CN106727337A - A kind of Enrofloxacin soluble powder and preparation method thereof - Google Patents
A kind of Enrofloxacin soluble powder and preparation method thereof Download PDFInfo
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- CN106727337A CN106727337A CN201611146814.1A CN201611146814A CN106727337A CN 106727337 A CN106727337 A CN 106727337A CN 201611146814 A CN201611146814 A CN 201611146814A CN 106727337 A CN106727337 A CN 106727337A
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- enrofloxacin
- soluble powder
- palmitic acid
- macrogol
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- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 title claims abstract description 130
- 229960000740 enrofloxacin Drugs 0.000 title claims abstract description 130
- 239000000843 powder Substances 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 84
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 48
- 235000021314 Palmitic acid Nutrition 0.000 claims abstract description 42
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims abstract description 42
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229960003511 macrogol Drugs 0.000 claims abstract description 36
- 239000002994 raw material Substances 0.000 claims abstract description 25
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 16
- 229930006000 Sucrose Natural products 0.000 claims abstract description 16
- 239000005720 sucrose Substances 0.000 claims abstract description 16
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 13
- 239000008101 lactose Substances 0.000 claims abstract description 13
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 86
- 239000000203 mixture Substances 0.000 claims description 43
- 238000003756 stirring Methods 0.000 claims description 28
- 238000001035 drying Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 235000019629 palatability Nutrition 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000006184 cosolvent Substances 0.000 abstract description 2
- 230000029087 digestion Effects 0.000 abstract description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 241000204031 Mycoplasma Species 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Enrofloxacin soluble powder, it is made up of the raw material of following percentage by weight：Enrofloxacin 5 15%, palmitic acid 5 20%, natrium carbonicum calcinatum 8 15%, Macrogol 6000 5 15%, balance of carrier.Relative to prior art, beneficial effects of the present invention：The Enrofloxacin soluble powder preparation manipulation that the present invention is provided is easy, it is adapted to industrialization, palmitic acid can promote animal digestion to absorb simultaneously, the present invention is using natrium carbonicum calcinatum and palmitic acid as the cosolvent of Enrofloxacin, increase solubility of the Enrofloxacin soluble powder in water, the present invention increases the palatability of Enrofloxacin soluble powder using anhydrous sucrose and lactose as the odor mask of Enrofloxacin.
Description
Technical field
The invention belongs to veterinary science technical field, and in particular to a kind of Enrofloxacin soluble powder and preparation method thereof.
Background technology
Enrofloxacin（Enrofloxacin）Also known as ENR or Enrofloxacin, belong to the promise ketone of chemical synthesis
Class medicine, is slightly yellow or light yellow crystalline powder, and bitter is water insoluble, is soluble in sodium hydroxide solution, methyl alcohol and cyanogen first
The organic solvents such as alkane.
This medicine is the broad-spectrum sterilization medicine of animal specific, has special efficacy to mycoplasma, is mainly used in a livestock and poultry and pet etc.
The infection that respiratory tract, alimentary canal, Genitourinary etc. are caused by bacterium or mycoplasma.Enrofloxacin is most normal on veterinary clinic
Medicine, is also animal specific medicine.
Common Enrofloxacin formulation has tablet, soluble powder, solution, injection etc. in current veterinary drug clinic.But by
There is strong impulse bitter taste in itself in Enrofloxacin, palatability is poor, be not easy to be administered orally.Enrofloxacin also has a kind of spy
Different bad smell, and the smell of people is difficult to realize.So, improving solubility of the Enrofloxacin in water and covering its bitter taste is
The key of development and application Enrofloxacin.
The content of the invention
The technical problem to be solved in the present invention is that solubility of the Enrofloxacin in water is low and palatability is poor, above-mentioned to solve
Problem, the present invention provides a kind of Enrofloxacin soluble powder and preparation method thereof.
The purpose of the present invention is realized in the following manner：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 5-15%, palmitic acid 5-
20%, natrium carbonicum calcinatum 8-15%, Macrogol 6000 5-15%, balance of carrier.
It is made up of the raw material of following percentage by weight：Enrofloxacin 5-12%, palmitic acid 5-15%, natrium carbonicum calcinatum 8-12%,
Macrogol 6000 5-12%, balance of carrier.
It is made up of the raw material of following percentage by weight：Enrofloxacin 10%, palmitic acid 10%, natrium carbonicum calcinatum 10%, poly- second two
Alcohol 6,000 10%, balance of carrier.
The carrier is at least one in anhydrous sucrose or lactose.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 80-90 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
The ethanol is with the mass ratio of Enrofloxacin（30-50）：1.
Relative to prior art, beneficial effects of the present invention：
1. the Enrofloxacin soluble powder preparation manipulation that the invention is provided is easy, is adapted to industrialization.
2. palmitic acid can promote animal digestion to absorb simultaneously.
3. the present invention increases Enrofloxacin soluble using natrium carbonicum calcinatum and palmitic acid as the cosolvent of Enrofloxacin
Solubility of the powder in water.
4. the present invention increases Enrofloxacin soluble powder using anhydrous sucrose and lactose as the odor mask of Enrofloxacin
Palatability.
Specific embodiment
Embodiment 1：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 5-15%, palmitic acid 5-
20%, natrium carbonicum calcinatum 8-15%, Macrogol 6000 5-15%, balance of carrier.
It is made up of the raw material of following percentage by weight：Enrofloxacin 5-12%, palmitic acid 5-15%, natrium carbonicum calcinatum 8-12%,
Macrogol 6000 5-12%, balance of carrier.
It is made up of the raw material of following percentage by weight：Enrofloxacin 10%, palmitic acid 10%, natrium carbonicum calcinatum 10%, poly- second two
Alcohol 6,000 10%, balance of carrier.
The carrier is at least one in anhydrous sucrose or lactose.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 80-90 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is with the mass ratio of Enrofloxacin（30-50）：1.
Embodiment 2：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 5%, palmitic acid 5% is anhydrous
Sodium carbonate 8%, Macrogol 6000 5%, anhydrous sucrose 37%, lactose 40%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 80 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 30 with the mass ratio of Enrofloxacin：1.
Embodiment 3：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 6%, palmitic acid 6% is anhydrous
Sodium carbonate 9%, Macrogol 6000 6%, anhydrous sucrose 33%, lactose 40%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 81 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 32 with the mass ratio of Enrofloxacin：1.
Embodiment 4：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 7%, palmitic acid 8% is anhydrous
Sodium carbonate 10%, Macrogol 6000 7%, anhydrous sucrose 34%, lactose 34%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 82 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 34 with the mass ratio of Enrofloxacin：1.
Embodiment 5：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 8%, palmitic acid 10% is anhydrous
Sodium carbonate 11%, Macrogol 6000 8%, anhydrous sucrose 33%, lactose 30%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 83 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 36 with the mass ratio of Enrofloxacin：1.
Embodiment 6：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 9%, palmitic acid 11% is anhydrous
Sodium carbonate 12%, Macrogol 6000 9%, anhydrous sucrose 29%, lactose 30%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 83 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 38 with the mass ratio of Enrofloxacin：1.
Embodiment 7：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 10%, palmitic acid 12%, nothing
Aqueous sodium carbonate 13%, Macrogol 6000 10%, lactose 55%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 84 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 40 with the mass ratio of Enrofloxacin：1.
Embodiment 8：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 11%, palmitic acid 13%, nothing
Aqueous sodium carbonate 14%, Macrogol 6000 11%, lactose 46%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 85 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 42 with the mass ratio of Enrofloxacin：1.
Embodiment 9：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 12%, palmitic acid 15%, nothing
Aqueous sodium carbonate 15%, Macrogol 6000 12%, lactose 44.5%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 86 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 44 with the mass ratio of Enrofloxacin：1.
Embodiment 10：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 13%, palmitic acid 16%, nothing
Aqueous sodium carbonate 8.5%, Macrogol 6000 13%, anhydrous sucrose 51%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 88 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 46 with the mass ratio of Enrofloxacin：1.
Embodiment 11：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 14%, palmitic acid 18%, nothing
Aqueous sodium carbonate 9.5%, Macrogol 6000 14%, anhydrous sucrose 49.5%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 89 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 48 with the mass ratio of Enrofloxacin：1.
Embodiment 12：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 15%, palmitic acid 20%, nothing
Aqueous sodium carbonate 10.5%, Macrogol 6000 15%, anhydrous sucrose 39.5%.
The preparation method of above-mentioned Enrofloxacin soluble powder, comprises the following steps that：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 90 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
Ethanol is 50 with the mass ratio of Enrofloxacin：1.
Embodiment 13：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 5%, palmitic acid 5% is anhydrous
Sodium carbonate 8%, Macrogol 6000 5%, anhydrous sucrose 77%.
Other are with embodiment 2.
Embodiment 14：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 12%, palmitic acid 15%, nothing
Aqueous sodium carbonate 12%, Macrogol 6000 12%, anhydrous sucrose 49%.
Other are with embodiment 2.
Embodiment 15：
A kind of Enrofloxacin soluble powder, is made up of the raw material of following percentage by weight：Enrofloxacin 10%, palmitic acid 10%, nothing
Aqueous sodium carbonate 10%, Macrogol 6000 10%, anhydrous sucrose 60%.
Other are with embodiment 2.
Embodiment 2-4 gained Enrofloxacin soluble powders are detected according to veterinary drug national standard compilation specified content, wherein
Including：Proterties, discriminating, loss on drying, appearance uniform degree, dissolubility, content, concrete outcome are as shown in table 1.
As shown in Table 1：Enrofloxacin soluble powder prepared by the present invention is white powder, and every quality inspection index meets beast
Medicine national standard collects.
Dissolubility is determined：Enrofloxacin soluble powder 1g described in above-described embodiment 2-4 is added in 100 ml water, water
Solution clear, any dilution, occurs without turbid phenomenon, temperature is raised and lowered and does not also have anomaly.Illustrate the present invention
Embodiment has good dissolubility, and solubility is higher.
The preparation process is simple of the Enrofloxacin soluble powder that the present invention is provided, raw material is cheap and easy to get, with low cost, and its
Due to being pulvis, gained compound preparation stable performance, be difficult because by ambient temperature, the influence of humidity and caused by pulvis change colour
With active ingredient failure etc., it is easier to store and transports compared to liquid preparation, meet pharmacopeia relevant regulations, it is adapted to the big rule of industrialization
Mould is produced, and application prospect is very wide.Enrofloxacin soluble powder prepared by the present invention just has very well in common drinking water
Dissolubility, solution clarification carries out arbitrary proportion and dilutes appearance without exception, without purifying water, greatly facilitates culturist
Medication, very well, be administered orally easily to be taken in by poultry absorbs palatability.
Above-described is only the preferred embodiment of the present invention, it is noted that for a person skilled in the art,
Under the premise of general idea of the present invention is not departed from, some changes and improvements can also be made, these should also be considered as of the invention
Protection domain.
Claims (6)
1. a kind of Enrofloxacin soluble powder, it is characterised in that：It is made up of the raw material of following percentage by weight：Enrofloxacin 5-
15%, palmitic acid 5-20%, natrium carbonicum calcinatum 8-15%, Macrogol 6000 5-15%, balance of carrier.
2. Enrofloxacin soluble powder according to claim 1, it is characterised in that：By the raw material of following percentage by weight
It is made：Enrofloxacin 5-12%, palmitic acid 5-15%, natrium carbonicum calcinatum 8-12%, Macrogol 6000 5-12%, balance of carrier.
3. Enrofloxacin soluble powder according to claim 1, it is characterised in that：By the raw material of following percentage by weight
It is made：Enrofloxacin 10%, palmitic acid 10%, natrium carbonicum calcinatum 10%, Macrogol 6000 10%, balance of carrier.
4. Enrofloxacin soluble powder according to claim 1, it is characterised in that：The carrier is anhydrous sucrose or lactose
In at least one.
5. the preparation method of the Enrofloxacin soluble powder as described in claim 1-4 is any, it is characterised in that：Specific steps are such as
Under：
（1）By in Enrofloxacin and palmitic acid addition blending tank, it is well mixed；
（2）To step（1）Ethanol is added in obtained mixture, stirring makes ethanol volatilize at 80-90 DEG C again after stirring；
（3）Carrier is added to step（2）In obtained mixture, drying is sufficiently mixed；
（4）Natrium carbonicum calcinatum and Macrogol 6000 are added to step（3）In obtained mixture, crush, be well mixed, i.e.,
Obtain Enrofloxacin soluble powder.
6. the preparation method of Enrofloxacin soluble powder according to claim 5, it is characterised in that：The ethanol and grace promise
The mass ratio of Sha Xing is（30-50）：1.
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