CN105194713A - 一种含抗菌促愈合防粘连功能的医用海绵及其制备方法 - Google Patents
一种含抗菌促愈合防粘连功能的医用海绵及其制备方法 Download PDFInfo
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- CN105194713A CN105194713A CN201510563468.6A CN201510563468A CN105194713A CN 105194713 A CN105194713 A CN 105194713A CN 201510563468 A CN201510563468 A CN 201510563468A CN 105194713 A CN105194713 A CN 105194713A
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Abstract
Description
样品 | 表观密度(g/cm3) | 吸水率(%) | 垂直吸水率(%) | 杀菌率(%) |
实施例1 | 0.068 | 1892 | 135 | 95 |
实施例2 | 0.075 | 1786 | 130 | 91 |
实施例3 | 0.071 | 1853 | 128 | 92 |
对比例1 | 0.151 | 1043 | 85 | 78 |
对比例2 | 0.132 | 1154 | 93 | 81 |
组别 | 样本数量 | 痊愈 | 好转 | 无效 |
实施例1 | 20 | 18 | 2 | 0 |
实施例2 | 20 | 17 | 2 | 1 |
实施例3 | 20 | 17 | 2 | 1 |
对比例1 | 20 | 11 | 3 | 6 |
对比例2 | 20 | 12 | 2 | 6 |
项目 | 结果 |
菌落总数,cfu/g | 0 |
大肠杆菌 | 0 |
绿脓杆菌 | 0 |
金黄色葡萄球菌 | 0 |
溶血性链球菌 | 0 |
真菌菌落总数 | 0 |
Claims (6)
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106344951A (zh) * | 2016-07-26 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | 一种止血防粘连生物膜及其制备方法 |
CN106729943A (zh) * | 2016-11-24 | 2017-05-31 | 阜阳市汇康医疗器械有限公司 | 一种长效抗菌镇痛促愈合的医用棉签 |
CN108079362A (zh) * | 2017-12-29 | 2018-05-29 | 广州润虹医药科技股份有限公司 | 一种聚氨酯泡沫敷料及其制备方法 |
CN110152052A (zh) * | 2019-05-17 | 2019-08-23 | 武汉大学 | 一种多功能医用材料及其制备方法 |
CN111686296A (zh) * | 2020-06-29 | 2020-09-22 | 宁波旸曜医疗科技有限公司 | 一种载布地纳德壳聚糖海绵 |
CN116574300A (zh) * | 2023-05-12 | 2023-08-11 | 华南理工大学 | 一种长效抗菌的聚乙烯醇缩醛海绵及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101613512A (zh) * | 2009-07-16 | 2009-12-30 | 中国科学院长春应用化学研究所 | 一种抗菌性快速吸液泡沫材料及其制备方法 |
CN101654537A (zh) * | 2009-09-04 | 2010-02-24 | 宋炜 | 一种羧甲基壳聚糖/聚乙烯醇复合海绵及其制备方法 |
CN101974189A (zh) * | 2010-10-28 | 2011-02-16 | 樊李红 | 一种羧丁酰壳聚糖/聚乙烯醇复合海绵及其制备方法 |
CN102302797A (zh) * | 2011-09-15 | 2012-01-04 | 德州海利安生物科技股份有限公司 | 一种医用胶体敷料及其应用 |
US20130150763A1 (en) * | 2011-12-07 | 2013-06-13 | Esmaeil Mirzaei | Electro spun nanofibrous wound dressing and a method of synthesizing the same |
-
2015
- 2015-09-08 CN CN201510563468.6A patent/CN105194713B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101613512A (zh) * | 2009-07-16 | 2009-12-30 | 中国科学院长春应用化学研究所 | 一种抗菌性快速吸液泡沫材料及其制备方法 |
CN101654537A (zh) * | 2009-09-04 | 2010-02-24 | 宋炜 | 一种羧甲基壳聚糖/聚乙烯醇复合海绵及其制备方法 |
CN101974189A (zh) * | 2010-10-28 | 2011-02-16 | 樊李红 | 一种羧丁酰壳聚糖/聚乙烯醇复合海绵及其制备方法 |
CN102302797A (zh) * | 2011-09-15 | 2012-01-04 | 德州海利安生物科技股份有限公司 | 一种医用胶体敷料及其应用 |
US20130150763A1 (en) * | 2011-12-07 | 2013-06-13 | Esmaeil Mirzaei | Electro spun nanofibrous wound dressing and a method of synthesizing the same |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106344951A (zh) * | 2016-07-26 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | 一种止血防粘连生物膜及其制备方法 |
CN106344951B (zh) * | 2016-07-26 | 2019-04-19 | 青岛琛蓝海洋生物工程有限公司 | 一种止血防粘连生物膜及其制备方法 |
CN106729943A (zh) * | 2016-11-24 | 2017-05-31 | 阜阳市汇康医疗器械有限公司 | 一种长效抗菌镇痛促愈合的医用棉签 |
CN108079362A (zh) * | 2017-12-29 | 2018-05-29 | 广州润虹医药科技股份有限公司 | 一种聚氨酯泡沫敷料及其制备方法 |
CN110152052A (zh) * | 2019-05-17 | 2019-08-23 | 武汉大学 | 一种多功能医用材料及其制备方法 |
CN111686296A (zh) * | 2020-06-29 | 2020-09-22 | 宁波旸曜医疗科技有限公司 | 一种载布地纳德壳聚糖海绵 |
CN116574300A (zh) * | 2023-05-12 | 2023-08-11 | 华南理工大学 | 一种长效抗菌的聚乙烯醇缩醛海绵及其制备方法 |
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Address after: 510000, No. 10 (6) building fifth, Yongsheng Road, Yonghe Economic Zone, Guangzhou economic and Technological Development Zone, Guangdong Patentee after: GUANGZHOU RAINHOME PHARM&TECH Co.,Ltd. Address before: 510000, No. 10 (6) building fifth, Yongsheng Road, Yonghe Economic Zone, Guangzhou economic and Technological Development Zone, Guangdong Patentee before: GUANGZHOU RAINHOME PHARM & TECH CO.,LTD. |
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Inventor after: Zhao Peng Inventor after: Chen Liangyan Inventor after: Hou Changbin Inventor after: Che Qishi Inventor before: Zhao Peng Inventor before: Chen Liangyan Inventor before: Hou Changbin |
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Denomination of invention: The invention relates to a medical sponge with antibacterial, healing and adhesion promoting function and a preparation method thereof Effective date of registration: 20210322 Granted publication date: 20161214 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: GUANGZHOU RAINHOME PHARM&TECH Co.,Ltd. Registration number: Y2021440000094 |
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Granted publication date: 20161214 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: GUANGZHOU RAINHOME PHARM&TECH Co.,Ltd. Registration number: Y2021440000094 |
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Denomination of invention: A medical sponge containing antibacterial, healing promoting and anti adhesive functions and its preparation method Granted publication date: 20161214 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: GUANGZHOU RAINHOME PHARM&TECH Co.,Ltd. Registration number: Y2024980007361 |