CN105209073A - 包含B-Raf抑制剂和第二抑制剂的组合疗法 - Google Patents

包含B-Raf抑制剂和第二抑制剂的组合疗法 Download PDF

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Publication number
CN105209073A
CN105209073A CN201480026686.XA CN201480026686A CN105209073A CN 105209073 A CN105209073 A CN 105209073A CN 201480026686 A CN201480026686 A CN 201480026686A CN 105209073 A CN105209073 A CN 105209073A
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Prior art keywords
inhibitor
raf
patient
compound
formula
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CN201480026686.XA
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Chinese (zh)
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G·卡波尼格罗
D·斯图尔特
L·德帕塞瓦尔
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Novartis AG
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Novartis AG
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Application filed by Novartis AG filed Critical Novartis AG
Priority to CN202011614062.3A priority Critical patent/CN112641787A/zh
Publication of CN105209073A publication Critical patent/CN105209073A/zh
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
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    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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CN201480026686.XA 2013-03-21 2014-03-19 包含B-Raf抑制剂和第二抑制剂的组合疗法 Pending CN105209073A (zh)

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US201361804056P 2013-03-21 2013-03-21
US61/804,056 2013-03-21
PCT/IB2014/059975 WO2014147573A2 (en) 2013-03-21 2014-03-19 Combination therapy

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US (3) US9913844B2 (pt)
EP (1) EP2976106B1 (pt)
JP (2) JP6449234B2 (pt)
KR (2) KR102446839B1 (pt)
CN (2) CN105209073A (pt)
AR (1) AR095699A1 (pt)
AU (1) AU2014233805B2 (pt)
BR (1) BR112015023483B8 (pt)
CA (1) CA2907704C (pt)
CL (2) CL2015002807A1 (pt)
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PE (1) PE20151785A1 (pt)
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PL (1) PL2976106T3 (pt)
PT (1) PT2976106T (pt)
SG (2) SG11201507730UA (pt)
SI (1) SI2976106T1 (pt)
TN (1) TN2015000389A1 (pt)
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CN106659788A (zh) * 2014-06-13 2017-05-10 基因泰克公司 治疗和预防癌症耐药性的方法
CN107058565A (zh) * 2016-08-31 2017-08-18 郭军 肢端型黑色素瘤的诊断和治疗
CN109562103A (zh) * 2016-02-19 2019-04-02 国家医疗保健研究所 用于治疗pik3ca相关过度生长综合征群的方法
CN116036278A (zh) * 2017-05-16 2023-05-02 生物医学谷探索股份有限公司 用于治疗具有非典型braf突变的癌症的组合物和方法

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RU2759669C2 (ru) 2016-06-03 2021-11-16 Аррэй Байофарма Инк. Фармацевтические комбинации
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