CN108210464A - A kind of compound florfenicol soluble powder and preparation method thereof - Google Patents
A kind of compound florfenicol soluble powder and preparation method thereof Download PDFInfo
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- CN108210464A CN108210464A CN201611147670.1A CN201611147670A CN108210464A CN 108210464 A CN108210464 A CN 108210464A CN 201611147670 A CN201611147670 A CN 201611147670A CN 108210464 A CN108210464 A CN 108210464A
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- florfenicol
- soluble powder
- compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A kind of compound florfenicol soluble powder, is made of the raw material of following parts by weight：5 25 parts of Florfenicol, 49 88 parts of carrier, 6 23 parts of cosolvent, 13 parts of solubilizer；The carrier is soluble starch, one or two kinds of combinations of glucose, lactose；Cosolvent is one or both of acetamide, sodium succinate；Solubilizer is lauryl sodium sulfate.Compound florfenicol soluble powder provided by the invention, wherein carrier can play the role of dispersion, lauryl sodium sulfate is as surfactant dissolution, and acetamide and sodium succinate can form molecular association and double salt with Florfenicol in aqueous solution, and then achieve the purpose that solubilising, therefore compound florfenicol soluble powder provided by the invention is water-soluble good, and solubility can reach 15 30mg/ml in water, be far longer than the solubility 1.3mg/ml of Florfenicol under normal circumstances.
Description
Technical field
The invention belongs to veterinary fields, more particularly to veterinary drug, and in particular to a kind of compound florfenicol is soluble
Pulvis and preparation method thereof.
Background technology
Florfenicol is the broad-spectrum antibiotic of novel animal specific, for gram-positive bacteria, Gram-negative bacteria and first
The drug resistant fish of hyrazin, ox, pig, fowl derived bacterium disease.Its maximum feature is has a broad antifungal spectrum, absorbs good, distribution in vivo
Extensively, noresidue or residual quantity are relatively low in vivo, are particularly acted on without potential induced aplastic anemia.The fluorobenzene applied at present
It is mainly pre-mixing agent, injection and soluble powder etc. at present that Buddhist nun, which is examined with preparation,.The application purpose of different preparations is different, and curative effect also has
Different.Numerous studies and production practices are the results show that compared with similar antibiotic, Florfenicol function admirable, but water-soluble
Property is poor.The water solubility of Florfenicol can influence its bioavilability.There is researcher to be proposed many fluorobenzene from the solvent that starts with
Buddhist nun examines injection and oral dedicated solvent.Though this improves its water solubility to a certain extent, there are still some in use
Problem.If as that will be precipitated with the presence of water, Florfenicol in course of dissolution, solution turbid, under low temperature solution rate it is relatively slow or
The solution prepared has Florfenicol precipitation；With the florfenicol solution of organic solvent hydrotropy when grouping of the world economy cultivates concentrated compounding, often
Water fountain blocks caused by precipitation, and very big inconvenience is brought to large-scale cultivation.Currently used 30% florfenicol injection is all
It is prepared with organic solvent, often causes local stimulation and toxic reaction：The addition of organic solvent also improves preparation cost, to raiser
Increase financial burden.
In addition, either infiltration rate or uptake are related with the solubility of drug.The solubility of drug affects
The dissolution rate of drug, the dissolution rate of drug have a certain impact to the bioavilability of drug；Increase drug solubility
There are many method, but there is not been reported for the solid pharmaceutical preparation research in relation to improving florfenicol solubility.
Invention content
The present invention is directed to overcome the existing technological deficiency of above-mentioned technology, it is therefore an objective to it is soluble to provide a kind of compound florfenicol
Pulvis and preparation method thereof.
The purpose of the present invention is what is realized in the following manner：
A kind of compound florfenicol soluble powder, is made of the raw material of following parts by weight：5-25 parts of Florfenicol, carrier 49-
88 parts, 6-23 parts of cosolvent, 1-3 parts of solubilizer；The carrier is soluble starch, glucose, one or two kinds of groups of lactose
It closes；Cosolvent is one or both of acetamide, sodium succinate；Solubilizer is lauryl sodium sulfate.
Preferably, it is made of the raw material of following parts by weight：10-20 parts of Florfenicol, 62-83 parts of lactose, acetamide 7-10
With 6-10 parts of sodium succinate, 1-3 parts of lauryl sodium sulfate.
The preparation method of compound florfenicol soluble powder as described above, includes the following steps：Raw material is weighed, it is just mixed
Afterwards, it is put into batch mixer and mixes 20 ~ 30 minutes, dispense after the assay was approved to obtain the final product.
Its ingredient of compound florfenicol soluble powder provided by the invention is simple, and raw material is marketable material, cheap easy
, it is safe, and facilitate application；And preparation process is simple, and it is simple to mix.Wherein carrier can play dispersion
Effect, lauryl sodium sulfate is as surfactant dissolution, and acetamide and sodium succinate can be with fluorobenzene in aqueous solution
Buddhist nun examines to form molecular association and double salt, and then achievees the purpose that solubilising, therefore compound florfenicol provided by the invention is soluble
Pulvis is water-soluble good, and solubility can reach 15-30mg/ml in water, be far longer than the dissolving of Florfenicol under normal circumstances
Spend 1.3mg/ml.
Specific embodiment
Embodiment 1
A kind of compound florfenicol soluble powder, is made of the raw material of following parts by weight：5-25 parts of Florfenicol, carrier 49-
88 parts, 6-23 parts of cosolvent, 1-3 parts of solubilizer；The carrier is soluble starch, glucose, one or two kinds of groups of lactose
It closes；Cosolvent is one or both of acetamide, sodium succinate；Solubilizer is lauryl sodium sulfate.
The preparation method of above-mentioned compound florfenicol soluble powder, includes the following steps：Raw material is weighed, after just mixed, is put
Enter in batch mixer and mix 20 ~ 30 minutes, dispense after the assay was approved to obtain the final product.
2-20 compound florfenicol soluble powder formula tables of the embodiment of the present invention are shown in Table 1-2, remaining is the same as embodiment 1.
2-7 Florfenicols of the embodiment of the present invention are in aqueous solution（25℃）In middle 5min solubility be respectively 26.5,28.2,
32.2nd, 24.3,23.7,29.8mg/mL, and being generated after standing 48h without precipitation, it is demonstrated experimentally that using lactose, acetamide,
Sodium succinate, lauryl sodium sulfate solubilising effect are best.
What has been described above is only a preferred embodiment of the present invention, it is noted that for those skilled in the art,
Under the premise of general idea of the present invention is not departed from, several changes and improvements can also be made, these should also be considered as the present invention's
Protection domain.
Claims (3)
1. a kind of compound florfenicol soluble powder, it is characterised in that be made of the raw material of following parts by weight：Florfenicol 5-
25 parts, 49-88 parts of carrier, 6-23 parts of cosolvent, 1-3 parts of solubilizer；The carrier is soluble starch, glucose, lactose
One or two combination；Cosolvent is one or both of acetamide, sodium succinate；Solubilizer is lauryl sodium sulfate.
2. compound florfenicol soluble powder as described in claim 1, it is characterised in that by the raw material system of following parts by weight
Into：10-20 parts of Florfenicol, 62-83 parts of lactose, acetamide 7-10 and 6-10 parts of sodium succinate, lauryl sodium sulfate 1-3
Part.
3. the preparation method of the compound florfenicol soluble powder as described in claim 1-2, it is characterised in that including following
Step：It weighs raw material, after just mixed, be put into batch mixer and mix 20 ~ 30 minutes, dispense after the assay was approved to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611147670.1A CN108210464A (en) | 2016-12-13 | 2016-12-13 | A kind of compound florfenicol soluble powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611147670.1A CN108210464A (en) | 2016-12-13 | 2016-12-13 | A kind of compound florfenicol soluble powder and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108210464A true CN108210464A (en) | 2018-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611147670.1A Pending CN108210464A (en) | 2016-12-13 | 2016-12-13 | A kind of compound florfenicol soluble powder and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700768A (en) * | 2019-01-29 | 2019-05-03 | 江西九信药业有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
| CN110302163A (en) * | 2019-07-23 | 2019-10-08 | 东莞正大康地饲料有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
| CN111588698A (en) * | 2020-06-23 | 2020-08-28 | 南京大方生物工程有限公司 | Florfenicol powder for improving water solubility and preparation method and application thereof |
| CN112121016A (en) * | 2020-10-09 | 2020-12-25 | 清远海贝生物技术有限公司 | Water-soluble florfenicol powder and preparation method thereof |
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|---|---|---|---|---|
| CN1582909A (en) * | 2003-08-18 | 2005-02-23 | 王玉万 | Composite preparation containing florfenicol for animals |
| CN101289416A (en) * | 2008-03-03 | 2008-10-22 | 西南大学 | High-water-solubility florfenicol prodrug quickly released in vivo |
| CN102697730A (en) * | 2012-05-07 | 2012-10-03 | 郑州后羿制药有限公司 | Florfenicol soluble power and preparation method thereof |
| CN102813627A (en) * | 2012-09-19 | 2012-12-12 | 上海同仁药业有限公司 | Preparation method of florfenicol soluble powder |
| CN105079818A (en) * | 2015-08-31 | 2015-11-25 | 王玉万 | Preparation of florfenicol soluble powder from acetamide and cyclodextrin |
| CN105213315A (en) * | 2015-10-12 | 2016-01-06 | 河南新正好生物工程有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
-
2016
- 2016-12-13 CN CN201611147670.1A patent/CN108210464A/en active Pending
Patent Citations (6)
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| CN1582909A (en) * | 2003-08-18 | 2005-02-23 | 王玉万 | Composite preparation containing florfenicol for animals |
| CN101289416A (en) * | 2008-03-03 | 2008-10-22 | 西南大学 | High-water-solubility florfenicol prodrug quickly released in vivo |
| CN102697730A (en) * | 2012-05-07 | 2012-10-03 | 郑州后羿制药有限公司 | Florfenicol soluble power and preparation method thereof |
| CN102813627A (en) * | 2012-09-19 | 2012-12-12 | 上海同仁药业有限公司 | Preparation method of florfenicol soluble powder |
| CN105079818A (en) * | 2015-08-31 | 2015-11-25 | 王玉万 | Preparation of florfenicol soluble powder from acetamide and cyclodextrin |
| CN105213315A (en) * | 2015-10-12 | 2016-01-06 | 河南新正好生物工程有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 张光杰: "《药用辅料应用技术》", 31 December 1991, 中国医药科技出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700768A (en) * | 2019-01-29 | 2019-05-03 | 江西九信药业有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
| CN110302163A (en) * | 2019-07-23 | 2019-10-08 | 东莞正大康地饲料有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
| CN111588698A (en) * | 2020-06-23 | 2020-08-28 | 南京大方生物工程有限公司 | Florfenicol powder for improving water solubility and preparation method and application thereof |
| CN112121016A (en) * | 2020-10-09 | 2020-12-25 | 清远海贝生物技术有限公司 | Water-soluble florfenicol powder and preparation method thereof |
| CN112121016B (en) * | 2020-10-09 | 2022-11-22 | 清远海贝生物技术有限公司 | Water-soluble florfenicol powder and preparation method thereof |
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