CN102038643A - Enrofloxacin soluble powder and preparation method and application thereof - Google Patents
Enrofloxacin soluble powder and preparation method and application thereof Download PDFInfo
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- CN102038643A CN102038643A CN 201010582317 CN201010582317A CN102038643A CN 102038643 A CN102038643 A CN 102038643A CN 201010582317 CN201010582317 CN 201010582317 CN 201010582317 A CN201010582317 A CN 201010582317A CN 102038643 A CN102038643 A CN 102038643A
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Abstract
The invention provides enrofloxacin soluble powder and a preparation method and application thereof, and can solve the problem of poor sterilizing effect due to lower solubility of enrofloxacin in water in the prior art. A technical scheme is that: the enrofloxacin soluble powder is a mixture of enrofloxacin and solid inorganic alkali or organic alkali according to a weight ratio of (1-10):1. The invention also provides a preparation method and application of the enrofloxacin soluble powder. The invention solves the problem of low solubility of the enrofloxacin in the water, and overcomes the defect of poor curative effect due to low enrofloxacin concentration caused by taking the medicine with water.
Description
Technical field
The invention belongs to the medicine new technical field, specifically, relate to a kind of enrofloxacin soluble powder and its production and application.
Background technology
Quinolones (quinolones) is the bactericidal properties antimicrobial drug of a class synthetic, has has a broad antifungal spectrum, characteristics that antimicrbial power is strong.What be widely used at present is third generation product-fluoroquinolones, as ciprofloxacin, enrofloxacin, ofloxacin, norfloxacin, pefloxacin etc.Wherein enrofloxacin enjoys veterinary circle to pay attention to as the animal specific antibacterials.China succeeded in developing in 1993, now had been widely used in veterinary clinic.Enrofloxacin has has a broad antifungal spectrum, sterilizing power is strong, effect is rapid, body is interior widely distributed based on characteristics such as no cross resistances between other antibiotic, and bacterial infection and the mycoplasma of prevention and treatment poultry also obtain good effect.
The enrofloxacin molecular formula is C
19H
22FN
3O
3, molecular weight is 359.40.Outward appearance is little yellow or greenish orange yellow crystalline powder, odorless, bitter in the mouth; Meet photochromic fade to orange red.Easily molten in chloroform, molten in the dimethyl formamide part omitted, slightly soluble in ethanol, soluble,very slightly in water, 221～226 ℃ of fusing points.
Enrofloxacin is at its female ring C
6The fluorine atom of last introducing is the feature substituent group of fluoroquinolones, and it can strengthen the inhibition ability to the DNA of bacteria helicase, and can improve the bacterium to G+, as staphylococcic antibacterial action; C
7The piperazinyl of introducing on the position not only can strengthen the antibacterial ability of medicine, but also can enlarge the antimicrobial spectrum of medicine, has side effects but also can induce.Enrofloxacin has also been introduced ethyl on piperazinyl, when the enhancing medicine is to tissue penetration, also reduced the toxic action of medicine to the central nervous system.Enrofloxacin has been widely used in livestock and poultry breeding industry at present, is mainly used in treatment fowl bacterial disease and mycoplasma infection.
Enrofloxacin metabolism in animal body is comparatively complicated, and the different genera animal there are differences, and is ciprofloxacin but all can take off the ethyl metabolism to some extent.The animal species difference, the metabolic rate difference of ciprofloxacin.Because ciprofloxacin is better than enrofloxacin to the antibacterial activity of poultry various pathogens, to consider the concentration of enrofloxacin and ciprofloxacin when therefore enrofloxacin is active in estimating blood plasma and tissue simultaneously.After Van-cutsem etc. (1990) report enrofloxacin entered animal body, about 10%～50% can be absorbed by animal body, and is distributed in very soon in body tissue and the body fluid.Xiao Tianan etc. (2002) studies show that enrofloxacin eliminates slowly in vivo, and long half time is 19.47h pig during with intravenous injection.Enrofloxacin is mainly by renal excretion, and secondly by liver, major metabolite is original shape and ciprofloxacin.Enrofloxacin and metabolite ciprofloxacin thereof combined effect in animal body are the maximum characteristics of this medicine, also are that this drug effect really is better than other similar medicines and a major reason of extensive use in animal.
Meinen etc. (1995) studies show that the enrofloxacin bactericidal action has concentration dependent, and in tissue and blood plasma, the concentration of enrofloxacin must be higher and be kept the sufficiently long time and could play inhibitory action to the target pathogen.So improve the concentration of enrofloxacin, increase the bactericidal effect that the dissolubility of enrofloxacin in water can improve enrofloxacin.But how improving the dissolubility of enrofloxacin in water then is the problem that the present invention faced.
Summary of the invention
The invention provides a kind of enrofloxacin soluble powder and its production and application, can solve that prior art exists because the low bad problem of bactericidal effect that causes of the dissolubility of enrofloxacin in water.
For solving the problems of the technologies described above, the present invention adopts following technical proposals,
A kind of enrofloxacin soluble powder, described enrofloxacin soluble powder are the mixture of enrofloxacin and solid inorganic bases or organic bases, and its mass ratio is 1～10: 1.
The present invention adopts and adds cosolvent as the technological means that increases drug solubility, cosolvent adopts solid inorganic bases or organic bases, by with enrofloxacin and solid inorganic bases or organic bases being 1～10: 1 mixed according to mass ratio, the enrofloxacin soluble powder that makes has solved enrofloxacin insoluble problem in water, has remedied the insufficient problem of enrofloxacin curative effect of prior art.
Specifically, described solid inorganic bases or organic bases comprise one or more in carboxylate, amine, phosphate, sulphite, bicarbonate, carbonate, the alkali metal hydroxide.Certainly be not limited to the above-mentioned classification of enumerating.
For example, described solid inorganic bases or organic bases can adopt one or more in sodium acetate, potassium acetate, sodium propionate, potassium butyrate, meglumine, sodium phosphate, sodium sulfite, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, sodium hydroxide, the potassium hydroxide.
A kind of preparation method of enrofloxacin soluble powder may further comprise the steps:
(1) pulverize, sieve: according to the mass ratio of enrofloxacin and solid inorganic bases or organic bases is 1～10: 1 prescription extraction raw material, and pulverizes respectively, sieves respectively then;
(2) mix: will mix mix homogeneously 30-60 minute in the enrofloxacin behind the above-mentioned crushing screening and solid inorganic bases or the organic bases input mixer;
(3) packing gets the enrofloxacin soluble powder.
Described enrofloxacin soluble powder preparation be used for the treatment of mycoplasma gallinarum disease (chronic respiratory tract disease), avian colibacillosis, Pullorum Disease, fowl salmonellosis, fowl pasteurellosis, piglet pujos blancos, yellow scours, in application in the medicine of the mycoplasma of the swollen property bronchopneumonia of mycoplasma, pleuropneumonia, baby swine paratyphoid and cattle, sheep, rabbit, dog of big bowel oedema disease type colibacillosis, pig and bacterial disease.In addition, all kinds of bacterial infections that also can be used for aquatic animal.
Wherein, the purity of the enrofloxacin that is adopted is 90%～100%, and the solid inorganic alkali that is adopted or the purity of organic bases are 90～100%.
The enrofloxacin soluble powder that the present invention makes is light yellow to white powder, and its advantage is soluble in water, is convenient to store and transportation cold and hot stable storing.During use it is added in the water, through stirring, powder can very fast diffusion dissolution in water, have the concentration height, water blockoff line is not easy to animal and takes in and good advantage such as absorb, and its companion is used in feedstuff also can.
The specific embodiment
The present invention is described in further detail below in conjunction with examples of implementation.
A kind of enrofloxacin soluble powder, described enrofloxacin soluble powder are the mixture of enrofloxacin and solid inorganic bases or organic bases, and its mass ratio is 1～10: 1.
Describe in detail below in conjunction with the concrete preparation method of enrofloxacin soluble powder.
Embodiment 1
A kind of enrofloxacin soluble powder is the mixture of enrofloxacin and sodium hydroxide, and its preparation method is as follows:
(1), crosses 50 mesh sieves respectively with enrofloxacin and sodium hydroxide pulverize separately;
(2) enrofloxacin and sodium hydroxide are pressed mass ratio drops in mixer and mixed 30 minutes at 5: 1;
(3) packing.
Embodiment 2
A kind of enrofloxacin soluble powder is the mixture of enrofloxacin and potassium acetate, and its preparation method is as follows:
(1), crosses 50 mesh sieves respectively with enrofloxacin and potassium acetate pulverize separately;
(2) enrofloxacin and potassium acetate are pressed mass ratio drops in mixer and mixed 30 minutes at 3: 1;
(3) packing.
Embodiment 3
A kind of enrofloxacin soluble powder is the mixture of enrofloxacin and potassium hydroxide, and its preparation method is as follows:
(1), crosses 50 mesh sieves respectively with enrofloxacin and potassium hydroxide pulverize separately;
(2) enrofloxacin and potassium hydroxide are pressed mass ratio drops in mixer and mixed 30 minutes at 3: 1;
(3) packing.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment did, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (5)
1. enrofloxacin soluble powder, it is characterized in that: described enrofloxacin soluble powder is the mixture of enrofloxacin and solid inorganic bases or organic bases, its mass ratio is 1～10: 1.
2. enrofloxacin soluble powder according to claim 1 is characterized in that: described solid inorganic bases or organic bases comprise one or more in carboxylate, amine, phosphate, sulphite, bicarbonate, carbonate, the alkali metal hydroxide.
3. enrofloxacin soluble powder according to claim 2 is characterized in that: described solid inorganic bases or organic bases are one or more in sodium acetate, potassium acetate, sodium propionate, potassium butyrate, meglumine, sodium phosphate, sodium sulfite, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, sodium hydroxide, the potassium hydroxide.
4. the preparation method of the described enrofloxacin soluble powder of claim 1 is characterized in that may further comprise the steps:
(1) pulverize, sieve: extract enrofloxacin and solid inorganic bases or organic bases according to the described prescription of claim 1, and pulverize respectively, sieve respectively then, the order that sieves is counted scope between the 30-100 order;
(2) mix: will mix mix homogeneously 30-60 minute in the enrofloxacin behind the above-mentioned crushing screening and solid inorganic bases or the organic bases input mixer;
(3) packing gets the enrofloxacin soluble powder.
5. described enrofloxacin soluble powder preparation be used for the treatment of mycoplasma gallinarum disease, avian colibacillosis, Pullorum Disease, fowl salmonellosis, fowl pasteurellosis, piglet pujos blancos, yellow scours, in application in the medicine of the mycoplasma of the swollen property bronchopneumonia of mycoplasma, pleuropneumonia, baby swine paratyphoid and cattle, sheep, rabbit, dog of big bowel oedema disease type colibacillosis, pig and bacterial disease.
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| CN 201010582317 CN102038643A (en) | 2010-12-10 | 2010-12-10 | Enrofloxacin soluble powder and preparation method and application thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103126982A (en) * | 2013-03-07 | 2013-06-05 | 庞永中 | Novel veterinary medicament meglumine enrofloxacin injection and preparation method thereof |
| CN105213402A (en) * | 2015-09-30 | 2016-01-06 | 洛阳市兽药厂 | A kind of poultry compound enrofloxacin meloxicam soluble powder |
| CN105412019A (en) * | 2016-01-11 | 2016-03-23 | 郭敏 | Soluble enrofloxacin powder and preparation method thereof |
| CN105434359A (en) * | 2016-01-11 | 2016-03-30 | 郭敏 | Enrofloxacin preparation and preparation method thereof |
| CN105534916A (en) * | 2016-01-18 | 2016-05-04 | 郭敏 | Enrofloxacin soluble preparation and preparation method thereof |
| CN105902499A (en) * | 2016-06-16 | 2016-08-31 | 郑州百瑞动物药业有限公司 | Enrofloxacin soluble powder and preparation method thereof |
| CN105943503A (en) * | 2016-06-15 | 2016-09-21 | 广东海洋大学 | Efficient enrofloxacin powder and preparation method thereof |
| CN106727337A (en) * | 2016-12-13 | 2017-05-31 | 河南后羿实业集团有限公司 | A kind of Enrofloxacin soluble powder and preparation method thereof |
| CN107412189A (en) * | 2017-09-15 | 2017-12-01 | 浙江万方生物科技有限公司 | A kind of odor-masking enrofloxacin soluble powder and preparation method thereof |
| CN115737567A (en) * | 2022-10-19 | 2023-03-07 | 湖南中科汇智信息服务有限公司 | Enrofloxacin soluble powder capable of reducing bitter taste and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273092A (en) * | 2000-04-04 | 2000-11-15 | 华南农业大学 | Water-soluble powdered quinolone medicines |
| CN101810666A (en) * | 2010-04-23 | 2010-08-25 | 重庆金邦动物药业有限公司 | Veterinary synergic enrofloxacin injection and preparation method thereof |
-
2010
- 2010-12-10 CN CN 201010582317 patent/CN102038643A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273092A (en) * | 2000-04-04 | 2000-11-15 | 华南农业大学 | Water-soluble powdered quinolone medicines |
| CN101810666A (en) * | 2010-04-23 | 2010-08-25 | 重庆金邦动物药业有限公司 | Veterinary synergic enrofloxacin injection and preparation method thereof |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103126982A (en) * | 2013-03-07 | 2013-06-05 | 庞永中 | Novel veterinary medicament meglumine enrofloxacin injection and preparation method thereof |
| CN105213402A (en) * | 2015-09-30 | 2016-01-06 | 洛阳市兽药厂 | A kind of poultry compound enrofloxacin meloxicam soluble powder |
| CN105213402B (en) * | 2015-09-30 | 2018-12-18 | 洛阳市兽药厂 | A kind of livestock and poultry compound enrofloxacin Meloxicam soluble powder |
| CN105412019A (en) * | 2016-01-11 | 2016-03-23 | 郭敏 | Soluble enrofloxacin powder and preparation method thereof |
| CN105434359A (en) * | 2016-01-11 | 2016-03-30 | 郭敏 | Enrofloxacin preparation and preparation method thereof |
| CN105534916A (en) * | 2016-01-18 | 2016-05-04 | 郭敏 | Enrofloxacin soluble preparation and preparation method thereof |
| CN105943503A (en) * | 2016-06-15 | 2016-09-21 | 广东海洋大学 | Efficient enrofloxacin powder and preparation method thereof |
| CN105902499B (en) * | 2016-06-16 | 2018-10-19 | 郑州百瑞动物药业有限公司 | Enrofloxacin soluble powder and preparation method thereof |
| CN105902499A (en) * | 2016-06-16 | 2016-08-31 | 郑州百瑞动物药业有限公司 | Enrofloxacin soluble powder and preparation method thereof |
| CN106727337A (en) * | 2016-12-13 | 2017-05-31 | 河南后羿实业集团有限公司 | A kind of Enrofloxacin soluble powder and preparation method thereof |
| CN107412189A (en) * | 2017-09-15 | 2017-12-01 | 浙江万方生物科技有限公司 | A kind of odor-masking enrofloxacin soluble powder and preparation method thereof |
| CN107412189B (en) * | 2017-09-15 | 2019-12-17 | 浙江万方生物科技有限公司 | Taste-masking enrofloxacin soluble powder and preparation method thereof |
| CN115737567A (en) * | 2022-10-19 | 2023-03-07 | 湖南中科汇智信息服务有限公司 | Enrofloxacin soluble powder capable of reducing bitter taste and preparation method thereof |
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Owner name: QINGDAO KDN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: QINGDAO CONTINENT BIOTECH CO., LTD. Effective date: 20120508 |
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Address after: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Applicant after: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. Co-applicant after: Qingdao Agricultural University Address before: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Applicant before: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20120508 Address after: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Applicant after: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. Address before: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Applicant before: Qingdao Vland Biotech INC. |
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Application publication date: 20110504 |