CN105213712A - Hereditary spherocytosis and medicine thereof - Google Patents
Hereditary spherocytosis and medicine thereof Download PDFInfo
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Abstract
The present invention relates to hereditary spherocytosis and medicine thereof, medicine technology field, in order to solve the defect of this sick splenectomy of operative treatment, by analyzing hereditary spherocytosis, belong to congenital defect, caused by liver and kidney deficiency, the weak blood deficiency of gas, by with spleen invigorating nourishing the liver, the kidney invigorating and essence nourishing, liver heat removing is invigorated blood circulation, the Chinese Medicine and Clavicular of invigorating qi and benefiting blood takes treatment: Cornu Bubali 15 parts, Hirudo 15 parts, 20 parts, the Radix Rehmanniae, Semen Cassiae 10 parts, Herba Hyperici Japonici 15 parts, Radix Codonopsis 15 parts, Fructus Lycii 10 parts, Radix Achyranthis Bidentatae 18 parts, Carapax Trionycis 15 parts, the Radix Astragali 15 parts, Rhizoma Dioscoreae 20 parts, 7 parts, Radix Glycyrrhizae, can for old complaint, therapeutic effect is obvious, curative effect safety, stable.
Description
Technical field
The present invention relates to hereditary spherocytosis and medicine thereof, particularly with the medicine of Chinese medicine, belong to medicine technology field.
Background technology
Hereditary spherocytosis is a kind of hemolytic anemia that erythrocyte membrane has birth defect, and main manifestations is anemia, jaundice, splenomegaly, and diagnosis basis is that in blood, spherocyte increases.The mode of inheritance of this disease is that men and women can fall ill, and per all can there be a patient in generation, namely so-called " autosomal dominant inheritance, AD ".Onset age and the state of an illness weight of primary disease are widely different, how at child and childhood onset.If in neonate or the morbidity of the infancy stage within 1 years old, the general state of an illness is heavier.Hereditary spherocytosis, also referred to as acholuric familial jaundice, during normal condition, the flat cell that erythrocytic profile is intermediate thin, periphery is thick, profile has video disc.And when suffering from hereditary spherocytosis, erythrocyte just becomes spheroidal.This spherical erythrocyte, volume becomes large, deformability is poor, and when blood enters into spleen, erythrocyte just can not well by tiny blood vessel, and a lot of erythrocyte of result is trapped in spleen, and destroyed, and result just causes haemolysis, anemia.Change, the spleen of the nearly erythrocytic paramophia of etiology and pathogenesis of hereditary spherocytosis, the change of erythrocyte membrane chemical composition, erythrocyte metabolism function destroy the aspects such as the effect of sphaerocyst.Hereditary spherocytosis clinical manifestation: anemia, jaundice and splenomegaly, three can exist simultaneously also can singlely occur.Hereditary spherocytosis all can be fallen ill at any age, clinical manifestation weight differs, slight from the asymptomatic spherocytosis shape to life-threatening anemia 25%, though have haemolysis due to bone marrow red system compensatory hypertrophy general without anemia, without or slight jaundice, without or slight this kind of patient of splenomegaly only carrying out family investigation or owing to being just found when certain inducement increases the weight of hematoclasis.
The therapeutic scheme background technology of hereditary spherocytosis.The main method for the treatment of hereditary spherocytosis is splenectomy.Splenectomy is that anemia is occurred completely and the most effective therapy of durable remissions.When hemolytic crisis occurs the patient not doing splenectomy, mainly take to transfuse blood and the infection of haemolysis is brought out in treatment.The generation of aplastic bone marrow crisis is also relevant with infection, and its treatment is also blood transfusion and infection control.After sb.'s illness took a favorable turn, also should do splenectomy operation.As there is huge juvenile cell in bone marrow, can every day 5 ~ 10 milligrams, oral folic acid.Although splenectomy is effective lastingly, spleen is as the organ of people, and spleen has hemofiltration function, immunologic function, part hemopoietic function, storage blood function etc., and when spleen is cut, the function of spleen will disappear, and affect the part normal physiological function of people.
Summary of the invention
In order to overcome the shortcoming of operative treatment hereditary spherocytosis splenectomy, the necessary therapeutic scheme carrying out medicine, is the therapeutic scheme of safety and stability with traditional Chinese medical herbal treatment, had both remained spleen organ, can treat disease disease again.Treat hereditary spherocytosis, first will analyze the clear and definite cause of disease.With tcm theory analysis, hereditary spherocytosis, belongs to congenital defect, caused by liver and kidney deficiency, the weak blood deficiency of gas, should invigorate blood circulation, the Chinese medicine combined treatment of invigorating qi and benefiting blood with spleen invigorating nourishing the liver, the kidney invigorating and essence nourishing, liver heat removing.
Hereditary spherocytosis and medicine thereof combine by each Chinese medicine quality part ratio below: Cornu Bubali 15 parts, Hirudo 15 parts, 20 parts, the Radix Rehmanniae, Semen Cassiae 10 parts, Herba Hyperici Japonici 15 parts, Radix Codonopsis 15 parts, Fructus Lycii 10 parts, Radix Achyranthis Bidentatae 18 parts, Carapax Trionycis 15 parts, the Radix Astragali 15 parts, Rhizoma Dioscoreae 20 parts, 7 parts, Radix Glycyrrhizae.
Property of medicine effect of each Chinese medicine in lower surface analysis hereditary spherocytosis and medicine thereof: Cornu Bubali, Chinese medicine name, be the succedaneum of Chinese medicine Cornu rhinocerotis, function has heat clearing away, removing heat from blood, arresting convulsion, removing toxic substances; Cure the wound the cold pestilence pathogenic heat attacking blood system in febrile diseases, mania and irritation, irritated, delirium, and macule is yellow, spits blood, epistaxis, hematochezia, swollen ulcer drug.Hirudo, popular name Hirudo, salty in the mouth, darkish complexion, gas is rotten, and property is put down; For its taste becomes, therefore be apt to into blood system; For it is originally for biting the thing of blood, therefore kind removing blood stasis, there is the effect such as treatment apoplexy, hypertension, the clear stasis of blood, amenorrhea, traumatic injury.Radix Rehmanniae clearing away heat and cooling blood, hemostasis is invigorated blood circulation, YIN nourishing and the production of body fluid promoting.Its mildly bitter flavor of Semen Cassiae is micro-sweet, and property is put down, micro-cool; Return liver, kidney, large intestine channel; There is removing heat from the liver, effect of antiviral.Herba Hyperici Japonici: nature and flavor are sweet, light, are slightly cold; There is the effect of clearing away heat-damp and promoting diuresis, heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Radix Codonopsis effect: invigorating the spleen and regulating the stomach, lung moistening tonifying YIN, invigorating the spleen and replenishing QI, benefiting qi and nourishing blood.Fructus Lycii can the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough; It can control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy.Radix Achyranthis Bidentatae has invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite that (blood) is descending, relieving stranguria by diuresis, effect of alleviating pain and detumescence.Carapax Trionycis is flat, sweet in the mouth; Return Liver Channel; Effect: have in phencyclidine, tonification tune, reinforcing the kidney to strengthen the bone, eliminating stagnation disappear the effects such as painful abdominal mass; Can weak, the disease such as hepatosplenomegaly, pulmonary tuberculosis of anti-training the body void.The Radix Astragali has QI invigorating, nourishes blood, effect in benefit, is applicable to the diseases such as internal injury overstrain, diarrhea due to hypofunction of the spleen, the deficiency of vital energy, blood deficiency, weakness of QI.Rhizoma Dioscoreae, also claims Rhizomadioscoreae, Rhizoma dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China etc.; Because it is nutritious, delicious flavour, food and medicament dual-purpose, Rhizoma Dioscoreae sweet in the mouth, property is put down; Return lung, spleen, kidney channel, energy spleen reinforcing; Support lung; Reinforce the kidney; Benefit essence.Radix Glycyrrhizae, sweet in the mouth is sweet, and property is gentle, enters the heart, spleen, lung, stomach warp; Raw with cooler, can eliminating fire and detoxication, relieving spasm to stop pain, processs by temperature partially, exterior cold of faling apart, invigorating the spleen and replenishing QI; Radix Glycyrrhizae is also good at being in harmonious proportion the property of medicine, separates the poison of hundred medicines.
The beneficial effect of hereditary spherocytosis and medicine thereof is: by with tcm theory analysis, hereditary spherocytosis, belong to congenital defect, caused by liver and kidney deficiency, the weak blood deficiency of gas, invigorate blood circulation with spleen invigorating nourishing the liver, the kidney invigorating and essence nourishing, liver heat removing, the Chinese medicine combined treatment of invigorating qi and benefiting blood, successful is stablized, and exempts the defect of operation splenectomy.
Detailed description of the invention
Hereditary spherocytosis and medicine thereof combine by each Chinese medicine quality part ratio below: Cornu Bubali 15 parts, Hirudo 15 parts, 20 parts, the Radix Rehmanniae, Semen Cassiae 10 parts, Herba Hyperici Japonici 15 parts, Radix Codonopsis 15 parts, Fructus Lycii 10 parts, Radix Achyranthis Bidentatae 18 parts, Carapax Trionycis 15 parts, the Radix Astragali 15 parts, Rhizoma Dioscoreae 20 parts, 7 parts, Radix Glycyrrhizae.According to above medication ratio, it is combine by each Chinese medicine quality below that hereditary spherocytosis and medicine thereof are suitable for a dosage dose that a patient takes: Cornu Bubali 15 grams, Hirudo 15 grams, 20 grams, the Radix Rehmanniae, Semen Cassiae 10 grams, Herba Hyperici Japonici 15 grams, Radix Codonopsis 15 grams, Fructus Lycii 10 grams, Radix Achyranthis Bidentatae 18 grams, Carapax Trionycis 15 grams, the Radix Astragali 15 grams, Rhizoma Dioscoreae 20 grams, 7 grams, Radix Glycyrrhizae.Using method: will wherein Hirudo, Carapax Trionycis pulverize after being baked to detonation Chinese medicine each with other mix and appropriate decocting soup take medicinal liquid orally, day takes dose, serveing on fortnight is first course for the treatment of, taking a dosage can be effective, can subtract dose after symptom disappears substantially and take dose in two days, then medication 1 ~ 3 month is with consolidate curative effect.
Claims (1)
1. hereditary spherocytosis and medicine thereof, is characterized in that combining by each Chinese medicine quality part ratio below: Cornu Bubali 15 parts, Hirudo 15 parts, 20 parts, the Radix Rehmanniae, Semen Cassiae 10 parts, Herba Hyperici Japonici 15 parts, Radix Codonopsis 15 parts, Fructus Lycii 10 parts, Radix Achyranthis Bidentatae 18 parts, Carapax Trionycis 15 parts, the Radix Astragali 15 parts, Rhizoma Dioscoreae 20 parts, 7 parts, Radix Glycyrrhizae.
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CN103417799A (en) * | 2012-05-22 | 2013-12-04 | 石家庄以岭药业股份有限公司 | Applications of a traditional Chinese medicine composition in preparing medicines treating anaemia |
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CN103417799A (en) * | 2012-05-22 | 2013-12-04 | 石家庄以岭药业股份有限公司 | Applications of a traditional Chinese medicine composition in preparing medicines treating anaemia |
Non-Patent Citations (3)
Title |
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何太清等: "《常见内科疾病的中西医诊治》", 31 August 2004, 第四军医大学出版社 * |
李海燕等: "中药治疗遗传性球形红细胞增多症", 《中医杂志》 * |
李海燕等: "中药治疗遗传性球形红细胞增多症30例", 《中医杂志》 * |
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