CN105229171A - 在人pi3kca (pik3ca)基因中检测突变的方法和组合物 - Google Patents

在人pi3kca (pik3ca)基因中检测突变的方法和组合物 Download PDF

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Publication number
CN105229171A
CN105229171A CN201480013282.7A CN201480013282A CN105229171A CN 105229171 A CN105229171 A CN 105229171A CN 201480013282 A CN201480013282 A CN 201480013282A CN 105229171 A CN105229171 A CN 105229171A
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CN
China
Prior art keywords
oligonucleotide
nucleotide
seqidno
sudden change
gene
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CN201480013282.7A
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English (en)
Chinese (zh)
Inventor
A.詹
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority to CN201810088883.4A priority Critical patent/CN108130373A/zh
Publication of CN105229171A publication Critical patent/CN105229171A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201480013282.7A 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物 Pending CN105229171A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810088883.4A CN108130373A (zh) 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361780017P 2013-03-13 2013-03-13
US61/780017 2013-03-13
PCT/EP2014/054766 WO2014140061A2 (en) 2013-03-13 2014-03-12 Methods and compositions for detecting mutations in the human pi3kca (pik3ca) gene

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810088883.4A Division CN108130373A (zh) 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物

Publications (1)

Publication Number Publication Date
CN105229171A true CN105229171A (zh) 2016-01-06

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CN201810088883.4A Pending CN108130373A (zh) 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物
CN201480013282.7A Pending CN105229171A (zh) 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物

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US (2) US20140272961A1 (enExample)
EP (1) EP2971075B1 (enExample)
JP (1) JP6453781B2 (enExample)
CN (2) CN108130373A (enExample)
CA (1) CA2899712C (enExample)
ES (1) ES2691306T3 (enExample)
WO (1) WO2014140061A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018094569A1 (zh) * 2016-11-22 2018-05-31 深圳华大基因研究院 多肽及其应用
CN111363827A (zh) * 2020-04-30 2020-07-03 北京和合医学诊断技术股份有限公司 用于检测pik3ca基因突变的引物组及其应用方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201206486D0 (en) * 2012-04-12 2012-05-30 Sequessome Technology Holdings Ltd Vesicular formulations and uses thereof
CN109913481B (zh) * 2019-04-24 2020-04-03 无锡市第五人民医院 PIK3CA基因g.179224821G＞A突变及其在乳腺癌辅助诊断中的应用
KR102813811B1 (ko) * 2020-03-27 2025-05-30 주식회사 젠큐릭스 Pik3ca 돌연변이 검출용 조성물 및 이를 포함하는 키트
CN114410790B (zh) * 2022-01-27 2024-04-12 湖南大学 一种用于检测ctDNA的生物传感检测系统及其检测方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119222A (zh) * 2007-09-28 2011-07-06 Dxs有限公司 多核苷酸引物
WO2011087928A1 (en) * 2010-01-12 2011-07-21 Siemens Healthcare Diagnostics Inc. Oligonucleotides and methods for detecting kras and pik3ca mutations
CN102234685A (zh) * 2010-04-23 2011-11-09 广州益善生物技术有限公司 一种pik3ca基因突变检测液相芯片

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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PT3556866T (pt) * 2004-03-02 2021-04-30 Univ Johns Hopkins Mutações do gene de pik3ca em cancros humanos
JP5624044B2 (ja) * 2008-10-20 2014-11-12 エフ．ホフマン−ラ ロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 改善されたアレル−特異的増幅
US20100286143A1 (en) * 2009-04-24 2010-11-11 Dora Dias-Santagata Methods and materials for genetic analysis of tumors
US9238832B2 (en) * 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
KR101825121B1 (ko) * 2010-08-13 2018-02-06 주식회사 파나진 Ｐｎａ 기반의 실시간 ｐｃｒ 클램핑을 이용한 ｐｉｋ3ｃａ 돌연변이 검출 방법 및 키트
WO2013041194A1 (en) * 2011-09-23 2013-03-28 Roche Diagnostics Gmbh Use of g-clamp for improved allele-specific pcr

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119222A (zh) * 2007-09-28 2011-07-06 Dxs有限公司 多核苷酸引物
WO2011087928A1 (en) * 2010-01-12 2011-07-21 Siemens Healthcare Diagnostics Inc. Oligonucleotides and methods for detecting kras and pik3ca mutations
CN102234685A (zh) * 2010-04-23 2011-11-09 广州益善生物技术有限公司 一种pik3ca基因突变检测液相芯片

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARCO GYMNOPOULOS ET AL.: "Rare cancer-specific mutations in PIK3CA show gain of function", 《PNAS》 *
李泰霖 等: "ＡＳ－ＰＣＲ检测ＡＢＣＧ２　３４Ｇ＞Ａ多态性", 《中国临床药理学与治疗学》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018094569A1 (zh) * 2016-11-22 2018-05-31 深圳华大基因研究院 多肽及其应用
US11466053B2 (en) 2016-11-22 2022-10-11 Bgi Shenzhen Polypeptide and use thereof
CN111363827A (zh) * 2020-04-30 2020-07-03 北京和合医学诊断技术股份有限公司 用于检测pik3ca基因突变的引物组及其应用方法

Also Published As

Publication number Publication date
US20140272961A1 (en) 2014-09-18
CN108130373A (zh) 2018-06-08
EP2971075A2 (en) 2016-01-20
WO2014140061A2 (en) 2014-09-18
EP2971075B1 (en) 2018-08-15
US20160160297A1 (en) 2016-06-09
CA2899712A1 (en) 2014-09-18
WO2014140061A3 (en) 2014-10-30
JP2016510982A (ja) 2016-04-14
CA2899712C (en) 2021-01-05
JP6453781B2 (ja) 2019-01-16
ES2691306T3 (es) 2018-11-26

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