JP2016510796A - 大環状ｒｉｐ２キナーゼ阻害剤 - Google Patents
大環状ｒｉｐ２キナーゼ阻害剤 Download PDFInfo
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Classifications
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- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
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- Rheumatology (AREA)
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- Immunology (AREA)
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- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2013066732 | 2013-03-15 | ||
| EPPCT/EP2013/066732 | 2013-03-15 | ||
| GBGB1304714.7A GB201304714D0 (en) | 2013-03-15 | 2013-03-15 | Macrocyclic RIP2 Kinase inhibitors |
| GB1304714.7 | 2013-03-15 | ||
| PCT/EP2014/055139 WO2014140299A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic rip2 kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016510796A true JP2016510796A (ja) | 2016-04-11 |
| JP2016510796A5 JP2016510796A5 (enExample) | 2017-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2015562211A Withdrawn JP2016510796A (ja) | 2013-03-15 | 2014-03-14 | 大環状ｒｉｐ２キナーゼ阻害剤 |
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| Country | Link |
|---|---|
| US (1) | US20160024114A1 (enExample) |
| JP (1) | JP2016510796A (enExample) |
| KR (1) | KR20150133765A (enExample) |
| CN (1) | CN105228625A (enExample) |
| AU (1) | AU2014230111A1 (enExample) |
| BR (1) | BR112015022982A2 (enExample) |
| CA (1) | CA2906257A1 (enExample) |
| EA (1) | EA201591773A1 (enExample) |
| HK (1) | HK1218263A1 (enExample) |
| IL (1) | IL241250A0 (enExample) |
| MX (1) | MX2015012526A (enExample) |
| SG (1) | SG11201507594YA (enExample) |
| WO (1) | WO2014140299A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019527230A (ja) * | 2016-07-28 | 2019-09-26 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 大環状キナーゼ阻害剤 |
| JP2020505401A (ja) * | 2017-01-26 | 2020-02-20 | ハンミ ファーマシューティカル カンパニー リミテッド | イミダゾピリダジン化合物 |
| JP2021521239A (ja) * | 2018-04-16 | 2021-08-26 | 深▲チェン▼市塔吉瑞生物医薬有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ， Ｉｎｃ． | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| JP2023516551A (ja) * | 2020-01-31 | 2023-04-20 | オンコデザイン エス．ア． | 大環状ｒｉｐ２－キナーゼ阻害剤 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016146651A1 (en) * | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Macrocyclic activin-like receptor kinase inhibitors |
| EP3458072B1 (en) | 2016-05-19 | 2020-09-30 | Universiteit Antwerpen | Bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of par-related diseases |
| AU2019364336B2 (en) | 2018-10-22 | 2023-11-16 | Alumis Inc. | TYK2 inhibitors and uses thereof |
| CN117659043A (zh) * | 2022-09-07 | 2024-03-08 | 苏州朗睿生物医药有限公司 | 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
| WO2025212514A2 (en) * | 2024-04-02 | 2025-10-09 | Interline Therapeutics, Inc. | Methods of treating inflammatory diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ120999A0 (en) * | 1999-06-25 | 1999-07-22 | Industrial Automation Services Pty Ltd | Vibration suppressing piston |
| JP2004089182A (ja) * | 2002-06-24 | 2004-03-25 | Takeda Chem Ind Ltd | がんの予防・治療剤 |
| TWI547494B (zh) * | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| EA025881B1 (ru) * | 2011-09-30 | 2017-02-28 | Онкодизайн С.А. | Макроциклические ингибиторы flt3-киназы |
| EP2760453B1 (en) * | 2011-09-30 | 2016-05-25 | Ipsen Pharma S.A.S. | Macrocyclic lrrk2 kinase inhibitors |
| CN105209040A (zh) * | 2013-03-15 | 2015-12-30 | 昂科迪塞恩股份有限公司 | 大环的盐可诱导的激酶抑制剂 |
| CN105143232A (zh) * | 2013-03-15 | 2015-12-09 | 益普生制药股份有限公司 | 大环的lrrk2激酶抑制剂 |
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2014
- 2014-03-14 SG SG11201507594YA patent/SG11201507594YA/en unknown
- 2014-03-14 JP JP2015562211A patent/JP2016510796A/ja not_active Withdrawn
- 2014-03-14 EA EA201591773A patent/EA201591773A1/ru unknown
- 2014-03-14 CA CA2906257A patent/CA2906257A1/en not_active Abandoned
- 2014-03-14 AU AU2014230111A patent/AU2014230111A1/en not_active Abandoned
- 2014-03-14 US US14/776,889 patent/US20160024114A1/en not_active Abandoned
- 2014-03-14 WO PCT/EP2014/055139 patent/WO2014140299A1/en not_active Ceased
- 2014-03-14 CN CN201480023821.5A patent/CN105228625A/zh active Pending
- 2014-03-14 KR KR1020157029469A patent/KR20150133765A/ko not_active Withdrawn
- 2014-03-14 BR BR112015022982A patent/BR112015022982A2/pt not_active IP Right Cessation
- 2014-03-14 MX MX2015012526A patent/MX2015012526A/es unknown
- 2014-03-14 HK HK16106342.4A patent/HK1218263A1/zh unknown
-
2015
- 2015-09-07 IL IL241250A patent/IL241250A0/en unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019527230A (ja) * | 2016-07-28 | 2019-09-26 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 大環状キナーゼ阻害剤 |
| JP2020505401A (ja) * | 2017-01-26 | 2020-02-20 | ハンミ ファーマシューティカル カンパニー リミテッド | イミダゾピリダジン化合物 |
| JP7057366B2 (ja) | 2017-01-26 | 2022-04-19 | ハンミ ファーマシューティカル カンパニー リミテッド | イミダゾピリダジン化合物 |
| JP2021521239A (ja) * | 2018-04-16 | 2021-08-26 | 深▲チェン▼市塔吉瑞生物医薬有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ， Ｉｎｃ． | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| JP7092405B2 (ja) | 2018-04-16 | 2022-06-28 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| JP2023516551A (ja) * | 2020-01-31 | 2023-04-20 | オンコデザイン エス．ア． | 大環状ｒｉｐ２－キナーゼ阻害剤 |
| JP7713461B2 (ja) | 2020-01-31 | 2025-07-25 | オンコデザイン プリシジャン メディシン（オーピーエム） | 大環状ｒｉｐ２－キナーゼ阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201591773A1 (ru) | 2016-01-29 |
| WO2014140299A1 (en) | 2014-09-18 |
| KR20150133765A (ko) | 2015-11-30 |
| IL241250A0 (en) | 2015-11-30 |
| US20160024114A1 (en) | 2016-01-28 |
| SG11201507594YA (en) | 2015-10-29 |
| MX2015012526A (es) | 2016-04-26 |
| CA2906257A1 (en) | 2014-09-18 |
| HK1218263A1 (zh) | 2017-02-10 |
| BR112015022982A2 (pt) | 2017-07-18 |
| CN105228625A (zh) | 2016-01-06 |
| AU2014230111A1 (en) | 2015-10-29 |
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