CN105194458B - Traditional Chinese medicine for treating diabetic nephropathy - Google Patents
Traditional Chinese medicine for treating diabetic nephropathy Download PDFInfo
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- CN105194458B CN105194458B CN201510682434.9A CN201510682434A CN105194458B CN 105194458 B CN105194458 B CN 105194458B CN 201510682434 A CN201510682434 A CN 201510682434A CN 105194458 B CN105194458 B CN 105194458B
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Abstract
the invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating diabetic nephropathy. The technical scheme of the invention is as follows: a traditional Chinese medicine for treating diabetic nephropathy comprises the following traditional Chinese medicines in parts by weight: 10-20 parts of red ginseng, 10-20 parts of fried Chinese yam, 15-20 parts of mulberry, 15-20 parts of flatstem milkvetch seed, 10-20 parts of tripterygium wilfordii, 10-15 parts of scorpion, 10-20 parts of saffron crocus, 15-30 parts of black nightshade, 15-30 parts of gordon euryale seed, 20-30 parts of winged euonymus twig, 12-20 parts of phyllanthus urinaria, 20-30 parts of glabrous greenbrier rhizome, 15-30 parts of gynostemma pentaphylla, 12-20 parts of fiveleaf akebia fruit and 15-30 parts of diverse wormwood herb. The invention has the effects of strengthening spleen and tonifying kidney, promoting blood circulation by removing blood stasis, detoxifying and promoting diuresis, can obviously relieve symptoms and delay illness state, and has no toxic or side effect.
Description
the technical field is as follows:
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating diabetic nephropathy.
Background art:
the diabetic nephropathy is one of common chronic microvascular complications, the main pathological change of the diabetic nephropathy is glomerular sclerosis, the incidence rate of the diabetic nephropathy in a diabetic patient group is 20% -40%, 30% -40% of type 1 diabetic patients with the disease course of more than 10 years are accumulated to have diabetic nephropathy, and the diabetic nephropathy is the first cause of death of the type 1 diabetic patients; diabetic nephropathy occurs cumulatively in about 20% of type 2 diabetic patients, second only to cardiovascular and cerebrovascular diseases among the causes of death of type 2 diabetic patients. At present, western medicine for treating diabetic nephropathy mainly adopts measures such as protein diet restriction, blood sugar control, blood pressure control, lipid metabolism disorder correction, antioxidant stress and the like, and uses drugs such as Angiotensin Converting Enzyme Inhibitor (ACEI) or angiotensin II receptor Antagonist (ARB). To date, there is a lack of more effective prevention and treatment regimens that delay the progression of diabetic nephropathy.
The invention content is as follows:
the invention aims to overcome the defects of the prior art, and provides a traditional Chinese medicine formula for treating diabetic nephropathy.
In order to solve the technical problems, the technical scheme of the invention is as follows: a traditional Chinese medicine for treating diabetic nephropathy comprises the following traditional Chinese medicines in parts by weight: 10-20 parts of red ginseng, 10-20 parts of fried Chinese yam, 15-20 parts of mulberry, 15-20 parts of flatstem milkvetch seed, 10-20 parts of tripterygium wilfordii, 10-15 parts of scorpion, 10-20 parts of saffron crocus, 15-30 parts of black nightshade, 15-30 parts of gordon euryale seed, 20-30 parts of winged euonymus twig, 12-20 parts of phyllanthus urinaria, 20-30 parts of glabrous greenbrier rhizome, 15-30 parts of gynostemma pentaphylla, 12-20 parts of fiveleaf akebia fruit and 15-30 parts of diverse wormwood herb.
further, the traditional Chinese medicine composition comprises the following components: 10-15 parts of red ginseng, 15-20 parts of fried Chinese yam, 18-20 parts of mulberry, 18-20 parts of flatstem milkvetch seed, 15-20 parts of tripterygium wilfordii, 10-12 parts of scorpion, 10-15 parts of saffron crocus, 20-30 parts of black nightshade, 15-20 parts of gordon euryale seed, 20-25 parts of winged euonymus twig, 15-20 parts of phyllanthus urinaria, 20-25 parts of glabrous greenbrier rhizome, 20-30 parts of gynostemma pentaphylla, 15-20 parts of fiveleaf akebia fruit and 20-30 parts of diverse wormwood herb.
A preparation method of a traditional Chinese medicine for treating diabetic nephropathy comprises mixing the above components, grinding into powder, and making into capsule or decocting 150-200 parts by weight.
The medicine principle of the traditional Chinese medicine formula is shown as follows:
red ginseng: sweet, slightly bitter and warm, entering heart, spleen and lung meridians. The efficacy is as follows: tonify primordial qi, tonify spleen and lung, promote fluid production, induce tranquilization. The recipe has the effect of invigorating spleen and replenishing qi to supplement acquired deficiency. Modern pharmacological research shows that the compound has the effects of resisting shock, resisting fatigue, reducing blood sugar, promoting protein synthesis, regulating cholesterol metabolism and the like.
Frying the Chinese yam: sweet and neutral in nature, they enter spleen, lung and kidney meridians. Has the effects of supplementing qi and nourishing yin, tonifying spleen, lung and kidney, and stopping emission and leukorrhagia. The recipe can tonify spleen, lung and kidney, nourish yin of lung and kidney, and astringe kidney essence. Modern pharmacological research shows that the Chinese medicinal composition has the effects of nourishing, helping digestion, relieving cough, reducing phlegm, reducing blood sugar and the like.
Mulberry: sweet and cold in nature, it enters liver and kidney meridians. The efficacy is as follows: nourish yin and enrich blood, promote fluid production and moisten intestines. The formula can nourish yin of liver and kidney. Modern pharmacological research shows that the traditional Chinese medicine composition has the effects of enhancing immunity, stimulating lymphocyte transformation and the like.
Flatstem milkvetch seed: sweet and warm in nature, they enter liver and kidney meridians. The efficacy is as follows: to tonify kidney, secure essence, nourish liver and improve vision. In the recipe, the recipe can tonify kidney yang and kidney yin, and secure essence. Modern pharmacological research shows that the traditional Chinese medicine composition has the effects of resisting inflammation, improving blood rheology, inhibiting platelet aggregation, enhancing body immunity and the like.
thunder god vine: bitter and cold, entering heart and liver meridians. The efficacy is as follows: dispel wind and remove dampness, activate blood and dredge collaterals, and relieve swelling and pain. Tripterygium wilfordii contains wilfordine, has the effect of immunosuppression, and has obvious curative effect on chronic nephritis, lupus nephritis, nephrotic syndrome and other nephropathies shown by modern research, and can obviously reduce proteinuria.
Scorpion: pungent and mild herbs enter liver meridian. The efficacy is as follows: extinguish wind and stop spasm, counteract toxic pathogen and dissipate nodulation, unblock collaterals and alleviate pain. The prescription has the functions of promoting blood circulation and removing obstruction in channels, and can obviously improve the hypercoagulable state of diabetic nephropathy.
Saffron: pungent and warm herbs enter heart and liver meridians. The efficacy is as follows: promoting blood circulation, dredging channels, removing blood stasis and relieving pain. The formula has the effects of promoting blood circulation and removing blood stasis, and modern pharmacological research shows that the formula has the effects of inhibiting platelet aggregation, increasing fibrinolysis and reducing blood fat, and is matched with scorpion to improve the hypercoagulable state of diabetic nephropathy.
Black nightshade: bitter and cold. The efficacy is as follows: clear away heat and toxic material, activate blood and resolve swelling. The formula has the effects of promoting blood circulation, removing blood stasis, inducing diuresis and relieving swelling. Modern pharmacological research shows that the traditional Chinese medicine composition has the effects of resisting inflammation, regulating immunity, reducing blood sugar and the like, and can relieve diabetic nephropathy edema.
Gorgon fruit: sweet, astringent and neutral, entering spleen and kidney meridians. The efficacy is as follows: tonify kidney, secure essence, invigorate spleen, check diarrhea, remove dampness and stop leukorrhagia. The recipe has the actions of astringing, tonifying kidney and arresting seminal emission, and invigorating spleen. Can obviously reduce proteinuria caused by diabetic nephropathy.
Winged euonymus twig: bitter taste and cold nature, entering liver meridian, has the actions of breaking blood, dredging meridians and killing parasites. Ramulus Euonymi contains flavone, flavonoid glycoside, cardiac glycoside, pentacyclic triterpene, steroid and polysaccharide. Modern pharmacological studies show that the winged euonymus twig and the active ingredients thereof have the effects of reducing blood sugar, regulating lipid, resisting bacteria, resisting oxidation and the like.
Phyllanthus urinaria L: slightly bitter and sweet, cool in nature, entering liver and spleen meridians. Has the functions of clearing away heat and toxic material, calming the liver and improving eyesight. Can be used for treating urinary tract infection, nephritis edema, and nyctalopia.
Glabrous greenbrier rhizome: sweet, bland and neutral, enter liver and stomach meridians. The efficacy is as follows: remove toxicity and dampness, and induce joint movement. Can be used for treating stranguria with turbid urine, leukorrhagia, damp-heat and sore.
Gynostemma pentaphylla: bitter and sweet in taste, cool in nature, and entering lung, spleen and kidney meridians. The efficacy is as follows: to replenish qi, invigorate the spleen, clear heat and remove toxicity. Modern pharmacological research shows that the health-care tea has the effects of reducing blood pressure, regulating blood fat, regulating blood sugar, regulating body immunity, regulating physiological functions of a human body, delaying senility and the like.
And (3) Bayuezhao: sweet in flavor and cold in nature, entering liver, spleen and kidney meridians. Has effects in promoting blood circulation, removing blood stasis, relieving restlessness, promoting urination, and relieving diabetic nephropathy edema.
Diverse wormwood herb: bitter taste, warm nature, heart, liver and spleen meridians entered. Has the functions of promoting blood circulation, relieving pain and stopping bleeding. Can be used for treating hematuria of nephritis and nephropathy with good therapeutic effect.
The traditional Chinese medicine has great potential and prospect for preventing and treating diabetic nephropathy, can make up for the defects and shortcomings of pure western medicine treatment, and can obviously relieve symptoms, reduce proteinuria, protect kidney functions and relieve illness conditions.
According to the traditional Chinese medicine formula, multiple experiments and strict comparison are carried out, the traditional Chinese medicines are reasonably proportioned, the traditional Chinese medicine has the effects of tonifying spleen and kidney, promoting blood circulation to remove blood stasis, detoxifying and promoting diuresis, can effectively treat diabetic nephropathy, and is free of toxic and side effects, safe and reliable. The traditional Chinese medicine has the advantages of simple preparation, low cost and obvious drug effect.
The specific implementation mode is as follows:
The present invention is further illustrated by the following specific examples.
Example 1:
A traditional Chinese medicine formula for treating diabetic nephropathy is prepared from 10 parts by mass of red ginseng, 12 parts by mass of fried Chinese yam, 20 parts by mass of mulberry, 15 parts by mass of flastem milkvetch seed, 20 parts by mass of common threewingnut root, 10 parts by mass of scorpion, 10 parts by mass of saffron crocus, 18 parts by mass of black nightshade, 25 parts by mass of gordon euryale seed, 20 parts by mass of winged euonymus twig, 18 parts by mass of phyllanthus urinaria, 24 parts by mass of glabrous greenbrier rhizome, 15 parts by mass of fiveleaf gynostemma herb, 15 parts by mass of fiveleaf. Mixing the above materials, grinding into powder, and making into capsule for administration.
Example 2:
A traditional Chinese medicine formula for treating diabetic nephropathy is prepared from 12 parts by mass of red ginseng, 15 parts by mass of fried Chinese yam, 18 parts by mass of mulberry, 18 parts by mass of flastem milkvetch seed, 15 parts by mass of common threewingnut root, 10 parts by mass of scorpion, 12 parts by mass of saffron crocus, 20 parts by mass of black nightshade, 20 parts by mass of gordon euryale seed, 20 parts by mass of winged euonymus twig, 20 parts by mass of phyllanthus urinaria, 20 parts by mass of glabrous greenbrier rhizome, 20 parts by mass of fiveleaf gynostemma herb, 15 parts by mass of fiveleaf. Mixing the above materials, grinding into powder, and making into capsule for administration.
example 3:
A traditional Chinese medicine formula for treating diabetic nephropathy is prepared from 15 parts by mass of red ginseng, 20 parts by mass of fried Chinese yam, 20 parts by mass of mulberry, 20 parts by mass of flastem milkvetch seed, 18 parts by mass of common threewingnut root, 12 parts by mass of scorpion, 15 parts by mass of saffron crocus, 24 parts by mass of black nightshade, 18 parts by mass of gordon euryale seed, 22 parts by mass of winged euonymus twig, 20 parts by mass of phyllanthus urinaria, 24 parts by mass of glabrous greenbrier rhizome, 25 parts by mass of fiveleaf gynostemma herb, 18 parts by mass of fiveleaf. Mixing the above materials, grinding into powder, and making into capsule for administration.
Example 4:
A traditional Chinese medicine formula for treating diabetic nephropathy is prepared from 10 parts by mass of red ginseng, 18 parts by mass of fried Chinese yam, 20 parts by mass of mulberry, 20 parts by mass of flastem milkvetch seed, 15 parts by mass of common threewingnut root, 10 parts by mass of scorpion, 12 parts by mass of saffron crocus, 30 parts by mass of black nightshade, 15 parts by mass of gordon euryale seed, 24 parts by mass of winged euonymus twig, 18 parts by mass of phyllanthus urinaria, 25 parts by mass of glabrous greenbrier rhizome, 25 parts by mass of fiveleaf gynostemma herb, 20 parts by mass of fiveleaf. The components are mixed and prepared into decoction, and the decoction is concentrated and decocted into 150-200 parts by mass for taking.
Example 5:
A traditional Chinese medicine formula for treating diabetic nephropathy is prepared from 12 parts by mass of red ginseng, 20 parts by mass of fried Chinese yam, 18 parts by mass of mulberry, 18 parts by mass of flastem milkvetch seed, 20 parts by mass of common threewingnut root, 12 parts by mass of scorpion, 15 parts by mass of saffron crocus, 25 parts by mass of black nightshade, 18 parts by mass of gordon euryale seed, 25 parts by mass of winged euonymus twig, 18 parts by mass of phyllanthus urinaria, 24 parts by mass of glabrous greenbrier rhizome, 30 parts by mass of fiveleaf gynostemma herb, 18 parts by mass of fiveleaf. The components are mixed and prepared into decoction, and the decoction is concentrated and decocted into 150-200 parts by mass for taking.
example 6:
a traditional Chinese medicine formula for treating diabetic nephropathy is prepared from 15 parts by mass of red ginseng, 15 parts by mass of fried Chinese yam, 20 parts by mass of mulberry, 18 parts by mass of flastem milkvetch seed, 18 parts by mass of common threewingnut root, 10 parts by mass of scorpion, 12 parts by mass of saffron crocus, 30 parts by mass of black nightshade, 15 parts by mass of gordon euryale seed, 24 parts by mass of winged euonymus twig, 20 parts by mass of phyllanthus urinaria, 25 parts by mass of glabrous greenbrier rhizome, 25 parts by mass of fiveleaf gynostemma herb, 20 parts by mass of fiveleaf. The components are mixed and prepared into decoction, and the decoction is concentrated and decocted into 150-200 parts by mass for taking.
the medicine formula treats 180 patients with diabetic nephropathy, observation indexes of the medicine formula include lumbago, edema, nocturia increase, fatigue, weakness, shortness of breath, disinclination to talk and other symptoms and urine protein, 90% of patients who have no or relieved lumbago symptoms after 4 weeks of treatment, 89% of patients who have no or relieved edema symptoms, 92% of patients who have no or relieved symptoms of nocturia increase, 93% of patients who have no or relieved symptoms of tiredness, weakness and weakness, 89% of patients who have no or relieved symptoms of shortness of breath, 92% of patients who have no or relieved urine protein, 93% of total effective rate and no toxic or side effect.
Typical cases are:
case 1: zhangyi, male, 57 years old, and 13 years old in the history of diabetes, lumbago and edema of both lower limbs appeared, and the disease was diagnosed as diabetic nephropathy by examining urine protein 3+, and the lumbago and edema of both lower limbs were obviously reduced and urine protein was reduced after taking the traditional Chinese medicine capsule of the invention example 1 for 14 days, and the lumbago and edema of both lower limbs disappeared and urine protein was reduced to 1+ after taking the traditional Chinese medicine of the invention for 28 days, and the curative effect was significant.
Case 2: li Yi and woman, 64 years old, 17 years old diabetes, appear listlessness hypodynamia, short breath lazy speaking, both lower limbs edema is obvious, find out diabetic nephropathy through looking for urine protein 4+, after taking the Chinese medicinal capsule of embodiment 2 of the invention 14 days, listlessness hypodynamia, short breath lazy speaking, both lower limbs edema obviously reduce, urine protein reduces, after taking the Chinese medicinal capsule of the invention 28 days, listlessness hypodynamia, short breath lazy speaking, both lower limbs edema disappear, urine protein reduces to 1+, the curative effect is apparent.
case 3: when a woman is in age 51 and the history of diabetes is 8 years, lumbago and nocturia are obviously increased, and the patient is diagnosed as diabetic nephropathy by checking urine protein 2+, the lumbago and the nocturia are obviously reduced and the urine protein is reduced after the patient takes the traditional Chinese medicine decoction of the embodiment 4 for 14 days, and the lumbago and the nocturia are obviously increased and disappear after the patient takes the traditional Chinese medicine decoction of the embodiment 4 for 28 days, so that the urine protein is turned to negative, and the curative effect is obvious.
Case 4: if the male is aged for 72 years, the history of diabetes is 19 years, lassitude and hypodynamia appear, and the diabetic nephropathy is confirmed by checking urine protein for 3+, the lassitude and hypodynamia and the edema of the lower limbs are obviously reduced and urine protein is reduced after the traditional Chinese medicine decoction of the embodiment 5 of the invention is taken for 14 days, and the lassitude and the hypodynamia and the edema of the lower limbs disappear after the traditional Chinese medicine decoction of the invention is taken for 28 days, and the urine protein is reduced to 1+, and the curative effect is obvious.
Case 5: wu Ching, 46 years old, has a history of diabetes of 7 years, has obvious lumbago and shortness of breath, is diagnosed as diabetic nephropathy by checking urine protein 1+, and after taking the traditional Chinese medicine decoction of the embodiment 6 of the invention for 14 days, the lumbago and the shortness of breath and the laziness of speech are obviously reduced, urine protein is reduced, and after taking the traditional Chinese medicine of the invention for 28 days, the lumbago and the shortness of breath and the laziness of speech disappear, the urine protein turns to negative, and the curative effect is obvious.
Claims (1)
1. A traditional Chinese medicine for treating diabetic nephropathy is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 12 parts of red ginseng, 15 parts of fried Chinese yam, 18 parts of mulberry, 18 parts of flatstem milkvetch seed, 15 parts of tripterygium wilfordii, 10 parts of scorpion, 12 parts of saffron, 20 parts of black nightshade, 20 parts of gordon euryale seed, 20 parts of winged euonymus twig, 20 parts of phyllanthus urinaria, 20 parts of glabrous greenbrier rhizome, 20 parts of gynostemma pentaphylla, 15 parts of fiveleaf akebia fruit and 24 parts of diverse wormwood herb;
Mixing the above materials, grinding into powder, and making into capsule.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843803A (en) * | 2009-10-28 | 2010-09-29 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating diabetic nephropathy |
| CN102228536A (en) * | 2011-06-09 | 2011-11-02 | 首都医科大学 | Chinese herbal extract for treating diabetic nephropathy and preparation method thereof |
| CN104971102A (en) * | 2014-04-03 | 2015-10-14 | 成都中医药大学附属医院 | Drug composition for treating diabetic nephropathy, preparation method and uses thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843803A (en) * | 2009-10-28 | 2010-09-29 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating diabetic nephropathy |
| CN102228536A (en) * | 2011-06-09 | 2011-11-02 | 首都医科大学 | Chinese herbal extract for treating diabetic nephropathy and preparation method thereof |
| CN104971102A (en) * | 2014-04-03 | 2015-10-14 | 成都中医药大学附属医院 | Drug composition for treating diabetic nephropathy, preparation method and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中西医结合治疗糖尿病肾病疗效观察;张书明;《实用中西医结合临床》;20050425;第4卷(第2期);第42-43页 * |
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