CN105213107A - 一种菠萝酶凝胶敷料 - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/38—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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Abstract
一种菠萝酶凝胶敷料，将菠萝酶按0.05%-5%比例添加至凝胶基质，搅拌1-100min至混匀，经灌装、灭菌处理为无菌产品；本发明的优点是：自本发明的优点是：生产工艺简单，易规模化生产；成本低，对于患者和国家来说，可有效降低医疗费用，节约医疗资源；使用方便，易于患者自行护理。
Description
技术领域
本发明涉及敷料和绷带的技术领域，尤其是涉及一种菠萝酶凝胶敷料。
背景技术
目前，医学临床对于创面护理采用的敷料产品种类和方案较多，有传统型纱布敷料、现代型的功能性敷料。传统型纱布敷料仅作为创面简单覆盖，无功能性敷料所具备的性能和促进愈合功能，如抗菌、止血、止痛、预防疤痕、维持湿润环境等。功能性敷料往往生产工艺复杂，企业固定资产投入大；功能性敷料价格较高，给患者、国家和社会医疗负担较重；医护人员在创面护理过程中，尤其是清创处理仍较多采用机械性方式，而盲目的机械性清创在某些严重的感染坏死期创面，正常与坏死组织无明显分界线时，清创很难彻底，同时清御造成局部屏障的破坏，反而使感染因而扩散。同时在创口换药过程中受消毒操作方式、质量环境、人员无菌意识等各种因素影响，易产生感染风险而形成炎症。因炎症的存在，会继续刺激组织出现炎症反应出现红肿、疼痛。如不慎破坏了局部血运，加重了组织缺血，从而加重坏死组织的进程。
《菠萝蛋白酶在创面修复中的作用》（张朝晖，徐强，马静，刘现周，朱朝军，卢旭亚，孙玉芝，李品川，彭娟，殷明，田影，孙俊超，天津中医药2012年6月第29卷第3期）中提到采用酶类清创，其中提到菠萝酶，但是并未提及菠萝酶采用何种剂型和治疗方式。
发明内容
为克服上述问题，本发明采用如下技术方案：
一种菠萝酶凝胶敷料，包括弹性绷带层，所述弹性绷带层上涂覆有一层涂胶层，所述的涂胶层上覆盖有防粘纸，弹性绷带层的经线为弹性编织物。在弹性绷带层的一端粘有1片藻酸盐敷料。
所述1片藻酸盐敷料，规格尺寸为7.0cm×7.0cm，外观要求干净整洁，克重应≥120g/m2，具较好的吸水性。
本发明的优点是：生产工艺简单，易规模化生产；成本低，对于患者和国家来说，可有效降低医疗费用，节约医疗资源；使用方便，易于患者自行护理。
具体实施方式
实施例1：
称取5g卡波姆与丙二醇50g、丙三醇50g混合，加入500ml纯化水混合；称取2g氢氧化钠溶于100ml水，溶解后加入上述混合物；再称取1g菠萝酶粉末加入前两次的混合物，最后补加纯化水至重量为1000g，混合均匀。
实施例2：
称取10g聚乙烯醇、1.5g聚乙烯吡络烷酮加入70ml水，加热至完全溶解，冷却加入丙二醇5g、丙三醇5g、菠萝酶2g、调节pH范围6.5-7.5，再加纯化水若干ml，补足凝胶总重至100g，混合均匀。
实施例3：
称取明胶2g、海藻酸钠2g溶胀于80ml纯化水溶解后加入丙二醇5g、丙三醇5g，调节pH范围6.5-7.5，添加0.5g菠萝酶粉至上述混合物，最后补加纯化水至重量为100g，混合均匀。
Claims (5)
1.一种菠萝酶凝胶敷料，将菠萝酶按0.05%-5%比例添加至凝胶基质，搅拌1-100min至混匀，经灌装、灭菌处理为无菌产品。
2.根据权利要求1所述的一种菠萝酶凝胶敷料，全称菠萝蛋白酶，亦称为凤梨酶或凤梨酵素，由菠萝果、茎、叶、皮提取。
3.根据权利要求2所述的一种菠萝酶凝胶敷料，其主要成分应包括巯基蛋白酶、磷酸酯酶、糖苷酶、过氧化物酶、三甲丁酯物质。
4.根据权利要求1所述一种菠萝酶凝胶敷料，是由卡波姆、聚乙烯醇、聚乙烯吡络烷酮、羧甲基素钠、甲基纤维素、聚丙烯酸钠、海藻酸钠、聚乙二醇、明胶、西黄蓍胶、黄芪胶、琼脂中的一种物质或一种以上物质为主要成分的凝胶。
5.根据权利要求1所述一种菠萝酶凝胶敷料，其辅助成分包括丙二醇、丙三醇中至少一种。
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| CN201510521409.2A CN105213107A (zh) | 2015-08-24 | 2015-08-24 | 一种菠萝酶凝胶敷料 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017183018A1 (en) | 2016-04-18 | 2017-10-26 | Mediwound Ltd | Methods of debridement of chronic wounds |
| CN108884453A (zh) * | 2016-01-31 | 2018-11-23 | 麦迪伍德有限公司 | 用于治疗伤口的清创组合物 |
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| JP2008154868A (ja) * | 2006-12-25 | 2008-07-10 | Michiko Tomiyama | 使い捨ておむつ |
| CN102223858A (zh) * | 2008-10-02 | 2011-10-19 | L.R.R.&D.有限公司 | 界面层伤口敷料 |
| CN103495199A (zh) * | 2013-10-08 | 2014-01-08 | 山东赛克赛斯药业科技有限公司 | 一种治疗激光灼伤和烧烫伤的水凝胶伤口敷料及其制备方法 |
| CN103747814A (zh) * | 2011-08-31 | 2014-04-23 | 凯希特许有限公司 | 减压治疗与清创系统以及方法 |
| CN104374724A (zh) * | 2014-11-25 | 2015-02-25 | 苏州东辰林达检测技术有限公司 | 一种使用菠萝蛋白酶检测重金属汞的方法 |
-
2015
- 2015-08-24 CN CN201510521409.2A patent/CN105213107A/zh active Pending
Patent Citations (5)
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| JP2008154868A (ja) * | 2006-12-25 | 2008-07-10 | Michiko Tomiyama | 使い捨ておむつ |
| CN102223858A (zh) * | 2008-10-02 | 2011-10-19 | L.R.R.&D.有限公司 | 界面层伤口敷料 |
| CN103747814A (zh) * | 2011-08-31 | 2014-04-23 | 凯希特许有限公司 | 减压治疗与清创系统以及方法 |
| CN103495199A (zh) * | 2013-10-08 | 2014-01-08 | 山东赛克赛斯药业科技有限公司 | 一种治疗激光灼伤和烧烫伤的水凝胶伤口敷料及其制备方法 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108884453A (zh) * | 2016-01-31 | 2018-11-23 | 麦迪伍德有限公司 | 用于治疗伤口的清创组合物 |
| EP3408387A4 (en) * | 2016-01-31 | 2019-11-13 | Mediwound Ltd | DEBRIDING COMPOSITION FOR TREATING WOUNDS |
| AU2017211721B2 (en) * | 2016-01-31 | 2022-01-13 | Mediwound Ltd. | Debriding composition for treating wounds |
| US11382958B2 (en) | 2016-01-31 | 2022-07-12 | Mediwound Ltd. | Debriding composition for treating wounds |
| CN108884453B (zh) * | 2016-01-31 | 2022-07-29 | 麦迪伍德有限公司 | 用于治疗伤口的清创组合物 |
| WO2017183018A1 (en) | 2016-04-18 | 2017-10-26 | Mediwound Ltd | Methods of debridement of chronic wounds |
| CN109475608A (zh) * | 2016-04-18 | 2019-03-15 | 麦迪伍德有限公司 | 慢性伤口清创的方法 |
| EP3445389A4 (en) * | 2016-04-18 | 2020-01-22 | Mediwound Ltd | METHODS OF DEBRIDING CHRONIC WOUNDS |
| RU2742331C1 (ru) * | 2016-04-18 | 2021-02-04 | Медивунд Лтд | Способы очищения хронических ран |
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