CN105168046A - Hair growth promoting composition containing plant extracts - Google Patents
Hair growth promoting composition containing plant extracts Download PDFInfo
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- CN105168046A CN105168046A CN201510563413.5A CN201510563413A CN105168046A CN 105168046 A CN105168046 A CN 105168046A CN 201510563413 A CN201510563413 A CN 201510563413A CN 105168046 A CN105168046 A CN 105168046A
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Abstract
The invention relates to a hair growth promoting composition containing plant extracts. The composition is characterized by consisting of a wild soybean germ extract, a bistort extract, a lepidium sativum sprout extract and methyl dihydrojasmanate according to mass ratio of (3-10) to (1-5) to (1-5) to (0.05-0.3). The composition disclosed by the invention has a beneficial effect of promoting hair growth.
Description
Background technology
The growth of hair depends on that whether the hair follicle cell of root of hair is healthy, and the dermal papilla quantity be positioned at bottom hair follicle cell is the key that hair follicle cell produces hair.Dermal papilla produces multiple hair growth promoting promotive factor, and as the keratinocyte proliferation factor, insulin-like growth factor-i etc., these hair growth promoting promotive factor act on hair follicle cell, promotes the growth of hair.If dermal papilla is impaired or quantity reduces, just there will be hair follicle cell and stop division, the new problem sending out not regrowth.With advancing age, dermal papilla reduces, and new hypertrophy of sending out then can slow down, and therefore, only has and repairs and regeneration dermal papilla, just can reach good hair-growing effects.
At present, industry generally believes that the main cause that dermal papilla reduces has following, and one is that scalp blood microcirculation is insufficient, causes dermal papilla oxygen content and undernutrition; Two is that in skin, polyamine content reduces, and dermal papilla stops hypertrophy along with the age becomes large; Three is oxygen-derived free radicals attacks to dermal papilla, causes the damage of dermal papilla.
Summary of the invention
The technology that the present invention will solve is, provide a kind of hair growth composition containing plant extract, said composition has trichogenous beneficial effect.
For solving the problems of the technologies described above, technical scheme provided by the invention is: a kind of hair growth composition containing plant extract, is characterized in that: formed formed according to the ratio of mass percent 3 ~ 10:1 ~ 5:1 ~ 5:0.05 ~ 0.3 by Wild soybean embryo extract, snakewort extract, cultivated pepperweed seed bud extract, MDJ.
For improving the hair-growing effects of hair growth composition, the present invention carries out preferably the Wild soybean embryo extract in hair growth composition and snakewort extract, and preferred version is as follows: described Wild soybean embryo extract Content of Chlorogenic Acid is not less than 250ppm, quercetin content is not less than 80ppm, rutin content is not less than 150ppm; Sulforaphen content in described snakewort extract is not less than 30ppm.
The present invention is also optimized the consumption of Wild soybean embryo extract, snakewort extract, cultivated pepperweed seed bud extract, MDJ, and optimum ratio is 4.5 ~ 8:1 ~ 3:1 ~ 3:0.1 ~ 0.3.
Wild soybean embryo extract in the present invention, plant latin name GLYCINESOJA, sequence number in 2010 version " international cosmetic raw material standard Chinese catalogue " is 5600, Plant Polyamines is rich in Wild soybean embryo extract, three wherein main kind of plant polyamines are putrescine Putrescine, molecular formula is NH2 (CH2) 4NH2, spermidine Spermidine, molecular formula is NH2 (CH2) 3NH (CH2) 4NH2 and spermine Spermine, molecular formula is NH2 (CH2) 3NH (CH2) 4NH (CH2) 3NH2, this three polyamine species can participate in the many biological processes in organism, transcribe as regulator gene and transcribe rear process, modulation of ion channels opens and closes, protein kinase biological activity, cell cycle, the Structure and stability etc. of membrane structure and function and nucleic acid.The present invention, by Wild soybean embryo extract, supplements and increases with the age, the loss of polyamines in skin.Wild soybean embryo extract in the present invention, it can be the plumule extraction gained of 3-10 days after soybean germination, obtain juice through squeezing plumule, then use Macroporous weak acid cation exchange resin enrichment and eluting, in eluate, the total amount of putrescine, spermidine and spermine is not less than 150ppm.
Snakewort extract in the present invention, plant latin name POLYGONUMBISTORTA, sequence number in 2010 version " international cosmetic raw material standard Chinese catalogue " is 11250, main active in snakewort extract is chlorogenic acid, Quercetin, rutin etc., for reaching better hair-growing effects, the preferred chlorogenic acid content of the present invention is not less than 250ppm, and quercetin content is not less than 80ppm, and rutin content is not less than the snakewort extract of 150ppm.Snakewort extract is by promoting the propagation of dermal papilla and the expression of perlecan albumen and dystrophin polysaccharide, increase the quantity of dermal papilla, make the epidermis of skin and hair follicle cell group again obtain nutrition, hair follicle division synthesis increases, and then promotes hair growth.
Cultivated pepperweed seed bud extract in the present invention, plant latin name LEPIDIUMSATIVUM, the sequence number in 2010 version " international cosmetic raw material standard Chinese catalogue " is 7558.Sulforaphen in cultivated pepperweed seed bud extract, the accumulation that can reduce free radical in skin and the damage caused dermal papilla, strengthen blood circulation, for scalp provides sufficient nutrient, and then promotes hair growth.For reaching better hair-growing effects, the preferred sulforaphen content of the present invention is not less than the cultivated pepperweed seed bud extract of 30ppm.
The present invention uses MDJ, its INCI english name is METHYLDIHYDROJASMONATE, sequence number in 2010 version " international cosmetic raw material standard Chinese catalogue " is 2182, coordinate with Wild soybean embryo extract, snakewort extract, cultivated pepperweed seed bud extract, the activity of three can be improved, impel three to reach the effect of Synergistic.MDJ or excellent flavouring agent, can hide the bad smell of Wild soybean embryo extract, snakewort extract, cultivated pepperweed seed bud extract, provides the graceful jasmine note of pleasant.
The present invention adopts Wild soybean embryo extract, snakewort extract, cultivated pepperweed seed bud extract, MDJ to combine according to a certain percentage, four kinds of material synergism, reaches hair growth promoting, educates the effect sent out.It is that the normal saline solution of 1%-50% is directly applied in scalp surface and uses that this compositions can be made into mass ratio, also can be composite to shampoo, hair conditioner, use in the multiple products such as hair growth promoting gel, this compositions is composite is preferably 1% ~ 50% to the ratio in cosmetics.
The present composition can promote scalp blood microcirculation, supplementary dermal papilla grows necessary polyamines composition, simultaneously can scavenging activated oxygen be active well, promote dermal papilla growth, reduce the dermal papilla damage that free radical causes, experiment proof can have promotion dermal papilla growth result, also can have good hair-growing effects.
The action effect experiment of hair growth composition to the growth of depilation mouse hair is as follows:
Inject 0.5 microgram ethylene Nitrosourea, continuous 2 weeks every day to inbred line C57BL/6J mice, injury dermal papilla, can cause mouse systemic to lose hair or feathers.Adopt the aqueous solution of hair growth composition of the present invention, the hair growth composition aqueous solution action effect of 15 days is smeared continuously to depilation mice epilating area and observes.
Often organize 10 mices, totally 11 groups, specific as follows:
(1) 1 group, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=0:1:1:0.1;
(2) 2 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=10:0:1:0.1;
(3) 3 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=10:1:0:0.1;
(4) 4 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=10:1:1:0;
(5) 5 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=10:1:1:0.3;
(6) 6 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=1:1:1:0.1;
(7) 7 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=4.5:3:2:0.1;
(8) 8 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=4.5:3:3:0.1;
(9) 9 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=8:2:1:0.1;
(10) 10 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=10:2:1:0.1;
(11) 10 groups, sample: be Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: 10% normal saline solution of the hair growth composition of MDJ=0.5:0.5:0.5:0.01;
(12) blank group (11 groups, sample): normal saline solution is smeared in depilation district.
Smear 1 every day, continuous 15 days, within the 16th day, carry out biological tissue to application area and observe, use Vivascope3000 counts the dermal papilla in 1 square micron, the results are shown in following table.
Note: composition A represents Wild soybean embryo extract, B represents snakewort extract, and C represents cultivated pepperweed seed bud extract, and D represents MDJ.
As can be seen from the above table, the increment of sample 5 pairs of mouse hair follicles cells is all higher than sample 1,2,3,4 and blank group, show that Wild soybean embryo extract, snakewort extract, cultivated pepperweed seed bud extract and MDJ combinationally use, there is the significant collaborative effect increasing hair follicle.9 groups, sample is than the better effects if of sample 5,6,7,8,10, and show that the proportioning of its active matter is more preferred, when especially Wild soybean embryo extract content is higher, effect is comparatively obvious.But when Wild soybean embryo extract content exceedes certain limit, effect declines on the contrary to some extent, therefore preferred part by weight scope is 4.5 ~ 8:1 ~ 3:1 ~ 3:0.1 ~ 0.3.
The Efficacy experiments of hair growth composition to scalp dermal papilla is as follows:
Volunteer Wang, man 45 years old, has slight alopecia symptom, before using this hair growth promoting to combine, the dermal papilla situation adopting its scalp of VivaScope3000 Reflectance confocal microscope photographing subcutaneous and the situation of basement membrane, as depicted in figs. 1 and 2.
The hair care gel using embodiment 5 preparation once a day, continues use after 60 days, again takes the situation of its dermal papilla situation and basement membrane, as shown in Figure 3 and Figure 4.
Conclusion: comparison diagram 1 and Fig. 3 can find out, in Fig. 3, the number of volunteer's scalp dermal papilla obviously increases.Comparison diagram 2 and Fig. 4 can find out, volunteer's scalp dermal papilla more multi-synapses in Fig. 4, the quantity of skin dermal papilla is significantly increased, and indicates that scalp is more healthy.
The human body hair-growing effects test of hair growth composition
Volunteer is the disease that 24 years old ~ 55 years old 50 have alopecia or oligotrichosis, wherein male 35, women 15, the hair-growing and hair care gel prepared by embodiment 5 is coated in the usual manner the right half a head.Every day uses once, continues 60 days.Evaluation methodology: visual valuation, the number of hairs in counting regulation 10 square centimeters, region.
Statistical result showed, use after 28 days, in volunteer's regulation region, number of hairs increases to 32%; Use after 60 days, in volunteer's regulation region, hair total quantity increases to 47%.
Accompanying drawing explanation
Fig. 1 is the number photo of the dermal papilla of front VivaScope3000 Reflectance confocal microscope photographing on probation;
Fig. 2 is the photo of the basement membrane of front VivaScope3000 Reflectance confocal microscope photographing on probation;
Fig. 3 is the number photo of the dermal papilla of VivaScope3000 Reflectance confocal microscope photographing after 60 days on probation;
Fig. 4 is the photo of the basement membrane of VivaScope3000 Reflectance confocal microscope photographing after 60 days on probation.
Detailed description of the invention
Embodiment 1:
Containing the preparation of the hair tonic shampoo of this hair growth composition
Hair tonic shampoo formula containing this hair growth composition, its constituent and ratio as follows, formula each Ingredients Weight ratio summation is 100%; Wherein hair growth composition active matter consists of Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: MDJ=3:1:1:0.05.
Hair growth composition 1.0%
AES(surfactant) 20%
Coconut oleoyl amine MEA(surfactant) 1%
Cocamido propyl betaine (surfactant) 3%
Antiseptic 0.08%
Essence 0.5%
Pure water is added into 100%
It is below this product human body hair-growing effects test of the present embodiment
Volunteer is the disease that 24 years old ~ 55 years old 50 have alopecia or oligotrichosis, wherein male 35, women 15, the hair tonic shampoo prepared by embodiment 5 is coated in the usual manner the right half a head.Every day uses once, continues 60 days.Evaluation methodology: visual valuation, the number of hairs in counting regulation 10 square centimeters, region.
Statistical result showed, use after 28 days, in volunteer's regulation region, number of hairs increases to 4%; Use after 60 days, in volunteer's regulation region, hair total quantity increases to 9%.
Embodiment 2:
Containing the preparation of the hair tonic shampoo of this hair growth composition
Hair tonic shampoo formula containing this hair growth composition, its constituent and ratio as follows, formula each Ingredients Weight ratio summation is 100%.Wherein hair growth composition active matter consists of Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: MDJ=10:5:5:0.3.
Hair growth composition 10%
Laureth sulfuric ester ammonium 20%
Coconut oleoyl amine MEA1%
Cocamido propyl betaine 3%
Antiseptic 0.08%
Essence 0.5%
Pure water is added into 100%
It is below this product human body hair-growing effects test of the present embodiment
Volunteer is the disease that 24 years old ~ 55 years old 50 have alopecia or oligotrichosis, wherein male 35, women 15, the hair tonic shampoo prepared by embodiment 5 is coated in the usual manner the right half a head.Every day uses once, continues 60 days.Evaluation methodology: visual valuation, the number of hairs in counting regulation 10 square centimeters, region.
Statistical result showed, use after 28 days, in volunteer's regulation region, number of hairs increases to 9%; Use after 60 days, in volunteer's regulation region, hair total quantity increases to 15%.
Embodiment 3:
Containing the preparation of the hair tonic shampoo of this hair growth composition
Hair tonic shampoo formula containing this hair growth composition, its constituent and ratio as follows, formula each Ingredients Weight ratio summation is 100%; Wherein hair growth composition active matter consists of Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: MDJ=8:3:3:0.3.
Hair growth composition 15%
AES20%
Coconut oleoyl amine MEA1%
Cocamido propyl betaine 3%
Antiseptic 0.08%
Essence 0.5%
Pure water is added into 100%
It is below this product human body hair-growing effects test of the present embodiment
Volunteer is the disease that 24 years old ~ 55 years old 50 have alopecia or oligotrichosis, wherein male 35, women 15, the hair tonic shampoo prepared by embodiment 5 is coated in the usual manner the right half a head.Every day uses once, continues 60 days.Evaluation methodology: visual valuation, the number of hairs in counting regulation 10 square centimeters, region.
Statistical result showed, use after 28 days, in volunteer's regulation region, number of hairs increases to 12%; Use after 60 days, in volunteer's regulation region, hair total quantity increases to 19%.
Embodiment 4:
Containing the preparation of the hair-growing and hair care element of hair growth composition of the present invention
Containing hair growth composition of the present invention hair-growing and hair care element formula, its constituent and ratio as follows, formula each Ingredients Weight ratio summation is 100%; Wherein hair growth composition active matter consists of Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: MDJ=4.5:1:1:0.1.
Hair growth composition 5%
Mountain Yu base trimethyl ammonium chloride 2%
Cetearyl alcohol 8%
Antiseptic 0.08%
Essence 0.5%
Pure water is added into 100%
It is below this product human body hair-growing effects test of the present embodiment
Volunteer is the disease that 24 years old ~ 55 years old 50 have alopecia or oligotrichosis, wherein male 35, women 15, the hair-growing and hair care element prepared by embodiment 5 is coated in the usual manner the right half a head.Every day uses once, continues 60 days.Evaluation methodology: visual valuation, the number of hairs in counting regulation 10 square centimeters, region.
Statistical result showed, use after 28 days, in volunteer's regulation region, number of hairs increases to 8%; Use after 60 days, in volunteer's regulation region, hair total quantity increases to 16%.
Embodiment 5:
Containing the preparation of the hair-growing and hair care gel of hair growth composition of the present invention
The formula of the hair-growing and hair care gel containing hair growth composition of the present invention, its constituent and ratio as follows, formula each Ingredients Weight ratio summation is 100%; Wherein hair growth composition active matter consists of Wild soybean embryo extract: snakewort extract: cultivated pepperweed seed bud extract: MDJ=8:2:1:0.1.
Hair growth composition 50%
Carbomer 0.6%
Glycerol 10%
Sorbitol 8%
Triethanolamine 0.2%
Essence 0.5%
Antiseptic 0.08%
Pure water is added into 100%
It is below this product human body hair-growing effects test of the present embodiment
Volunteer is the disease that 24 years old ~ 55 years old 50 have alopecia or oligotrichosis, wherein male 35, women 15, the hair-growing and hair care gel prepared by embodiment 5 is coated in the usual manner the right half a head.Every day uses once, continues 60 days.Evaluation methodology: visual valuation, the number of hairs in counting regulation 10 square centimeters, region.
Statistical result showed, use after 28 days, in volunteer's regulation region, number of hairs increases to 32%; Use after 60 days, in volunteer's regulation region, hair total quantity increases to 47%.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (4)
1., containing a hair growth composition for plant extract, it is characterized in that: formed formed according to the ratio of mass percent 3 ~ 10:1 ~ 5:1 ~ 5:0.05 ~ 0.3 by Wild soybean embryo extract, snakewort extract, cultivated pepperweed seed bud extract, MDJ.
2. the hair growth composition containing plant extract according to claim 1, is characterized in that: described Wild soybean embryo extract Content of Chlorogenic Acid is not less than 250ppm, quercetin content is not less than 80ppm, rutin content is not less than 150ppm.
3. the hair growth composition containing plant extract according to claim 1, is characterized in that: the sulforaphen content in described snakewort extract is not less than 30ppm.
4. the hair growth composition containing plant extract according to claim 1 or 2 or 3, is characterized in that: the mass ratio of Wild soybean embryo extract, snakewort extract, cultivated pepperweed seed bud extract, MDJ is preferably 4.5 ~ 8:1 ~ 3:1 ~ 3:0.1 ~ 0.3.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111246868A (en) * | 2017-10-20 | 2020-06-05 | 株式会社爱茉莉太平洋 | Composition for preventing hair loss or promoting hair growth comprising extract of cultured tissue of beans and preparation method thereof |
| CN112120953A (en) * | 2019-06-24 | 2020-12-25 | 珀莱雅化妆品股份有限公司 | Preparation method of freeze-dried liposome containing hair-nourishing composition |
| CN113425636A (en) * | 2021-05-21 | 2021-09-24 | 广州德谷个人护理用品有限公司 | Preparation method of tea bran flavone and application of tea bran flavone in anti-hair loss product |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0639368A1 (en) * | 1992-04-23 | 1995-02-22 | Shiseido Company Limited | Scalp care product composition |
| CN101810695A (en) * | 2010-04-26 | 2010-08-25 | 任芳芳 | Pilatory for preventing trichomadesis |
-
2015
- 2015-09-08 CN CN201510563413.5A patent/CN105168046B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0639368A1 (en) * | 1992-04-23 | 1995-02-22 | Shiseido Company Limited | Scalp care product composition |
| CN101810695A (en) * | 2010-04-26 | 2010-08-25 | 任芳芳 | Pilatory for preventing trichomadesis |
Non-Patent Citations (1)
| Title |
|---|
| 邓小英等: ""一种新型生发剂的研制和应用"", 《香料香精化妆品》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111246868A (en) * | 2017-10-20 | 2020-06-05 | 株式会社爱茉莉太平洋 | Composition for preventing hair loss or promoting hair growth comprising extract of cultured tissue of beans and preparation method thereof |
| CN112120953A (en) * | 2019-06-24 | 2020-12-25 | 珀莱雅化妆品股份有限公司 | Preparation method of freeze-dried liposome containing hair-nourishing composition |
| CN112120953B (en) * | 2019-06-24 | 2022-01-14 | 珀莱雅化妆品股份有限公司 | Preparation method of freeze-dried liposome containing hair-nourishing composition |
| CN113425636A (en) * | 2021-05-21 | 2021-09-24 | 广州德谷个人护理用品有限公司 | Preparation method of tea bran flavone and application of tea bran flavone in anti-hair loss product |
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