CN105228625A - 大环rip2激酶抑制剂 - Google Patents
大环rip2激酶抑制剂 Download PDFInfo
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- CN105228625A CN105228625A CN201480023821.5A CN201480023821A CN105228625A CN 105228625 A CN105228625 A CN 105228625A CN 201480023821 A CN201480023821 A CN 201480023821A CN 105228625 A CN105228625 A CN 105228625A
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- alkyl
- het
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- cycloalkyl
- halogen
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- ZCAGUOCUDGWENZ-UHFFFAOYSA-N thiomorpholinyl sulfoxide group Chemical group N1(CCSCC1)S(=O)N1CCSCC1 ZCAGUOCUDGWENZ-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| EP2013066732 | 2013-03-15 | ||
| GB1304714.7 | 2013-03-15 | ||
| EPPCT/EP2013/066732 | 2013-03-15 | ||
| GBGB1304714.7A GB201304714D0 (en) | 2013-03-15 | 2013-03-15 | Macrocyclic RIP2 Kinase inhibitors |
| PCT/EP2014/055139 WO2014140299A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic rip2 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
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| CN105228625A true CN105228625A (zh) | 2016-01-06 |
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| CN201480023821.5A Pending CN105228625A (zh) | 2013-03-15 | 2014-03-14 | 大环rip2激酶抑制剂 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20160024114A1 (enExample) |
| JP (1) | JP2016510796A (enExample) |
| KR (1) | KR20150133765A (enExample) |
| CN (1) | CN105228625A (enExample) |
| AU (1) | AU2014230111A1 (enExample) |
| BR (1) | BR112015022982A2 (enExample) |
| CA (1) | CA2906257A1 (enExample) |
| EA (1) | EA201591773A1 (enExample) |
| HK (1) | HK1218263A1 (enExample) |
| IL (1) | IL241250A0 (enExample) |
| MX (1) | MX2015012526A (enExample) |
| SG (1) | SG11201507594YA (enExample) |
| WO (1) | WO2014140299A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115698020A (zh) * | 2020-01-31 | 2023-02-03 | 昂科迪塞恩精密医药公司(Opm) | 大环rip2-激酶抑制剂 |
| WO2024051631A1 (zh) * | 2022-09-07 | 2024-03-14 | 苏州朗睿生物医药有限公司 | 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016146651A1 (en) * | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Macrocyclic activin-like receptor kinase inhibitors |
| JP2019516715A (ja) | 2016-05-19 | 2019-06-20 | ユニバーシタット アントウェルペン | Ｐａｒ関連疾患の予防および／または治療における使用のためのビス（アセトアミドフェニル）グアニジノフェニルエチルホスホネート |
| US10689400B2 (en) * | 2016-07-28 | 2020-06-23 | Turning Point Therapeutics, Inc. | Macrocycle kinase inhibitors |
| KR102719387B1 (ko) * | 2017-01-26 | 2024-10-21 | 한미약품 주식회사 | 이미다조피리다진 화합물 |
| JP7092405B2 (ja) * | 2018-04-16 | 2022-06-28 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| FI3870579T3 (fi) | 2018-10-22 | 2025-01-02 | Alumis Inc | Tyk2-inhibiittoreita ja niiden käyttöjä |
| WO2025212514A2 (en) * | 2024-04-02 | 2025-10-09 | Interline Therapeutics, Inc. | Methods of treating inflammatory diseases |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000346A1 (en) * | 1999-06-25 | 2001-01-04 | Industrial Automation Services Pty Ltd | Vibration damping apparatus |
| WO2013025958A1 (en) * | 2011-08-18 | 2013-02-21 | Glaxo Group Limited | Amino quinazolines as kinase inhibitors |
| CN104023728A (zh) * | 2011-09-30 | 2014-09-03 | 益普生制药股份有限公司 | 大环lrrk2激酶抑制剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004089182A (ja) * | 2002-06-24 | 2004-03-25 | Takeda Chem Ind Ltd | がんの予防・治療剤 |
| EA025881B1 (ru) * | 2011-09-30 | 2017-02-28 | Онкодизайн С.А. | Макроциклические ингибиторы flt3-киназы |
| KR20150133767A (ko) * | 2013-03-15 | 2015-11-30 | 온코디자인 에스.에이. | 거대고리 염-유도성 키나아제 억제제 |
| CN105143232A (zh) * | 2013-03-15 | 2015-12-09 | 益普生制药股份有限公司 | 大环的lrrk2激酶抑制剂 |
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2014
- 2014-03-14 AU AU2014230111A patent/AU2014230111A1/en not_active Abandoned
- 2014-03-14 KR KR1020157029469A patent/KR20150133765A/ko not_active Withdrawn
- 2014-03-14 SG SG11201507594YA patent/SG11201507594YA/en unknown
- 2014-03-14 CN CN201480023821.5A patent/CN105228625A/zh active Pending
- 2014-03-14 US US14/776,889 patent/US20160024114A1/en not_active Abandoned
- 2014-03-14 HK HK16106342.4A patent/HK1218263A1/zh unknown
- 2014-03-14 MX MX2015012526A patent/MX2015012526A/es unknown
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- 2014-03-14 WO PCT/EP2014/055139 patent/WO2014140299A1/en not_active Ceased
- 2014-03-14 CA CA2906257A patent/CA2906257A1/en not_active Abandoned
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- 2015-09-07 IL IL241250A patent/IL241250A0/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000346A1 (en) * | 1999-06-25 | 2001-01-04 | Industrial Automation Services Pty Ltd | Vibration damping apparatus |
| WO2013025958A1 (en) * | 2011-08-18 | 2013-02-21 | Glaxo Group Limited | Amino quinazolines as kinase inhibitors |
| CN104023728A (zh) * | 2011-09-30 | 2014-09-03 | 益普生制药股份有限公司 | 大环lrrk2激酶抑制剂 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115698020A (zh) * | 2020-01-31 | 2023-02-03 | 昂科迪塞恩精密医药公司(Opm) | 大环rip2-激酶抑制剂 |
| CN115698020B (zh) * | 2020-01-31 | 2025-02-25 | 昂科迪塞恩精密医药公司(Opm) | 大环rip2-激酶抑制剂 |
| WO2024051631A1 (zh) * | 2022-09-07 | 2024-03-14 | 苏州朗睿生物医药有限公司 | 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015012526A (es) | 2016-04-26 |
| BR112015022982A2 (pt) | 2017-07-18 |
| KR20150133765A (ko) | 2015-11-30 |
| WO2014140299A1 (en) | 2014-09-18 |
| CA2906257A1 (en) | 2014-09-18 |
| SG11201507594YA (en) | 2015-10-29 |
| US20160024114A1 (en) | 2016-01-28 |
| EA201591773A1 (ru) | 2016-01-29 |
| HK1218263A1 (zh) | 2017-02-10 |
| JP2016510796A (ja) | 2016-04-11 |
| IL241250A0 (en) | 2015-11-30 |
| AU2014230111A1 (en) | 2015-10-29 |
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