CN105194458A - Traditional Chinese medicine for treating diabetic nephropathy - Google Patents
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating diabetic nephropathy. The technical scheme provided by the invention is that the traditional Chinese medicine for treating the diabetic nephropathy is prepared from the following traditional Chinese medicinal materials in parts by mass: 10 to 20 parts of red ginseng, 10 to 20 parts of fried yam, 15 to 20 parts of mulberry, 15 to 20 parts of milkvetch seed, 10 to 20 parts of tripterygium wilfordii, 10 to 15 parts of scorpio, 10 to 20 parts of saffron crocus, 15 to 30 parts of black nightshade, 15 to 30 parts of gordon euryale, 20 to 30 parts of euonymus alatus, 12 to 20 parts of phyllanthus urinaria, 20 to 30 parts of glabrous greenbrier rhizome, 15 to 30 parts of gynostemma pentaphyllum, 12 to 20 parts of fiveleaf akebia fruit and 15 to 30 parts of artemisia anomala. The traditional Chinese medicine disclosed by the invention has the efficacies of invigorating spleen and kidney, activating blood to remove stasis, and detoxifying and promoting urination, can be used for obviously alleviating symptoms and delaying disease progress, and has no toxic or side effects.
Description
technical field:
The present invention relates to technical field of Chinese medicines, specifically treat the Chinese medicine of diabetic nephropathy.
background technology:
Diabetic nephropathy is one of common chronic microvascular complication, its main pathological change is glomerular sclerosis, incidence rate in diabetics group is 20% ~ 40%, the type 1 diabetes patient accumulation of the course of disease more than 10 years has 30% ~ 40% diabetic nephropathy occurs, and is the first cause of the death of type 1 diabetes patient; The type 2 diabetes mellitus patient of about 20% accumulates generation diabetic nephropathy, in the type 2 diabetes mellitus patient cause of the death, be only second to Cardial or cerebral vascular diseases.At present, western medical treatment diabetic nephropathy, mainly take limit protein diet, control blood glucose, control the measures such as blood pressure, correcting lipid disorder, anti-oxidation stress, and the medicine such as application angiotensin-convertion enzyme inhibitor (ACEI) or angiotensin ii receptor antagonist (ARB).Still lack the more effective control prece delaying Progress of Diabetic Nephropathy so far.
summary of the invention:
The object of the invention is to, overcome the deficiencies in the prior art, the invention provides a kind of Chinese medicine formula for the treatment of diabetic nephropathy, the present invention has strengthening spleen, tonifying kidney, blood circulation promoting and blood stasis dispelling, detoxification and promoting urination effect, and energy is mitigation symptoms obviously, delays the state of an illness, has no side effect.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of Chinese medicine for the treatment of diabetic nephropathy, be made up of the Chinese medicine of following weight proportion: Radix Ginseng Rubra 10-20 mass parts, Rhizoma dioscoreae (parched) 10-20 mass parts, Fructus Mori 15-20 mass parts, Semen Astragali Complanati 15-20 mass parts, Radix Tripterygii Wilfordii 10-20 mass parts, Scorpio 10-15 mass parts, Stigma Croci 10-20 mass parts, Herba Solani Nigri 15-30 mass parts, Semen Euryales 15-30 mass parts, Ramulus Euonymi 20-30 mass parts, Cacumen Securinegae Suffruticosae 12-20 mass parts, Rhizoma Smilacis Glabrae 20-30 mass parts, Herb Gynostemmae Pentaphylli 15-30 mass parts, Fructus Akebiae 12-20 mass parts, Herba Artemisiae Anomalae 15-30 mass parts.
Further, Chinese medicinal components of the present invention is: Radix Ginseng Rubra 10-15 mass parts, Rhizoma dioscoreae (parched) 15-20 mass parts, Fructus Mori 18-20 mass parts, Semen Astragali Complanati 18-20 mass parts, Radix Tripterygii Wilfordii 15-20 mass parts, Scorpio 10-12 mass parts, Stigma Croci 10-15 mass parts, Herba Solani Nigri 20-30 mass parts, Semen Euryales 15-20 mass parts, Ramulus Euonymi 20-25 mass parts, Cacumen Securinegae Suffruticosae 15-20 mass parts, Rhizoma Smilacis Glabrae 20-25 mass parts, Herb Gynostemmae Pentaphylli 20-30 mass parts, Fructus Akebiae 15-20 mass parts, Herba Artemisiae Anomalae 20-30 mass parts.
Treat a preparation method for the Chinese medicine of diabetic nephropathy, pulverize after the mixing of above-mentioned component is dressed up capsule or densely decocted into 150-200 mass parts.
the medicine principle of Chinese medicine formula of the present invention shows:
radix Ginseng Rubra:sweet, micro-hardship, tepor, GUIXIN, spleen, lung meridian.Effect: strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.There is the merit of invigorating the spleen and benefiting QI, to mend the deficiency of the day after tomorrow in side.Modern pharmacological research shows it and has shock, resisting fatigue, reduces blood glucose, promotes the effect such as protein synthesis and cholesterol regulating metabolism.
rhizoma dioscoreae (parched):sweet, flat, return spleen, lung, kidney channel.Effect: supplementing QI and nourishing YIN, spleen reinforcing lung kidney, treating spontaneous emission and leukorrhagia.Can spleen reinforcing lung kidney, again the moon of lung benefiting kidney in side, and can astringent or styptic treatment for spontaneous sweating kidney essense.Modern pharmacological research shows it and has nourishing, aid digestion, cough-relieving, reduce phlegm and the effect such as blood sugar lowering.
fructus Mori:sweet, cold, return liver, kidney channel.Effect: nourishing YIN and supplementing blood, intestine moistening of promoting the production of body fluid.The moon of nourishing the liver and kidney in side.Modern pharmacological research shows it and has enhancing immunity, excites the effects such as lymphocyte transformation.
semen Astragali Complanati:sweet, warm, return liver, kidney channel.Effect: tonifying the kidney to consolidate the essence, nourishing the liver to improve visual acuity.Can kidney-replenishing kidney yin in side, again can controlling nocturnal emission with astringent drugs.Modern pharmacological research shows it and has antiinflammatory, improve hemorheology, the effect such as anticoagulant, enhancing human body immunity power.
radix Tripterygii Wilfordii:bitter, cold, GUIXIN, Liver Channel.Effect: expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain.Radix Tripterygii Wilfordii containing wilfordine, has immunosuppressant effect, and modern study shows that it is evident in efficacy to nephropathy such as chronic nephritis, lupus nephritis, nephrotic syndromes, significantly can reduce albuminuria.
scorpio:pungent, flat, return Liver Channel.Effect: endogenous wind stopping relieving convulsion, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.There is in side the merit of promoting blood circulation to remove obstruction in the collateral, significantly can improve the hypercoagulability of diabetic nephropathy.
stigma Croci:pungent, warm, GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Have the merit of blood circulation promoting and blood stasis dispelling in side, modern pharmacological research shows it to be had anticoagulant and increases fibrinolysis activity, and has reduction blood fat, coordinates Scorpio to improve the hypercoagulability of diabetic nephropathy.
herba Solani Nigri:bitter, cold.Effect: heat-clearing and toxic substances removing, promoting blood circulation and detumescence.In side, there is blood circulation promoting and blood stasis dispelling, the merit of inducing diuresis to remove edema.Modern pharmacological research shows it to be had antiinflammatory, immunity moderation and reduces the effects such as blood glucose, can alleviate diabetic nephropathy edema.
semen Euryales:sweet, puckery, flat, return spleen, kidney channel.Effect: supplementing the kidney to control the nocturnal, invigorating the spleen to arrest diarrhea, eliminating dampness and arresting leucorrhea.Can sweet puckery convergence in side, again can supplementing the kidney to control the nocturnal, have the merit of spleen invigorating concurrently.Obviously can reduce proteinuria caused by diabetic nephropathy.
ramulus Euonymi:bitter in the mouth, cold in nature, return Liver Channel, there is removing blood stasis, stimulate the menstrual flow, the merit of parasite killing.Ramulus Euonymi contains the plurality of active ingredients such as flavone, flavonoid glycoside, cardiac glycoside, pentacyclic triterpene, steroidal and polysaccharide.Modern pharmacology research shows, Ramulus Euonymi and effective ingredient thereof have blood sugar lowering, adjust the effects such as fat, antibacterial, antioxidation.
cacumen Securinegae Suffruticosae: micro-hardship, sweet, cool in nature, return liver, spleen channel.There is heat-clearing and toxic substances removing, the merit of suppressing the hyperactive liver improving eyesight.Cure mainly the diseases such as urinary tract infection, oedema due to nephritis, nyctalopia.
rhizoma Smilacis Glabrae: sweet, light, flat, return liver, stomach warp.Effect: removing toxic substances dehumidifying, easing joint movement.Can be used for stranguria with turbid discharge, leukorrhagia, the diseases such as damp and hot sore.
herb Gynostemmae Pentaphylli: bitter in the mouth, sweet, cool in nature, return lung, spleen, kidney channel.Effect: replenishing QI to invigorate the spleen, heat-clearing and toxic substances removing.Modern pharmacological research shows that it has and reduces blood pressure, adjusting blood lipid, regulates blood glucose, regulates immunity of organism, regulates human physiological functions, the effects such as slow down aging.
fructus Akebiae: sweet in the mouth, cold in nature, return liver,spleen,kidney warp.There is the merit of blood circulation promoting and blood stasis dispelling, relieving restlessness diuresis, can diabetic nephropathy edema be alleviated.
herba Artemisiae Anomalae: bitter in the mouth, warm in nature, GUIXIN, liver, spleen channel.Have invigorate blood circulation, pain relieving, hemostasis merit.Can be used for the hematuria for the treatment of various nephritis, nephropathy, evident in efficacy.
Chinese medicine prevention diabetic nephropathy has huge potentiality and prospect, can make up defect and the deficiency of simple western medicine treatment, can obvious mitigation symptoms, minimizing albuminuria, renal function protecting, mitigate the disease.
Chinese medicine formula of the present invention, through many experiments, strictly contrasts, and by above-mentioned Chinese crude drug rational proportion, has the merit of strengthening spleen, tonifying kidney, blood circulation promoting and blood stasis dispelling, detoxification and promoting urination, effectively can treat diabetic nephropathy, and have no side effect, safe and reliable.This Chinese medicine formula makes simple, and with low cost, drug effect is remarkable.
detailed description of the invention:
Below in conjunction with specific embodiment, the present invention will be further described.
embodiment 1:
Treat a Chinese medicine formula for diabetic nephropathy, get Radix Ginseng Rubra 10 mass parts, Rhizoma dioscoreae (parched) 12 mass parts, Fructus Mori 20 mass parts, Semen Astragali Complanati 15 mass parts, Radix Tripterygii Wilfordii 20 mass parts, Scorpio 10 mass parts, Stigma Croci 10 mass parts, Herba Solani Nigri 18 mass parts, Semen Euryales 25 mass parts, Ramulus Euonymi 20 mass parts, Cacumen Securinegae Suffruticosae 18 mass parts, Rhizoma Smilacis Glabrae 24 mass parts, Herb Gynostemmae Pentaphylli 15 mass parts, Fructus Akebiae 15 mass parts, Herba Artemisiae Anomalae 20 mass parts.After said components is mixed, be developed into powder, dress up capsule and take.
embodiment 2:
Treat a Chinese medicine formula for diabetic nephropathy, get Radix Ginseng Rubra 12 mass parts, Rhizoma dioscoreae (parched) 15 mass parts, Fructus Mori 18 mass parts, Semen Astragali Complanati 18 mass parts, Radix Tripterygii Wilfordii 15 mass parts, Scorpio 10 mass parts, Stigma Croci 12 mass parts, Herba Solani Nigri 20 mass parts, Semen Euryales 20 mass parts, Ramulus Euonymi 20 mass parts, Cacumen Securinegae Suffruticosae 20 mass parts, Rhizoma Smilacis Glabrae 20 mass parts, Herb Gynostemmae Pentaphylli 20 mass parts, Fructus Akebiae 15 mass parts, Herba Artemisiae Anomalae 24 mass parts.After said components is mixed, be developed into powder, dress up capsule and take.
embodiment 3:
Treat a Chinese medicine formula for diabetic nephropathy, get Radix Ginseng Rubra 15 mass parts, Rhizoma dioscoreae (parched) 20 mass parts, Fructus Mori 20 mass parts, Semen Astragali Complanati 20 mass parts, Radix Tripterygii Wilfordii 18 mass parts, Scorpio 12 mass parts, Stigma Croci 15 mass parts, Herba Solani Nigri 24 mass parts, Semen Euryales 18 mass parts, Ramulus Euonymi 22 mass parts, Cacumen Securinegae Suffruticosae 20 mass parts, Rhizoma Smilacis Glabrae 24 mass parts, Herb Gynostemmae Pentaphylli 25 mass parts, Fructus Akebiae 18 mass parts, Herba Artemisiae Anomalae 20 mass parts.After said components is mixed, be developed into powder, dress up capsule and take.
embodiment 4:
Treat a Chinese medicine formula for diabetic nephropathy, get Radix Ginseng Rubra 10 mass parts, Rhizoma dioscoreae (parched) 18 mass parts, Fructus Mori 20 mass parts, Semen Astragali Complanati 20 mass parts, Radix Tripterygii Wilfordii 15 mass parts, Scorpio 10 mass parts, Stigma Croci 12 mass parts, Herba Solani Nigri 30 mass parts, Semen Euryales 15 mass parts, Ramulus Euonymi 24 mass parts, Cacumen Securinegae Suffruticosae 18 mass parts, Rhizoma Smilacis Glabrae 25 mass parts, Herb Gynostemmae Pentaphylli 25 mass parts, Fructus Akebiae 20 mass parts, Herba Artemisiae Anomalae 25 mass parts.After said components being mixed, make decoct, dense 150-200 mass parts of decocting into is taken.
embodiment 5:
Treat a Chinese medicine formula for diabetic nephropathy, get Radix Ginseng Rubra 12 mass parts, Rhizoma dioscoreae (parched) 20 mass parts, Fructus Mori 18 mass parts, Semen Astragali Complanati 18 mass parts, Radix Tripterygii Wilfordii 20 mass parts, Scorpio 12 mass parts, Stigma Croci 15 mass parts, Herba Solani Nigri 25 mass parts, Semen Euryales 18 mass parts, Ramulus Euonymi 25 mass parts, Cacumen Securinegae Suffruticosae 18 mass parts, Rhizoma Smilacis Glabrae 24 mass parts, Herb Gynostemmae Pentaphylli 30 mass parts, Fructus Akebiae 18 mass parts, Herba Artemisiae Anomalae 20 mass parts.After said components being mixed, make decoct, dense 150-200 mass parts of decocting into is taken.
embodiment 6:
Treat a Chinese medicine formula for diabetic nephropathy, get Radix Ginseng Rubra 15 mass parts, Rhizoma dioscoreae (parched) 15 mass parts, Fructus Mori 20 mass parts, Semen Astragali Complanati 18 mass parts, Radix Tripterygii Wilfordii 18 mass parts, Scorpio 10 mass parts, Stigma Croci 12 mass parts, Herba Solani Nigri 30 mass parts, Semen Euryales 15 mass parts, Ramulus Euonymi 24 mass parts, Cacumen Securinegae Suffruticosae 20 mass parts, Rhizoma Smilacis Glabrae 25 mass parts, Herb Gynostemmae Pentaphylli 25 mass parts, Fructus Akebiae 20 mass parts, Herba Artemisiae Anomalae 30 mass parts.After said components being mixed, make decoct, dense 150-200 mass parts of decocting into is taken.
Pharmaceutical formulation treatment diabetic nephropathy patient 180 example of the present invention, observation index has symptom and the urine protein such as lumbago, edema, nocturia increase, lassitude and weak, lazyness of breathing hard speech, after treating 4 weeks, lumbago transference cure or alleviation person account for 90%, edematous condition disappears or alleviation person accounts for 89%, nycturia shape disappears or alleviation person accounts for 92%, lassitude and weak transference cure or alleviation person account for 93%, lazyness of breathing hard speech transference cure or alleviation person account for 89, urine protein disappears or alleviation person accounts for 92%, total effective rate is 93%, and has no side effect.
model case:
case 1:zhang, man, 57 years old, diabetes medical history 13 years, occurs that lumbago, two lower limbs edema are obvious, through the albumen 3+ that has urine examined, be diagnosed as diabetic nephropathy, take the Chinese medicinal capsule of the embodiment of the present invention 1 after 14 days, lumbago and two lower limbs edema obviously alleviate, and urine protein reduces, take Chinese medicine of the present invention after 28 days, lumbago and two lower limbs edema disappear, and urine protein is reduced to 1+, evident in efficacy.
case 2:lee, female, 64 years old,, there is fatigue and weakness, breathe hard lazy speech, two lower limbs edema obviously, through the albumen 4+ that has urine examined in diabetes medical history 17 years, be diagnosed as diabetic nephropathy, take the embodiment of the present invention 2 Chinese medicinal capsule after 14 days, fatigue and weakness, lazy speech of breathing hard, two lower limbs edema obviously alleviate, and urine protein reduces, take Chinese medicine of the present invention after 28 days, fatigue and weakness, lazy speech of breathing hard, two lower limbs edema disappear, and urine protein is reduced to 1+, evident in efficacy.
case 3:jiang, female, 51 years old,, there is lumbago, nocturia increase obviously, through the albumen 2+ that has urine examined in diabetes medical history 8 years, be diagnosed as diabetic nephropathy, take the embodiment of the present invention 4 Chinese medicine decoction after 14 days, lumbago, nocturia increase and obviously alleviate, and urine protein reduces, take Chinese medicine of the present invention after 28 days, lumbago and nocturia increase disappearance, and urine protein is turned out cloudy, evident in efficacy.
case 4:chen, man, 72 years old, diabetes medical history 19 years, occurs that fatigue and weakness, two lower limbs edema are obvious, through the albumen 3+ that has urine examined, be diagnosed as diabetic nephropathy, take the embodiment of the present invention 5 Chinese medicine decoction after 14 days, fatigue and weakness, two lower limbs edema obviously alleviate, and urine protein reduces, take Chinese medicine of the present invention after 28 days, fatigue and weakness, two lower limbs edema disappear, and urine protein is reduced to 1+, evident in efficacy.
case 5:wu, female, 46 years old,, there is lumbago, lazyness of breathing hard explain aobvious, through the albumen 1+ that has urine examined in diabetes medical history 7 years, be diagnosed as diabetic nephropathy, take the embodiment of the present invention 6 Chinese medicine decoction after 14 days, lumbago, lazyness of breathing hard explain aobvious alleviating, and urine protein reduces, take Chinese medicine of the present invention after 28 days, lumbago, lazy speech of breathing hard disappear, and urine protein is turned out cloudy, evident in efficacy.
Claims (3)
1. treat a Chinese medicine for diabetic nephropathy, it is characterized in that: be made up of the Chinese medicine of following weight proportion: Radix Ginseng Rubra 10-20 mass parts, Rhizoma dioscoreae (parched) 10-20 mass parts, Fructus Mori 15-20 mass parts, Semen Astragali Complanati 15-20 mass parts, Radix Tripterygii Wilfordii 10-20 mass parts, Scorpio 10-15 mass parts, Stigma Croci 10-20 mass parts, Herba Solani Nigri 15-30 mass parts, Semen Euryales 15-30 mass parts, Ramulus Euonymi 20-30 mass parts, Cacumen Securinegae Suffruticosae 12-20 mass parts, Rhizoma Smilacis Glabrae 20-30 mass parts, Herb Gynostemmae Pentaphylli 15-30 mass parts, Fructus Akebiae 12-20 mass parts, Herba Artemisiae Anomalae 15-30 mass parts.
2. a kind of Chinese medicine for the treatment of diabetic nephropathy according to claim 1, it is characterized in that: be made up of the Chinese medicine of following weight proportion: Radix Ginseng Rubra 10-15 mass parts, Rhizoma dioscoreae (parched) 15-20 mass parts, Fructus Mori 18-20 mass parts, Semen Astragali Complanati 18-20 mass parts, Radix Tripterygii Wilfordii 15-20 mass parts, Scorpio 10-12 mass parts, Stigma Croci 10-15 mass parts, Herba Solani Nigri 20-30 mass parts, Semen Euryales 15-20 mass parts, Ramulus Euonymi 20-25 mass parts, Cacumen Securinegae Suffruticosae 15-20 mass parts, Rhizoma Smilacis Glabrae 20-25 mass parts, Herb Gynostemmae Pentaphylli 20-30 mass parts, Fructus Akebiae 15-20 mass parts, Herba Artemisiae Anomalae 20-30 mass parts.
3. a kind of preparation method for the treatment of the Chinese medicine of diabetic nephropathy according to claim 1 or 2, is characterized in that: pulverize after the mixing of each component dressed up capsule by proportioning or densely decoct into 150-200 mass parts.
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| CN101843803A (en) * | 2009-10-28 | 2010-09-29 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating diabetic nephropathy |
| CN102228536A (en) * | 2011-06-09 | 2011-11-02 | 首都医科大学 | Chinese herbal extract for treating diabetic nephropathy and preparation method thereof |
| CN104971102A (en) * | 2014-04-03 | 2015-10-14 | 成都中医药大学附属医院 | Drug composition for treating diabetic nephropathy, preparation method and uses thereof |
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| CN101843803A (en) * | 2009-10-28 | 2010-09-29 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating diabetic nephropathy |
| CN102228536A (en) * | 2011-06-09 | 2011-11-02 | 首都医科大学 | Chinese herbal extract for treating diabetic nephropathy and preparation method thereof |
| CN104971102A (en) * | 2014-04-03 | 2015-10-14 | 成都中医药大学附属医院 | Drug composition for treating diabetic nephropathy, preparation method and uses thereof |
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