CN105454685A - Application of tannin micro-capsule in preparation of pig feed additive - Google Patents
Application of tannin micro-capsule in preparation of pig feed additive Download PDFInfo
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- CN105454685A CN105454685A CN201510908286.8A CN201510908286A CN105454685A CN 105454685 A CN105454685 A CN 105454685A CN 201510908286 A CN201510908286 A CN 201510908286A CN 105454685 A CN105454685 A CN 105454685A
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Abstract
The invention discloses an application of a tannin micro-capsule in preparation of a pig feed additive. According to the tannin micro-capsule and an oral preparation thereof, the problem about tannin palatability to pigs is remarkably solved, meanwhile, the oral preparation adopting gastrointestinal drug delivery is provided for the tannin as an antidiarrheal agent and a pig growth accelerant, and the tannin micro-capsule and the oral preparation thereof are the novel and safe pig feed additive with low side effects, are used for promoting pig growth and have broad application prospect in the pig breeding industry.
Description
Technical field:
The invention belongs to feed additive field, be specifically related to tannin micro-capsule and preparing the application in pig's feed additive.
Background technology:
Utilize macromolecular material that is natural or synthesis as cyst membrane wall shell, diameter solid-state drug or liquid drug wrapped up, at the small Drug Storage type capsule of 1-5000 micron, is called microencapsulation or micro-capsule.The preparation process of microencapsulation is called microencapsulation.Medicament microcapsuleization can improve the stability of medicine, the bad stink covering medicine and taste, prevent medicine intestines and stomach inactivation, reduce medicine to GI excitant, slowly-releasing or controlled release drug, make liquid drug solid state, reduce the compatible change of medicine and make drug accumulation in features such as target areas.Microencapsulation medicine also can make the microencapsulated formulation such as tablet, capsule, injection further.
Tannin, also known as tannic acid or tannin, be the plant component with skin of tanning, complex structure, main body is multivalence phenol, odorless, micro-have special odor, and taste is extremely puckery, energy precipitating proteins, form insoluble compound with alkaloid, glucoside or heavy metal, pharmaceutically acceptable as astringent, local is used for various wound and inflammation and combines the diarrhoea caused for acute chronic enteritis, functional or irritable bowel syndrome with antimicrobial or antiviral agent.Tannin low toxicity, has stronger chronic injury to stomach, oral irritant to stomach lining, and can cause nausea vomiting, and it is even dead that local has absorbed the poisoning liver serious toxicity that causes for breakage.Thus, solve by formulation the problem that the special odor of tannin, puckery and toxic and side effect etc. be unfavorable for using, at present formulation have glycerinum acidi tannici, tannic acid ointment and tannalbin.The people of tannalbin has tablet, powder and capsule by formulation.But in animal-use drug field, the enabled production of tannic acid has tannalbin, be used from the treatment of the functional or challenges diarrhoea of the infectivity of domestic birds and animals with antimicrobial, antiviral agent and fluid infusion salt one.Visible, in animal-use drug field, the product category of tannic acid occupation mode that is limited and specific products limited and due to do not have formulation specification cause medication inconvenience.
Summary of the invention:
The object of this invention is to provide tasteless non-irritating tannin micro-capsule and prepare the application in pig's feed additive.
Tannin is polyphenols, has special taste, taste extremely puckery, has convergence, precipitable albumen and alkaloid, and the treatment for the digestive system inflammation of animal or human has protection enteron aisle effect impaired further.Tannin has excitant, and oral medication has excitant to intestines and stomach and then has chronic injury.The tannin (tannin capsule) of microencapsulation, the stability that can improve tannin to a certain extent slows down the oxidation of polyphenol, cover the peculiar taste that tannin itself has, overcome puckery to improve the compliance used, and enter into enteron aisle by alimentary canal with the destruction that stable form removes various enzyme and chemical environment in gastric juice from and to dissociate under the effect of corresponding pH value and biology enzyme system tannic acid and play pharmacologically active, make the protein precipitation in intestinal mucosa top layer, form layer protecting film and abirritate, reduce inflammatory exudate and reduce enterocinesia and play astringing to arrest diarrhea.
The present invention is found by test, in study on the stability test, get Chinese tannin and Chinese tannin gelatin microcapsule is placed in clean measuring cup in right amount, stand straticulation, the interior placement after 10 days of insulating box being placed in 60 DEG C respectively tests purity, and result shows that Chinese tannin gelatin microcapsule significantly can improve the stability of Chinese tannin.What test Chinese tannin gelatin microcapsule was taken food on animal subject affects situation, and add multi-form Chinese tannin in feed after, the feed intake of Chinese tannin gelatin microcapsule group test pig is unaffected; And the feed intake of Chinese tannin group test pig all significantly reduces, the Chinese tannin test group test pig of wherein adding 200ppm all shows food refusal.Then in pork pig feed, add the Chinese tannin gelatin microcapsule of various dose, to feed respectively again pork pig, the Chinese tannin gelatin microcapsule of result of the test display various dose all can improve the weightening finish of test pig compared with control group, and has improvement in various degree to feedstuff-meat ratio.Illustrate thus, Chinese tannin gelatin microcapsule has growth promoting function, can use, particularly use as pig growth promoter as pig's feed additive.
Therefore, the invention provides tasteless non-irritating tannin micro-capsule and prepare the application in pig's feed additive, particularly as the application in pig growth promoter.
Described tannin micro-capsule and microencapsulation tannin, be made up of capsule material and capsule core material, and described capsule core material is tannin.
In a technical scheme, the capsule material of tannin micro-capsule is selected from gelatin, Arabic gum, sodium alginate, shitosan, protein substance etc.
In another technical scheme, the capsule material of tannin micro-capsule is selected from sodium carboxymethylcellulose, CAP, ethyl cellulose, methylcellulose etc.
In another technical scheme, the capsule material of tannin micro-capsule is selected from polyacrylic resin, polyvinyl alcohol, poly-carbon ester, polyaminoacid, glycolide copolymer, the polylactic acid-polyglycol section of owing copolymer etc.
In another technical scheme, the capsule core material tannin of tannin micro-capsule is selected from the vegatable tannins such as Chinese tannin, Valonia tannin, black wattle bark tannins, chestnut tannin, talas of tannic acid or larch tannin.
The independent enforcement of above-mentioned either a program or under not conflicting precursor Joint Implementation tasteless non-irritating tannin micro-capsule is provided.
On the other hand, the invention provides the preparation method of tannin micro-capsule, can carry out in the liquid phase.In tannin and capsule material mixed solution, add another kind of material or poor solvent, or by proper method, capsule material solubility reduced and condense upon around tannin, form micro-capsule.
In another arrangement, the preparation of tannin micro-capsule is dispersed in by tannin in capsule material solution to obtain micro-capsule by spraying dry.
In another arrangement, tannin is dispersed in the capsule material of melting and obtains micro-capsule by congealing spray.
In another arrangement, tannin is at the effect low suspension of vertical air blast in dressing room, and capsule material solution is sprayed in tannin surface by nozzle, and thermal current volatilizes capsule material solvent and obtains micro-capsule.
On the other hand, the present inventor is used at tannin micro-capsule finding while tannin micro-capsule has the symptom of diarrhea alleviating infected test pig, healthy test pig to be had to the effect of growth promoting effects in the feeding experiment of pork pig.
In a scheme, tannin micro-capsule, at the 50-2000ppm of the consumption that the growth promotion of healthy test pig is studied to be effective dose tannin be test feed, is preferably 500-1000ppm.
On the other hand, described tannin micro-capsule can take, takes through drinking-water or take through feed by per os tank.
Described tannin micro-capsule and pharmaceutically acceptable excipient, carrier, antioxidant, anti-caking agent, diluent, disintegrant, solvent or their combination are prepared into peroral dosage form easy to use through preparation process.
Described peroral dosage form can take, takes through drinking-water or take through feed by per os tank.
Described peroral dosage form comprises tablet, granule, powder, pulvis, pre-mixing agent, drinking agent, pill, capsule, supensoid agent, emulsion.
Described peroral dosage form has specific standard, and each independently medication unit has the effective content of regulation.
Tannin micro-capsule provided by the invention and peroral dosage form thereof, change the palatability problems of pig to tannin significantly, simultaneously for providing the peroral dosage form through alimentary canal administration as the tannin of antidiarrheic and pig growth promoter, for the pig's feed additive of novel, safety, few side effects, for promoting the growth of pig, be with a wide range of applications in swine rearing industry.
Detailed description of the invention:
In order to describe the present invention, below list embodiment.But need be appreciated that and the invention is not restricted to these embodiments, only be to provide and put into practice method of the present invention.
The preparation of embodiment 1 Chinese tannin gelatin microcapsule
At temperature is 25 DEG C, Chinese tannin 10g is dissolved in the gelatin solution of mass fraction 4%, adds mass fraction 10% acetum and be adjusted to pH3.5-3.8, add mass fraction 60%Na
2sO
4the aqueous solution makes gelatin separate out in right amount.Reactant liquor is cooled to 15 DEG C, it is appropriate to add mass fraction 37% formalin under stirring, then adds mass fraction 20%NaOH solution and be adjusted to pH7 and obtain Chinese tannin gelatin solidification capsule, suction filtration, is washed to formaldehydeless Chinese tannin gelatin microcapsule.The content of Chinese tannin in micro-capsule is mass fraction 27.4%.
The stability study of embodiment 2 Chinese tannin gelatin microcapsule
Respectively Chinese tannin gelatin microcapsule (prepared by embodiment 1) and Chinese tannin are placed in measuring cup, place 10 days under 60 DEG C of conditions, in the 0th day, the 5th day and sampling in the 10th day, by purity analysis condition test purity, result shows that Chinese tannin all there occurs larger change in the 5th day and the 10th day purity under temperature 60 C, and Chinese tannin gelatin microcapsule then purity keeps stable (table 1).
Purity analysis after the high-temperature process of table 1 Chinese tannin and micro-capsule thereof
| Test sample | 0 day/% | 5 days/% | 10 days/% |
| Chinese tannin | 94.70 | 76.32 | 40.34 |
| Chinese tannin gelatin microcapsule | 94.10 | 94.07 | 94.06 |
Embodiment 3 Chinese tannin gelatin microcapsule is on the impact of pig feed palatability
The DLY ternary that 70 105 age in days body weight are close healthy pork pig such as table 2 of mixing is divided into 7 test group, often organizes 10 pigs.Often group adds the Chinese tannin of multi-form various dose as shown in table 2 respectively in basal feed, and wherein micro-capsule represents Chinese tannin gelatin microcapsule prepared by embodiment 1.The synchronous fasting of 12h before all test pig tests, after 12h each group test pig respectively free choice feeding contain the feed of the given the test agent of various dose, observe 30-60 minute, until when test pig is no longer searched for food, the feed consumption of statistics different tests group, evaluates and add the impact of multi-form Chinese tannin on pig feed intake in feed.Not add the only simple feed of any type of Chinese tannin as a control group.Result shows, add multi-form Chinese tannin in feed after, the feed intake of Chinese tannin gelatin microcapsule group test pig is unaffected; And the feed intake of Chinese tannin group test pig all significantly reduces, the Chinese tannin test group test pig of wherein adding 200ppm all shows food refusal (table 2).
Table 2 Chinese tannin gelatin microcapsule is on the test grouping of the impact of pig feed food mouth
Embodiment 4 Chinese tannin gelatin microcapsule is to pork pig growth promotion test effect
65 ages in days Du that 120 body weight are close greatly enhance ternary lean meat species piggy of mixing and are divided into 6 groups at random, often organize 20.The Chinese tannin gelatin microcapsule adding various dose is often organized by table 3.Experimental period free choice feeding and drinking-water, totally 28 days experimental period.The Chinese tannin gelatin microcapsule of result of the test display various dose all can improve the weightening finish of test pig compared with control group, and has improvement in various degree to feedstuff-meat ratio, test grouping and the results are shown in Table 3.
The different Chinese tannin gelatin microcapsule of table 3 is on the packet design of pork pig production performance impact test and result of the test
| Group | Experiment quantity | Add material | Dosage (ppm) | Average daily gain (g) | Feedstuff-meat ratio |
| 1 | 20 | - | - | 484 | 1.796 |
| 2 | 20 | Chinese tannin gelatin microcapsule | 200 | 482 | 1.803 |
| 3 | 20 | Chinese tannin gelatin microcapsule | 500 | 495 | 1.756 |
| 4 | 20 | Chinese tannin gelatin microcapsule | 1000 | 687 | 1.265 |
| 5 | 20 | Chinese tannin gelatin microcapsule | 2000 | 688 | 1.263 |
| 6 | 20 | Chinese tannin gelatin microcapsule | 4000 | 690 | 1.260 |
Claims (10)
1. tannin micro-capsule is preparing the application in pig's feed additive.
2. application according to claim 1, is characterized in that, described tannin micro-capsule comprise form micro-capsule shell capsule material and shell in capsule core material tannin.
3. application according to claim 2, is characterized in that, described capsule material is protein-based, natural plant gum class, polysaccharide or cellulose and cellulose derivative family macromolecule material.
4. application according to claim 2, it is characterized in that, described capsule material is gelatin, Arabic gum, sodium alginate, shitosan, sodium carboxymethylcellulose, CAP, ethyl cellulose, methylcellulose, polyacrylic resin, polyvinyl alcohol, poly-carbon ester, polyaminoacid, glycolide copolymer or the polylactic acid-polyglycol section of owing copolymer.
5. application according to claim 2, is characterized in that, described tannin is Chinese tannin, Valonia tannin, black wattle bark tannins, chestnut tannin, talas of tannic acid or larch tannin.
6. application according to claim 1, is characterized in that, described pig's feed additive is pig growth promoter.
7. application according to claim 6, is characterized in that, the weight ratio of tannin content in feed of described pig growth promoter is 50-2000ppm.
8. application according to claim 7, is characterized in that, the weight ratio of tannin content in feed of described pig growth promoter is 500-1000ppm.
9. application according to claim 1 and 2, is characterized in that, described pig's feed additive is oral formulations.
10. application according to claim 9, is characterized in that, described oral formulations comprises tablet, supensoid agent, emulsion, pill, drinking agent, pre-mixing agent or powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510908286.8A CN105454685A (en) | 2015-12-09 | 2015-12-09 | Application of tannin micro-capsule in preparation of pig feed additive |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106490338A (en) * | 2016-11-07 | 2017-03-15 | 四川亭江新材料股份有限公司 | Tower draws application and its feed addictive of the powder in feed, feed |
| CN107307205A (en) * | 2017-07-07 | 2017-11-03 | 深圳市金新农科技股份有限公司 | It is a kind of for the compositions of additives of pig starter feed, compound premix and nonreactive pig starter feed |
| CN110012976A (en) * | 2019-02-25 | 2019-07-16 | 周荣 | A kind of preparation method of microencapsulation pannage enzyme preparation |
| CN112314780A (en) * | 2020-11-25 | 2021-02-05 | 天津邦元生物科技有限公司 | Reinforcing agent for regulating and controlling intestinal health of livestock and poultry and preparation method thereof |
| CN114831222A (en) * | 2022-05-24 | 2022-08-02 | 上海美农生物科技股份有限公司 | Coated tannin pellet feed additive and preparation method thereof |
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| CN102715352A (en) * | 2012-05-11 | 2012-10-10 | 北京农学院 | Application of chestnut involucre extract in improving health and growth performance of livestock and poultry |
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| CN102715352A (en) * | 2012-05-11 | 2012-10-10 | 北京农学院 | Application of chestnut involucre extract in improving health and growth performance of livestock and poultry |
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| 冯怡等: "中药提取物微囊化防潮技术及其机理研究", 《2006年第六届中国药学会学术年会论文集》 * |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106490338A (en) * | 2016-11-07 | 2017-03-15 | 四川亭江新材料股份有限公司 | Tower draws application and its feed addictive of the powder in feed, feed |
| CN107307205A (en) * | 2017-07-07 | 2017-11-03 | 深圳市金新农科技股份有限公司 | It is a kind of for the compositions of additives of pig starter feed, compound premix and nonreactive pig starter feed |
| CN110012976A (en) * | 2019-02-25 | 2019-07-16 | 周荣 | A kind of preparation method of microencapsulation pannage enzyme preparation |
| CN112314780A (en) * | 2020-11-25 | 2021-02-05 | 天津邦元生物科技有限公司 | Reinforcing agent for regulating and controlling intestinal health of livestock and poultry and preparation method thereof |
| CN114831222A (en) * | 2022-05-24 | 2022-08-02 | 上海美农生物科技股份有限公司 | Coated tannin pellet feed additive and preparation method thereof |
| CN114831222B (en) * | 2022-05-24 | 2023-10-13 | 上海美农生物科技股份有限公司 | Coated tannin micropill feed additive and preparation method thereof |
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Application publication date: 20160406 |