AU2014230111A1 - Macrocyclic RIP2 kinase inhibitors - Google Patents
Macrocyclic RIP2 kinase inhibitors Download PDFInfo
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- AU2014230111A1 AU2014230111A1 AU2014230111A AU2014230111A AU2014230111A1 AU 2014230111 A1 AU2014230111 A1 AU 2014230111A1 AU 2014230111 A AU2014230111 A AU 2014230111A AU 2014230111 A AU2014230111 A AU 2014230111A AU 2014230111 A1 AU2014230111 A1 AU 2014230111A1
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- 235000010487 tragacanth Nutrition 0.000 description 1
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- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
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Classifications
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
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- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| EP2013066732 | 2013-03-15 | ||
| GB1304714.7 | 2013-03-15 | ||
| EPPCT/EP2013/066732 | 2013-03-15 | ||
| GBGB1304714.7A GB201304714D0 (en) | 2013-03-15 | 2013-03-15 | Macrocyclic RIP2 Kinase inhibitors |
| PCT/EP2014/055139 WO2014140299A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic rip2 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
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| AU2014230111A1 true AU2014230111A1 (en) | 2015-10-29 |
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| AU2014230111A Abandoned AU2014230111A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic RIP2 kinase inhibitors |
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| Country | Link |
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| JP (1) | JP2016510796A (enExample) |
| KR (1) | KR20150133765A (enExample) |
| CN (1) | CN105228625A (enExample) |
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| EA (1) | EA201591773A1 (enExample) |
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| MX (1) | MX2015012526A (enExample) |
| SG (1) | SG11201507594YA (enExample) |
| WO (1) | WO2014140299A1 (enExample) |
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| WO2016146651A1 (en) * | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Macrocyclic activin-like receptor kinase inhibitors |
| JP2019516715A (ja) | 2016-05-19 | 2019-06-20 | ユニバーシタット アントウェルペン | Ｐａｒ関連疾患の予防および／または治療における使用のためのビス（アセトアミドフェニル）グアニジノフェニルエチルホスホネート |
| US10689400B2 (en) * | 2016-07-28 | 2020-06-23 | Turning Point Therapeutics, Inc. | Macrocycle kinase inhibitors |
| KR102719387B1 (ko) * | 2017-01-26 | 2024-10-21 | 한미약품 주식회사 | 이미다조피리다진 화합물 |
| JP7092405B2 (ja) * | 2018-04-16 | 2022-06-28 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| FI3870579T3 (fi) | 2018-10-22 | 2025-01-02 | Alumis Inc | Tyk2-inhibiittoreita ja niiden käyttöjä |
| UY39061A (es) * | 2020-01-31 | 2022-01-31 | Oncodesign Sa | Inhibidores macrocíclicos de rip2-cinasa |
| CN117659043A (zh) * | 2022-09-07 | 2024-03-08 | 苏州朗睿生物医药有限公司 | 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
| WO2025212514A2 (en) * | 2024-04-02 | 2025-10-09 | Interline Therapeutics, Inc. | Methods of treating inflammatory diseases |
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| AUPQ120999A0 (en) * | 1999-06-25 | 1999-07-22 | Industrial Automation Services Pty Ltd | Vibration suppressing piston |
| JP2004089182A (ja) * | 2002-06-24 | 2004-03-25 | Takeda Chem Ind Ltd | がんの予防・治療剤 |
| TWI547494B (zh) * | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| UA113186C2 (xx) * | 2011-09-30 | 2016-12-26 | Макроциклічні інгібітори lrrk2 кінази | |
| EA025881B1 (ru) * | 2011-09-30 | 2017-02-28 | Онкодизайн С.А. | Макроциклические ингибиторы flt3-киназы |
| KR20150133767A (ko) * | 2013-03-15 | 2015-11-30 | 온코디자인 에스.에이. | 거대고리 염-유도성 키나아제 억제제 |
| CN105143232A (zh) * | 2013-03-15 | 2015-12-09 | 益普生制药股份有限公司 | 大环的lrrk2激酶抑制剂 |
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2014
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- 2014-03-14 KR KR1020157029469A patent/KR20150133765A/ko not_active Withdrawn
- 2014-03-14 SG SG11201507594YA patent/SG11201507594YA/en unknown
- 2014-03-14 CN CN201480023821.5A patent/CN105228625A/zh active Pending
- 2014-03-14 US US14/776,889 patent/US20160024114A1/en not_active Abandoned
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- 2014-03-14 WO PCT/EP2014/055139 patent/WO2014140299A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| MX2015012526A (es) | 2016-04-26 |
| BR112015022982A2 (pt) | 2017-07-18 |
| KR20150133765A (ko) | 2015-11-30 |
| WO2014140299A1 (en) | 2014-09-18 |
| CA2906257A1 (en) | 2014-09-18 |
| SG11201507594YA (en) | 2015-10-29 |
| US20160024114A1 (en) | 2016-01-28 |
| EA201591773A1 (ru) | 2016-01-29 |
| HK1218263A1 (zh) | 2017-02-10 |
| JP2016510796A (ja) | 2016-04-11 |
| IL241250A0 (en) | 2015-11-30 |
| CN105228625A (zh) | 2016-01-06 |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |