CN106727692A - A kind of antibacterial skin spray and preparation method thereof - Google Patents
A kind of antibacterial skin spray and preparation method thereof Download PDFInfo
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- CN106727692A CN106727692A CN201611040784.6A CN201611040784A CN106727692A CN 106727692 A CN106727692 A CN 106727692A CN 201611040784 A CN201611040784 A CN 201611040784A CN 106727692 A CN106727692 A CN 106727692A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
The present invention relates to a kind of antibacterial skin spray and preparation method thereof, belong to Antimicrobe compound or its composition technical field.The specification of pure glue silver is 20~280ppm（Content of nanometer silver）, the mass percentage concentration of the pyrithione urea aqueous solution is 5~15%, and the mass percentage concentration of polyvinylpyrrolidone is 1~10%, seven parts of pure glue silver, two parts of pyrithione urea aqueous solution and a polyvinylpyrrolidones is mixed and is got product.Apply the present invention to antibacterial skin antipruritic, have the advantages that instant effect, security are good.
Description
Technical field
The present invention relates to a kind of antibacterial skin spray and preparation method thereof, belong to Antimicrobe compound or its composition skill
Art field.
Background technology
Skin superficial part bacterium infection, such as epifolliculitis, tinea of feet and hands, favus of the scalp are very common, have brought endless tired
It is angry, influence normal study and work.Although there are various targetedly antibacterial skin preparations market, their major parts are that Chinese medicine is matched somebody with somebody
Side or containing antibiotic and hormone.The action of Chinese medicine preparation is slow, rehabilitation is slow；It is invalid to variation bacterium infection containing antibiotic；
And the use that contains hormone is more can then make local resistance reduction, also aggravation, other side effects.
Nano Silver, is often referred to simple substance Argent grain of the particle diameter in 1~100nm yardsticks, and powder, colloid, load are included in practice
Various existence forms of body.Glue silver (English Colloidal Silver), i.e., 1~100nm of particle diameter simple substance Argent grain is suspended in pure
Liquid in water, is the colloid existence form of Nano Silver, so this liquid is also referred to as nano silver colloid.Chinese invention is special
Sharp " production equipment and method of a kind of nano silver colloid " (200810086707.3) employ micro-processor controlled " electricity " and " film "
The design that technology is combined, the glue silver for being produced, (dispersant is 100% water to very high purity in colloid；Dispersate is 100% single
Matter Argent grain), silver ion content is very low in colloid, therefore security is very high.And before this on the market glue silver in silver ion content
Higher, so potential more safety issue, the glue silver for especially being prepared in chemical industry method, silver ion content is very high, also
Containing many chemical reaction residues, its potential safety issue is more prominent.Above patented technology is produced by contrast
Its purity of glue silver is much higher (more than " analysis is pure "), so referred to as pure glue silver, is suitable for use in pharmaceutically.
In recent years, Nano Silver gradually increases for developing the product of healthy correlation, and with the development health of people of society
Consciousness constantly enhancing, requirement to Nano Silver security also more and more higher, scientists for this pointedly carried out it is a series of
Research experiment, conclusion is using high quality nano silver and reduces its consumption in the formulation and can effectively improve security.Therefore, going out
In the consideration to human health, how to realize that nano silver material is included antibiotic preparation and ensures it in system by more " green " safety
Consumption is reduced as far as possible in agent prescription, is technical problem urgently to be resolved hurrily.
Based on this, the application is made.
The content of the invention
For the drawbacks described above existing for existing antibacterial skin preparation, the application provide firstly a kind of instant effect, safety
The good antibacterial skin spray of property.
To achieve the above object, the technical scheme that the application takes is as follows：
A kind of antibacterial skin spray, is made up of each component of following mass percent：
Pure 7 parts of glue silver；
2 parts of pyrithione urea (PM) aqueous solution；
1 part of polyvinylpyrrolidone (PVP-K30~90)；
Wherein, the specification of described pure glue silver is 20~280ppm (content of nanometer silver), pyrithione urea (PM) aqueous solution
Mass percentage concentration be 5~15%, the mass percentage concentration of polyvinylpyrrolidone (PVP-K30~90) is 1~10%.
Further, as preferred：
Described pure glue silver is the colloid being dispersed in by 100%Ag in 100% water, nano-Ag particles particle diameter in colloid
It is 1~100nm, without cladding, nano-Ag particles particle diameter distribution is 90% ＜ 20nm, nano-Ag particles particle diameter distribution to nano-Ag particles
2~5nm of medium particle diameter.
Meanwhile, the application also provides a kind of preparation method of antibacterial skin spray as characterized above, comprises the following steps：
(1) A, B, C liquid are prepared：Nano silver colloid stoste (100~280PPm) is directly taken or adds deionized water to be configured to
20~280ppm, as A liquid；Deionized water is added to be made into 5~15% pyrithione ureas in medicinal pyrithione urea (PM) pulvis
(PM) aqueous solution (in acidity), adjusts pH value to 6.5~7, as B liquid with NaOH；Polyvinylpyrrolidone (PVP-K30~
90) pulvis adds deionized water dissolving to be configured to 1~10% polyvinylpyrrolidone (PVP-K30~90) aqueous solution, used as C liquid；
(2) 2 parts of B liquid, 1 part of C liquid are poured into agitator tank successively, 25 revs/min of rotating speed is stirred 20 minutes, Ran Houxiang under normal temperature
7 parts of A liquid is wherein poured into, continues 25 revs/min of rotating speed, stirred under normal temperature 10 minutes and the antibacterial skin filling liquid of spray is obtained；I.e. two
The speed for locating stirring is controlled in 25 revs/min, the duration of stirring 10~20 minutes；
(3) it is filling：The antibacterial skin sprinkling irrigation dress liquid that will be prepared loads bottle placer feed barrel, quantitatively pours into 25~100ml
In manual pump spraying bottle, that is, form antibacterial skin spray.
The pure glue silver of specification has that purity is high, security is good, broad-spectrum antiseptic, antimicrobial efficiency are high, nothing employed in the application
Malicious, non-stimulated, promoting healing, will not by resistance the characteristics of, disclosure satisfy that security includes drug-fast bacteria with skin various bacteriums are suppressed
The basic demand of infection, because bacterial skin infections are mostly that fungi causes, fungus breeding is realized by spore, and pure glue is silver-colored
Destruction fungal spore needs to act on the long period, but spray residence time on skin is again limited, so also need to add increasing
The material of dosing thing adhesion and the material with the use of energy rapid damage fungal spore.Screened by scientific experiment, increase medicine
The material of thing adhesion uses polyvinylpyrrolidone (PVP)；The material of rapid damage fungal spore is using appropriate pharmaceutical
Pyrithione urea (PM).Because pyrithione urea (PM) belongs to organic, long use can make bacterium produce resistance, so needing pure glue silver
The synergy for closing 5 with pyrithione urea (PM) just can reach and efficiently kill fungi including drug-fast bacteria and destroy fungal spore
Effect.
The invention has the advantages that：
(1) without hormone, without the side-effect problem that hormone is produced；Without antibiotic, therefore produced in the absence of antibiotic resistance to
The problem of medicine bacterium.
(2) broad-spectrum antiseptic, pure glue silver can effectively suppress hundreds of kinds of bacteriums simultaneously, far beyond any antibiotic only
There is suppression to several bacteriums.
(3) silver content is very low in product (being no more than a ten thousandth)；The pure glue silver of so low silver amount is carried significantly in security
Closed with pyrithione urea (PM) on the premise of height 5 but reached the quick kill fungi that is not contemplated to include drug-fast bacteria body and
Destroy the effect of fungal spore.
(4) manual pump spraying bottle is used, it is filling simple, low cost, easy to use.
Specific embodiment
Embodiment 1
(1) it is formulated (by weight)：
Pure 7 parts of the glue silver of 100ppm；
10% 2 parts of pyrithione urea (PM) aqueous solution；
1 part of 1% polyvinylpyrrolidone (PVP-K30~90).
(2) production method：
1. the first step is prepared：
a:The pure glue silver of 100ppm is directly taken as A liquid.
b:Deionized water is added to be made into 10% pyrithione urea (PM) aqueous solution in medicinal pyrithione urea (PM) pulvis；Then
Adjust pH value 6.5~7 as B liquid with NaOH.
c:Polyvinylpyrrolidone (PVP-K30~90) pulvis adds deionized water dissolving to be configured to 1% polyvinylpyrrolidine
Ketone (PVP-K30~90) aqueous solution；As C liquid.
2. second step is prepared：
2 parts of B liquid, 1 part of C liquid pours into agitator tank successively, 25 revs/min of rotating speed, stirs 20 minutes under normal temperature, then wherein
7 parts of A liquid is poured into, continues 25 revs/min of rotating speed, stirred under normal temperature and antibacterial skin sprinkling irrigation dress liquid is obtained within 10 minutes.
3. it is filling：
The antibacterial skin sprinkling irrigation dress liquid that will be prepared loads bottle placer feed barrel, quantitatively pours into 30ml manual pump spraying bottles
In, that is, form antibacterial skin spray.
Embodiment 2
(1) it is formulated (by weight)：
Pure 7 parts of the glue silver of 150ppm；
5% 2 parts of pyrithione urea (PM) aqueous solution；
1 part of 1% polyvinylpyrrolidone (PVP-K30~90).
(2) production method：
1. the first step is prepared：
a:The pure glue silver of 150ppm is directly taken as A liquid.
b:Deionized water is added to be made into 5% pyrithione urea (PM) aqueous solution in medicinal pyrithione urea (PM) pulvis；Then
Adjust pH value 6.5~7 as B liquid with NaOH.
c:Polyvinylpyrrolidone (PVP-K30~90) pulvis adds deionized water dissolving to be configured to 1% polyvinylpyrrolidine
Ketone (PVP-K30~90) aqueous solution；As C liquid.
2. second step is prepared：
2 parts of B liquid, 1 part of C liquid, pours into mix tank successively, 25 revs/min of rotating speed, is stirred 20 minutes under normal temperature, then falls wherein
Enter 7 parts of A liquid, continue 25 revs/min of rotating speed, stirred under normal temperature 10 minutes and the antibacterial skin filling liquid of spray is obtained.
3. it is filling：
The filling liquid of antibacterial skin spray that will be prepared loads bottle placer feed barrel, quantitatively pours into 30ml manual pump spraying bottles
In, that is, form antibacterial skin spray.
Embodiment 3
(1) it is formulated (by weight)：
Pure 7 parts of the glue silver of 180ppm；
10% 2 parts of pyrithione urea (PM) aqueous solution；
1 part of 5% polyvinylpyrrolidone (PVP-K30~90).
(2) production method：
1. the first step is prepared：
a:The pure glue silver of 180ppm is directly taken as A liquid.
b:Deionized water is added to be made into 10% pyrithione urea (PM) aqueous solution in medicinal pyrithione urea (PM) pulvis；Then
Adjust pH value 6.5~7 as B liquid with NaOH.
c:Polyvinylpyrrolidone (PVP-K30~90) pulvis adds deionized water dissolving to be configured to 5% polyvinylpyrrolidine
Ketone (PVP-K30~90) aqueous solution；As C liquid.
2. second step is prepared：
2 parts of B liquid, 1 part of C liquid pours into agitator tank successively, 25 revs/min of rotating speed, stirs 20 minutes under normal temperature, then wherein
7 parts of A liquid is poured into, continues 25 revs/min of rotating speed, stirred under normal temperature and antibacterial skin sprinkling irrigation dress liquid is obtained within 10 minutes.
3. it is filling：
The antibacterial skin sprinkling irrigation dress liquid that will be prepared loads bottle placer feed barrel, quantitatively pours into 30ml manual pump spraying bottles
In, that is, form antibacterial skin spray.
Embodiment 4
(1) it is formulated (by weight)：
Pure 7 parts of the glue silver of 200ppm；
10% 2 parts of pyrithione urea (PM) aqueous solution；
1 part of 5% polyvinylpyrrolidone (PVP-K30~90).
(2) production method：
1. the first step is prepared：
a:The pure glue silver of 200ppm is directly taken as A liquid.
b:Deionized water is added to be made into 10% pyrithione urea (PM) aqueous solution in medicinal pyrithione urea (PM) pulvis；Then
Adjust pH value 6.5~7 as B liquid with NaOH.
c:Polyvinylpyrrolidone (PVP-K30~90) pulvis adds deionized water dissolving to be configured to 5% polyvinylpyrrolidine
Ketone (PVP-K30~90) aqueous solution；As C liquid.
2. second step is prepared：
2 parts of B liquid, 1 part of C liquid pours into agitator tank successively, 25 revs/min of rotating speed, stirs 20 minutes under normal temperature, then wherein
7 parts of A liquid is poured into, continues 25 revs/min of rotating speed, stirred under normal temperature and antibacterial skin sprinkling irrigation dress liquid is obtained within 10 minutes.
3. it is filling：
The antibacterial skin sprinkling irrigation dress liquid that will be prepared loads bottle placer feed barrel, quantitatively pours into 30ml manual pump spraying bottles
In, that is, form antibacterial skin spray.
Embodiment 5
(1) it is formulated (by weight)：
Pure 7 parts of the glue silver of 230ppm；
15% 2 parts of pyrithione urea (PM) aqueous solution；
1 part of 1% polyvinylpyrrolidone (PVP-K30~90).
(2) production method：
1. the first step is prepared：
a:The pure glue silver of 230ppm is directly taken as A liquid.
b:Deionized water is added to be made into 15% pyrithione urea (PM) aqueous solution in medicinal pyrithione urea (PM) pulvis；Then
Adjust pH value 6.5~7 as B liquid with NaOH.
c:Polyvinylpyrrolidone (PVP-K30~90) pulvis adds deionized water dissolving to be configured to 1% polyvinylpyrrolidine
Ketone (PVP-K30~90) aqueous solution；As C liquid.
2. second step is prepared：
2 parts of B liquid, 1 part of C liquid pours into agitator tank successively, 25 revs/min of rotating speed, stirs 20 minutes under normal temperature, then wherein
7 parts of A liquid is poured into, continues 25 revs/min of rotating speed, stirred under normal temperature and antibacterial skin sprinkling irrigation dress liquid is obtained within 10 minutes.
3. it is filling：
The antibacterial skin sprinkling irrigation dress liquid that will be prepared loads bottle placer feed barrel, quantitatively pours into 30ml manual pump spraying bottles
In, that is, form antibacterial skin spray.
Embodiment 6
(1) it is formulated (by weight)：
Pure 7 parts of the glue silver of 260ppm；
15% 2 parts of pyrithione urea (PM) aqueous solution；
1 part of 10% polyvinylpyrrolidone (PVP-K30~90).
(2) production method：
1. the first step is prepared：
a:The pure glue silver of 260ppm is directly taken as A liquid.
b:Deionized water is added to be made into 15% pyrithione urea (PM) aqueous solution in medicinal pyrithione urea (PM) pulvis；Then
Adjust pH value 6.5~7 as B liquid with NaOH.
c:Polyvinylpyrrolidone (PVP-K30~90) pulvis adds deionized water dissolving to be configured to 10% polyvinylpyrrolidine
Ketone (PVP-K30~90) aqueous solution；As C liquid.
2. second step is prepared：
2 parts of B liquid, 1 part of C liquid pours into agitator tank successively, 25 revs/min of rotating speed, stirs 20 minutes under normal temperature, then wherein
7 parts of A liquid is poured into, continues 25 revs/min of rotating speed, stirred under normal temperature 10 minutes and the antibacterial skin filling liquid of spray is obtained.
3. it is filling：
The filling liquid of antibacterial skin spray that will be prepared loads bottle placer feed barrel, quantitatively pours into 30ml manual pump spraying bottles
In, that is, form antibacterial skin spray.
Embodiment 7
(1) it is formulated (by weight)：
Pure 7 parts of the glue silver of 280ppm；
15% 2 parts of pyrithione urea (PM) aqueous solution；
1 part of 10% polyvinylpyrrolidone (PVP-K30~90).
(2) production method：
1. the first step is prepared：
a:The pure glue silver of 280ppm is directly taken as A liquid.
b:Deionized water is added to be made into 15% pyrithione urea (PM) aqueous solution in medicinal pyrithione urea (PM) pulvis；Then
Adjust pH value 6.5~7 as B liquid with NaOH.
c:Polyvinylpyrrolidone (PVP-K30~90) pulvis adds deionized water dissolving to be configured to 10% polyvinylpyrrolidine
Ketone (PVP-K30~90) aqueous solution；As C liquid.
2. second step is prepared：
2 parts of B liquid, 1 part of C liquid pours into agitator tank successively, 25 revs/min of rotating speed, stirs 20 minutes under normal temperature, then wherein
7 parts of A liquid is poured into, continues 25 revs/min of rotating speed, stirred under normal temperature and antibacterial skin sprinkling irrigation dress liquid is obtained within 10 minutes.
3. it is filling：
The filling liquid of antibacterial skin spray that will be prepared loads bottle placer feed barrel, quantitatively pours into 30ml manual pump spraying bottles
In, that is, form antibacterial skin spray.
Application method：
Spraying bottle nozzle alignment affected part is pressed under manual pump button 2~3, the appropriate antimicrobial fluid of ejection, daily 1~2 time, continuously
3~5 days.If any allergy, disable immediately, clear-cutting forestland.
Fungistatic effect is checked
Test basis：The Ministry of Public Health《Disinfection technology standard》Version 2.1.1 in 2002.
Testing conditions：25 DEG C of test temperature, relative humidity 70%.
Bacteriostasis rate is tested：The fresh slant cultures of test organisms 24h are washed down with PBS, 5 × 10 are made5Cfu/ml~5 ×
106Cfu/ml bacteria suspensions.Take by test liquid and control sample liquid 5ml, be placed in sterile test tube (each 4 pipe), take above-mentioned bacteria suspension point
0.1ml is not added dropwise in each is by test liquid and control sample liquid, mixes, start timing, after effect 5min, sample liquid is drawn respectively
In 0.5ml test tubes of the input containing 4.5mlPBS, fully mix, make appropriate dilution, then take wherein 2~3 dilution factors, inhale respectively
1ml is taken, is inoculated in agar medium with tilt-pour process, 35 DEG C of ± 2 DEG C of culture 72h do viable bacteria colony counting.Experiment is repeated 3 times.
The test result table of comparisons of table 1
Main antimicrobial component of the application using pure glue silver as antimicrobial spray, antimicrobial efficiency is high, to candida albicanses, greatly
Enterobacteria, staphylococcus aureus, the pseudomonas aeruginosa minimum inhibitory concentration MIC of 5 minutes are 5ppm, and 5 minutes minimum is killed
Bacteria concentration MBC is 15ppm, without sensitization, non-stimulated, super broad-spectrum antiseptic, by resistance, and will not have the work for promoting wound healing concurrently
With, in its practical application silver-colored consumption can with very little, such as weight than 0.0005%, security is relatively very high；By itself and appropriate pyrrole
Pyridine thioketones urea (PM) closes 5 and is used as antibacterial skin preparation, can solve the technological deficiency that existing antibacterial skin preparation is present.
Above content is combine that the preferred embodiment of the invention made to provided technical scheme further detailed
Describe in detail bright, it is impossible to assert that the invention specific implementation is confined to above-mentioned these explanations, for the affiliated technology of the invention
For the those of ordinary skill in field, without departing from the concept of the premise of the invention, some simple deductions can also be made
Or replace, should all be considered as belonging to the protection domain of the invention.
Claims (8)
1. a kind of antibacterial skin spray, it is characterised in that be made up of each component of following mass percent：
Pure 7 parts of glue silver；
Pyrithione urea（PM）2 parts of the aqueous solution；
Polyvinylpyrrolidone（PVP-K30~90）1 part；
Wherein, the specification of described pure glue silver is 20~280ppm（Content of nanometer silver）.
2. a kind of antibacterial skin spray as claimed in claim 1, it is characterised in that：Described pure glue silver is by 100% Ag points
The colloid in 100% water is dispersed in, in colloid, nano-Ag particles particle diameter is 1~100nm, and nano-Ag particles particle diameter distribution is
90% ＜ 20nm, 2~5nm of nano-Ag particles particle diameter distribution medium particle diameter.
3. a kind of antibacterial skin spray as claimed in claim 1, it is characterised in that：The matter of the described pyrithione urea aqueous solution
Amount percentage concentration is 5~15%.
4. a kind of antibacterial skin spray as claimed in claim 1, it is characterised in that：The quality of described polyvinylpyrrolidone
Percentage concentration is 1~10%.
5. as described in claim any one of 1-4 antimicrobial spray preparation method, it is characterised in that comprise the following steps：
（1）Prepare A liquid：Nano silver colloid stoste is directly taken or adds deionized water to be configured to 20~280ppm, used as A liquid；
（2）Prepare B liquid：Add deionized water to be made into 5~15% pyrithione urea aqueous solution in medicinal pyrithione urea pulvis, adjust pH
Value, as B liquid；
（3）Prepare C liquid：It is water-soluble that polyvinylpyrrolidone pulvis adds deionized water dissolving to be configured to 1~10% polyvinylpyrrolidone
Liquid, as C liquid；
（4）2 parts of B liquid, 1 part of C liquid are poured into after being stirred under agitator tank, normal temperature successively, 7 parts of A liquid is poured into thereto, continue normal
Stirred under temperature.
6. the preparation method of antimicrobial spray as claimed in claim 5, it is characterised in that：Step（4）It is additionally provided with afterwards filling
Operation, by step（4）Gained stirring liquid loads bottle placer feed barrel, quantitatively pours into spraying bottle, that is, form antimicrobial spray.
7. the preparation method of antimicrobial spray as claimed in claim 5, it is characterised in that：Step（2）In, the pH of B liquid for 6.5~
7。
8. the preparation method of antimicrobial spray as claimed in claim 5, it is characterised in that：Step（4）In, described mixing speed
It is 25 revs/min, the duration for stirring every time 10~20 minutes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110143707.8A CN112891371A (en) | 2016-11-24 | 2016-11-24 | Skin antibacterial spray and preparation method thereof |
| CN201611040784.6A CN106727692A (en) | 2016-11-24 | 2016-11-24 | A kind of antibacterial skin spray and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IT202100000848A1 (en) | 2021-01-19 | 2022-07-19 | Univ Degli Studi Roma La Sapienza | WATER RESISTANT REMOVABLE MULTILAYER ANTIMICROBIAL COATING FOR CONTACT SURFACES AND ITS PREPARATION METHOD |
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| CN1364056A (en) * | 1999-06-25 | 2002-08-14 | 阿奇化工公司 | Pyrithione biocides enhanced by silver, copper, or zinc ions |
| CN102258064A (en) * | 2011-05-12 | 2011-11-30 | 赵正坤 | Antibacterial composition and application thereof |
| CN102499944A (en) * | 2011-10-28 | 2012-06-20 | 秦社宣 | Nanometer silver antibiotic and antiviral compound liquid and its preparation method and products |
| WO2014075185A1 (en) * | 2012-11-14 | 2014-05-22 | Orthopaedic Innovation Center Inc. | Antimicrobial articles produced by additive manufacturing |
| CN105284860A (en) * | 2014-06-16 | 2016-02-03 | 盐城市聚科化工有限公司 | Multiple-effect antibacterial agent composition for wet tissue and production method thereof |
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| IT202100000848A1 (en) | 2021-01-19 | 2022-07-19 | Univ Degli Studi Roma La Sapienza | WATER RESISTANT REMOVABLE MULTILAYER ANTIMICROBIAL COATING FOR CONTACT SURFACES AND ITS PREPARATION METHOD |
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