CN102499944A - Nanometer silver antibiotic and antiviral compound liquid and its preparation method and products - Google Patents
Nanometer silver antibiotic and antiviral compound liquid and its preparation method and products Download PDFInfo
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- CN102499944A CN102499944A CN2011103337460A CN201110333746A CN102499944A CN 102499944 A CN102499944 A CN 102499944A CN 2011103337460 A CN2011103337460 A CN 2011103337460A CN 201110333746 A CN201110333746 A CN 201110333746A CN 102499944 A CN102499944 A CN 102499944A
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- 239000004332 silver Substances 0.000 title claims abstract description 115
- 229910052709 silver Inorganic materials 0.000 title claims abstract description 115
- 239000007788 liquid Substances 0.000 title claims abstract description 53
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 41
- 150000001875 compounds Chemical class 0.000 title claims abstract description 19
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- 238000002360 preparation method Methods 0.000 title abstract description 11
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
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- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
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Abstract
The invention discloses a nanometer silver antibiotic and antiviral compound liquid and its preparation method and products. The compound liquid is prepared by using materials of nanometer silver colloid and polyvinylpyrrolidone, wherein the weight of polyvinylpyrrolidone is 0.01-40% of the weight of the nanometer silver colloid. The invention solves problem that the silver nanometer particles have poor affinity with cells and partially coagulate in long-term preservation when the nanometer silver colloid is in antibiotic and antiviral practical application; the nanometer silver antibiotic and antiviral compound liquid has characteristics of practicability, economy, intoxicity and high efficiency.
Description
Technical field
The present invention relates to a kind of nanometer silver antimicrobial antiviral combination liquid and preparation method thereof and product.
Background technology
Human for many years to environment damage and antibiotic abuse; Cause fastbacteria and variant viral to emerge in an endless stream; Serious threat is to people's health; When country strengthened improvement environment dynamics and the careless use of restriction antibiotic, it was antibiotic drug resistance and the antiviral nanometer silver of being difficult for again that scientists begins to pay attention to, and applies it in actual the preventing and curing diseases with research.Along with going deep into to nanometer silver research; Not ccontaining the doubting of its advantage antibiotic, that spectrum is wide; Antiviral effect also constantly is proved and announces, such as " modern preventive medicine " 2009 the 36th the 21st phases of volume " the external HIV-resistant activity research of nanometer silver ", 2010 the 19th the 7th phases of volume of Chinese Journal of New Drugs " nanometer silver suppresses the experimentation of seasonal influenza virus H1N1 " the periodical content.
Nano silver colloid is exactly a domestic general call to " collargol "." collargol " one literal translated by English " Colloidal Silver "; Present domestic being also referred to as " glue silver " " nano silver colloid " " nano silver colloid aqueous solution " " nanometer silver solution " " nanometer silver liquid " " nano silver suspending liquid " " silver colloid " or the like; Collargol or silver colloid promptly are that dispersant, silver are the colloid of dispersate with water in fact; Be silver particles by particle diameter 1nm～100nm receive the effect of hydrone and suspend in water form; Nano level silver particles or silver-colored granule are also referred to as " nano-Ag particles " or " silver nano-grain ".
The method of producing nano silver colloid is varied; Like chemical deposition, direct-reduction process, microemulsion method, laser vapor phase method, chemical radiation, silver electrode-electric spark blast technique, silver electrode-electric current stabilization method or the like; These methods are each has something to recommend him, require difference and application scenario difference can adopt diverse ways.Use the nano silver colloid of chemical method and Chemical Physics method preparation to be mostly to adopt silver nitrate as raw material production; Its product cost is lower; But there is chemical residual to exist, is used on anti-bacteria cloth, antibiotic paint, the antibiotic plastic more, need consider the influence of its manufacturability chemical residual when medical.And physical method such as silver electrode-electric current stabilization method is a fine silver with 99.99 % is raw material; In deionized water, through stabling current silver is distributed to the method for producing nano silver colloid in the water with the particle of particle diameter 1nm～100nm between the fine silver electrode; The production overall process does not add any chemical material; It is a kind of generally acknowledged method of producing the high quality nano silver colloid; So-called high-quality its product that is meant is that water white transparency, no chemical residue, its dispersate are simple substance silver nano-grain (the simple substance silver nano-grain is the banking group bunch of particle diameter 1～100nm) and narrow diameter distribution; Be suitable for medical usage; But the production process of this method slowly and owing to electrophoretic objective reality, generally about 20PPM, production cost is higher for the nano silver colloid concentration of output; Nano silver colloid by U.S. company prepares is in this way gone up with " glue silver " commodity selling in " Taobao " after bottled, and its 15PPM concentration 118 ml are sold for more than 200 yuan of RMB.And the nano silver colloid that " a kind of production equipment of nano silver colloid and method " (200810086707.3) patented technology is produced has been accomplished the nano silver colloid concentration of this method more than the 200PPM; And industrialization reduces its cost greatly, is one of preferred raw materials of the present invention.
Nano silver colloid is used in merely finds in skin, the mucosa anti-bacteria and anti-virus that effect is unsatisfactory, and analyzing main cause is that silver nano-grain and cellular affinity are relatively poor, and silver nano-grain has the self aggregation characteristic in the nano silver colloid in addition, and long preservation can the part coagulation.
Summary of the invention
The object of the present invention is to provide a kind of nanometer silver antimicrobial antiviral combination liquid and preparation method thereof; Nano silver colloid silver nano-grain and cellular affinity is relatively poor and long preservation can the part coagulation problem in the anti-bacteria and anti-virus practical application have been solved; Have economical, nontoxic, characteristics of high efficiency.
In order to reach above-mentioned purpose, solution of the present invention is:
A kind of nanometer silver antimicrobial antiviral combination liquid be prepared from nano silver colloid and polyvinylpyrrolidone, and the amount of used polyvinylpyrrolidone is 0.01～40% of a nano silver colloid weight.
The simple substance silver nano-grain that contains in the described nano silver colloid, particle diameter 90% are distributed in 1 nanometer between 20 nanometers, and silver content is alkalescence at 3～1000mg/L.
A kind of method for preparing of nanometer silver antimicrobial antiviral combination liquid; Comprise the steps: to adopt at normal temperatures and pressures nano silver colloid according to claim 1 or claim 2; The polyvinylpyrrolidone that wherein adds used nano silver colloid weight 0.01～40% is stirred to abundant dissolving; Sealing lucifuge then placed 30 days; Because this nano silver colloid is alkalescence, silver ion is the overwhelming majority of cation in the liquid, silver ion be easy to polyvinylpyrrolidone lactams group on N, O Atomic coordinate produce the coordination compound of polyvinylpyrrolidone and silver; But also since the silver nano-grain particle diameter major part of its nano silver colloid dispersate below 30 nanometers; Little with the polyvinylpyrrolidone steric hindrance, also make silver nano-grain banking group bunch outer field silver ion be easy to polyvinylpyrrolidone lactams group on N, O Atomic coordinate, thereby further produce polyvinylpyrrolidone with silver coordination compound.At normal temperatures and pressures polyvinylpyrrolidone add exist banking group bunch periphery behind the nano silver colloid silver ion gradually with polyvinylpyrrolidone lactams group on N, the process of O Atomic coordinate; Place through certain hour normal temperature and pressure lucifuge, the banking group in the nanometer silver antimicrobial antiviral combination liquid bunch, silver ion, hydroxy, polyvinylpyrrolidone and polyvinylpyrrolidone reach dynamic equilibrium with silver-colored coordination compound on ratio.
A kind of nanometer silver antimicrobial antiviral combination liquid product is made up of polyvinylpyrrolidone and coordination compound, silver nano-grain, polyvinylpyrrolidone and the water of silver.
Polyvinylpyrrolidone (the Polyvinylpyrrolidonc that the present invention relates to; Be called for short PVP) be a kind of hydrophilic polymer; No antibiotic effect own, but it has excellent biological compatibility, nontoxic; To skin, mucosa do not have any stimulation and and cell good affinity interaction is arranged, be one of common drug adjuvant.
Beneficial effect of the present invention is: 1. add in the nano silver colloid behind the polyvinylpyrrolidone because polyvinylpyrrolidone is connected with the silver ion coordination of banking group bunch periphery in the nano silver colloid; Silver nano-grain is embedded on the long-chain of polyvinylpyrrolidone; Again since under aqueous solution state the affinity interaction of polyvinylpyrrolidone pair cell; Thereby can silver nano-grain directly be guided to cell surface; Improved silver nano-grain and cellular affinity, the anti-bacteria and anti-virus actual effect of nanometer silver is strengthened.
2. silver nano-grain is surrounded by polyvinylpyrrolidone after adding polyvinylpyrrolidone in the nano silver colloid, makes between the silver nano-grain to be separated by the long-chain of polyvinylpyrrolidone, has avoided the silver nano-grain coagulation.
3. because polyvinylpyrrolidone has high adhesion; Again owing to polyvinylpyrrolidone after adding polyvinylpyrrolidone in the nano silver colloid is connected with the silver ion coordination of banking group bunch periphery in the nano silver colloid; Silver nano-grain is embedded on the long-chain of polyvinylpyrrolidone; Thereby can carry silver nano-grain and well be attached on and be applied the surface; Played fixedly nanometer silver in the effect of antibiosis and antiviral functions object, and, made the antiviral effect of nanometer silver antimicrobial obtain slow release because silver nano-grain is surrounded by the polyvinylpyrrolidone long-chain twines; Can effectively prolong administration time, reduce administration number of times, further improve the antiviral actual effect of nanometer silver antimicrobial.
4. polyvinylpyrrolidone is general medicine adjuvant, and to prepare anti-bacteria and anti-virus combination liquid technology simple with nano silver colloid, gained nanometer silver antimicrobial antiviral combination liquid economy, nontoxic, efficient.
The specific embodiment
Embodiment 1
A kind of nanometer silver antimicrobial antiviral combination liquid of present embodiment is to be that feedstock production forms with nano silver colloid and polyvinylpyrrolidone, and main component is polyvinylpyrrolidone and silver-colored coordination compound, silver nano-grain, polyvinylpyrrolidone and water.The simple substance silver nano-grain that contains in the used nano silver colloid of its raw material, particle diameter 90% is distributed in 1 nanometer between 20 nanometers, and silver content is alkalescence at 234mg/L; The amount of the polyvinylpyrrolidone that raw material is used is 3% of a nano silver colloid weight.
Its preparation method is following: to adopt dispersate at normal temperatures and pressures be simple substance silver nano-grain and particle size distribution 90% 1 nanometer between 20 nanometers, silver content 234mg/L, be weakly alkaline nano silver colloid (by " a kind of production equipment of nano silver colloid and method " (200810086707.3) patented technology production); The polyvinylpyrrolidone that wherein adds used nano silver colloid weight 3% " PVP-K90 " (purchasing the special article company in the U.S.) is stirred to abundant dissolving; Sealing lucifuge then placed 30 days; Make silver ion and the polyvinylpyrrolidone abundant coordination of combination in the liquid, further make banking group bunch, silver ion, hydroxy, polyvinylpyrrolidone and polyvinylpyrrolidone and silver-colored coordination compound in the combination liquid on ratio, reach dynamic equilibrium.The gained brown liquid is a nanometer silver antimicrobial antiviral combination liquid, and combination liquid product is made up of polyvinylpyrrolidone and coordination compound, silver nano-grain, polyvinylpyrrolidone and the water of silver.Present embodiment has solved nano silver colloid silver nano-grain and cellular affinity is relatively poor and long preservation can the part coagulation problem in the anti-bacteria and anti-virus practical application; Have economical, nontoxic, characteristics of high efficiency.More than combination liquid can be filled into spraying bottle, is used to treat skin bacterium, fungus, viral infection, like acne, beriberi, eczema, herpes, also can be used for treating pharyngitis, otitis media, rhinitis, gingivitis etc.
The nanometer silver antimicrobial antiviral combination liquid of above practical implementation is after actual room temperature lucifuge is stored 1 year; With after 45 times of the deionized water dilutions (the about 5ml ∕ of silver content L, the result sees shown in the table 1 according to Ministry of Public Health " disinfection technology standard " its bacteriostatic test of version 2.1.11. in 2002; The sterilization experiment assay is seen shown in the table 2.
Embodiment 2
A kind of nanometer silver antimicrobial antiviral combination liquid of present embodiment; Be prepared from nano silver colloid and polyvinylpyrrolidone, the simple substance silver nano-grain that wherein contains in the nano silver colloid, particle diameter 90% are distributed in 1 nanometer between 20 nanometers; Silver content is alkalescence at 3mg/L; And the amount of used polyvinylpyrrolidone is 0.01% of a nano silver colloid weight.
Its preparation method is following: to adopt dispersate at normal temperatures and pressures be simple substance silver nano-grain and particle size distribution 90% 1 nanometer between 20 nanometers, silver content 3mg/L, be weakly alkaline nano silver colloid (by " a kind of production equipment of nano silver colloid and method " (200810086707.3) patented technology production); The polyvinylpyrrolidone that wherein adds used nano silver colloid weight 0.01% " PVP-K90 " (purchasing the special article company in the U.S.) is stirred to abundant dissolving; Sealing lucifuge then placed 30 days; Make silver ion and the abundant coordination of polyvinylpyrrolidone in the combination liquid; Further make the banking group of combination in the liquid bunch, silver ion, hydroxy, polyvinylpyrrolidone and polyvinylpyrrolidone on ratio, reach dynamic equilibrium with silver-colored coordination compound; Gained liquid is nanometer silver antimicrobial antiviral combination liquid, and combination liquid product is made up of polyvinylpyrrolidone and coordination compound, silver nano-grain, polyvinylpyrrolidone and the water of silver.
Present embodiment has solved nano silver colloid silver nano-grain and cellular affinity is relatively poor and long preservation can the part coagulation problem in the anti-bacteria and anti-virus practical application; Have economical, nontoxic, characteristics of high efficiency.More than combination liquid can be used as the filling liquid of wet sanitary napkins, can avoid the bacteria breed of wet sanitary napkins in packing.
Embodiment 3
A kind of nanometer silver antimicrobial antiviral combination liquid of present embodiment; Be prepared from nano silver colloid and polyvinylpyrrolidone, the simple substance silver nano-grain that wherein contains in the nano silver colloid, particle diameter 90% are distributed in 1 nanometer between 20 nanometers; Silver content is alkalescence at 1000mg/L; And the amount of used polyvinylpyrrolidone is 10% of a nano silver colloid weight.
Its preparation method is following: to adopt dispersate at normal temperatures and pressures be simple substance silver nano-grain and particle size distribution 90% 1 nanometer between 20 nanometers, silver content 1000mg/L, be weakly alkaline nano silver colloid (by " a kind of production equipment of nano silver colloid and method " (200810086707.3) patented technology production); The polyvinylpyrrolidone that wherein adds used nano silver colloid weight 10% " PVP-K90 " (purchasing the special article company in the U.S.) is stirred to abundant dissolving; Sealing lucifuge then placed 30 days; Make silver ion and the polyvinylpyrrolidone abundant coordination of combination in the liquid, further make banking group bunch, silver ion, hydroxy, polyvinylpyrrolidone and polyvinylpyrrolidone and silver-colored coordination compound in the combination liquid on ratio, reach dynamic equilibrium.The gained brown liquid is a nanometer silver antimicrobial antiviral combination liquid, and combination liquid product is made up of polyvinylpyrrolidone and coordination compound, silver nano-grain, polyvinylpyrrolidone and the water of silver.Present embodiment has solved nano silver colloid silver nano-grain and cellular affinity is relatively poor and long preservation can the part coagulation problem in the anti-bacteria and anti-virus practical application, has economy, nontoxic a, characteristics of high efficiency.More than the combination liquid special injector of packing into can supply to treat dermatosiss such as acne, beriberi, eczema, herpes.
Embodiment 4
A kind of nanometer silver antimicrobial antiviral combination liquid of present embodiment; Be prepared from nano silver colloid and polyvinylpyrrolidone, the simple substance silver nano-grain that wherein contains in the nano silver colloid, particle diameter 90% are distributed in 1 nanometer between 20 nanometers; Silver content is alkalescence at 1000mg/L; And the amount of used polyvinylpyrrolidone is 40% of a nano silver colloid weight.
Its preparation method is following: to adopt dispersate at normal temperatures and pressures be simple substance silver nano-grain and particle size distribution 90% 1 nanometer between 20 nanometers, silver content 1000mg/L, be weakly alkaline nano silver colloid (by " a kind of production equipment of nano silver colloid and method " (200810086707.3) patented technology production); The polyvinylpyrrolidone that wherein adds used nano silver colloid weight 40% " PVP-K90 " (purchasing the special article company in the U.S.) is stirred to abundant dissolving; Sealing lucifuge then placed 30 days; Make silver ion and the polyvinylpyrrolidone abundant coordination of combination in the liquid, further make banking group bunch, silver ion, hydroxy, polyvinylpyrrolidone and polyvinylpyrrolidone and silver-colored coordination compound in the combination liquid on ratio, reach dynamic equilibrium.The gained brown liquid is a nanometer silver antimicrobial antiviral combination liquid, and combination liquid product is made up of polyvinylpyrrolidone and coordination compound, silver nano-grain, polyvinylpyrrolidone and the water of silver.Present embodiment has solved nano silver colloid silver nano-grain and cellular affinity is relatively poor and long preservation can the part coagulation problem in the anti-bacteria and anti-virus practical application, has economy, nontoxic a, characteristics of high efficiency.More than the combination liquid special injector of packing into can supply to treat the gynaecologic vaginal inflammation.
Embodiment 5
The nanometer silver antimicrobial antiviral combination liquid of above embodiment 1-4 preparation can directly (also can add adjuvant and be mixed with like spray, gel, practical dosage form such as ointment) and is applied to the human antimicrobial antiviral and other need the place of anti-bacteria and anti-virus, and practical application is following:
1. the nanometer silver antimicrobial antiviral makes up the application examples of liquid in health care
Nanometer silver antimicrobial antiviral combination liquid can be killed many pathogenic bacterias such as escherichia coli, staphylococcus aureus, bacillus pyocyaneus, Candida albicans simultaneously.Be mainly used in gynecological inflammation, burn, oral inflammation, gingivitis, pharyngitis, rhinitis, otitis media, bladder inflammation, gastroenteritis, oral ulcer, skin ulcer tinea scytitis and various wounds etc.Working concentration and method: nanometer silver antimicrobial antiviral combination liquid can dilute with deionized water, also can prepare corresponding concentration according to antibiotic object, and working concentration and method are seen shown in the table 3.
Nanometer silver antimicrobial antiviral combination liquid the application examples nanometer silver antimicrobial antiviral combination liquid (5PPM-25PPM adds 0.1～1 %PVP) of aquaculture regularly feed birds with (add 1～3%PVP) with 50-200PPM and give birds drip nose, can prevent and treat birds antibacterial, viral infection and disease.
Above embodiment 1-5 shows that nanometer silver antimicrobial antiviral combination liquid has the antibiosis and antiviral functions very nearly the same with nano silver colloid under laboratory condition; But what it had again in practical application that simple nano silver colloid do not possess makes the high and advantage with long preservation period of anti-bacteria and anti-virus efficient well with cellular affinity, and the present invention has shifted the nano silver colloid anti-bacteria and anti-virus onto practical aspect.Nanometer silver antimicrobial antiviral combination liquid application surface is very wide, and method for using is varied, and is too numerous to enumerate at this.
Claims (4)
1. a nanometer silver antimicrobial antiviral combination liquid is characterized in that: be prepared from nano silver colloid and polyvinylpyrrolidone, and the amount of used polyvinylpyrrolidone is 0.01～40% of a nano silver colloid weight.
2. a kind of nanometer silver antimicrobial antiviral combination liquid as claimed in claim 1, it is characterized in that: the simple substance silver nano-grain that contains in the described nano silver colloid, particle diameter 90% are distributed in 1 nanometer between 20 nanometers, and silver content is alkalescence at 3～1000mg/L.
3. the method for preparing of nanometer silver antimicrobial antiviral combination liquid; It is characterized in that comprising the steps: to adopt at normal temperatures and pressures nano silver colloid according to claim 1 or claim 2; The polyvinylpyrrolidone that wherein adds used nano silver colloid weight 0.01～40% is stirred to abundant dissolving; Seal lucifuge then and place 30 days, so that the banking group in the nanometer silver antimicrobial antiviral combination liquid bunch, silver ion, hydroxy, polyvinylpyrrolidone and polyvinylpyrrolidone reach dynamic equilibrium with silver-colored coordination compound on ratio.
4. a nanometer silver antimicrobial antiviral combination liquid product as claimed in claim 1 is made up of polyvinylpyrrolidone and coordination compound, silver nano-grain, polyvinylpyrrolidone and the water of silver.
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069128A (en) * | 2014-06-25 | 2014-10-01 | 东南大学 | Application of poly vinyl pyrrolidone (PVP) modified nano-silver and imidazole medicines in preparation of drug tolerance resistant fungus active combined medicines |
| CN104588645A (en) * | 2015-02-04 | 2015-05-06 | 山西大学 | Silver nanometer cluster compound with antibacterial activity and preparation method thereof |
| CN106727692A (en) * | 2016-11-24 | 2017-05-31 | 浙江三禾纳米科技有限公司 | A kind of antibacterial skin spray and preparation method thereof |
| CN111449086A (en) * | 2020-05-11 | 2020-07-28 | 武汉工程大学 | Colloidal silver/polymer mixed disinfectant and preparation method and application thereof |
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| WO2020201812A1 (en) * | 2019-04-02 | 2020-10-08 | Wutthinitikornkit Yanee | Dynamic clusters of atom particles activated in extracellular fluid |
| CN112335680A (en) * | 2020-11-03 | 2021-02-09 | 天津尚蒙科技有限公司 | Preparation method of colorless nano silver-copper colloidal dispersion liquid |
| CN112618382A (en) * | 2020-10-20 | 2021-04-09 | 华凯科技(广州)有限公司 | Mild wet tissue compound liquid |
| CN112717197A (en) * | 2020-09-30 | 2021-04-30 | 合肥天太科技有限公司 | Sterilizing and antiviral liquid dressing capable of inhibiting viruses and preparation method thereof |
| CN113679620A (en) * | 2021-06-07 | 2021-11-23 | 广州市巨诚化工有限公司 | Antibacterial and antiseptic composition containing colloidal silver and preparation method thereof |
| CN115322390A (en) * | 2022-08-26 | 2022-11-11 | 厦门稀土材料研究所 | Antibacterial silver complex crystal, preparation method and application thereof |
| CN115427628A (en) * | 2020-04-24 | 2022-12-02 | 赛杰法拉利股份有限公司 | Silver-containing coatings and varnish films, method for the production thereof and use thereof as antiviral agents |
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| CN104588645A (en) * | 2015-02-04 | 2015-05-06 | 山西大学 | Silver nanometer cluster compound with antibacterial activity and preparation method thereof |
| CN112891371A (en) * | 2016-11-24 | 2021-06-04 | 浙江三禾纳米科技有限公司 | Skin antibacterial spray and preparation method thereof |
| CN106727692A (en) * | 2016-11-24 | 2017-05-31 | 浙江三禾纳米科技有限公司 | A kind of antibacterial skin spray and preparation method thereof |
| CN114901261A (en) * | 2019-04-02 | 2022-08-12 | 淅川海灵生物科技有限公司 | Dynamic clustering of activated atomic particles in extracellular fluid |
| WO2020201812A1 (en) * | 2019-04-02 | 2020-10-08 | Wutthinitikornkit Yanee | Dynamic clusters of atom particles activated in extracellular fluid |
| CN111466407A (en) * | 2020-03-10 | 2020-07-31 | 董南 | Nano-silver sprays and methods for combating coronavirus |
| CN115427628A (en) * | 2020-04-24 | 2022-12-02 | 赛杰法拉利股份有限公司 | Silver-containing coatings and varnish films, method for the production thereof and use thereof as antiviral agents |
| CN111449086A (en) * | 2020-05-11 | 2020-07-28 | 武汉工程大学 | Colloidal silver/polymer mixed disinfectant and preparation method and application thereof |
| CN112717197A (en) * | 2020-09-30 | 2021-04-30 | 合肥天太科技有限公司 | Sterilizing and antiviral liquid dressing capable of inhibiting viruses and preparation method thereof |
| CN112618382A (en) * | 2020-10-20 | 2021-04-09 | 华凯科技(广州)有限公司 | Mild wet tissue compound liquid |
| CN112335680A (en) * | 2020-11-03 | 2021-02-09 | 天津尚蒙科技有限公司 | Preparation method of colorless nano silver-copper colloidal dispersion liquid |
| CN112335680B (en) * | 2020-11-03 | 2022-01-14 | 尚蒙科技无锡有限公司 | Preparation method of colorless nano silver-copper colloidal dispersion liquid |
| CN113679620A (en) * | 2021-06-07 | 2021-11-23 | 广州市巨诚化工有限公司 | Antibacterial and antiseptic composition containing colloidal silver and preparation method thereof |
| CN115322390A (en) * | 2022-08-26 | 2022-11-11 | 厦门稀土材料研究所 | Antibacterial silver complex crystal, preparation method and application thereof |
| CN115322390B (en) * | 2022-08-26 | 2023-06-13 | 厦门稀土材料研究所 | Antibacterial silver complex crystal, preparation method and application thereof |
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