monorchis, 4-8 parts of stauntonia latifolia, 4-8 parts of delavay greenleaf elaeagnus leaves, 4-8 parts of bulbophyllum psychoon, 4-8 parts of aspidopterys glabriuscula, 4-8 parts of adder's-fern and 4-8 parts of licorice root tips. According to the traditional Chinese medicine, all ingredients act in a synergistic mode to achieve the effects of enriching yin, nourishing the kidney, soothing the liver, eliminating dampness and clearing heat.

Description

A kind of Chinese medicine for the treatment of old women idiopath ic overactive bladder

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of old women idiopath ic overactive bladder.

Background technology

Idiopath ic overactive bladder (IOAB) is the disease of the common urinary dysfunction of old women, patient's main manifestations is urgent micturition, and (or) urge incontinence, and can with frequent micturition and nocturia, but without urinary tract infection and other pathological abnormalities.Modern medicine is not yet clear to old women IOAB etiology and pathogenesis, and medicine is limited, and curative effect is general, untoward reaction is larger.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine for the treatment of old women idiopath ic overactive bladder.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for old women idiopath ic overactive bladder, be made up of the Chinese medicine of following weight portion:

Herba lathyri davidii 4-8 part, thick leaf Radix Vladimiriae 4-8 part, Rhizoma Pedicularis Davidii 4-8 part, musk orchid 4-8 part, Fructus Akebiae 4-8 part, Folium Elaeagni delavayi 4-8 part, solely leaf rock pearl 4-8 part, Caulis Aspidopterydis obcordatae 4-8 part, adder's-fern 4-8 part, Radix Glycyrrhizae uralensis 4-8 part.

Preferably, the Chinese medicine of above-mentioned treatment old women idiopath ic overactive bladder, is made up of the Chinese medicine of following weight portion:

Herba lathyri davidii 5-7 part, thick leaf Radix Vladimiriae 5-7 part, Rhizoma Pedicularis Davidii 5-7 part, musk orchid 5-7 part, Fructus Akebiae 5-7 part, Folium Elaeagni delavayi 5-7 part, solely leaf rock pearl 5-7 part, Caulis Aspidopterydis obcordatae 5-7 part, adder's-fern 5-7 part, Radix Glycyrrhizae uralensis 5-7 part.

Preferred, the Chinese medicine of above-mentioned treatment old women idiopath ic overactive bladder, is made up of the Chinese medicine of following weight portion:

Herba lathyri davidii 6 parts, thick leaf Radix Vladimiriae 6 parts, Rhizoma Pedicularis Davidii 6 parts, musk orchid 6 parts, Fructus Akebiae 6 parts, Folium Elaeagni delavayi 6 parts, solely 6 parts, leaf rock pearl, Caulis Aspidopterydis obcordatae 6 parts, adder's-fern 6 parts, Radix Glycyrrhizae uralensis 6 parts.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of old women idiopath ic overactive bladder.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine of the present invention,

Herba lathyri davidii another name Semen Cassiae Sopherae Herba Lathyri quinquenerii, large Semen Pisi sativi.For the seed of leguminous plant Semen Cassiae Sopherae sweet pea LathyrusdavidiiHance.Acrid in the mouth; Warm in nature.Return Liver Channel.Function depressed liver-energy dispersing and QI regulating; Menstruction regulating and pain relieving.Main dysmenorrhea; Have through uncomfortable.

Thick leaf Radix Vladimiriae another name Radix Aristolochiae, the Radix Aucklandiae are feverfew thick leaf Radix Vladimiriae Dolomiaeabe-rardioidea(Franch.) root of Shih.Function depressed liver-energy dispersing and QI regulating, benefiting stomach and stopping pain.For chronic gastroenteritis, dyspepsia, bronchitis.

Rhizoma Pedicularis Davidii another name david woodbetony rhizome, black Radix Panacis Quinquefolii.For the rhizome of goatweed David Radix seu Herba Pedicularis, rough Radix seu Herba Pedicularis, Deng Shi Radix seu Herba Pedicularis, Radix seu Herba Pedicularis attractive in appearance etc.Sweet micro-hardship, temperature.Enriching yin and nourishing kidney, invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach.Control physical weakness, osteopyrexia and fever of suffering from a deficiency of the kidney, arthralgia, anorexia.

Musk orchid another name Rhizoma Tupistrae Chinensis, Herba Herminii, derive from the orchid family Herminium plant musk orchid Herminiummonorchis(L.) R.Brown., is used as medicine with whole herb with root.Nature and flavor are sweet, temperature.Function enriching yin and nourishing kidney, nourishing the stomach, regulating menstruation.For neurasthenia, dizzy insomnia, irritated thirsty inappetence, early whitening of beard and hair, menoxenia.

Fructus Akebiae another name cattle kidney fruit, June melon, little eight melons, any melon, Testis et Pentis Canis, wooden Fructus Trichosanthis Cucumeroidis, August fruit, savage's melon, Ramulus seu Fructus Caesalpiniae fruit, the lazy bag of cattle really.For the fruit of plants of Lardizabalaceae tendencies rattan HolboelliafargesiiReaub., wide leaf Fructus Akebiae HolboellialatifoliaWall. and little Hua Fructus Akebiae Holboelliaparviflora (Hemsl.) Gagnep..Bitter in the mouth; Cool in nature.Return bladder; The heart; Liver Channel.Function clearing away heat-damp and promoting diuresis; Blood circulation and channel invigorating; Promoting the circulation of QI to relieve pain.Main oliguria with reddish urine; Stranguria with turbid discharge; Edema; Rheumatic arthralgia; Traumatic injury; Galactostasis; Colicky; Uterine prolapse; Orchitis.

Folium Elaeagni delavayi another name elaeagnus conferta fruits, Yang Leishu, Radix Rubi Parvifolii, sheep milk milk, little elaeagnus conferta fruits.For leaf and the root bark of Elaeangnaceae plant Folium Elaeagni delavayi ElaeagnusviridisServ.var.delavayiLecte..Sweet in the mouth; Acid; Light; Property is put down.Return lung; Kidney; Urinary bladder channel.Function clearing away heat-damp and promoting diuresis; Tonglin Paishi; Relieving cough and asthma.Main chronic nephritis; Renal calculus; Urinary tract infection; Icterohepatitis; Chronic bronchitis; Bronchial asthma; Stomachache.

Only leaf rock pearl another name Herba Bulbophylli radiati, Moghania fluminalis(C. B. Clarke) Li, Herba sagittariae pygmaeae are blue, are the herb of orchid tooth lobe Bulbophyllum BulbopyllumpsychoonReichb.f. [B.levineiSchltr.].Sweet in the mouth; Light; Cold in nature.Function nourishing YIN and clearing away heat; Removing toxic substances and promoting subsidence of swelling.Main yin asthenia generating intrinsic heat; Calentura is thirsty; Lung-heat cough with asthma; Laryngopharynx swelling and pain; Stomatitis; Rheumatic arthralgia; Traumatic injury; Acute mastitis; Furuncle swells.

Caulis Aspidopterydis obcordatae another name is shouted lid and is passed through, and is the rattan of the Malpighiaceae plant Caulis Aspidopterydis obcordatae of falling lobus cardiacus AspidopterysobcordataHemsl..Lightly seasoned; Puckery; Cold nature.Return urinary bladder channel.Function clearing away heat and promoting diuresis; Dispelling wind and removing obstruction in the collateral.Main pyretic stranguria; Stranguria caused by urinary stone; Beriberoid pyretic arthralgia.

Adder's-fern is the rhizome of Plants of Polypodiaceae adder's-fern PolypodiumvulgareL. and Rhizoma Polygoni vivipari PolypodiumvirginianumL. ［ P.vulgareL.var.virginianumA.Eaton ］.Bitter in the mouth; Sweet; Cold nature.Function clearing away heat-damp and promoting diuresis detoxifies.Main damp and hot stranguria; Beriberoid pyretic arthralgia; Furuncle carbuncle; Rubella pruritus; Traumatic injury.

Radix Glycyrrhizae uralensis is that the last ending of glycyrrhizic legume GlycyrrhizauralensisFisch. root is divided or radicula.Sweet in the mouth; Cold in nature.GUIXIN, liver, spleen channel.Function eliminating fire and detoxication; Inducing diuresis for treating stranguria syndrome.Main pyretic stranguria; Oliguria; Pain in penis; Accumulated heat in the heart.

Overactive bladder is equivalent to the category of the traditional Chinese medical science " stranguria ".The stranguria origin cause of formation has inside and outside dividing, and its basic pathogenesis is that damp-heat in lower-JIAO pents up, and disturbance in functioning of QI, sick position is at kidney and bladder.The kidney dominating water metabolism, the urinary bladder being the viscus likened to a pond, both common main channel, conditioning aqueous vapor all over the body.When damp-heat accumulation bladder, or prolonged illness causes visceral dysfunction, then kidney and functioning of bladder unfavorable and cause stranguria.Propose in " General Treatise on the Cause and Symptoms of Diseases " " Zhu Linzhe, by suffer from a deficiency of the kidney bladder heat thus also ", " then frequent micturition of suffering from a deficiency of the kidney, bladder heat is then excessive under water, several and excessive, does not drippingly declare ".Later age doctor using this by kidney asthenia as the principal aspect, bladder heat for mark is as the pathogenesis basis of diagnosis and treatment stranguria, no matter deficiency-heat or excess-heat, all needs to consider the impact of damp-heat in the urinary bladder in prognosis of disease when treatment stranguria.The category that during prostatic hyperplasia belongs to, " essence is infirmity " is sick, patient mostly is gerontal patient, and suffering from a deficiency of the kidney is the Etiological pathogenesis that it is fallen ill.Exterior and interior relation between kidney and bladder, the prosperity and decline of kidney qi, directly affects gasification and the folding of bladder.With the passing of time stranguria does not heal, and thermal burn is cloudy, and wet impairment of YANG, easily causes and suffer from a deficiency of the kidney; Suffer from a deficiency of the kidney with the passing of time, damp and hot foul evil poison easily invades bladder, causes the recurrent exerbation of stranguria.Therefore, suffer from a deficiency of the kidney and to have great importance in the generation of stranguria, development and change of pathogenesis with damp-heat in the urinary bladder.The angry impairing the liver of the easy stagnation of QI due to depression of the liver of women, the liver failing to maintain the normal flow of QI, or the stagnation of QI can not, strongly fragrant in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, cause depression of liver-QI, functioning of bladder is unfavorable, sends out as qi stranguria.Therefore, suffer from a deficiency of the kidney and to have great importance in the generation of stranguria, development and change of pathogenesis with damp-heat in the urinary bladder, stagnation of QI due to depression of the liver.The differentiation of tcm of old women idiopath ic overactive bladder should from suffering from a deficiency of the kidney, stagnation of QI due to depression of the liver stays and damp-heat in the urinary bladder opinion is controlled, treatment when with enriching yin and nourishing kidney, depressed liver-energy dispersing and QI regulating, eliminating damp-heat.

In the present invention, Rhizoma Pedicularis Davidii, musk orchid merit are with enriching yin and nourishing kidney; Herba lathyri davidii, thick leaf Radix Vladimiriae depressed liver-energy dispersing and QI regulating are monarch drug.Fructus Akebiae, Folium Elaeagni delavayi merit take eliminating damp-heat as ministerial drug.Only leaf rock pearl merit is with nourishing YIN and clearing away heat; Caulis Aspidopterydis obcordatae merit is with clear sharp damp-heat in the urinary bladder.Adder's-fern merit is detoxified with clearing away heat-damp and promoting diuresis.Radix Glycyrrhizae uralensis merit is with heat-clearing and toxic substances removing, and inducing diuresis for treating stranguria syndrome is adjuvant.We's compatibility is reasonable, and all medicines share plays enriching yin and nourishing kidney altogether, soothing the liver reason, the effect of eliminating damp-heat.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Herba lathyri davidii 6g, thick leaf Radix Vladimiriae 6g, Rhizoma Pedicularis Davidii 6g, musk orchid 6g, Fructus Akebiae 6g, Folium Elaeagni delavayi 6g, solely leaf rock pearl 6g, Caulis Aspidopterydis obcordatae 6g, adder's-fern 6g, Radix Glycyrrhizae uralensis 6g.

Embodiment 2

Treat a Chinese medicine for old women idiopath ic overactive bladder, each crude drug weight proportion is as follows:

Herba lathyri davidii 5g, thick leaf Radix Vladimiriae 5g, Rhizoma Pedicularis Davidii 5g, musk orchid 5g, Fructus Akebiae 5g, Folium Elaeagni delavayi 5g, solely leaf rock pearl 5g, Caulis Aspidopterydis obcordatae 5g, adder's-fern 5g, Radix Glycyrrhizae uralensis 5g.

Embodiment 3

Treat a Chinese medicine for old women idiopath ic overactive bladder, each crude drug weight proportion is as follows:

Herba lathyri davidii 7g, thick leaf Radix Vladimiriae 7g, Rhizoma Pedicularis Davidii 7g, musk orchid 7g, Fructus Akebiae 7g, Folium Elaeagni delavayi 7g, solely leaf rock pearl 7g, Caulis Aspidopterydis obcordatae 7g, adder's-fern 7g, Radix Glycyrrhizae uralensis 7g.

Embodiment 4

Treat a Chinese medicine for old women idiopath ic overactive bladder, each crude drug weight proportion is as follows:

Herba lathyri davidii 8g, thick leaf Radix Vladimiriae 8g, Rhizoma Pedicularis Davidii 8g, musk orchid 8g, Fructus Akebiae 8g, Folium Elaeagni delavayi 8g, solely leaf rock pearl 8g, Caulis Aspidopterydis obcordatae 8g, adder's-fern 8g, Radix Glycyrrhizae uralensis 8g.

Embodiment 5

Treat a Chinese medicine for old women idiopath ic overactive bladder, each crude drug weight proportion is as follows:

Herba lathyri davidii 4g, thick leaf Radix Vladimiriae 4g, Rhizoma Pedicularis Davidii 4g, musk orchid 4g, Fructus Akebiae 4g, Folium Elaeagni delavayi 4g, solely leaf rock pearl 4g, Caulis Aspidopterydis obcordatae 4g, adder's-fern 4g, Radix Glycyrrhizae uralensis 4g.

Carried out clinical pharrnacokinetics test to Chinese medicine of the present invention, Details as Follows:

1 data and method.

1.1 physical data: the patient of 60 routine patient's old women IOAB, age 5l ~ 77 year old, the course of disease is the shortest 6 months, the longest 2 years.

1.2 diagnosis person standards

1.2.1 Western medicine diagnose standard: wait " overactive bladder clinical guidance principle " in 2002 with reference to golden stannum is imperial, with without in clear and definite cause of disease situation, occur the symptoms such as frequent micturition, urgent micturition, urge incontinence in various degree, the course of disease at least 6 months, is diagnosed as IOAB.

1.2.2 Standards of Chinese Medical Syndrome Differentiation: with reference to version study of tcm new drug guideline in 2002 ", in conjunction with clinical, as follows from the standard of plan: 1. primary symptom: a. urgent micturition; B. frequent micturition; C. urethra scorching hot; D. dysurea.2. secondary disease: a. soreness of the waist and knees, b. urinates line situation, c. dysuria; D. abdomen is uncomfortable less.Above primary symptom, secondary disease all continue at least 6 months.Tongue arteries and veins: pale tongue, white and thin fur, thready and weak pulse.All possess above primary symptom 2 and 2 with disease last time, and knot totaglossa arteries and veins, diagnosable is IOAB.

1.3 exclusion standards: meet lower routine any one person, all get rid of: 1. 7. the average each urine volume >200mL or isuria number of times <8 person I of 24h has clear and definite cause of disease person, as the l such as urinary system infection, neural source bladder, urological cancer, vesical calculus 3. obvious hepatic and renal function exception person 4. anticholinergic agents taboo person or allergy sufferers.

1.4 Therapeutic Method.

60 routine patients are divided into 2 groups at random, treatment group and matched group, often organize 30 examples.Treatment group patient gives the Chinese medicine of the embodiment of the present invention 1, is decocted in water for oral dose, and every day 1 dose, add water 1000ml, decocts and be condensed into 300-500ml, and points 2 times oral, each 1 time sooner or later.

Matched group is with He Niting (Meirui Pharmaceutical Co., Ltd, Nanjing, traditional Chinese medicines accurate word H20000602, specification 2mg), and 2mg/ time, every day 2 times is oral, all treats 4 weeks for three groups.Before 90 routine patient treatments, 3d starts the other drug of inactive treatment primary disease.

1.5 observation of curative effect.Formulate with reference to " study of tcm new drug guideline ": it is clinical cure that symptom, somatic feature score reduce >=90%, it is effective that symptom, somatic feature score reduce >=70%; It is effectively that symptom, somatic feature score reduce >=30%, and it is invalid that symptom, somatic feature score reduce 30%.Observe blood in treatment, after treatment, urine, feces are conventional, electrocardiogram, liver function, kidney merit have without exception.

1.6 statistical procedures: the process of research the data obtained application SPSS13.0 software package, ranked data adopt Ridit inspection, and P<O.05 has significant difference.

2 results

Treatment group therapeutic effect is obviously better than She Niting group (P<0.01).In two groups of treatments, blood, urine, feces routine after treatment, electrocardiogram, liver function, kidney function test are all without exception; Treatment group does not find untoward reaction, and matched group 2 has 2 routine patients to occur xerostomia malaise symptoms.Concrete outcome is in table 1.

Table 1 two groups of clinical efficacy results contrast (n, %)

Group	n	Clinical cure	Effective	Effectively	Invalid	Cure rate (%)	Total effective rate (%)
								Treatment group	30	7	11	11	1	23.33**	96.67**
Matched group	30	2	10	9	9	6.66	70.00

Compare with matched group, * * P < 0.01.

Claims (3)

1. treat a Chinese medicine for old women idiopath ic overactive bladder, be made up of the Chinese medicine of following weight portion:

Herba lathyri davidii 4-8 part, thick leaf Radix Vladimiriae 4-8 part, Rhizoma Pedicularis Davidii 4-8 part, musk orchid 4-8 part, Fructus Akebiae 4-8 part, Folium Elaeagni delavayi 4-8 part, solely leaf rock pearl 4-8 part, Caulis Aspidopterydis obcordatae 4-8 part, adder's-fern 4-8 part, Radix Glycyrrhizae uralensis 4-8 part.

2. the Chinese medicine for the treatment of old women idiopath ic overactive bladder according to claim 2, is characterized in that, be made up of the Chinese medicine of following weight portion:

Herba lathyri davidii 5-7 part, thick leaf Radix Vladimiriae 5-7 part, Rhizoma Pedicularis Davidii 5-7 part, musk orchid 5-7 part, Fructus Akebiae 5-7 part, Folium Elaeagni delavayi 5-7 part, solely leaf rock pearl 5-7 part, Caulis Aspidopterydis obcordatae 5-7 part, adder's-fern 5-7 part, Radix Glycyrrhizae uralensis 5-7 part.

3. the Chinese medicine for the treatment of old women idiopath ic overactive bladder according to claim 2, is characterized in that, be made up of the Chinese medicine of following weight portion:

Herba lathyri davidii 6 parts, thick leaf Radix Vladimiriae 6 parts, Rhizoma Pedicularis Davidii 6 parts, musk orchid 6 parts, Fructus Akebiae 6 parts, Folium Elaeagni delavayi 6 parts, solely 6 parts, leaf rock pearl, Caulis Aspidopterydis obcordatae 6 parts, adder's-fern 6 parts, Radix Glycyrrhizae uralensis 6 parts.