CN105168725A - Drug composite for preventing and treating piglet diarrhea and preparing method thereof - Google Patents
Drug composite for preventing and treating piglet diarrhea and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a drug composite for preventing and treating piglet diarrhea and a preparing method thereof. The composite is prepared from pig bile soybean meal and traditional Chinese medicine liquid, wherein the pig bile soybean meal contains soybean meal, pig bile and smectite powder, the traditional Chinese medicine liquid contains a traditional Chinese medicine extracting solution and a supplimental salt solution, and the traditional Chinese medicine extracting solution is prepared from ash bark, coptis chinensis, radix paeoniae alba, the roots of Chinese pulsatilla, purslane, xiongbai, elecampane, areca-nuts, the roots of kudzu vine and mangnolia officinalis. The drug composite can repair intestinal mucosa, adsorb harmful pathogeny inside the alimentary canal, ease intestinal smooth muscle peristalsis, resist bacteria and diminish inflammation, and resist virus and coccidium while supplementing liquid for piglets suffering from diarrhea.
Description
Technical field
Of the present inventionly belong to field of veterinary, be specifically related to a kind of prevention and therapy baby pig diarrhea composition and method of making the same.
Background technology
Baby pig diarrhea is the significant problem of puzzlement China pig industry, these disease four seasons are often sent out, occurred frequently at winter-spring season, and piglet is occurred frequently at 4 to 15 ages in days, the piglet birth had time serious just starts to draw yellow-white watery stool for latter 2 hours, the feces of morbidity piglet is water sample, in yellow-white or canescence, has loose bowels and causes piglet rapid dehydration dead, as fluid infusion and symptomatic treatment not in time, mortality rate is up to more than 90%, and resistance to piglet dysplasia, poor growth excessively, lose cultivation and be worth.
Cause the factor of baby pig diarrhea a lot, specific as follows:
1, feeding and management factor, as produced house cool, damp, causing piglet to be suffered from cold, having loose bowels.
2, sow mastitis causes agalactia or refusal suckling, causes piglet to eat less than colostrum, resistance poor, and then cause of disease susceptible to external world, has loose bowels.
3, bacteriological infection: based on escherichia coli, clostridieum welchii, Salmonella, Brachyspira hyodysenteriae.
4, viral infection: based on epidemic diarrhea, transmissible gastroenteritis, rotavirus, swine fever, pseudorabies etc. infect and also can cause baby pig diarrhea sometimes.
5, parasitic infection: what cause as coccidiosis etc. has loose bowels.
The bacillary vaccine of having loose bowels of current prevention has bacillus coli vaccine K88-99-987P, the vaccine that preventing viral is had loose bowels has epidemic diarrhea transmissible gastroenteritis bigeminy vaccine etc., even if in some cases to the above-mentioned vaccine of boar, maternal antibody bioactivity is up to standard, but also often send out baby pig diarrhea, this illustrates and causes baby pig diarrhea to be the result of many factors comprehensive function.
When piglet has loose bowels, Epithelium of intestinal villus cell damage evil is serious in departing from, Villus atrophy, so that intestinal effective absorbing area reduces, and absorption of nutrient ingredients obstacle, causes intestinal osmotic pressure to change, body fluid infiltrates enteric cavity, finally cause exudative having loose bowels, serious having loose bowels causes dehydration, piglet is died of exhaustion and dies.
General therapeutic baby pig diarrhea top priority is first taken stopgap measures, and namely prevents piglet from dewatering, therefore need to carry out fluid infusion, and piglet is survived, and for successive treatment is raced against time, then carries out immunotherapy targeted autoantibody.
According to the feature of baby pig diarrhea, inventor studies through this, finds a kind of compositions for the treatment of both the principal and secondary aspects of a disease, and said composition is prepared by Chinese medicine, vegetalitas and the natural material such as animal raw materials and mineral and obtains, no drug residue and drug resistance.Also the effect of repairing harmful cause of disease in intestinal mucosa, absorption digestive tract, alleviating intestinal smooth wriggling, anti-inflammation, antiviral, anticoccidial is reached while said composition fluid infusion in sight.
Summary of the invention
The object of the present invention is to provide a kind of prevention and therapy baby pig diarrhea composition and method of making the same, said composition is prepared by Chinese medicine, vegetalitas and the natural material such as animal raw materials and mineral and obtains, no drug residue and drug resistance.Also the effect of repairing harmful cause of disease in intestinal mucosa, absorption digestive tract, alleviating intestinal smooth wriggling, anti-inflammation, antiviral, anticoccidial is reached while said composition fluid infusion in sight.
For realizing object of the present invention, provide following embodiment.
In one embodiment, the pharmaceutical composition of a kind of prevention and therapy baby pig diarrhea of the present invention, comprise diad to divide, first module: Fel Sus domestica analysis for soybean powder, comprise analysis for soybean powder, Fel Sus domestica and montmorillonite powder, wherein analysis for soybean powder and Fel Sus domestica mass ratio are 1: 0.6-1: 1, and montmorillonite powder is the 12-15% of analysis for soybean powder and Fel Sus domestica matter gross weight; Second unit: herb liquid, comprises by the obtained Chinese medicine extraction liquid of medical material comprising Cortex Fraxini 10-20kg, Rhizoma Coptidis 15-25kg, Radix Paeoniae Alba 5-15kg, Radix Pulsatillae 5-15kg, Herba Portulacae 8-12kg, rhizome of chuanxiong cypress 18-25kg, Radix Aucklandiae 12-18kg, Semen Arecae 15-24kg, Radix Puerariae 8-12kg magnolia obovata 14-24kg.
In the above-described embodiment, compositions of the present invention, described herb liquid, comprise by the obtained Chinese medicine extraction liquid of medical material comprising Cortex Fraxini 15kg, Rhizoma Coptidis 20kg, Radix Paeoniae Alba 10kg, Radix Pulsatillae 10kg, Herba Portulacae 10kg, rhizome of chuanxiong cypress 20kg, Radix Aucklandiae 15kg, Semen Arecae 20kg, Radix Puerariae 10kg magnolia obovata 20kg, every ml extracting solution correspondence crude drug 2g in described Chinese medicine extraction liquid.
The weight of each Chinese crude drug of above-mentioned herb liquid can according to the proportional minimizing of production-scale large I or increase, and be not limited to fixed weight, that is the weight of above-mentioned each medical material also can understand weight portion.
In the above-described embodiment, compositions of the present invention, described herb liquid, comprises fluid infusion saline further, and the volume ratio of Chinese medicine extraction liquid and fluid infusion saline is 1: 1-1: 2, and preferably 1: 1.Described fluid infusion saline can be seemed by commercial sources, but also oneself preparation, preferably, described compositions, described fluid infusion saline bag sodium chloride-containing 7g, sodium bicarbonate 5g, potassium chloride 3g, glucose 40g and water for injection 1000ml, in described benefit saline solution, the weight of each composition also can be regarded as weight portion, to adapt to different production-scale needs.
In the above-described embodiment, compositions of the present invention, analysis for soybean powder and Fel Sus domestica mass ratio are 1: 0.8.
The compositions of the invention described above, described unit one and unit two are respective independently component unit or their mixture.
In another embodiment, the invention provides a kind of method preparing prevention and therapy baby pig diarrhea compositions of the present invention, comprising:
1) preparation of Fel Sus domestica analysis for soybean powder, comprises:
A) by Semen Glycines and Fel Sus domestica in mass ratio 1: 0.6-1: 1, preferably 1: 0.8 mixing, sealing, places 1-2 days, bile is fully absorbed by Semen Glycines under room temperature and lucifuge condition,
B) upwards walk in Semen Glycines and add feed grade montmorillonite powder by the 1.5-2.0% of Semen Glycines and bile total amount, make Montmorillonitum evenly be wrapped in Semen Glycines surface, enter in frying pan to fry to Semen Glycines crisp, epidermis pitchy, pulverize after being cooled to room temperature,
C) add remaining feed grade montmorillonite powder again, mixing, ultra micro efflorescence obtain Fel Sus domestica Semen Glycines powder, fully vapor away steam after be packed as 50g/ bottle,
2) preparation of Chinese medicine extraction liquid, comprises:
A), after Cortex Fraxini, Rhizoma Coptidis, the Radix Paeoniae Alba, the Radix Pulsatillae, Herba Portulacae, rhizome of chuanxiong cypress, the Radix Aucklandiae, Semen Arecae, Radix Puerariae, Cortex Magnoliae Officinalis being pulverized, enter Chinese medicine extracting tank, add 50-60 DEG C, 300-400kg water for injection, soak 2-4 hour;
B) heat infusion to 1/2 of original volume, be cooled to room temperature, centrifugalize, collect centrifugal liquid, boil, till making to contain crude drug in whole 2g in every milliliter of medicinal liquid, obtain Chinese medicine extraction liquid;
3) optional, step 2) Chinese medicine extraction liquid and fluid infusion saline to mix at 1: 1 by volume, stir and obtain herb liquid, subpackage is preserved, 100ml/ bottle.
In the method for the invention described above, described fluid infusion saline, preferably, by sodium chloride 7g, sodium bicarbonate 5g, potassium chloride 3g, glucose 40g mix, and inject water to 1000ml and dissolve and obtain;
In the method for the invention described above, the preparation of described Chinese medicine extraction liquid, the temperature of its step water for injection a) is 55 DEG C, and the water yield is 350kg, soaks 3 hours.
Fang Xie: compositions of the present invention, wherein, described Chinese medicine extraction liquid, in medical material prescription, Rhizoma Coptidis, rhizome of chuanxiong cypress, Semen Arecae, Cortex Magnoliae Officinalis have antibacterial, antiviral, antiinflammatory anti-diarrhea effect, are monarch drug.Cortex Fraxini, the Radix Paeoniae Alba, Herba Portulacae, the Radix Aucklandiae, the Radix Pulsatillae, Radix Puerariae strengthen monarch drug effect, are ministerial drug.Fel Sus domestica bitter in the mouth, cold, have heat clearing away and internal heat reducing, suppress intestinal smooth irritability, Montmorillonitum can be repaired intestinal mucosa, non-specificly only to have loose bowels, absorb intestinal endotoxin and cause of disease, is adjuvant drug.Usual pig has loose bowels and can cause dehydration, need to mend saline solution regulating intestinal canal acid-base balance, anti-dehydration and acidosis, benefit saline solution and compositions of the present invention are share, play the merit of anti-inflammation, antiviral, parasiticide, reparation intestinal mucosa, absorption enterotoxin, regulating intestinal canal acid-base balance altogether, and then reach the effect of better only having loose bowels.
Advantage of the present invention:
Compositions of the present invention has the effect for the treatment of both the principal and secondary aspects of a disease, and Chinese medicine, vegetalitas and the natural material such as animal raw materials and mineral are prepared and obtain, no drug residue and drug resistance, green, safety.Also the effect of repairing harmful cause of disease in intestinal mucosa, absorption digestive tract, alleviating intestinal smooth wriggling, anti-inflammation, antiviral, anticoccidial is reached while said composition fluid infusion in sight.Through clinical verification, wide spectrum, determined curative effect, this oral formulations achieves better effects clinically, and by pig farm, 26, Sichuan Province, the clinical case treatment of about 1400 baby pig diarrheas, has loose bowels for bacillary merely, the average cure rate 93.5% of 1 medication; Virally have loose bowels, continuous use 2 average cure rates reach 87.6%, and continuous use 3 average cure rates reach 94.3%, and with the matched group ratio for the treatment of with antibiotic, antiviral drugs or the two drug combination, cure rate improves about 30.3-55.8%; The a drug cure rate more than 95% of having loose bowels caused reloading, rehabilitation piglet grows fine, and does not affect fanning economics.Clinical in prevention, prophylactic tria is carried out to about 2700 piglets, effective percentage 95.5%.
The usage of compositions of the present invention, consumption:
Get Fel Sus domestica analysis for soybean powder 50g and herb liquid 50ml or the herb liquid 100ml containing fluid infusion saline, pour in container, stir.
Be used for the treatment of: draw with the 20ml syringe not with syringe needle, gavage, piglet 10ml/ head within 7 ages in days, 7 ages in days are to ablactational baby pig 15ml/ head, and every day 1 time, depending on effect after medication, being used in conjunction is for 1-3 time a course for the treatment of.2 times can be used in conjunction, two minor tick 6-8 hours when first day for the serious piglet of dehydration.
For prevention: newborn piglet to be had after colostrum 5 hours, gavages, 5ml/ head; 4-7 age in days gavages 1 time again, and dosage is the same; The above piglet of 10 age in days, gets appropriate administration of mixing homogeneously with creep feed, adds suitable amount of sucrose simultaneously and improves palatability.
Detailed description of the invention
Following examples are used for understanding spirit of the present invention further, but the scope do not limited the present invention in any way.
The pharmaceutical composition of embodiment 1 prevention and therapy baby pig diarrhea, comprises Fel Sus domestica analysis for soybean powder and herb liquid
Fel Sus domestica analysis for soybean powder, comprises analysis for soybean powder, Fel Sus domestica and montmorillonite powder, and wherein analysis for soybean powder and Fel Sus domestica mass ratio are 1: 0.8, and montmorillonite powder is 15% of analysis for soybean powder and Fel Sus domestica matter gross weight;
Cortex Fraxini 15kg, Rhizoma Coptidis 20kg, Radix Paeoniae Alba 10kg, Radix Pulsatillae 10kg, Herba Portulacae 10kg, rhizome of chuanxiong cypress 20kg, Radix Aucklandiae 15kg, Semen Arecae 20kg, Radix Puerariae 10kg, Cortex Magnoliae Officinalis 20kg
Fluid infusion saline, sodium chloride 7g, sodium bicarbonate 5g, potassium chloride 3g, glucose 40g, injects water to 1000ml.
Preparation technology:
1) preparation of Fel Sus domestica analysis for soybean powder: get slaughterhouse and to quarantine qualified swine gallbladder, gallbladder wall is cut open with surgical scissors, take out gallbladder juice, Heilongjiang soybean tap water cleans up and loads in bucket, by bile: the mass ratio of Semen Glycines is add gallbladder juice at 1: 0.8, sealing, in room temperature, 1-2 days is placed under lucifuge condition, stir 3 every day, bile is fully absorbed by Semen Glycines, then take out Semen Glycines, pour in stainless steel disc, 2.0% adds feed grade montmorillonite powder in mass ratio, stir with stainless steel shovel, Montmorillonitum is made evenly to be wrapped in Semen Glycines surface, enter drum-type frying pan, fry crisp to Semen Glycines, epidermis pitchy, then take out, spread out in stainless steel disc, steam is fully volatilized, return to room temperature, collect, pulverize for the first time with pulverizer, then add remaining feed grade montmorillonite powder, mixing, pulverize with super micron mill, collect Fel Sus domestica Semen Glycines powder, spread out in stainless steel disc, steam is fully volatilized, return to room temperature, be packed as 50g/ bottle, room temperature is preserved.
2), prepared by herb liquid: Cortex Fraxini (15kg), Rhizoma Coptidis (20kg), the Radix Paeoniae Alba (10kg), the Radix Pulsatillae (10kg), Herba Portulacae (10kg), rhizome of chuanxiong cypress (20kg), the Radix Aucklandiae (15kg), Semen Arecae (20kg), Radix Puerariae (10kg), Cortex Magnoliae Officinalis (20kg), in above-mentioned, medicinal pulverizer is pulverized, enter Chinese medicine extracting tank, add 55 DEG C, 350kg water for injection, soak 3 hours, then infusion is to 1/2 of original volume, be cooled to room temperature, continuous pipe type centrifuge is conveyed into peristaltic pump, collect centrifugal liquid, boil, make in every milliliter of medicinal liquid containing above-mentioned crude drug in whole 2g, obtain Chinese medicine extraction liquid.
3), 1: 1 mixing by volume of fluid infusion saline and Chinese medicine extraction liquid, stir, obtained herb liquid, subpackage, 100ml/ bottle, 116 DEG C of sterilizings 30 minutes, room temperature is preserved.
The compositions of embodiment 2 prevention and therapy baby pig diarrhea, comprises Fel Sus domestica analysis for soybean powder and herb liquid
Fel Sus domestica analysis for soybean powder: comprise analysis for soybean powder, Fel Sus domestica and montmorillonite powder, wherein analysis for soybean powder and Fel Sus domestica mass ratio are 1: 0.6, and montmorillonite powder is 12% of analysis for soybean powder and Fel Sus domestica matter gross weight;
The Chinese crude drug formula of herb liquid: containing Cortex Fraxini 10kg, Rhizoma Coptidis 15kg, Radix Paeoniae Alba 5kg, Radix Pulsatillae 5kg, Herba Portulacae 8kg, rhizome of chuanxiong cypress 18kg, Radix Aucklandiae 12kg, Semen Arecae 15kg, Radix Puerariae 8kg magnolia obovata 14kg
3), fluid infusion saline: sodium chloride 7g, sodium bicarbonate 5g, potassium chloride 3g, glucose 40g, injects water to 1000ml.
Preparation technology:
1) preparation of Fel Sus domestica analysis for soybean powder:
Get slaughterhouse to quarantine qualified swine gallbladder, gallbladder wall is cut open with surgical scissors, take out gallbladder juice, Heilongjiang soybean tap water cleans up and loads in bucket, by bile: the mass ratio of Semen Glycines is add gallbladder juice at 1: 0.8, sealing, in room temperature, 1-2 days is placed under lucifuge condition, stir 3 every day, bile is fully absorbed by Semen Glycines, then take out Semen Glycines, pour in stainless steel disc, 1.5% adds feed grade montmorillonite powder in mass ratio, stir with stainless steel shovel, Montmorillonitum is made evenly to be wrapped in Semen Glycines surface, enter drum-type frying pan, fry crisp to Semen Glycines, epidermis pitchy, then take out, spread out in stainless steel disc, steam is fully volatilized, return to room temperature, collect, pulverize for the first time with pulverizer, then add remaining feed grade montmorillonite powder, mixing, pulverize with super micron mill, collect Fel Sus domestica Semen Glycines powder, spread out in stainless steel disc, steam is fully volatilized, return to room temperature, be packed as 50g/ bottle, room temperature is preserved.
2) Chinese medicine extraction liquid preparation: pulverizer medicinal in recipe quantity is pulverized, enter Chinese medicine extracting tank, add 50-60 DEG C, 300kg water for injection, soak 2-3 hour, then infusion is to 1/2 of original volume, be cooled to room temperature, be conveyed into continuous pipe type centrifuge with peristaltic pump, collect centrifugal liquid, boil, make to contain above-mentioned crude drug in whole 2g in every milliliter of medicinal liquid, obtain Chinese medicine extraction liquid.
3) fluid infusion saline and Chinese medicine extraction liquid 1: 1 mixing by volume, stirs, obtained herb liquid, subpackage, 100ml/ bottle, and 116 DEG C of sterilizings 30 minutes, room temperature is preserved.
The compositions of embodiment 3 prevention and therapy baby pig diarrhea, comprises Fel Sus domestica analysis for soybean powder and herb liquid
Fel Sus domestica analysis for soybean powder: comprise analysis for soybean powder, Fel Sus domestica and montmorillonite powder, wherein analysis for soybean powder and Fel Sus domestica mass ratio are 1: 1, and montmorillonite powder is 14% of analysis for soybean powder and Fel Sus domestica matter gross weight;
The Chinese crude drug formula of herb liquid: containing Cortex Fraxini 20kg, Rhizoma Coptidis 25kg, Radix Paeoniae Alba 15kg, Radix Pulsatillae 15kg, Herba Portulacae 12kg, rhizome of chuanxiong cypress 25kg, Radix Aucklandiae 18kg, Semen Arecae 24kg, Radix Puerariae 12kg magnolia obovata 24kg
Fluid infusion saline: sodium chloride 7g, sodium bicarbonate 5g, potassium chloride 3g, glucose 40g, injects water to 1000ml.
Preparation technology:
1) preparation of Fel Sus domestica analysis for soybean powder is identical with the method for embodiment 1,
2) Chinese medicine extraction liquid preparation: pulverizer medicinal in recipe quantity is pulverized, enter Chinese medicine extracting tank, add 55-60 DEG C, 400kg water for injection, soak 3-4 hour, then infusion is to 1/2 of original volume, be cooled to room temperature, be conveyed into continuous pipe type centrifuge with peristaltic pump, collect centrifugal liquid, boil, make to contain above-mentioned crude drug in whole 2g in every milliliter of medicinal liquid, obtain Chinese medicine extraction liquid.
3) fluid infusion saline and Chinese medicine extraction liquid 1: 1 mixing by volume, stirs, obtained herb liquid, subpackage, 100ml/ bottle, and 116 DEG C of sterilizings 30 minutes, room temperature is preserved.
Clinical treatment application case
Sichuan Province's Mianyang City scale pig breeding farm, livestock on hand sow 370 remainder, have altogether 7 nests, meter 81 suckling pigs draw yellow-white loose stool; be yellow and white dysentery of piglet through laboratory diagnosis, antibiotic therapy poor effect, to fall ill in one week dead 46; cure 27, remaining 8 become cad pig.
Another piglet 12, has loose bowels, morbidity age in days be 6 ages in days, fall ill 5 days dead 11,1 (14 age in days) dysplasia of survival, becomes cad pig.Showing to have loose bowels is the higher disease of piglet fatality rate.
Afterwards, this pig farm adopted compositions of the present invention (compositions of embodiment 1), treated 63 piglets (having loose bowels) fallen ill, and usage and dosage is see aforementioned herein, and medication is 1-3 time, once-a-day, all cures.For wherein 8, hurdle piglet, baby pig diarrhea 4 days, it is dirty that health adheres to yellow excrement.Gavage compositions of the present invention (medicine) to morbidity piglet, only medication once, after medication 12 hours, the symptom of having loose bowels of piglet is significantly alleviated, the equal formed stools of full nest piglet after 24 hours, medication after 48 hours previous whole body be stained with the piglet of excrement dirt skin light hair be bright, return to one's perfect health.
Adopt the compositions of embodiment 1,2,3, by pig farm, 26, Sichuan Province, the clinical case treatment of about 1400 baby pig diarrheas, has loose bowels for bacillary merely, the average cure rate 93.5% of 1 medication; Virally have loose bowels, continuous use 2 average cure rates reach 87.6%, and continuous use 3 average cure rates reach 94.3%, and with the matched group ratio for the treatment of with antibiotic, antiviral drugs or the two drug combination, cure rate improves about 30.355.8%; The a drug cure rate more than 95% of having loose bowels caused reloading, rehabilitation piglet grows fine, and does not affect fanning economics.Clinical in prevention, prophylactic tria is carried out to about 2700 piglets, effective percentage 95.5%.The safety of compositions of the present invention, uses the compositions (medicine) of embodiment 1
1, the safety of single dose repeat administration
Different phase age in days sodium selenite, per stage each 10 of piglet, according to the dosage in usage and dosage, repeat administration 23 times, every minor tick 8 hours, then observes 7 days, compares, have no the mental status, search for food with the normal healthy controls piglet of identical age in days, feces etc. is abnormal.
2, the safety of heavy dose of single-dose
Different phase age in days piglet, per stage each 10 of piglet, according to the 3 times of administrations being used for the treatment of dosage in using method, then observe 7 days, compare with the normal healthy controls piglet of identical age in days, have no the mental status, search for food, feces etc. is abnormal.
3, clinical practice safety
Through clinical verification, for prevention, treat the piglet about 4100 that has loose bowels, wherein have 9 piglets gavage this test with medicine after choke and cough, dead 6,3 not dead piglets recovered normal in 1 day, by cuing open inspection to dead piglet, finding that medicinal liquid is poured in lungs, causing respiratory disorder and dead; Other applies the piglet no abnormality seen of this medicine.
4, conclusion
Under proper use of prerequisite, this medicine is safe to piglet.
Claims (11)
1. the pharmaceutical composition of a prevention and therapy baby pig diarrhea, comprise diad to divide, first module: Fel Sus domestica analysis for soybean powder, comprise analysis for soybean powder, Fel Sus domestica and montmorillonite powder, wherein analysis for soybean powder and Fel Sus domestica mass ratio are 1: 0.6-1: 1, and montmorillonite powder is the 12-15% of analysis for soybean powder and Fel Sus domestica matter gross weight; Second unit: herb liquid, comprises by the obtained Chinese medicine extraction liquid of medical material comprising Cortex Fraxini 10-20kg, Rhizoma Coptidis 15-25kg, Radix Paeoniae Alba 5-15kg, Radix Pulsatillae 5-15kg, Herba Portulacae 8-12kg, rhizome of chuanxiong cypress 18-25kg, Radix Aucklandiae 12-18kg, Semen Arecae 15-24kg, Radix Puerariae 8-12kg magnolia obovata 14-24kg.
2. compositions as claimed in claim 1, described herb liquid, comprises by the obtained Chinese medicine extraction liquid of medical material comprising Cortex Fraxini 15kg, Rhizoma Coptidis 20kg, Radix Paeoniae Alba 10kg, Radix Pulsatillae 10kg, Herba Portulacae 10kg, rhizome of chuanxiong cypress 20kg, Radix Aucklandiae 15kg, Semen Arecae 20kg, Radix Puerariae 10kg magnolia obovata 20kg.
3. compositions as claimed in claim 1 or 2, the corresponding crude drug 2g of every ml extracting solution in described Chinese medicine extraction liquid.
4. compositions as claimed in claim 3, containing fluid infusion saline in herb liquid.
5. compositions as claimed in claim 4, described fluid infusion saline bag sodium chloride-containing 7g, sodium bicarbonate 5g, potassium chloride 3g, glucose 40g and water for injection 1000ml.
6. compositions as claimed in claim 5, the volume ratio of Chinese medicine extraction liquid and fluid infusion saline is 1: 1.
7. compositions as claimed in claim 1, analysis for soybean powder and Fel Sus domestica mass ratio are 1: 0.8.
8. prepare a method for the pharmaceutical composition of the prevention and therapy baby pig diarrhea of claim 17, comprising:
1) preparation of Fel Sus domestica analysis for soybean powder, comprises:
A) Semen Glycines and Fel Sus domestica to be mixed in mass ratio at 1: 0.6-1: 1, place 1-2 days, bile is fully absorbed by Semen Glycines;
B) upwards walk in Semen Glycines and add feed grade montmorillonite powder by the 1.5-2.0% of Semen Glycines and Fel Sus domestica gross weight, make Montmorillonitum evenly be wrapped in Semen Glycines surface, enter in frying pan to fry to Semen Glycines crisp, epidermis pitchy, pulverize after being cooled to room temperature;
C) add remaining feed grade montmorillonite powder again, mixing, ultra micro efflorescence obtain Fel Sus domestica Semen Glycines powder, fully vapor away steam after be packed as 50g/ bottle;
2) preparation of herb liquid, comprises:
A), after Cortex Fraxini, Rhizoma Coptidis, the Radix Paeoniae Alba, the Radix Pulsatillae, Herba Portulacae, rhizome of chuanxiong cypress, the Radix Aucklandiae, Semen Arecae, Radix Puerariae, Cortex Magnoliae Officinalis being pulverized, enter Chinese medicine extracting tank, add 5060 DEG C, 300400kg water for injection, soak 3 hours;
B) heat infusion to 1/2 of original volume, be cooled to room temperature, centrifugalize, collect centrifugal liquid, boil, make to contain crude drug in whole 2g in every milliliter of medicinal liquid, obtain Chinese medicine extraction liquid or herb liquid;
3) preparation of fluid infusion saline, sodium chloride 7g, sodium bicarbonate 5g, potassium chloride 3g, glucose 40g injects water to 1000ml;
4) optional, step 2) Chinese medicine extraction liquid and fluid infusion saline to mix at 1: 1 by volume, stir
Obtain herb liquid, subpackage is preserved, 100ml/ bottle.
9. method as claimed in claim 8, the preparation of described Chinese medicine extraction liquid, the temperature of its step water a) is 55 DEG C, and the water yield is 350kg.
10. method as claimed in claim 8, the preparation of described Fel Sus domestica analysis for soybean powder, step a) middle Semen Glycines is carried out under absorbing bile sealing, room temperature and lucifuge condition.
11. as arbitrary in claim 1-7 as described in compositions, described unit one and unit two are separately independently combination or their mixture.
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Application publication date: 20151223 |