CN105213315A - A kind of florfenicol soluble powder and preparation method thereof - Google Patents
A kind of florfenicol soluble powder and preparation method thereof Download PDFInfo
- Publication number
- CN105213315A CN105213315A CN201510655733.3A CN201510655733A CN105213315A CN 105213315 A CN105213315 A CN 105213315A CN 201510655733 A CN201510655733 A CN 201510655733A CN 105213315 A CN105213315 A CN 105213315A
- Authority
- CN
- China
- Prior art keywords
- florfenicol
- soluble powder
- polyvinyl alcohol
- sodium lauryl
- lauryl sulphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention belongs to veterinary drug technical field, specifically disclose a kind of florfenicol soluble powder, it is made up of the raw material of following percentage by weight: florfenicol 5-20%, polyvinyl alcohol 2-4%, sodium lauryl sulphate 2-3%, and surplus is adjuvant.Soluble powder of the present invention effectively can improve florfenicol at the absorption of digestive system and blood drug level, strengthens the therapeutic effect of florfenicol; Simultaneously soluble in water due to it, convenient in Clinical practice.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind of florfenicol soluble powder and preparation method thereof.
Background technology
Florfenicol (Florfenicol) Chinese: fluprofen; Florfenicol is the special chloromycetin broad spectrum antibiotic of a kind of new veterinary successfully developed in the late nineteen eighties.Nineteen ninety, within 1993, Norway ratified the furunculosis of this medicine treatment salmon first in Japan's listing.Nineteen ninety-five France, Britain, Austria, Mexico and Spain approval be used for the treatment of cattle respiratory system bacterial disease.The feed additive being used as pig is also ratified, the bacterial disease (Qiu Yinsheng etc., 1996) of prevention and therapy pig in Japan and Mexico.China have passed the examination & approval of this medicine at present.
Florfenicol is a kind of antibiotic of wide spectrum, all has effect to multiple gram positive bacteria and gram negative bacteria and mycoplasma etc.Its Antibacterial Mechanism is mainly by being combined with 50S ribosomal subunit, key enzyme---peptidy transeferace needed for the synthesis of Profilin matter, thus stop the receptors bind on aminoacyl tRNA and ribosome specifically, suppress the prolongation of peptide chain and tropina can not be synthesized.
As animal specific antibiotics, florfenicol has a wide range of applications.But due to its poorly water-soluble, in pharmaceutical dosage form and Clinical practice, there is again very large restriction.Develop water-solubility florfenicol medicine, its absorbance problem in animal intestinal must be considered, especially in the middle of the Clinical practice of poultry disease.
Summary of the invention
The object of the invention is to overcome prior art defect, a kind of florfenicol soluble powder and preparation method thereof is provided.
For achieving the above object, the technical scheme taked of the present invention is as follows:
A kind of florfenicol soluble powder, it is made up of the raw material of following percentage by weight: florfenicol 5-20%, polyvinyl alcohol 2-4%, sodium lauryl sulphate 2-3%, and surplus is adjuvant.
Concrete, described adjuvant can be one or both the combination in anhydrous glucose and anhydrous sucrose.
Further, above-mentioned florfenicol soluble powder is preferably made up of the component of following percentage by weight: florfenicol 10%, polyvinyl alcohol 2.5%, sodium lauryl sulphate 2%, and surplus is anhydrous glucose.
A preparation method for above-mentioned florfenicol soluble powder, is specially: get mix homogeneously after florfenicol, polyvinyl alcohol and sodium lauryl sulphate in proportion, pulverize, sieve, then add adjuvant, and mixing, to obtain final product.
Compared to the prior art, beneficial effect of the present invention:
In the present invention, polyvinyl alcohol and sodium lauryl sulphate all can play good hydrotropy and solubilization, can well improve its water solublity with florfenicol is composite.Florfenicol soluble powder of the present invention effectively can improve florfenicol at the absorption of digestive system and blood drug level, strengthens the therapeutic effect of florfenicol; Simultaneously soluble in water due to it, convenient in Clinical practice.
Detailed description of the invention
Do to introduce in detail further to technical scheme of the present invention below in conjunction with embodiment, but protection scope of the present invention is not limited thereto.
Embodiment 1
As produced 100kg florfenicol soluble powder, then by florfenicol 10kg, polyvinyl alcohol 2.5kg and sodium lauryl sulphate 2kg mix homogeneously, pulverizing, crossing 150 mesh sieves, then adding anhydrous glucose 85.5kg, mixing, to obtain final product.
Embodiment 2
As produced 100kg florfenicol soluble powder, then by florfenicol 8kg, polyvinyl alcohol 3kg and sodium lauryl sulphate 2.5kg mix homogeneously, pulverizing, crossing 150 mesh sieves, then adding anhydrous glucose 86.5kg, mixing, to obtain final product.
Embodiment 3
As produced 100kg florfenicol soluble powder, then by florfenicol 5kg, polyvinyl alcohol 2.5kg and sodium lauryl sulphate 2kg mix homogeneously, pulverizing, crossing 150 mesh sieves, then adding anhydrous sucrose 90.5kg, mixing, to obtain final product.
Embodiment 4
Florfenicol soluble powder soluble test
Test equipment: beaker, Glass rod, distilled water, embodiment 1 prepare the florfenicol soluble powder sample 500g(of gained hereinafter referred to as embodiment 1 medicine), commercially available 10% florfenicol powder 500g(Henan Xinzhenghao Bio-Engineering Co., Ltd. provides).
Test objective: the molten water effect of observing commercially available 10% florfenicol powder and embodiment 1 medicine.
Test method: 1, get 9, clean beaker, add 1000ml distilled water respectively.2, except matched group is distilled water, all the other 8 beakers are divided into 2 groups, add florfenicol soluble powder sample 1g, 5g, 10g, 20g respectively, stir with Glass rod in embodiment 1 medicine group; Add commercially available 10% florfenicol powder sample 1g, 5g, 10g, 20g in commercially available 10% florfenicol powder group respectively, stir with Glass rod.3, observe the molten regimen condition of sample in beaker, and record, the results are shown in following table:
Above-mentioned result of the test shows: florfenicol soluble powder sample of the present invention has good water solublity, and commercially available 10% florfenicol powder is then water insoluble.
Claims (4)
1. a florfenicol soluble powder, is characterized in that, is made up of the raw material of following percentage by weight: florfenicol 5-20%, polyvinyl alcohol 2-4%, sodium lauryl sulphate 2-3%, and surplus is adjuvant.
2. florfenicol soluble powder as claimed in claim 1, it is characterized in that, described adjuvant is one or both the combination in anhydrous glucose, anhydrous sucrose.
3. florfenicol soluble powder as claimed in claim 2, it is characterized in that, be made up of the component of following percentage by weight: florfenicol 10%, polyvinyl alcohol 2.5%, sodium lauryl sulphate 2%, surplus is anhydrous glucose.
4. a preparation method for the arbitrary described florfenicol soluble powder of claims 1 to 3, is characterized in that, gets mix homogeneously after florfenicol, polyvinyl alcohol and sodium lauryl sulphate in proportion, pulverizes, sieves, then add adjuvant, and mixing, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510655733.3A CN105213315A (en) | 2015-10-12 | 2015-10-12 | A kind of florfenicol soluble powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510655733.3A CN105213315A (en) | 2015-10-12 | 2015-10-12 | A kind of florfenicol soluble powder and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105213315A true CN105213315A (en) | 2016-01-06 |
Family
ID=54982839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510655733.3A Pending CN105213315A (en) | 2015-10-12 | 2015-10-12 | A kind of florfenicol soluble powder and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105213315A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210464A (en) * | 2016-12-13 | 2018-06-29 | 河南后羿实业集团有限公司 | A kind of compound florfenicol soluble powder and preparation method thereof |
| CN109700768A (en) * | 2019-01-29 | 2019-05-03 | 江西九信药业有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843586A (en) * | 2010-04-29 | 2010-09-29 | 山东迅达康兽药有限公司 | Water-soluble micro powder containing florfenicol and preparation method thereof |
| CN104922073A (en) * | 2015-05-29 | 2015-09-23 | 广东腾骏动物药业股份有限公司 | Soluble florfenicol powder and preparation method thereof |
-
2015
- 2015-10-12 CN CN201510655733.3A patent/CN105213315A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843586A (en) * | 2010-04-29 | 2010-09-29 | 山东迅达康兽药有限公司 | Water-soluble micro powder containing florfenicol and preparation method thereof |
| CN104922073A (en) * | 2015-05-29 | 2015-09-23 | 广东腾骏动物药业股份有限公司 | Soluble florfenicol powder and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210464A (en) * | 2016-12-13 | 2018-06-29 | 河南后羿实业集团有限公司 | A kind of compound florfenicol soluble powder and preparation method thereof |
| CN109700768A (en) * | 2019-01-29 | 2019-05-03 | 江西九信药业有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101843586B (en) | Water-soluble micro powder containing florfenicol and preparation method thereof | |
| CN102488753B (en) | Fishing Chinese medicinal composition with antibacterial and antibiotic functions and preparation method thereof | |
| CN102318771B (en) | Chinese medicinal herb disease-resistant additive for prawn feed | |
| CN102870979B (en) | Chinese herbal medicine compound feed additive for preventing red leg of bullfrog | |
| CN101745049B (en) | Herbal preparation for aquaculture, preparation method and application | |
| CN104383136A (en) | Compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes and preparation method thereof | |
| CN105213315A (en) | A kind of florfenicol soluble powder and preparation method thereof | |
| CN103536536B (en) | Wettability solid dispersing powder of florfenicol composition and preparation method thereof | |
| CN102895203A (en) | Method for preparing azithromycin dispersible tablets | |
| CN106822253A (en) | Application of the circle bud isapgol husk dietary fiber in intestinal tract injury protection preparation is prepared | |
| CN102895378B (en) | Pharmaceutical compound preparation for treating livestock respiratory diseases and method for preparing pharmaceutical compound preparation for treating livestock respiratory diseases | |
| CN106137988A (en) | A kind of metronidazole solid preparation and preparation method thereof | |
| CN112375708A (en) | Preparation for resisting white spot syndrome virus and decapod iridovirus 1 and preparation method thereof | |
| CN103432162A (en) | Composition for treating poultry intestinal bacteria and anaerobic bacteria mixing infection and preparation method thereof | |
| CN101450069A (en) | Soluble powder for treating poultry respiratory infection | |
| CN102813630A (en) | Enrofloxacin enteric pellets and preparation method thereof | |
| CN102727596B (en) | A kind of Chinese herbal granules for preventing chicken coccidiasis and preparation method thereof | |
| CN103623313A (en) | Traditional Chinese medicine composition for preventing and treating swine mycoplasmal pneumonia and preparation method and application thereof | |
| CN105267977A (en) | Dissolvable doxycycline powder and preparation method thereof | |
| CN102579733A (en) | Compound traditional Chinese medicine powder for treating sow constipation | |
| CN102335416A (en) | Compound Chinese medicinal composition for treating hog cholera and preparation method thereof | |
| CN102688477B (en) | Medicinal composition for treating respiratory diseases of livestock | |
| CN102895379B (en) | Pharmaceutical preparation for treating livestock respiratory diseases and method for preparing pharmaceutical preparation for treating livestock respiratory diseases | |
| CN103446171A (en) | Composition for treating swine respiratory tract infection and preparation method thereof | |
| CN108567790A (en) | A kind of Gamithromycin pharmaceutical composition and its application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160106 |
|
| WD01 | Invention patent application deemed withdrawn after publication |