CN106491534A - A kind of nanometer silver antimicrobial is controlled tinea pedis spraying and prepares and apply - Google Patents
A kind of nanometer silver antimicrobial is controlled tinea pedis spraying and prepares and apply Download PDFInfo
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- CN106491534A CN106491534A CN201610953104.3A CN201610953104A CN106491534A CN 106491534 A CN106491534 A CN 106491534A CN 201610953104 A CN201610953104 A CN 201610953104A CN 106491534 A CN106491534 A CN 106491534A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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Abstract
The invention discloses a kind of nanometer silver antimicrobial is controlled tinea pedis spraying and prepares and apply, mixed by following components by weight percentage：Skin moisturizing agent 0.1% 3%；Nano silver colloidal sol dispersion liquid 0.005% 0.05%；Water adds to 100%；Product spraying is colourless, transparent, stability is strong, antibacterial/bacteriostasis property is good, and pH controls scope 6 ~ 8.The present invention without organic antibacterial agent, but with Nano Silver as antibacterial, bacteriostatic agent, and have functions that anti-inflammation, accelerate to repair impaired skin.Also, the present invention has, and great spectrum is antibacterial, bactericidal action, can long-acting antimycotic and not produce drug resistance.Originally control sprayed after tinea pedis spray is swung very convenient, and can also be antipruritic, eliminate tinea pedis germ, reach the purpose for curing tinea pedis, can solve pin itch, rotten, rotten hardship.
Description
Technical field
The present invention relates to beriberi liquor technical field, and in particular to a kind of nanometer silver antimicrobial is controlled tinea pedis spraying and prepares and answer
With.
Background technology
Tinea pedis, is commonly called as athlete's foot, and its pathogen is fungi, has red mentagrophytes, cotton-shaped tinea in the main fungal for causing tinea pedis
Bacterium or Candida albicans etc..Though tinea pedis is true bacterium infection, different types, such as the papule scales of skin that peel off can be divided into according to symptom
Type, hyperkeratotic pattern, bubble type, interphalangeal erosion type etc..
The medicine for the treatment of tinea pedis is a lot, but all there are some shortcomings：Western medicine antimycotic medicine general all water insoluble and
Alcohol, it is impossible to make water soluble preparation, makes ointment and is unfavorable for that skin absorption, medicine can not be fully utilized.And it is such
Medicine has been used many and has easily been developed immunity to drugs, and makes tinea pedis delay difficulty heal；Some are such as in the pharmaceutical formulation of Compound Flavescent Sophora and Salicylic Acid Powder, JIAOXIAN YICIJING etc.
Benzoic acid, salicylic acid, glacial acetic acid etc. is used, for promoting to peel（Cuticula is made to come off）, cause locally to occur after use red
Spot, itch, shouting pain or allergic phenomena, and it is possible to be easier to cause to infect.Because cuticula is skin resist extraneous infection,
The first line of defence of radiation, after removing cuticula, the phylactic power defensive power of skin can be deteriorated.The aqua for the treatment of tinea pedis is a lot of now, but
Can be very effective few, if after there is effect treatment a period of time, can recurrent exerbation.
The eighties, the extensive application of antibiotic produced drug resistance, side effect, people re-recognize silver be only real wide
Spectrum natural antibiotics.Nowadays, silver element had no drug resistance with it, nontoxic, without allergy, disturb without crossover drug the advantages of cause generation
The extensive concern of various countries of boundary.
In recent years, the cross development for developing into the subjects such as physics, chemistry, materialogy, biology of nanosecond science and technology is provided
New opportunity, has driven developing rapidly for many new branch of science related to nanometer technology.Silver-colored simple substance itself has splendid
Antibacterial effect, and the appearance of nanometer technology, make bactericidal property of the silver under nm regime generate qualitative leap.Nano Silver with
Powerful bactericidal effect just can be produced to fungies such as Candida albicans in the case that amount is little, and permeability is strong, bactericidal action wide spectrum,
Have no drug resistance；And Nano Silver can promote the healing of wound, the growth of cell and the reparation of damaged cell, and without any toxicity
Reaction, to skin without any IR.Therefore, Nano Silver is sprayed for controlling tinea pedis, with very excellent effect.
Numerous studies find, silver why broad-spectrum sterilization and do not injure beneficial bacterium and normal cell, be because that pathogen is
Unicellular microorganism, it have respiratory enzyme to survive, and silver runs into respiratory enzyme, and it is in connection just to become ion, makes bacterial death.
Silver is trace element, and in prostate, content is higher.Silver can promote the raising of immunologic function（Support T cell antagonism exotic）,
So silver is not only sterilized, moreover it is possible to be conducive to cell growth, wound healing.
Therefore, it is applied to control in tinea pedis spraying by nano silver antimicrobials, acts not only as the fungies such as Candida albicans
Administer, and add anti-inflammation, accelerate the effect for repairing impaired skin for which.But, due to Nano Silver particle diameter less, table
Face can be higher, is inclined to extremely strong reunion.Therefore, in tinea pedis spraying, it is ensured that the stability of nano-Ag particles, single dispersing
Property, the transparency and permanent stability, and ensure that moisturizing composition is coexisted with stablizing for nano-Ag particles, become nanometer silver antimicrobial tinea pedis
Key problem in technology in spraying preparation process.At present, nano silver antimicrobials are there is no to be applied to the relevant report for controlling tinea pedis spray product.
Content of the invention
For overcoming the deficiencies in the prior art, the present invention to provide a kind of nanometer silver antimicrobial and control tinea pedis spraying and prepare and apply.
The present invention seeks to be achieved through the following technical solutions：A kind of nanometer silver antimicrobial controls tinea pedis spraying, and its feature exists
In being mixed by following components by weight percentage：
Skin moisturizing agent 0.1%-3%；
Nano silver colloidal sol dispersion liquid 0.005%-0.05%；
Water adds to 100%；
Product property：Spraying is colourless, transparent, stability is strong, antibacterial/bacteriostasis property is good, and pH controls scope 6 ~ 8.
Described skin moisturizing agent is oat polypeptide, fruit extract, taurine, proline, arginine, lucid asparagus
Acid, glutamic acid, glycine, citrulling, leucine, the one kind in histidine or its combine.
Nano silver colloidal sol dispersion liquid is by complexing agent, reducing agent, dispersant, protective agent, pH adjusting agent and silver salt composition, complexing
Agent is disodium ethylene diamine tetraacetate, calgon is therein a kind of or which combines, and reducing agent is mannitol, xylitol, grape
One kind in sugar alcohol, fructose alcohol, lactitol, glycerine or its combine, dispersant is ammonium lauryl sulfate, dodecyl sodium sulfonate
Ammonium, DBSA ammonium, one kind in ammonium dodecyl ether sulfate or its combine, protective agent be sodium carboxymethylcellulose,
Polyethylene glycol, hydroxyethyl cellulose, polyvinylpyrrolidone, poly- second, the one kind or its combination in enol, Carbomer, pH are adjusted
Agent is ammoniacal liquor, boric acid, the one kind in lactic acid or its combine；Silver salt is silver nitrate, silver acetate, and silver citrate, in silver tartrate
A kind of or its combination.
In final nanometer silver antimicrobial skin-moisturizing, skin water, the percentage by weight of silver element accounts for 0.005%-0.05%.
According to the preparation method that any of the above-described nanometer silver antimicrobial controls tinea pedis spraying, it is characterised in that including following step
Suddenly：
（1）Skin moisturizing agent is added the solution for forming transparent and stable in purified water；
（2）The preparation of nano-class silver colloidal solution：By taking 100 milliliters of nano-class silver colloidal solutions as an example, by complexing agent, reducing agent, point
Powder and protective agent are added in reactor, plus purified water is to 95 milliliters, stirring and dissolving；PH adjusting agent is subsequently added, adjusting pH is
6-8；Silver salt is subsequently adding, dissolving adds purified water after finishing be 100 milliliters to liquor capacity, obtains nano-class silver colloidal solution.
（3）To step（1）Middle interpolation step（2）The nano-silver colloid dispersion liquid of preparation, stirs, and obtains Nano Silver and resists
Bacterium controls tinea pedis spraying.
A kind of nanometer silver antimicrobial controls the application that tinea pedis is sprayed at antibacterial.
A kind of advantage of the manufacture method for controlling tinea pedis spray of the present invention is：Very convenient, Er Qieke has been sprayed after swinging
With antipruritic, eliminate tinea pedis germ, reach the purpose for curing tinea pedis, can solve pin itch, rotten, rotten hardship.And preparation method has behaviour
The features such as making simplicity, Parameter adjustable wide ranges, low energy consumption, cycle is short, is especially suitable for enlarged experiment and industrialized production.
The present invention without organic antibacterial agent, but with Nano Silver as antibacterial, bacteriostatic agent, and have anti-inflammation, acceleration
Repair effect of impaired skin.Also, the present invention has, and great spectrum is antibacterial, bactericidal action, can be long-acting antimycotic and not
Produce drug resistance.Originally control sprayed after tinea pedis spray is swung very convenient, and can also be antipruritic, eliminate tinea pedis germ, reach
Cure the purpose of tinea pedis.
Specific embodiment
Below by embodiment, the present invention is further elaborated, and its purpose is only that and is best understood from present disclosure.
Therefore, the cited case is not intended to limit protection scope of the present invention.
Embodiment 1
（1）Nano-silver colloid dispersion liquid is prepared from by weight percentage by following raw material components：
（2）Nanometer silver antimicrobial is controlled tinea pedis spraying and can be mixed with by following raw material components by weight percentage and forms：
Anti-microbial property is detected：Foundation《Disinfection technology standard》Version in 2002, carries out anti-microbial property detection.Test result shows, on
State nanometer silver antimicrobial tinea pedis spraying is controlled to Candida albicans（10231 types of ATCC）Killing rate be more than 80%.
Embodiment 2
（1）Nano-silver colloid dispersion liquid is prepared from by weight percentage by following raw material components：
（2）Nanometer silver antimicrobial is controlled tinea pedis spraying and can be mixed with by following raw material components by weight percentage and forms：
Anti-microbial property is detected：Foundation《Disinfection technology standard》Version in 2002, carries out anti-microbial property detection.Test result shows, on
State nanometer silver antimicrobial tinea pedis spraying is controlled to Candida albicans（10231 types of ATCC）Killing rate be more than 80%.
Embodiment 3
（1）Nano-silver colloid dispersion liquid is prepared from by weight percentage by following raw material components：
（2）Nanometer silver antimicrobial is controlled tinea pedis spraying and can be mixed with by following raw material components by weight percentage and forms：
Anti-microbial property is detected：Foundation《Disinfection technology standard》Version in 2002, carries out anti-microbial property detection.Test result shows, on
State nanometer silver antimicrobial tinea pedis spraying is controlled to Candida albicans（10231 types of ATCC）Killing rate be more than 90%.
The spraying can be used for treating the tinea manuum, the ringworm of the foot, ringworm of the body etc., and skin will not be produced stimulates and damage, safety non-toxic
Side effect.The development of tinea pedis symptom typically after continuously using this product 3 ~ 7 days, can antipruritic and be further controlled, is reached and is killed
The antibacterial purpose of bacterium, the lighter can just be taken effect using the same day.It can be suitably used for all types of tinea pedis, and have quite significantly pre-
Anti- and therapeutic action, total effective rate reach 98%.
Embodiment 4
（1）Nano-silver colloid dispersion liquid is prepared from by weight percentage by following raw material components：
（2）Nanometer silver antimicrobial is controlled tinea pedis spraying and can be mixed with by following raw material components by weight percentage and forms：
Anti-microbial property is detected：Foundation《Disinfection technology standard》Version in 2002, carries out anti-microbial property detection.Test result shows, on
State nanometer silver antimicrobial tinea pedis spraying is controlled to Candida albicans（10231 types of ATCC）Killing rate be more than 95%.
The spraying can be used for treating the tinea manuum, the ringworm of the foot, ringworm of the body etc., and skin will not be produced stimulates and damage, safety non-toxic
Side effect.The development of tinea pedis symptom typically after continuously using this product 3 ~ 7 days, can antipruritic and be further controlled, is reached and is killed
The antibacterial purpose of bacterium, the lighter can just be taken effect using the same day.It can be suitably used for all types of tinea pedis, and have quite significantly pre-
Anti- and therapeutic action, total effective rate reach 98%.
Embodiment 5
（1）Nano-silver colloid dispersion liquid is prepared from by weight percentage by following raw material components：
（2）Nanometer silver antimicrobial is controlled tinea pedis spraying and can be mixed with by following raw material components by weight percentage and forms：
Anti-microbial property is detected：Foundation《Disinfection technology standard》Version in 2002, carries out anti-microbial property detection.Test result shows, on
State nanometer silver antimicrobial tinea pedis spraying is controlled to Candida albicans（10231 types of ATCC）Killing rate be more than 99%.
The spraying can be used for treating the tinea manuum, the ringworm of the foot, ringworm of the body etc., and skin will not be produced stimulates and damage, safety non-toxic
Side effect.The development of tinea pedis symptom typically after continuously using this product 3 ~ 7 days, can antipruritic and be further controlled, is reached and is killed
The antibacterial purpose of bacterium, the lighter can just be taken effect using the same day.It can be suitably used for all types of tinea pedis, and have quite significantly pre-
Anti- and therapeutic action, total effective rate reach 98%.
Claims (6)
1. a kind of nanometer silver antimicrobial controls tinea pedis spraying, it is characterised in that mixed by following components by weight percentage：
Skin moisturizing agent 0.1%-3%；
Nano silver colloidal sol dispersion liquid 0.005%-0.05%；
Water adds to 100%；
Product property：Spraying is colourless, transparent, stability is strong, antibacterial/bacteriostasis property is good, and pH controls scope 6 ~ 8.
2. nanometer silver antimicrobial controls tinea pedis spraying according to claim 1, it is characterised in that：Described skin moisturizing agent is oat
Polypeptide, fruit extract, taurine, proline, arginine, aspartic acid, glutamic acid, glycine, citrulling, bright ammonia
One kind or its combination in acid, histidine.
3. nanometer silver antimicrobial controls tinea pedis spraying according to claim 1, it is characterised in that：Nano silver colloidal sol dispersion liquid is by being complexed
Agent, reducing agent, dispersant, protective agent, pH adjusting agent and silver salt composition, complexing agent are disodium ethylene diamine tetraacetate, hexa metaphosphoric acid
Sodium is therein a kind of or which combines, reducing agent be mannitol, xylitol, glucitol, fructose alcohol, lactitol, in glycerine
A kind of or its combine, dispersant is ammonium lauryl sulfate, dodecyl sodium sulfonate ammonium, DBSA ammonium, dodecyl
One kind or its combination in ether ammonium sulfate, protective agent is sodium carboxymethylcellulose, polyethylene glycol, hydroxyethyl cellulose, polyethylene
Pyrrolidones, poly- second, one kind in enol, Carbomer or its combine, pH adjusting agent is ammoniacal liquor, boric acid, the one kind in lactic acid or
Which combines；Silver salt is silver nitrate, silver acetate, silver citrate, one kind in silver tartrate or its combine.
4. nanometer silver antimicrobial according to claim 1 controls tinea pedis spraying, it is characterised in that：Final nanometer silver antimicrobial moisturizing
In lotion, the percentage by weight of silver element accounts for 0.005%-0.05%.
5. according to the arbitrary nanometer silver antimicrobial of claim 1-4 control tinea pedis spraying preparation method, it is characterised in that include with
Lower step：
（1）Skin moisturizing agent is added the solution for forming transparent and stable in purified water；
（2）The preparation of nano-class silver colloidal solution：By taking 100 milliliters of nano-class silver colloidal solutions as an example, by complexing agent, reducing agent, point
Powder and protective agent are added in reactor, plus purified water is to 95 milliliters, stirring and dissolving；PH adjusting agent is subsequently added, adjusting pH is
6-8；Silver salt is subsequently adding, dissolving adds purified water after finishing be 100 milliliters to liquor capacity, obtains nano-class silver colloidal solution；
（3）To step（1）Middle interpolation step（2）The nano-silver colloid dispersion liquid of preparation, stirs, and obtains nanometer silver antimicrobial and controls
Tinea pedis is sprayed.
6. the application that tinea pedis is sprayed at antibacterial is controlled according to the arbitrary nanometer silver antimicrobial of claim 1-4.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610953104.3A CN106491534A (en) | 2016-11-03 | 2016-11-03 | A kind of nanometer silver antimicrobial is controlled tinea pedis spraying and prepares and apply |
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| CN201610953104.3A CN106491534A (en) | 2016-11-03 | 2016-11-03 | A kind of nanometer silver antimicrobial is controlled tinea pedis spraying and prepares and apply |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107595883A (en) * | 2017-11-01 | 2018-01-19 | 上海纳米技术及应用国家工程研究中心有限公司 | Smelly eliminating/antibacterial/dry and comfortable/mould proof quadruple effect unifies foot odour spraying and its preparation method and application of dispelling |
| CN111450058A (en) * | 2020-04-17 | 2020-07-28 | 于力 | Preparation of nano zero-valent silver spray for sterilizing and healing animal wound and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107595883A (en) * | 2017-11-01 | 2018-01-19 | 上海纳米技术及应用国家工程研究中心有限公司 | Smelly eliminating/antibacterial/dry and comfortable/mould proof quadruple effect unifies foot odour spraying and its preparation method and application of dispelling |
| CN111450058A (en) * | 2020-04-17 | 2020-07-28 | 于力 | Preparation of nano zero-valent silver spray for sterilizing and healing animal wound and preparation method thereof |
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Application publication date: 20170315 |