CN104606578A - Traditional Chinese medicine composition for treating superficial thrombophebitis caused by medicine - Google Patents
Traditional Chinese medicine composition for treating superficial thrombophebitis caused by medicine Download PDFInfo
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- CN104606578A CN104606578A CN201510004247.5A CN201510004247A CN104606578A CN 104606578 A CN104606578 A CN 104606578A CN 201510004247 A CN201510004247 A CN 201510004247A CN 104606578 A CN104606578 A CN 104606578A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating superficial thrombophebitis caused by medicine. The traditional Chinese medicine composition is prepared from the following raw materials: raw liquorice, gynostemma pentaphylla, common andrographis herb, uniflower swisscentaury root, radices trichosanthis, rheum officinale, sargentgloryvine stem, sappanwood, concha meretricis seu cyclinae, edible tulip, gadfly and semen coicis. The traditional Chinese medicine composition for treating superficial thrombophebitis caused by medicine fulfils the blank of the special medicine for treating superficial thrombophebitis, is obvious in treatment effect and serves as a special medicine for treating superficial thrombophebitis caused by medicine. By applying the decoction of the traditional Chinese medicine composition for treating superficial thrombophebitis caused by medicine to 68 patients for 1-3 weeks, 35 patients are cured; 24 patients have obvious improvement; 6 patients have improvement; 3 patients have no improvement; the total effective rate is 95.6%.
Description
Technical field
The present invention relates to Chinese medicine sciemtifec and technical sphere, particularly the Chinese medicine composition of superficial thrombophlebitis that causes of a kind of medicine.
Background technology
Superficial thrombophlebitis is common peripheral vascular disease, and drug-induced superficial thrombophlebitis is topmost type.Venous transfusion is in wide clinical application, and the various medicinal liquid excitatory of vein input, as hypertonic glucose, various antibiotic solutions etc., all can cause chemical stimulation, cause damage and thrombosis, often involve whole piece superficial vein on the superficial vein inner membrance accepting injection.If active treatment thrombosis maybe can not invaded and Deep venou.Chinese medicine superficial thrombophlebitis reported literature is more, but discusses drug-induced superficial thrombophlebitis seldom separately, is necessary the pathogeny according to this disease self uniqueness, the special-purpose medicaments of the superficial thrombophlebitis that development medicine causes.
Summary of the invention
The deficiency that the object of the invention is to overcome not for the rational Chinese medicine composition of compatibility of drug-induced superficial thrombophlebitis in prior art puts forward, the Chinese medicine composition of the superficial thrombophlebitis namely providing a kind of medicine to cause.
In order to realize foregoing invention object, the invention provides following technical scheme:
A Chinese medicine composition for the superficial thrombophlebitis that medicine causes, the medicament be made up of the crude drug of following mass ratio:
Radix Glycyrrhizae 12 ~ 18 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Herba Andrographis 6 ~ 10 parts, Radix Rhapontici 6 ~ 10 parts, Radix Trichosanthis 9 ~ 15 parts, Radix Et Rhizoma Rhei 8 ~ 12 parts, Caulis Sargentodoxae 9 ~ 15 parts, Lignum Sappan 3 ~ 9 parts, Concha Meretricis seu Cyclinae 9 ~ 15 parts, Pseudobulbus Cremastrae Seu Pleiones 3 ~ 9 parts, Tabanus 0.2 ~ 0.4 part, Semen Coicis 20 ~ 40 parts.
Herbal pharmacology effect of the present invention is as follows:
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Radix Glycyrrhizae has antibacterial, antiviral, antiinflammatory, anti-allergic effects; Some poisonous substance is had to the Detoxication of similar glucuronic acid; There is the effect of similar adrenocortical hormone sample; Also have diuresis, blood fat reducing, the effect such as to protect the liver.
Herb Gynostemmae Pentaphylli: sweet, bitter, cold, returns spleen, lung meridian.Replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.Herb Gynostemmae Pentaphylli has resisting fatigue, anti-hypoxia, high temperature resistance, anti-cold service; Obviously can increase the function of nonspecific immunity, cellular immunization, humoral immunization, and tool immunoregulation effect; There is obvious blood fat reducing, hypoglycemic activity, and the synthesis rate of spleen, testis, brain and hematoglobin protein can be improved, and there is calmness, hypnosis, analgesia, increase coronary flow, resist myocardial ischemia, increase cerebral blood flow, inhibition thrombosis, protect the liver, the effect such as antiulcer.
Herba Andrographis: bitter, cold, GUIXIN, lung, large intestine, urinary bladder channel.Heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness.Herba Andrographis has bacteriostasis, can strengthen the phagocytic activity of human leukocytes to antibacterial; Have antipyretic, antiinflammatory, antitumor, function of gallbladder promoting protects the liver, venom and muscarinic action.
Radix Rhapontici: bitter, cold, returns stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, stimulating milk secretion of stimulating the menstrual flow, relaxing muscles and tendons is promoted blood circulation.Radix Rhapontici has significant antioxidation; And cholesterolemia and plasma lipid peroxide (LPO) content can be reduced, prostacyclin/thromboxane A can be recovered
2balance, reduce leukocyte in the infiltration of arterial wall, suppress smooth muscle cell proliferation, there is antiatherogenic effect; Significantly can strengthen the activity of superoxide dismutase in mice plasma (SOD); Significantly can suppress the activity of monoamine oxidase, MAO (MAO-B), there is obvious anti-aging effects; Significantly can also strengthen the phagocytosis of macrophage, improve the immunologic function of cell.
Radix Trichosanthis: sweet, micro-hardship, to be slightly cold, attaches to the lung and stomach meridians.Clearing away heat-fire, promoting the production of body fluid to quench thirst, detumescence and apocenosis.Radix Trichosanthis has immunostimulation and immunosuppressant two kinds effect; There are blood sugar lowering, bacteriostasis.
Radix Et Rhizoma Rhei: bitter, cold, returns spleen, stomach, large intestine, liver, pericardium channel.Heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Radix Et Rhizoma Rhei can increase enterokinesia, suppresses enteral moisture absorption, promotes defecation; There is anti-infectious function; There are function of gallbladder promoting and digestion promoting function; Stop blooding in addition, protect the liver, blood pressure lowering, the effect such as reduction serum cholesterol.
Caulis Sargentodoxae: bitter, flat, returns large intestine, Liver Channel.Heat-clearing and toxic substances removing, invigorates blood circulation, and dispels the wind, pain relieving.Caulis Sargentodoxae has stronger bacteriostasis, can increase coronary flow, inhibition thrombosis.
Lignum Sappan: sweet, salty, pungent, flat, GUIXIN, Liver Channel.Invigorate blood circulation and cure the wound, blood stasis dispelling stimulates the menstrual flow.Lignum Sappan can make heart contraction strengthen, and increases coronary flow, promotes microcirculation; The platelet aggregation that ADP brings out can be suppressed; There are calmness, syngignoscism, and the central excitation effect of strychnine and cocaine can be resisted; Lignum Sappan antibacterial, antiinflammatory in addition, the effect such as anticancer.
Concha Meretricis seu Cyclinae: salty, cold, attaches to the lung and stomach meridians.Removing heat from the lung and dissipating phlegm, hard masses softening and resolving.Concha Meretricis seu Cyclinae has anti-aging effects, obviously reduces, can significantly improve activity of SOD animal lipid peroxidation mass-energy; Separately have antiinflammatory action, the prescription of itself and Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Ostreae can suppress rat granulation tissue hyperplasia, and causing acute peritonitis to mice glacial acetic acid has remarkable inhibition.
Pseudobulbus Cremastrae Seu Pleiones: sweet, micro-pungent, cool, returns liver, spleen channel.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Pseudobulbus Cremastrae Seu Pleiones have anticancer, improve blood circulation, blood pressure lowering, antibacterial, the effect such as radioprotective, blood sugar lowering, spasmolytic.
Tabanus: bitter, be slightly cold, slightly poisonous, return Liver Channel.Removing blood stasis, loose Ji Xiao Disorder.Tabanus has antithrombase effect; There are antiinflammatory, analgesic activity; Hepatorrhagia necrotic lesion caused by induced by endotoxin be formed with remarkable inhibitory action.
Semen Coicis: sweet, light, cool, returns spleen, stomach, lung meridian.Inducing diuresis to remove edema, eliminating dampness by diuresis, spleen invigorating, eliminating impediment, clearing away heat and discharging pus.Semen Coicis has obvious inhibitory action to cancerous cell; Serum calcium, blood glucose can fall; And have antipyretic, calm, analgesic activity.
Superficial thrombophlebitis belongs to the category such as Chinese medicine " superficial obstructive phlebitis ", " BI-syndrome involved the blood vessels ".Drug-induced superficial thrombophlebitis is that passages through which vital energy circulates impatency, caused by pyretic toxicity pents up due to medicine and puncture needle damage vein.Control the removing heat from blood that should detoxify, blood stasis-eliminating and stagnation-dissipating.The present invention adopts Radix Glycyrrhizae, Herb Gynostemmae Pentaphylli, Herba Andrographis, Radix Rhapontici heat-clearing and toxic substances removing; Radix Trichosanthis, Radix Et Rhizoma Rhei cooling blood and removing stasis; Caulis Sargentodoxae, Lignum Sappan blood stasis dispelling are stimulated the menstrual flow; Concha Meretricis seu Cyclinae, Pseudobulbus Cremastrae Seu Pleiones, Tabanus hard masses softening and resolving, removing blood stasis; Semen Coicis eliminating dampness by diuresis spleen invigorating, heat clearing away eliminating impediment.The present invention selects medicine while meeting Chinese medical discrimination principle of medication, has antiinflammatory, anticoagulant, the effect such as antibacterial more, suits the doctor trained in Western medicine pathomechanism of drug-induced superficial thrombophlebitis.
Preferably, the medicament that the Chinese medicine composition of superficial thrombophlebitis that described medicine causes is made up of the crude drug of following mass ratio:
Radix Glycyrrhizae 14 ~ 16 parts, Herb Gynostemmae Pentaphylli 13 ~ 17 parts, Herba Andrographis 7 ~ 9 parts, Radix Rhapontici 7 ~ 9 parts, Radix Trichosanthis 11 ~ 13 parts, Radix Et Rhizoma Rhei 9 ~ 11 parts, Caulis Sargentodoxae 11 ~ 13 parts, Lignum Sappan 5 ~ 7 parts, Concha Meretricis seu Cyclinae 11 ~ 13 parts, Pseudobulbus Cremastrae Seu Pleiones 5 ~ 7 parts, Tabanus 0.2 ~ 0.4 part, Semen Coicis 25 ~ 35 parts.
Further preferred, the medicament that the Chinese medicine composition of the superficial thrombophlebitis that described medicine causes is made up of the crude drug of following mass ratio:
Radix Glycyrrhizae 15 parts, Herb Gynostemmae Pentaphylli 15 parts, Herba Andrographis 8 parts, Radix Rhapontici 8 parts, Radix Trichosanthis 12 parts, Radix Et Rhizoma Rhei 10 parts, Caulis Sargentodoxae 12 parts, Lignum Sappan 6 parts, Concha Meretricis seu Cyclinae 12 parts, Pseudobulbus Cremastrae Seu Pleiones 6 parts, Tabanus 0.3 part, Semen Coicis 30 parts.
The Chinese medicine composition of the superficial thrombophlebitis that described medicine causes can adopt existing Chinese medicine preparation technology to be prepared into any conventional oral preparations, such as can decocting be adopted to obtain water decoction said components, the Chinese medicine composition of the superficial thrombophlebitis that can also be caused by described medicine by other existing Chinese medicine preparation technology be prepared into tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
compared with prior art, beneficial effect of the present invention
The Chinese medicine composition of the superficial thrombophlebitis that medicine provided by the invention causes, has filled up the blank without this sick special-purpose medicaments for the treatment of, and therapeutic effect is obvious, is the special-purpose medicaments of the superficial thrombophlebitis that medicine causes.
a Chinese medicine composition for the superficial thrombophlebitis that medicine causes, clinical efficacy is summed up
1 physical data
In 68 routine patients, man 46 example, female 22 example; 21 ~ 72 years old age, average 43. 8 years old; The course of disease 2 days ~ 6 weeks, average 8. 3 days; Happening part, upper limb 50 example, lower limb 18 example.
2 diagnostic criterias
1. meet " peripheral vascular disease Chinese and western medicine diagnostics " (Chen Bainan, Hou Yufen, Zhou Tao. peripheral vascular disease Chinese and western medicine diagnostics. Beijing: China Traditional Chinese Medicine Publishing House, 1999:426-427.) in about the diagnostic criteria of superficial thrombophlebitis.2. intravenous administration history is had.
3 Therapeutic Method
Radix Glycyrrhizae 15 grams, Herb Gynostemmae Pentaphylli 15 grams, Herba Andrographis 8 grams, Radix Rhapontici 8 grams, Radix Trichosanthis 12 grams, Radix Et Rhizoma Rhei 10 grams, Caulis Sargentodoxae 12 grams, Lignum Sappan 6 grams, Concha Meretricis seu Cyclinae 12 grams, Pseudobulbus Cremastrae Seu Pleiones 6 grams, Tabanus (grind into powder and take after mixing it with water) 0.3 gram, Semen Coicis 30 grams.Conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
4 therapeutic outcomes
4.1 criterions of therapeutical effect: with reference to " peripheral vascular disease Chinese and western medicine diagnostics " (Chen Bainan, Hou Yufen, Zhou Tao. peripheral vascular disease Chinese and western medicine diagnostics. Beijing: China Traditional Chinese Medicine Publishing House, 1999:426-427.) criterion of therapeutical effect.1. fully recover: the local red and swollen heat pain of patient disappears, and vein streak property lump all disappears, and temperature recovery is normal.2. effective: the local red and swollen heat pain of patient disappears, and streak property lump disappears not yet completely.3. effective: the local red and swollen heat pain of patient alleviates, streak property lump exists.4. invalid: above symptom, sign are without change.
4.2 results: through treatment in 1 ~ 3 week, recovery from illness 35 example, effective 24 examples, effective 6 examples, invalid 3 examples, total effective rate 95.6%.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
The Chinese medicine composition of the superficial thrombophlebitis that a kind of medicine causes, by Radix Glycyrrhizae 18 grams, Herb Gynostemmae Pentaphylli 20 grams, Herba Andrographis 10 grams, Radix Rhapontici 10 grams, Radix Trichosanthis 15 grams, Radix Et Rhizoma Rhei 12 grams, Caulis Sargentodoxae 15 grams, Lignum Sappan 9 grams, Concha Meretricis seu Cyclinae 15 grams, Pseudobulbus Cremastrae Seu Pleiones 9 grams, Tabanus (grind into powder and take after mixing it with water) 0.4 gram, Semen Coicis 40 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 2
The Chinese medicine composition of the superficial thrombophlebitis that a kind of medicine causes, by Radix Glycyrrhizae 16 grams, Herb Gynostemmae Pentaphylli 17 grams, Herba Andrographis 9 grams, Radix Rhapontici 9 grams, Radix Trichosanthis 13 grams, Radix Et Rhizoma Rhei 11 grams, Caulis Sargentodoxae 13 grams, Lignum Sappan 7 grams, Concha Meretricis seu Cyclinae 13 grams, Pseudobulbus Cremastrae Seu Pleiones 7 grams, Tabanus (grind into powder and take after mixing it with water) 0.4 gram, Semen Coicis 35 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 3
The Chinese medicine composition of the superficial thrombophlebitis that a kind of medicine causes, by Radix Glycyrrhizae 15 grams, Herb Gynostemmae Pentaphylli 15 grams, Herba Andrographis 8 grams, Radix Rhapontici 8 grams, Radix Trichosanthis 12 grams, Radix Et Rhizoma Rhei 10 grams, Caulis Sargentodoxae 12 grams, Lignum Sappan 6 grams, Concha Meretricis seu Cyclinae 12 grams, Pseudobulbus Cremastrae Seu Pleiones 6 grams, Tabanus (grind into powder and take after mixing it with water) 0.3 gram, Semen Coicis 30 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 4
The Chinese medicine composition of the superficial thrombophlebitis that a kind of medicine causes, by Radix Glycyrrhizae 14 grams, Herb Gynostemmae Pentaphylli 13 grams, Herba Andrographis 7 grams, Radix Rhapontici 7 grams, Radix Trichosanthis 11 grams, Radix Et Rhizoma Rhei 9 grams, Caulis Sargentodoxae 11 grams, Lignum Sappan 5 grams, Concha Meretricis seu Cyclinae 11 grams, Pseudobulbus Cremastrae Seu Pleiones 5 grams, Tabanus (grind into powder and take after mixing it with water) 0.2 gram, Semen Coicis 25 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 5
The Chinese medicine composition of the superficial thrombophlebitis that a kind of medicine causes, by Radix Glycyrrhizae 12 grams, Herb Gynostemmae Pentaphylli 10 grams, Herba Andrographis 6 grams, Radix Rhapontici 6 grams, Radix Trichosanthis 9 grams, Radix Et Rhizoma Rhei 8 grams, Caulis Sargentodoxae 9 grams, Lignum Sappan 3 grams, Concha Meretricis seu Cyclinae 9 grams, Pseudobulbus Cremastrae Seu Pleiones 3 grams, Tabanus (grind into powder and take after mixing it with water) 0.2 gram, Semen Coicis 20 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Claims (4)
1. the Chinese medicine composition of superficial thrombophlebitis that causes of medicine, is characterized in that the medicament be made up of the crude drug of following mass ratio:
Radix Glycyrrhizae 12 ~ 18 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Herba Andrographis 6 ~ 10 parts, Radix Rhapontici 6 ~ 10 parts, Radix Trichosanthis 9 ~ 15 parts, Radix Et Rhizoma Rhei 8 ~ 12 parts, Caulis Sargentodoxae 9 ~ 15 parts, Lignum Sappan 3 ~ 9 parts, Concha Meretricis seu Cyclinae 9 ~ 15 parts, Pseudobulbus Cremastrae Seu Pleiones 3 ~ 9 parts, Tabanus 0.2 ~ 0.4 part, Semen Coicis 20 ~ 40 parts.
2. the Chinese medicine composition of superficial thrombophlebitis that causes of medicine as claimed in claim 1, is characterized in that the medicament be made up of the crude drug of following mass ratio:
Radix Glycyrrhizae 14 ~ 16 parts, Herb Gynostemmae Pentaphylli 13 ~ 17 parts, Herba Andrographis 7 ~ 9 parts, Radix Rhapontici 7 ~ 9 parts, Radix Trichosanthis 11 ~ 13 parts, Radix Et Rhizoma Rhei 9 ~ 11 parts, Caulis Sargentodoxae 11 ~ 13 parts, Lignum Sappan 5 ~ 7 parts, Concha Meretricis seu Cyclinae 11 ~ 13 parts, Pseudobulbus Cremastrae Seu Pleiones 5 ~ 7 parts, Tabanus 0.2 ~ 0.4 part, Semen Coicis 25 ~ 35 parts.
3. the Chinese medicine composition of superficial thrombophlebitis that causes of medicine as claimed in claim 1, is characterized in that the medicament be made up of the crude drug of following mass ratio:
Radix Glycyrrhizae 15 parts, Herb Gynostemmae Pentaphylli 15 parts, Herba Andrographis 8 parts, Radix Rhapontici 8 parts, Radix Trichosanthis 12 parts, Radix Et Rhizoma Rhei 10 parts, Caulis Sargentodoxae 12 parts, Lignum Sappan 6 parts, Concha Meretricis seu Cyclinae 12 parts, Pseudobulbus Cremastrae Seu Pleiones 6 parts, Tabanus 0.3 part, Semen Coicis 30 parts.
4. the preparation method of the Chinese medicine composition of superficial thrombophlebitis that causes of medicine as claimed in claim 1, is characterized in that the Chinese medicinal components of described mass ratio to be prepared into water decoction, tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232921A (en) * | 2015-11-23 | 2016-01-13 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine compound treating superficial thrombophlebitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1672699A (en) * | 2004-03-26 | 2005-09-28 | 哈药集团制药六厂 | Medicine for treating phlebothrombosis and thrombotic superficial phlebitis of lower limb and its prepn |
| CN102895560A (en) * | 2012-10-31 | 2013-01-30 | 裴元民 | Chinese medicine for treating superficial thrombophlebitis |
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- 2015-01-06 CN CN201510004247.5A patent/CN104606578A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1672699A (en) * | 2004-03-26 | 2005-09-28 | 哈药集团制药六厂 | Medicine for treating phlebothrombosis and thrombotic superficial phlebitis of lower limb and its prepn |
| CN102895560A (en) * | 2012-10-31 | 2013-01-30 | 裴元民 | Chinese medicine for treating superficial thrombophlebitis |
Non-Patent Citations (1)
| Title |
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| 肖国士，等: "《中医秘方全书》", 30 June 2012, 湖南科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232921A (en) * | 2015-11-23 | 2016-01-13 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine compound treating superficial thrombophlebitis |
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