CN105148236A - Medicine for treating coronary heart disease and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating a coronary heart disease. The medicine is mainly prepared from uncaria, a Chinese fevervine herb, himalayan teasel roots, salvia miltiorrhiza, Cherokee rose fruits, hairyvein agrimony, a herb of spanishneedles, rhizomes and roots of ocreate greenbrier, amomum villosum, pittosporum tubiflorum, hawthorn fruits, astragalus roots, gingers, gaultheria yunnanensis, a perfoliate knotweed herb, motherwort, forsythia, tuber fleeceflower stems, Chinese mahonia and radix berberidis. The medicine can improve coronary blood-flow volume and increase myocardial oxygen content, enables the myocardial oxygen demand to be increased, improves the activity of dredging coronary arterial wall, increases coronary arterial elasticity and the like, can be used for treating the coronary heart disease, is remarkable in treating effect, short in treatment period, safe and free of side effect and enables the coronary heart disease not to relapse.

Description

A kind of medicine for the treatment of coronary heart disease and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of coronary heart disease and preparation method thereof, belong to the field of medicine technology.

Technical background

Coronary heart disease (coronaryheartdisease) is a kind of commonly encountered diseases and frequently-occurring disease of serious harm human health, along with raising and the aged tendency of population of people's living standard, the sickness rate of primary disease and case fatality rate occupy first place in cardiovascular disease and ascendant trend is obvious year by year, becomes " first killer " of harm humans health.Point out in the report that World Health Organization (WHO) (WHO) is nearest, the mortality rate of 2000-2020 myocardial infarction will rise to the 1st by the 5th.The control of cardiovascular major disease is classified as priority research areas by " National Program for Medium-to Long-term Scientific and Technological Development (2006 ~ 2020) " and " scientific tcm research and development outline ".

The Etiological of coronary heart disease is atherosclerosis (atherosclerosis, AS), and the myocardial ischemia caused thus, downright bad pathological change.Its pathology pathogenesis is mainly because lipid metabolic disorder makes blood fat raise, blood vessel lipidosis, soak molten, blood vessel endothelium foam wanshing, the reaction of blood vessel wall chronic inflammatory makes the damage of coronary blood endothelial tube function and morphology, forms blood vessel endothelium atheromatous plaque, there is plaque rupture further, thrombosis, angiostenosis or obturation make coronary blood circulation obstacle, myocardial ischemia, myocardial cell damage, causes cardiac insufficiency.

At present for rate occurred frequently and the high mortality of coronary heart disease, still mainly rest on early prevention and improve clinical symptoms aspect, doctor trained in Western medicine aspect protective agents and Therapeutic Method there is no important breakthrough.The most important thing is once suffer from coronary heart disease, western medicine is emphasized will adhere to taking medicine throughout one's life, even if after cost huge fund placing rack, still need the medicine of long-term taking costliness, and Different therapeutical effect is larger.In recent years, along with the quickening of social rhythm and the raising of living standards of the people, the sickness rate of coronary heart disease has the trend obviously increased, the serious harm health of the people.Coronary heart disease belongs to the category of the traditional Chinese medical science " thoracic obstruction ", " angina pectoris ", " precordial pain with cold limbs ".The traditional Chinese medical science because it is with low cost, use the exclusive treatment of feature to coronary heart disease such as simple, safe and effective to make huge contribution.There is the Chinese patent medicine of multiple treatment coronary heart disease at present on the market, but curative effect is not remarkable mostly, treatment cycle is longer, and not easily effects a radical cure, and easily recurs.

Summary of the invention:

The object of the invention is to, a kind of medicine for the treatment of coronary heart disease and preparation method thereof is provided.Described medicine can improve coronary flow, strengthens myocardium oxygen content, makes the increase in demand of cardiac muscle to blood, reaches the activity of dredging coronary blood tube wall, makes the effects such as coronary artery elasticity increase, can be used for treating coronary heart disease.Evident in efficacy, treatment cycle is short, does not recur, and safety has no side effect.

For solving the problems of the technologies described above, the present invention realizes by the following technical solutions: a kind of medicine for the treatment of coronary heart disease, calculate by weight, primarily of Ramulus Uncariae Cum Uncis 5-30 part, Herba Paederiae 5-30 part, shaven head 5-30 part, Radix Salviae Miltiorrhizae 5-30 part, Fructus Rosae Laevigatae 5-30 part, Herba Agrimoniae 5-30 part, Herba Bidentis Bipinnatae 5-30 part, Rhizoma et Radix smilacis ocreatae 5-30 part, Fructus Amomi 5-30 part, Semen Pittospori Glabrati tea 5-30 part, Fructus Crataegi 5-30 part, Radix Astragali 5-30 part, Rhizoma Zingiberis Recens 20-60 part, Caulis et folium gaultheriae yunnanensis 5-30 part, Herba Lespedezae Cuneatae 5-30 part, Herba Leonuri 5-30 part, Fructus Forsythiae 15-30 part, Caulis Polygoni Multiflori 5-30 part, Mahonia fortunei (Lindl.) Fedde 5-30 part and Radix Berberidis 5-30 part are made.

In the medicine of aforesaid treatment coronary heart disease, calculate by weight, be made primarily of Ramulus Uncariae Cum Uncis 10-20 part, Herba Paederiae 10-20 part, shaven head 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Fructus Rosae Laevigatae 10-20 part, Herba Agrimoniae 10-20 part, Herba Bidentis Bipinnatae 10-20 part, Rhizoma et Radix smilacis ocreatae 10-20 part, Fructus Amomi 10-20 part, Semen Pittospori Glabrati tea 10-20 part, Fructus Crataegi 10-20 part, Radix Astragali 10-20 part, Rhizoma Zingiberis Recens 30-50 part, Caulis et folium gaultheriae yunnanensis 10-20 part, Herba Lespedezae Cuneatae 10-20 part, Herba Leonuri 10-20 part, Fructus Forsythiae 10-20 part, Caulis Polygoni Multiflori 10-20 part, Mahonia fortunei (Lindl.) Fedde 10-20 part and Radix Berberidis 10-20 part.

In the medicine of aforesaid treatment coronary heart disease, calculate by weight, be made primarily of Ramulus Uncariae Cum Uncis 15 parts, Herba Paederiae 15 parts, shaven head 15 parts, Radix Salviae Miltiorrhizae 15 parts, Fructus Rosae Laevigatae 15 parts, Herba Agrimoniae 15 parts, Herba Bidentis Bipinnatae 15 parts, Rhizoma et Radix smilacis ocreatae 15 parts, Fructus Amomi 15 parts, Semen Pittospori Glabrati tea 15 parts, Fructus Crataegi 15 parts, the Radix Astragali 15 parts, 50 parts, Rhizoma Zingiberis Recens, Caulis et folium gaultheriae yunnanensis 15 parts, Herba Lespedezae Cuneatae 15 parts, Herba Leonuri 15 parts, Fructus Forsythiae 15 parts, Caulis Polygoni Multiflori 15 parts, Mahonia fortunei (Lindl.) Fedde 15 parts and Radix Berberidis 15 parts.

A manufacture method for the medicine of aforesaid treatment coronary heart disease, gets said medicine, can add adjuvant, also can not add adjuvant, conveniently technique, make oral formulations.

In the manufacture method of the medicine of aforesaid treatment coronary heart disease, described oral formulations is decoction, capsule, tablet, granule or pill.

In the manufacture method of the medicine of aforesaid treatment coronary heart disease, described decoction makes like this: get said medicine, add the water soaking 10-15 minute of 4-6 times amount, first big fire decocts 10-15min to after boiling, then continues to decoct 15-25min with little fire, filter, filtering residue adds 4-6 times amount soak by water 2 times again, each 20-40min, filters, merging filtrate, to obtain final product.

In the manufacture method of the medicine of aforesaid treatment coronary heart disease, described capsule makes like this: get said medicine, adds the water soaking 10-15 minute of 8-10 times amount, first big fire decocts 10-15min, then continues to decoct 15-25min with little fire, decocts 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.20-1.25, separately get the starch of extractum amount 30% and the magnesium stearate of 0.7% and extractum to mix, with the alcohol granulation of 60%, dry, pulverize, filled capsules, to obtain final product.

In the manufacture method of the medicine of aforesaid treatment coronary heart disease, described tablet makes like this: get said medicine, adds the water soaking 10-15 minute of 8-10 times amount, first big fire decocts 10-15min, continue again to decoct 15-25min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.20-1.25, and the starch of extractum and extractum amount 20% mixes, tabletting, film coating, to obtain final product.

In the manufacture method of the medicine of aforesaid treatment coronary heart disease, described granule makes like this: get said medicine, adds the water soaking 10-15 minute of 8-10 times amount, and first big fire decocts 10-15min, continue again to decoct 15-25min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.15-1.20, the starch of extractum and extractum amount 20% and the dextrine powder mixing granulation of 20%, dry, to obtain final product.

In the manufacture method of the medicine of aforesaid treatment coronary heart disease, described pill makes like this: get said medicine, adds the water soaking 10-15 minute of 8-10 times amount, first big fire decocts 10-15min, continue again to decoct 15-25min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.15-1.20, and extractum mixes general ball with the starch of extractum amount 15%, dry, coating, to obtain final product.

Drug main of the present invention wants Ramulus Uncariae Cum Uncis, Herba Paederiae, shaven head, Radix Salviae Miltiorrhizae, Fructus Rosae Laevigatae, Herba Agrimoniae, Herba Bidentis Bipinnatae, Rhizoma et Radix smilacis ocreatae, Fructus Amomi, Semen Pittospori Glabrati tea, Fructus Crataegi, the Radix Astragali, Rhizoma Zingiberis Recens, Caulis et folium gaultheriae yunnanensis, Herba Lespedezae Cuneatae, Herba Leonuri, Fructus Forsythiae, Caulis Polygoni Multiflori, Mahonia fortunei (Lindl.) Fedde and Radix Berberidis to be made.Wherein, Ramulus Uncariae Cum Uncis, (Classification system: Uncariarhynchophylla (Miq.) Miq.exHavil.) is the evergreen liana of Rubiaceae wild gambier.Ramulus Uncariae Cum Uncis is used as medicine with the stem branch of buckle, and it has heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion effect, and modern pharmacology experiment also proves that Ramulus Uncariae Cum Uncis has hypotensive effect, therefore has very high medical value.Herba Paederiae, Chinese medicine name.For the herb of Maguireothamnus speciosus fevervine, herb of gathering summer, dries.Its sweet in the mouth, micro-hardship, property is put down.GUIXIN, liver, spleen, kidney channel.There is expelling wind and removing dampness, analgesic antidotal, promoting digestion and removing stagnation, effect of promoting blood circulation and detumescence.For bones and muscles pain due to rheumatism, traumatic injury, traumatic pain, liver and gall and gastrointestinal angor, dyspepsia, infantile malnutrition, bronchitis; Outer for dermatitis, eczema and sore swollen toxin.Shaven head, has another name called Radix Rhapontici (formal name used at school: Stemmacanthauniflora (L.) Dittrich), another name: Radix Rhapontici, terrible spunyarn, hammer flower.It is a kind of herbaceos perennial.Nature and flavor: bitter in the mouth, cold in nature.Return stomach warp.There is heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, effect that relaxing muscles and tendons is promoted blood circulation.Can be used for treatment acute mastitis to swell and ache, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture.Compendium of Material Medica: " Gu Dongyuan thinks hands, the positive bright medicine of foot, and ancient prescription controls carbuncle carbuncle on the back, claims also headed by Radix Rhapontici soup for Radix Rhapontici, lower milk, the pyretic toxicity that disappears, evacuation of pus, hemostasis, granulation promoting, parasite killing.Pang Anchang treatise on Febrile Diseases controls carbuncle and pre-row varioliform exanthema heat when separating, and uses Radix Rhapontici leaf, cloud without then with SHANZHIZI for it, also get its cold can be antipyretic, lid do not know its can enter sun bright thus also." Radix Salviae Miltiorrhizae, Chinese medicine name.For the dry root welding technology of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Nature and flavor: bitter in the mouth, are slightly cold.GUIXIN, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.Fructus Rosae Laevigatae, Chinese medicine name.For the dry mature fruit of rosaceous plant Fructus Rosae Laevigatae RosalaevigataMichx..Nature and flavor: sour in the mouth, sweet, puckery, property is put down.Gui Jing: return kidney, bladder, large intestine channel.There is controlling nocturnal emission with astringent drugs reducing urination, stopping metrorrhagia and leukorrhagia, effect of relieving diarrhea with astringents.Be used for the treatment of emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, chronic diarrhea chronic dysentery.Herba Agrimoniae, AgrimoniapilosaLedeb. is the aerial parts of rosaceous plant Agrimony AgrimoniapilosaLedeb..There is anticancer, the cooling blood for hemostasis of relieving internal heat, detumescent of healing the wounds.For astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, control effect that epistaxis has specially good effect, malaria, de-power impairment caused by overstrain, carbuncle.Herba Bidentis Bipinnatae (formal name used at school: BidenspilosaL.) Compositae, belong to annual herb, Herba Bidentis Bipinnatae is that folks of china commonly uses medical herbs, there is effect of heat-clearing and toxic substances removing, removing blood stasis and activating blood flow, cure mainly upper respiratory tract infection, laryngopharynx swelling and pain, acute appendicitis, acute icterohepatitis, gastroenteritis, Fengshi Guanjie pain, malaria, furuncle, venom, treating swelling and pain by traumatic injury are controlled in external.Modern pharmacology proves, Herba Bidentis Bipinnatae, containing compositions such as flavonoid glycoside, Saponin, tannin, polyhydric phenols, coumarin, bitter principle, iodine, choline, aminoacid, vitamin, has good effect to adjustment human blood-pressure.At present, Herba Bidentis Bipinnatae is used for treatment flu, laryngopharynx swelling and pain, chronic tracheitis, gastroenteritis etc., can improve or eliminate headache, dizziness, insomnia, dreaminess, numb limbs and tense tendons, cardiopalmus, the hypertension symptom such as tired out, cholesterolemia can also be reduced, low density lipoprotein, LDL, triglyceride, improve abnormal lectin from hemolymph effect.The retinal arteriosclerosis caused hypertension, vein blood vessel thromboembolism, edema also have good therapeutic effect.The most precious place of Herba Bidentis Bipinnatae is that it has blood pressure lowering, fat of dehematizing, the effect of the density that reduces blood pressure.Herba Bidentis Bipinnatae has growth in national most area, and medicine source is extensive, and lattice are cheap, determined curative effect, have no side effect again, and real is hyperpietic good medicine.Rhizoma et Radix smilacis ocreatae, SmilaxocreafaA.DC, Liliaceae smilax plant.Effect: clearing away heat-damp and promoting diuresis.Cure mainly: available dispelling the wind and dampness pathogens arthralgia pain, the person that is especially suitable for damp-heat syndrome.Meridian distribution of property and flavor: bitter, cold.Enter heart channel.Also has function of resisting myocardial ischemia.The Fructus Amomi mature fruit that Fructus Amomi (Classification system: AmomumvillosumLour.) is medicinal or seed are used as medicine.Fructus Amomi is a kind of comparatively gentle medical herbs.Mainly act on the stomach of human body, kidney and spleen, can circulation of qi promoting seasoning, stomach function regulating is amusing.Fructus Amomi often coordinates with Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae etc., is suitable for disease such as treatment fullness in the epigastrium and chest, abdominal distention and little diet etc.Nature and flavor: pungent, temperature.Gui Jing: enter spleen, stomach warp.Function cures mainly: during circulation of qi promoting is adjusted, stomach function regulating, is amusing.Control stomachache painful abdominal mass swollen, anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.Semen Pittospori Glabrati tea, has another name called, pittosporm root, is the dry root of Pittosporaceae plant sea gold PittosporumsahnianumGowda..Meridian distribution of property and flavor: bitter in the mouth, pungent, warm in nature.Function with cure mainly: there is calmness, effect of blood pressure lowering.Can be used for treating neurasthenia, insomnia and dreamful sleep, vascular hypertension.Fructus Crataegi (CrataeguspinnatifidaBunge) Rosaceae Crataegus, Fructus Crataegi is containing multiple organic acid.Oral rear enhancing gastric acidity, improves pepsin activity, promotes the digestion of protein; Fructus Crataegi sour in the mouth, stimulates gastric mucosa to promote gastric secretion; Fatty enzyme in Fructus Crataegi, can promote the digestion of fat; Fructus Crataegi contains the compositions such as vitamin C, oral can appetite stimulator; Fructus Crataegi has regulating action to gastrointestinal motility function, has inhibitory action to the gastrointestinal smooth muscle of spasticity, has excitation to the smooth muscle of relaxed state.Fructus Crataegi flavone significantly can reduce serum total cholesterol (TC), the low-density lipoprotein cholesterol (I of Experimental Hyperlipemia animal.DI。One C) and the concentration of apolipoprotein B (ApoB), remarkable high density lipoprotein increasing one cholesterol (HDL_C) and ApoA, (ApoA) concentration, but little on triglyceride (TG) impact.Fructus Crataegi effect for reducing blood fat is the synthesis by suppressing hepatic cholesterol, promotes that liver plays effect for reducing blood fat to the taking the photograph people of plasma cholesterol.Fructus Crataegi flavone also can reduce the danger that atherosclerosis (AS) occurs, and plays the effect that development occurs prevention AS.To acute experimental myocardial ischemia, there is protective effect.Fructus Crataegi has the effect strengthening myocardial contraction, increase cardiac output.The Radix Astragali, Astragalusmembranaceus (Fisch.) Bunge., the sweet temperature of property, returns lung meridian, has tonifying Qi and lifting yang, a function that benefit defends consolidating superficial resistance.Through the precious Ganoderma of conventional Radix Astragali compatibility fine jade decoct soup or soaked generation tea-drinking, there is good disease-prevention health effect.Rhizoma Zingiberis Recens, ZingiberofficinaleRoscoe, be the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens (ZingiberofficinaleRoscoe), CORTEX ZINGIBERIS RHIZOMAE is pungent cool, controls skin edema, the row severe edema due to hypofunction of the spleen; The pungent temperature of Rhizoma Zingiberis Recens juice, pungent loose cold syndrome of the stomach strength is strong, is used for vomiting; The pungent temperature of Rhizoma Zingiberis, warming middle-JIAO is instigated cold, and recuperating depleted YANG is promoted blood circulation, and warming the spleen trembles with fear strength greatly, and Rhizoma Zingiberis Preparatum acrid in the mouth hardship does not walk table in walking, and the warm part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is cold; Carbonized Rhizoma Zingiberis (processed) is warm in nature, and relatively homoiothermy divides cold; The bitter temperature of Roast Rhizoma Zingiberis Recens, relatively warming intestines and stomach is cold.Pungent and the loose temperature of Rhizoma Zingiberis Recens, strengthening the spleen stomach, kind warming middle-JIAO to send down the adverse QI preventing or arresting vomiting, dehumidify the painful abdominal mass that disappears, and eliminating phlegm and stopping cough take stopping nausea and vomiting by lowering the adverse flow of QI as length.Caulis et folium gaultheriae yunnanensis is Herb or the root of ericad Caulis et folium gaultheriae yunnanensis.Nature and flavor: pungent, temperature.Function cures mainly: expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.Dispelling the wind and dampness pathogens arthralgia, water spreads, traumatic injury, toothache, eczema." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control phlegm-fire, bones and muscles pain, steep in wine good with it.Its stalk, washes anemofrigid-damp arthralgia, bones and muscles pain, warm bone is diathermanous, endures washing." effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema, cures mainly: cough, and Serpentis string is red, venom for Herba Lespedezae Cuneatae, PolygonumperfoliatumL..The season that this grass haunts poisonous snake grows on trees, and is easy to find, if unfortunate by venom in the wild, when not having specific drug, this grass be can yet be regarded as a kind of good medicine.Herba Leonuri, Leonurusartemisia (Laur.) S.Y.HuF, acrid in the mouth is bitter, cool, invigorates blood circulation, silt of dispelling, regulating menstruation, disappear water, treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Fructus Forsythiae (Classification system: Forsythiasuspensa): machaka, Hong Kong is commonly called as a string gold, is Oleaceae forsythia.Nature and flavor: bitter, cool.Enter the heart, liver, gallbladder meridian.Function cures mainly: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Caulis Polygoni Multiflori, TuberFleeceflowerStem, belongs to perennial herb.Nourish heart, calm the nerves, dredging collateral, dispel the wind, cure mainly: control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.External: alone outer decocting is washed, treating skin wind skin ulcer prurigo, can receive effect of dispelling wind for relieving itching.Meridian distribution of property and flavor: sweet micro-hardship is flat.Mahonia fortunei (Lindl.) Fedde, Mahoniafortunei (Lindl.) Fedde, is Berberidaceae Mahonia fortunei (Lindl.) Fedde platymiscium, can does potted plant, Chinese garden planting and medicinal.There is heat clearing away tonify deficiency, effect of relieving cough and resolving phlegm.Be used for the treatment of pulmonary tuberculosis hemoptysis, osteopyrexia and fever, dizziness and tinnitus, waist soreness, vexed, conjunctival congestion.Radix Berberidis, Chinese medicine name.For Berberidaceae plant porcupine quill BerberissoulieanaSchneid., little Rhizoma Coptidis thorn BerberiswilsonaeHemsl., berberis poiretii BerberispoiretiiSchneid. or spoonleaf barbarry herb BerberisvernaeSchneid. etc. belong to the dry root of several plants together.There is heat clearing and damp drying, effect of eliminating fire and detoxication.Be usually used in damp-heat dysentery, jaundice, eczema, pharyngalgia conjunctival congestion, Ting discharging ear, the treatment of the diseases such as carbuncle sore tumefacting virus.

Compared with prior art, the present invention adopts above-mentioned raw materials to make medicine, each raw material has good synergism, all medicine phases and can coronary flow be improved, strengthen myocardium oxygen content, make the increase in demand of cardiac muscle to blood, reach the activity of dredging coronary blood tube wall, make the effects such as coronary artery elasticity increase, treatment coronary heart disease has that determined curative effect, instant effect, cure rate are high, the feature such as have no side effect.Effectively can regulate cardiac function.Can be used for treating coronary heart disease.Evident in efficacy, treatment cycle is short, does not recur, and safety has no side effect.

Applicant carried out following experiments, provable the present invention has effective effect;

Experimental example 1 treats coronary heart disease example

1 data and method

1.1 physical data choose infull patient 130 example of Diastolic Function of Left Ventricle in Patients with Coronary Heart Disease that In Qiannan hospital accepted for medical treatment from February ,-2014 in February, 2011, observation group and each 65 examples of matched group are divided into according to random number method, wherein in the routine patient of observation group 65, man 30 example, female 35 example, 60 ~ 78 years old age, average (68.1 ± 5.3) year; In the routine patient of matched group 65, man 32 example, female 33 example, 60 ~ 80 years old age, average (68.7 ± 5.4) year; Two groups of Genders, age, cardiac functional gradings and merging disease event comparing difference not statistically significant (P>0.05), have comparability.In table 1.

1.2 include in and all patients of exclusion standard all through inspection diagnosis, meet the diagnostic criteria for coronary heart disease formulated by WHO, be diagnosed as coronary heart disease, and merge left ventricle diastolic malfunction.Inclusive criteria: intentionally Insufficient clinical symptoms and sign; The ejection fraction of left ventricle is more than 50%; Cardiac function II ~ III grade; Exclusion standard: cardiac function I level or IV grade; Packmaker; Serious valve disease; Left ventricular aneurysm; Atrial fibrillation, room are flutterred; Bradycardia, tachycardia; With serious pulmonary disease; Left bundle branch block; Anemia; Serious Liver and kidney function is abnormal, and electrolyte disturbance.

A table 1 liang group patient merges disease and heart functional class

1.2 method

1.2.1 matched group is organized the infull patient of 65 routine Diastolic Function of Left Ventricle in Patients with Coronary Heart Diseases to this and is taked conventional therapy, gives diuretic, beta-blocker, nitrate esters medicine, angiotensin receptor antagonist and angiotensin-convertion enzyme inhibitor, continued treatment 15d.

1.2.2 this group of observation group patient is on matched group basis, takes medicine of the present invention (making by embodiment 1) to treat, oral, each 20m, 3 times/d, continued treatment 15d.

1.3 curative effect determinate standard efficacy assessment standards are divided into effective, effective and invalid three kinds.(1) effective: NYHA classification, cardiac function improves >=and 2 grades; (2) effective: cardiac function improves=1 grade; (3) invalid: cardiac function worsens without improvement.Total effective rate=(effective number of cases+effectively number of cases)/total number of cases × 100%.

1.4 Index of Left Ventricular Performance Index of Left Ventricular Performances mainly contain the early stage maximum Hemodynamic environment of diastole, the maximum Hemodynamic environment of late diastolic, peak velocity ratio.Peak velocity ratio is main health giving quality index.

1.5 observation index observe the adverse effect that the infull patient of two groups of Diastolic Function of Left Ventricle in Patients with Coronary Heart Diseases may occur, detect liver function, routine blood test, renal function, electrolyte and blood lipid level before treatment.Close observation observes adverse reaction rate, mainly with adverse reaction rate evaluation safety.

1.6 statistical procedures adopt SPSS13.0 software to carry out statistical analysis to the data obtained, measurement data represents with (x ± s), relatively adopt t inspection, enumeration data adopts statistical test, is that difference has statistical significance with P<0.05.

2 results

After the treatment of 2.1 liang of group Index of Left Ventricular Performance comparative observation groups, the early stage maximum Hemodynamic environment of diastole, the maximum Hemodynamic environment of late diastolic, peak velocity ratio and Doppler echocardiography compare with before treatment, and difference has statistical significance (P<0.05).After treatment of control group, the early stage maximum Hemodynamic environment of diastole, the maximum Hemodynamic environment of late diastolic, peak velocity ratio and Doppler echocardiography compare with before treatment, and difference has statistical significance (P<0.05).Comparing difference not statistically significant (P>0.05) before the early stage maximum Hemodynamic environment of diastole, the maximum Hemodynamic environment of late diastolic, peak velocity ratio and Doppler echocardiography and treatment of control group before observation group's treatment.After observation group's treatment, the early stage maximum Hemodynamic environment of diastole, the maximum Hemodynamic environment of late diastolic, peak velocity ratio compare with after treatment of control group, and difference has statistical significance (P<0.05), in table 2.

Table 2 liang group left ventricular ejection fraction Indexes Comparison

2.2 Liang Zu Clinical efficacy comparison observation group total effective rates 86.15% are apparently higher than 53.85% of matched group, and comparing difference has statistical significance (P<0.05), in table 3.

Table 3 liang group Clinical efficacy comparison

Compare with matched group, * P<0.05.

The safety of 2.3 liang of groups compares two groups of patients in this test, all completes clinical observation, untoward reaction does not occur.

3. can obviously to improve Diastolic Function of Left Ventricle in Patients with Coronary Heart Disease incomplete for conclusion medicine of the present invention, improve therapeutic effect, it is improving definite effect in patient's diastole maximum Hemodynamic environment in late period morning, and add on the basis of conventional therapy with medicine of the present invention can promote treatment total effective rate nearly 30%, there is quite high value in clinical treatment patients with coronary heart disease.

Detailed description of the invention:

Below in conjunction with embodiment, invention is further described, but not as the foundation limited the present invention.

Embodiment 1.

Formula: Ramulus Uncariae Cum Uncis 15g, Herba Paederiae 15g, shaven head 15g, Radix Salviae Miltiorrhizae 15g, Fructus Rosae Laevigatae 15g, Herba Agrimoniae 15g, Herba Bidentis Bipinnatae 15g, Rhizoma et Radix smilacis ocreatae 15g, Fructus Amomi 15g, Semen Pittospori Glabrati tea 15g, Fructus Crataegi 15g, Radix Astragali 15g, Rhizoma Zingiberis Recens 50g, Caulis et folium gaultheriae yunnanensis 15g, Herba Lespedezae Cuneatae 15g, Herba Leonuri 15g, Fructus Forsythiae 15g, Caulis Polygoni Multiflori 15g, Mahonia fortunei (Lindl.) Fedde 15g and Radix Berberidis 15g.

Technique: get said medicine, adds the water soaking 13 minutes of 5 times amount, and first big fire decocts 13min to after boiling, then continues to decoct 20min with little fire, and filter, filtering residue adds 5 times amount soak by water 2 times again, each 30min, and filter, merging filtrate, obtains decoction.

Usage and dosage: each 100-120ml, every day 2-3 time.

Embodiment 2.

Formula: Ramulus Uncariae Cum Uncis 5g, Herba Paederiae 5g, shaven head 5g, Radix Salviae Miltiorrhizae 5g, Fructus Rosae Laevigatae 5g, Herba Agrimoniae 5g, Herba Bidentis Bipinnatae 5g, Rhizoma et Radix smilacis ocreatae 5g, Fructus Amomi 5g, Semen Pittospori Glabrati tea 5g, Fructus Crataegi 5g, Radix Astragali 5g, Rhizoma Zingiberis Recens 20g, Caulis et folium gaultheriae yunnanensis 5g, Herba Lespedezae Cuneatae 5g, Herba Leonuri 5g, Fructus Forsythiae 5g, Caulis Polygoni Multiflori 5g, Mahonia fortunei (Lindl.) Fedde 5g and Radix Berberidis 5g.

Technique: get said medicine, adds the water soaking 13 minutes of 9 times amount, and first big fire decocts 13min, continue again to decoct 20min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.20-1.25, separately gets the starch of extractum amount 30% and the magnesium stearate of 0.7% and extractum and mixes, with the alcohol granulation of 60%, dry, pulverize, filled capsules, obtains capsule.

Specification: 5g/ grain.

Usage and dosage: each 2-3 grain, every day 2-3 time.

Embodiment 3.

Formula: Ramulus Uncariae Cum Uncis 30g, Herba Paederiae 30g, shaven head 30g, Radix Salviae Miltiorrhizae 30g, Fructus Rosae Laevigatae 30g, Herba Agrimoniae 30g, Herba Bidentis Bipinnatae 30g, Rhizoma et Radix smilacis ocreatae 30g, Fructus Amomi 30g, Semen Pittospori Glabrati tea 30g, Fructus Crataegi 30g, Radix Astragali 30g, Rhizoma Zingiberis Recens 60g, Caulis et folium gaultheriae yunnanensis 30g, Herba Lespedezae Cuneatae 30g, Herba Leonuri 30g, Fructus Forsythiae 30g, Caulis Polygoni Multiflori 30g, Mahonia fortunei (Lindl.) Fedde 30g and Radix Berberidis 30g.

Technique: get said medicine, add the water soaking 13 minutes of 9 times amount, first big fire decocts 13min, then continues to decoct 20min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.20-1.25, the starch of extractum and extractum amount 20% mixes, tabletting, film coating, obtains tablet.

Specification: 5g/ sheet.

Usage and dosage: each 2-3 sheet, every day 2-3 time.

Claims (10)

1. treat the medicine of coronary heart disease for one kind, it is characterized in that: calculate by weight, be made primarily of Ramulus Uncariae Cum Uncis 5-30 part, Herba Paederiae 5-30 part, shaven head 5-30 part, Radix Salviae Miltiorrhizae 5-30 part, Fructus Rosae Laevigatae 5-30 part, Herba Agrimoniae 5-30 part, Herba Bidentis Bipinnatae 5-30 part, Rhizoma et Radix smilacis ocreatae 5-30 part, Fructus Amomi 5-30 part, Semen Pittospori Glabrati tea 5-30 part, Fructus Crataegi 5-30 part, Radix Astragali 5-30 part, Rhizoma Zingiberis Recens 20-60 part, Caulis et folium gaultheriae yunnanensis 5-30 part, Herba Lespedezae Cuneatae 5-30 part, Herba Leonuri 5-30 part, Fructus Forsythiae 15-30 part, Caulis Polygoni Multiflori 5-30 part, Mahonia fortunei (Lindl.) Fedde 5-30 part and Radix Berberidis 5-30 part.

2. the medicine for the treatment of coronary heart disease as claimed in claim 1, it is characterized in that: calculate by weight, primarily of Ramulus Uncariae Cum Uncis 10-20 part, Herba Paederiae 10-20 part, shaven head 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Fructus Rosae Laevigatae 10-20 part, Herba Agrimoniae 10-20 part, Herba Bidentis Bipinnatae 10-20 part, Rhizoma et Radix smilacis ocreatae 10-20 part, Fructus Amomi 10-20 part, Semen Pittospori Glabrati tea 10-20 part, Fructus Crataegi 10-20 part, Radix Astragali 10-20 part, Rhizoma Zingiberis Recens 30-50 part, Caulis et folium gaultheriae yunnanensis 10-20 part, Herba Lespedezae Cuneatae 10-20 part, Herba Leonuri 10-20 part, Fructus Forsythiae 10-20 part, Caulis Polygoni Multiflori 10-20 part, Mahonia fortunei (Lindl.) Fedde 10-20 part and Radix Berberidis 10-20 part are made.

3. the medicine for the treatment of coronary heart disease as claimed in claim 2, it is characterized in that: calculate by weight, be made primarily of Ramulus Uncariae Cum Uncis 15 parts, Herba Paederiae 15 parts, shaven head 15 parts, Radix Salviae Miltiorrhizae 15 parts, Fructus Rosae Laevigatae 15 parts, Herba Agrimoniae 15 parts, Herba Bidentis Bipinnatae 15 parts, Rhizoma et Radix smilacis ocreatae 15 parts, Fructus Amomi 15 parts, Semen Pittospori Glabrati tea 15 parts, Fructus Crataegi 15 parts, the Radix Astragali 15 parts, 50 parts, Rhizoma Zingiberis Recens, Caulis et folium gaultheriae yunnanensis 15 parts, Herba Lespedezae Cuneatae 15 parts, Herba Leonuri 15 parts, Fructus Forsythiae 15 parts, Caulis Polygoni Multiflori 15 parts, Mahonia fortunei (Lindl.) Fedde 15 parts and Radix Berberidis 15 parts.

4. a manufacture method for the medicine of the treatment coronary heart disease according to any one of claim 1-3, is characterized in that: get said medicine, can add adjuvant, also can not add adjuvant, conveniently technique, make oral formulations.

5. the manufacture method of the medicine for the treatment of coronary heart disease as claimed in claim 4, is characterized in that: described oral formulations is decoction, capsule, tablet, granule or pill.

6. the manufacture method of the medicine for the treatment of coronary heart disease as claimed in claim 5, it is characterized in that: described decoction makes like this: get said medicine, add the water soaking 10-15 minute of 4-6 times amount, first big fire decocts 10-15min to after boiling, then continues to decoct 15-25min with little fire, filter, filtering residue adds 4-6 times amount soak by water 2 times again, each 20-40min, filters, merging filtrate, to obtain final product.

7. the manufacture method of the medicine for the treatment of coronary heart disease as claimed in claim 5, it is characterized in that: described capsule makes like this: get said medicine, add the water soaking 10-15 minute of 8-10 times amount, first big fire decocts 10-15min, continue again to decoct 15-25min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.20-1.25, separately get the starch of extractum amount 30% and the magnesium stearate of 0.7% and extractum to mix, with the alcohol granulation of 60%, dry, pulverize, filled capsules, to obtain final product.

8. the manufacture method of the medicine for the treatment of coronary heart disease as claimed in claim 5, is characterized in that: described tablet makes like this: get said medicine, adds the water soaking 10-15 minute of 8-10 times amount, first big fire decocts 10-15min, continue again to decoct 15-25min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.20-1.25, and the starch of extractum and extractum amount 20% mixes, tabletting, film coating, to obtain final product.

9. the manufacture method of the medicine for the treatment of coronary heart disease as claimed in claim 5, it is characterized in that: described granule makes like this: get said medicine, add the water soaking 10-15 minute of 8-10 times amount, first big fire decocts 10-15min, continue again to decoct 15-25min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.15-1.20, the starch of extractum and extractum amount 20% and the dextrine powder mixing granulation of 20%, dry, to obtain final product.

10. the manufacture method of the medicine for the treatment of coronary heart disease as claimed in claim 5, is characterized in that: described pill makes like this: get said medicine, adds the water soaking 10-15 minute of 8-10 times amount, first big fire decocts 10-15min, continue again to decoct 15-25min with little fire, decoct 3 times, filter, merging filtrate, when filtrate is condensed into 50-60 DEG C, relative density is the extractum of 1.15-1.20, and extractum mixes general ball with the starch of extractum amount 15%, dry, coating, to obtain final product.